Chapter 9 Conclution
9.3 Self-assemble iron oxide/silica (SAIO) core-shell carriers
1. The core-shell nanocarriers are able to well-disperse easily in an aqueous solution without using any interfacial molecules for stabilization.
2. The ultra-thin, 4-5 nm, outer silica shell coated on the SAIO core, a mixture of iron oxide nanoparticles and PVA, blocked the drug molecules effectively from therapeutically undesirable release from the core phase before subjecting to magnetic stimulation.
3. Under high-frequency magnetic field (HFMF) treatment, the SAIO@SiO2 nanocarriers displayed a fast-acting and precise stimulus-time-dependent dosing response to the environment and restored to original state.
4. SAIO@SiO2 nanocarriers were allowed a high efficiency uptake by HeLa cells within dozens of minutes and have been shown to exhibit excellent cytocompatibility, implying the nanocarriers are potentially capable of offering high-efficient cellular-based delivery following a fast-acting, accurate release of therapeutic agents for anti-cancer applications.
155
9.4 Thermosensitive yolk/shell capsules
1. The dense silica shell of capsules acts as a barrier that restricts undesired drug leakage before triggering.
2. Incorporating a small amount of magnetic nanoparticles into the core leaves a vast space for encapsulation of drug molecules, and the thermosensitive polymer exhibits a hydrophilic-to-hydrophobic transition at a characteristic temperature (CMT) that triggers a size contraction as large as 10 fold.
3. The thermal sensitivity of these yolk/shell capsules enables magnetic triggering of capsule rupture in response to the heat induced by the external magnetic field.
4. The iron oxide nanoparticles act as the energy absorbers, achieving rapid triggered drug release that is not available from conventional yolk/shell particles and inorganic capsules.
5. These capsules were efficiently taken up by healthy cell lines, and the cells maintain good viability under magnetic field treatment.
6. In vivo MR imaging of rat brains showed that the yolk/shell capsules can clearly enhance image contrast after injection.
156
Reference
[1] A. C. R. Grayson, I. S. Choi, B. M. Tyler, P. P. Wang, H. Brem, M. J. Cima, R.
Langer, Nature Materials 2003, 2, 767.
[2] Z. Hu, X. Xia, Adv. Mater. 2004, 16, 305.
[3] X. Z. Zhang, D. Q. Wu, C. C. Chu, Biomaterials 2004, 25, 3793.
[4] M. Das, S. Mardyani, W. C. W. Chan, E. Kumacheva, Adv. Mater. 2006, 18, 80.
[5] M. R. Abidian, D. H. Kim, D. C. Martin, Adv. Mater. 2006, 18, 405.
[6] B. G. De Geest, A. G. Skirtach, A. A. Mamedov, A. A. Antipov, N. A. Kotov, S. C.
De Smedt, G. B. Sukhorukov, Small 2007, 3, 804.
[7] H. J. Kim, H. Matsuda, H. Zhou, I. Honma, Adv. Mater. 2006, 18, 3083.
[8] E. R. Edelman, J. Kost, H. Bobeck, R. Langer, J. Biomed. Mater. Res. 1985, 19, 67.
[9] J. Kost, J. Wolfrum, R. Langer, J. Biomed. Mater. Res. 1987, 21, 1367.
[10] J. Kost, R. Noecker, E. Kunica, R. Langer, J. Biomed. Mater. Res. 1985, 19, 935.
[11] Z.vLu, M. D. Prouty, Z. Guo, V. O. Golub, C. S. S. R. Kumar, Y. M. Lvov,
Huh, S. Haam, Adv. Mater. 2009, 21, 4339– 4342.
[15] M. S. Yavuz, Y. Cheng, J. Chen, C. M. Cobley, Q. Zhang, M. Rycenga, J. Xie, C.
Kim, K. H. Song, A. G. Schwartz, L. V. Wang, Y. Xia, Nature Materials, 2009, 8, 935– 939.
[16] Z. Liu, A. C. Fan, K. Rakhra, S. Sherlock, A. Goodwin, X. Chen, Q. Yang, D. W.
Felsher, H. Dai, Angew. Chem. Int. Ed. 2009, 48, 7668 –7672.
[17] W. S. Kuo, C. N. Chang, Y. T. Chang, M. H. Yang, Y. H. Chien, S. J. Chen, C. S.
Yeh, Angew. Chem. Int. Ed. 2010, 49, 2711– 2715.
[18] D. V. Volodkin, A. G. Skirtach, H. Möhwald, Angew. Chem. Int. Ed. 2009, 48, 1807– 1809.
[19] S. H. Hu, S. Y. Chen, D. M. Liu, C. S. Hsiao, Adv. Mater. 2008, 20, 2690– 2695.
[20] S. H. Hu, T. Y. Liu, D. M. Liu, S. Y. Chen, Macromolecules 2007, 40, 6786–
6788.
[21] H. Rosen, T. Abribat, Nature Reviews Drug Discovery 2005, 4, 381.
[22] K. E. Uhrich, S.M. Cannizzaro, R. S. Langer, K.M. Shakesheff, Chemical Reviews, 1999, 99, 3181.
157
[23] L.Y. Chu, Y. Li, J.H. Zhu, H.D. Wang, Y.J. Liang, Journal of Controlled Release
2004, 97, 43.
[24] L. Chen, M.e Liu, H. Bai, P. Chen, F. Xia, D. Han, L. Jiang, J. Am. Chem. Soc.
2009, 131, 10467.
[25] S. Q. Liu, Y. Y. Yang, X. M. Liu, Y. W. Tong, Biomacromolecules 2003, 4, 1784.
[26] L. Bromberg, M. Temchenko, G. D. Moeser, T. A. Hatton, Langmuir, 2004, 20, 5683.
[27] C. Alvarez-Lorenzo, S. Deshmukh, L. Bromberg, T. A. Hatton, I. Sández-Macho, A. Concheiro, Langmuir, 2007, 23, 11475.
[28] K. Mortensen, J. Phys.: Condens. Matter 1996, 8, A13.
[29] P. Alexandridis, et al., Macromolecules 1994, 27, 2414.
[30] P. Alexandridis, et al., Langmuir 1995, 11, 1468.
[31] S. H. Choi, J. H. Lee, S. M. Choi, T. G. Park, Langmuir 2006, 22, 1758.
[32] A. I. Van D. Bulcke, B. Bogdanov, N. De Rooze, E. H. Schacht, M. Cornelissen, H. Berghmans, Biomacromolecules 2000, 1, 31.
[33] T. Mitsumata, K. Ikeda, J.P. Gong, Y. Osada, D. Szabó, M. Zrínyi, J. Applied Phys., 1999, 85, 8451.
[34] P.M. Xulu, G. Filipcsei, M. Zrínyi, Macromolecules 2000, 33, 1716.
[35] M. Zrínyi, D. Szabó, H.G. Kilian, Polymer Gels and Networks, 1998, 6, 441.
[36] O. Saslawski, C. Weingarten, J.P. Benoit, P. Couvreur, Life Science, 1998, 42, 1521.
[37] A.vK. Gupta, M. Gupta, Biomaterials 2005, 26, 3995.
[38] T. Neuberger, B. Schöpf, H. Hofmann, M. Hofmann, B.V. Rechenberg, J. Magn.
Mag. Mat. 2005, 293, 483.
[39] J. Fricker, F. Writer, Drug Delivery Today, 2001, 6, 387.
[40] T. Y. Liu, S. H. Hu, K. H. Liu, D. M. Liu, S. Y. Chen, J. Magn. Magn. Mater.
2006, 304, e397.
[41] X. Z. Zhang, Y. Y. Yang, T. S. Chung, K. X. Ma, Langmuir 2001, 17, 6094.
[42] T. D. Dziubla, M. C. Torjman, J. I. Joseph, M. Murphy-Tatum, A. M. Lowman, Biomaterials 2001, 22, 2893.
[43] H. Storrie, D. J. Mooney, Advanced Drug Delivery Reviews 2006, 58, 500.
[44] O. C. Farokhzad, R. Langer, ACS nano 2009, 3, 16.
[45] M. Bruchez, Jr., M. Moronne, P. Gin, S. Weiss, A. P. Alivisatos, Science 1998, 281, 2013.
[46] W. C. Chan, S. Nie, Science 1998, 281, 2016.
[47] K. Balasubramanian, M. Burghard, Small 2005, 1, 180.
[48] L. Lacerda, A. Bianco, M. Prato, K. Kostarelos, Adv. Drug Delivery Rev. 2006, 58, 1460.
158
[49] L. R. Hirsch, A. M. Gobin, A. R. Lowery, F. Tam, R. A. Drezek, N. J. Halas, J. L.
West, Ann. Biomed. Eng. 2006, 34, 15.
[50] D. L. Thorek, A. K. Chen, J. Czupryna, A. Tsourkas, Ann. Biomed. Eng. 2006, 34, 23.
[51] M. Ferrari, Nat. Rev. Cancer 2005, 5, 161.
[52] P. Grodzinski, M. Silver, L. K. Molnar, Expert Rev. Mol. Diagn. 2006, 6, 307.
[53] S. K. Sahoo, S. Parveen, J. J. Panda, Nanomedicine 2007, 3, 20.
[54] K. B. Keys, F. M. Andreopoulos, N. A. Peppas, Macromolecules 1998, 31, 8149.
[55] V. P. Torchilin, Adv. Drug Delivery Rev. 2006, 58, 1532.
[56] J. Chen, H. Park, K. Park, Proc. Int. Symp. Control. Rel. Bioact. Mater. 1998, 25, 60.
[57] W. Cai, X. Chen, Small 2007, 3, 1840.
[58] S. Liu, R. Maheshwari, K. L. Kiick, Macromolecules 2009, 42, 3.
[59] M. Arruebo, R. Fernández-Pacheco, M. R. Ibarra, J. Santamaría, NanoToady
2007, 2, 22.
[60] S. J. Lee, J. R. Jeong, S. C. Shin, J. C. Kim, Y. H. Chang YH, et al. J. Magn.
Magn. Mater. 2004, 272, 2432.
[61] D. L. J. Thorek, A. Chen, J. Czupryna, A. Tsourkas, Ann Biomed Eng 2006, 34, 23.
[62] C. H. Griffiths, M. P. Ohoro, T. W. Smith, J. Appl. Phys. 1979, 50, 7108.
[63] C. B. Murray, D. J. Norris, M. G. Bawendi, J. Am. Chem. Soc. 1993, 115, 8706.
[64] Z. A. Peng, X. G. Peng, J. Am. Chem. Soc. 2001, 123, 183.
[65] L. H. Qu, Z. A. Peng, X. G. Peng, Nano Lett 2001, 1, 333.
[66] M. A. Hines, P. Guyot-Sionnest, J. Phys. Chem. 1996, 100, 468.
[67] X. G. Peng, M. C. Schlamp, A. V. Kadavanich, A. P. Alivisatos, J. Am. Chem. Soc.
[70] M. Green. Chem. Commun. 2005, 24, 3002.
[71] U. Jeong, X. W. Teng, Y. Wang, H. Yang, Y. N. Xia, Adv. Mater. 2007, 19, 33.
159
583.
[76] L. L. Muldoon, M. Sandor, K. E. Pinkston, E. A. Neuwelt, Neurosurgery 2005, 57, 785.
[77] D. E. Sosnovik, M. Nahrendorf, R. Weissleder, Circulation 2007, 115, 2076.
[78] H. S. Choi, W. Liu, P. Misra, E. Tanaka, J. P. Zimmer, et al. Nat Biotechnol. 2007, 25, 1165.
[79] R. Weissleder, A.S . Lee, A.J . Fischman, P.Reimer , T.Shen, R. Wilkinson, R.J . Callahan, T. J. Brady, Radiology 1991, 181, 245.
[80] J.W.M. Bulte, D.L. Kraitchman, NMR Biomed. 2004, 17, 484.
[81] Y. X. J. Wang, S. M. Hussain, G. P. Krestin, Eur. Radiol. 2001, 11, 2319.
[82] M. F. Bellin, Eur. J. Radiol. 2006, 60, 314.
[83] R.W eissleder, A. Moore , U. Mahmood, R. Bhorade , H. Benveniste, E. A.
Chiocca, J. P. Basilion, Nat. Med. 2000, 6, 351.
[84] M. Zhao , D. A. Beauregard, L. Loizou, B. Davletov , K. M. Brindle, Nat. Med.
[87] T. Hyeon, Chem. Commun. 2003, 927.
[88] J. Park, K. An, Y. Hwang, J. G. Park, H. J. Noh, J. Y. Kim, J. H. Park, N.M.
Hwang, T. Hyeon, Nat. Mater. 2004, 3, 891.
[89] N. R. Jana, Y. Chen, X. Peng, Chem. Mater. 2004, 16, 3931.
160
Chem. Soc. 2005, 127, 9992.
[99] M. P. Morales , S. Veintemillas-Verdaguer, M. I. Montero, C. J. Serna, Chem.
Mater. 1999, 11, 3058.
[100] E. V. Shevchenko, D. V. Talapin, A. L. Rogach, A. Kornowski, M. Haase, H.
Weller, J. Am. Chem. Soc. 2002, 124, 11480.
[101] C. W. Jung, P. Jacobs, Magn. Reson. Imaging 1995, 13, 661.
[102] D. Hogemann, L. Josephson, R. Weissleder, J. P. Basilion, Bioconjug. Chem.
2000, 11, 941.
[103] R. Weissleder, A. Moore, U. Mahmood, R. Bhorade, H. Benveniste H, et al. Nat.
Med. 2000, 6, 351.
[109] A. K. Gupta, R. R. Naregalkar, V. D. Vaidya, M. Gupta. Nanomedicine 2007, 2, 23.
[110] X. H. Gao, Y. Y. Cui, R. M. Levenson, L. W. K. Chung, S. M. Nie, Nat.
Biotechnol. 2004, 22, 969.
[111] T. Pellegrino, L. Manna, S. Kudera, T. Liedl, D. Koktysh, et al. Nano Lett 2004, 4, 703.
[112] A. P. Philipse, M. P. B. Vanbruggen, C. Pathmamanoharan, Langmuir 1994, 10, 92.
[113] Y. Lu, Y. D. Yin, B. T. Mayers, Y. N. Xia, Nano Lett. 2002, 2, 183.
[114] M. Arruebo, et al., Chem. Mater. 2006, 18, 1911.
[115] R. Duncan, Materials Today 2005, 8, 16.
[116] U. Gaur, et al., Int. J. Pharmacol. 2000, 202, 1.
[117] T. Neuberger, et al., J. Magn. Magn. Mater. 2005, 293, 483.
[118] X.Wu, H. Liu, J. Liu, K. N. Haley, J. A. Treadway, J. P. Larson, N. Ge, F. Peale, M. P. Bruchez, Nat. Biotechnol. 2003, 21, 41.
[119] X. Gao , Y. Cui, R. M. Levenson, L.W. K. Chung, S. Nie, Nat. Biotechnol. 2004, 22, 969.
[120] D. B. Robinson, H. H. J. Persson , H. Zeng , G. Li, N. Pourmand, S. Sun, S. X.
Wang, Langmuir 2005, 21, 3096.
[121] N. Nitin, L. E. Laconte, O. Zurkiya, X. Hu, G. Bao, J. Biol. Inorg. Chem. 2004,
161
[127] A. S. Lubbe, C. Alexiou, C. Bergemann, J. Surg. Res. 2001, 95, 200.
[128] A. S. Lubbe, C. Bergemann, H. Riess, F. Schriever, P. Reichardt, et al. Cancer Res. 1996, 56, 4686.
Langer, D. S. Kohane, Nano Lett. 2009, 9, 3651.
[135] D. H. Kim, E. A. Rozhkova, I. V. Ulasov, S. D. Bader, T. Rajh, M. S. Lesniak,
[139] J. Kost, J. Wolfrum, R. Langer, R. J. Biomed. Mater. Res. 1987, 21, 1367.
[140] E. R. Edelman, J. Kost, H. Bobeck, R. Langer, J. Biomed. Mater. Res. 1985, 19, 67.
[141] O. Saslawski, C. Weingarten,J. P. Benoit, P. Couvreur, Life Sci. 1988, 42, 1521-1528.
[142] Z. Lu, M. D. Prouty, Z. Guo, V. O. Golub, C. S. S. R. Kumar, Y. M. Lvov, Langmuir 2005, 21, 2042.
[143] T. Y. Liu, S. H. Hu, T. Y. Liu, D. M. Liu, S. Y. Chen, Langmuir 2006, 22, 5974.
162
[144] Ting-Yu Liu, Shang-Hsiu Hu, Kun-Ho Liu, Dean-Mo Liu, San-Yuan Chen, J.
Controlled Release, 2008, 126, 228.
[145] V. Crescenzi, A. Francescangeli, A. Taglienti, Biomacromolecules 2002, 3, 1384.
[146] A. I. V. D. Bulcke, B. Bogdanov, N. D. Rooze, E. H. Schacht, M. Cornelissen, H.
Berghmans, Biomacromolecules 2000, 1, 31-38.
[147] H.Nakamura,W. Kato, M. Uehara, K. Nose, T. Omata, S. Otsuka-Yao-Matsuo, M. Miyazaki, H. Maeda, Chem. Mater. 2006, 18, 3330.
[148] W. Jiang, S. Mardyani, H. Fischer, W. C. W. Chan, Chem. Mater. 2006, 18, 872.
[149] P. S. Low, W. A. Henne, D. D. Doorneweerd, Acc. Chem. Res. 2008, 41, 120.
[150] A. Corma, U. Díaz, M. Arrica, E. Fernández, Í. Ortega, Angew. Chem. Int. Ed.
2009, 48, 6247.
[151] Y. Lu, Y. Zhao, L. Yu, L. Dong, C. Shi, M. J. Hu, Y. J. Xu, L. P. Wen, S. H. Yu, Adv. Mater. 2010, 22, 1407.
[152] Y. Yin, R. M. Rioux, C. K. Erdonmez, S. Hughes, G. A. Somorjai, A. P.
Alivisatos, Science 2004, 304, 711.
[153] Y. Sun, Y. Xia, Science 2002, 2176.
[154] X. J. Xu, D. Xu, J. Am. Chem. Soc. 2009, 131, 2774.
[155] X. J. Xu, D. Xu, Adv. Mater. 2010, 22, 1516.
[156] J. Yang, J. Lee, J. Kang, S. J. Oh, H. J. Ko, J. H. Son, K. Lee, J. S. Suh, Y. M.
Huh, S. Haam, Adv. Mater. 2009, 21, 4339.
[157] M. S. Yavuz, Y. Cheng, J. Chen, C. M. Cobley, Q. Zhang, M. Rycenga, J. Xie, C.
Kim, K. H. Song, A. G. Schwartz, L. V. Wang, Y. Xia, Nature Materials, 2009, 8, 935.
[158] S. H. Choi, J. H. Lee, S. M. Choi, T. G. Park, Langmuir 2006, 22, 1758– 1762.
[159] T. Y. Liu, K. H. Liu, D. M. Liu, S. Y. Chen, I. W. Chen, Adv. Funct. Mater. 2009, 19, 616.
[160] Y. Tian, P. Ravi, L. Bromberg, T. A. Hatton, K. C. Tam, Langmuir 2007, 23, 2638.
163
CURRICULUM VITAE
Shang-Hsiu Hu, Ph. D. Candidate
Add: 1001 Ta Hsueh Road, Hsinchu, Taiwan 30049, ROC Phone: +886-3-5712121#55394
E-mail: [email protected]
Education
Visiting Scholar, Department of Bioengineering, University of Washington, USA, 2009.5~2010.5.
Ph.D., Material Science and Engineering, National Chiao Tung University, Taiwan, ROC, 2006~2010.
M.S., Material Science and Engineering, National Chiao Tung University, Taiwan, ROC, 2004~2006.
B.S., Chemical Engineering, National Chung-Hsin University, Taiwan, ROC, 2000~2004.
Research Interests
1. Novel process development and controlled drug release in nano-biomaterial composites such as iron oxide nanoparticles, quantum dots and mesoporous silica.
2. Multifunctional nanomaterials for bioengineering and bioimaging.
3. Controlled rupture of novel core-shell spheres for drug delivery system which is able to be remotely controlled its rupturing behavior upon an external stimulation.
Selected Publications
1. Shang-Hsiu Hu, and Xiaohu Gao, "Nanocomposites with Spatially Separated Functionalities for Combined Imaging and Magnetolytic Therapy", J. Am. Chem. Soc., 2010, 7234-7237.
2. Shang-Hsiu Hu, San-Yuan Chen, Chi-Sheng Hsiao and Dean-Mo Liu, “Core/Single-Crystal-Shell Nanospheres for Controlled Drug Release via a Magnetically Triggered Rupturing Mechanism”, Adv. Mat., 2008, 20, 2690-2695.
3. Shang-Hsiu Hu, Wei-Lin Tung, Chen-Fu Liao, Dean-Mo Liu and San-Yuan Chen, Surfactant-free,
“Self-Assemble PVA-Iron Oxide /Silica Core-Shell Nanocarriers for High-Sensitive Magnetically Controlled Drug Release and Ultra-high Cancer Cell Uptake Efficiency”, Adv. Func. Mat., 2008, 18, 2946-2955.
4. Shang-Hsiu Hu, Kuan-Ting Kuo, Dean-Mo Liu, and San-Yuan Chen. “Synthesis of Drug Delivery Nano-device capable of Imagining, Targeting, and Self-Monitoring of Drug Release in Cancerous Cells”, Adv. Func. Mat., 2009, 19, 3396.
164
5. Shang-Hsiu Hu, Ting-Yu Liu, Dean-Mo Liu and San-Yuan Chen, “Controlled Pulsatile Drug Release from a Ferrogel by a High-Frequency Magnetic Field”, Macromolecules, 2007, 40, 6786-6788.
Honors
1. Silver medal of “National Innovation Award” for Biotechnology and Medicine Industry, 2008, Taiwan. (2008 國家新創獎 第二名)
2. Gold medal of “Creative Design and Implementation Competition on Biomedical Engineering”, 2008, Taiwan. (2008 醫學工程創意競賽 優勝)
3. Gold medal of “Taiwan Nano-Image Competition”, 2008, Taiwan.
(2008 台灣奈米影像攝影競賽 第一名)
4. Gold and copper medal of “Taiwan Nano-Image Competition”, 2009, Taiwan.
(2009 台灣奈米影像攝影競賽 第一名、第三名)
a. News by Material Views (2009-04-28): Magnetic Triggering of Drug Release with Precise and Localised Dosage. http://www.materialsviews.com/matview/display/en/352/TEXT
b. News by Material Views (2008-08-07): Magnetically Controlled Drug Release.
http://www.materialsviews.com/matview/display/en/739/TEXT c. News by NPG Asia Materials (2008-09-24): Magnetic precision http://www.natureasia.com/asia-materials/highlight.php?id=261
Publications
1. Shang-Hsiu Hu, and Xiaohu Gao, "Nanocomposites with Spatially Separated Functionalities for Combined Imaging and Magnetolytic Therapy", J. Am. Chem. Soc., 2010, 7234-7237.
2. Shang-Hsiu Hu, and Xiaohu Gao, "Stable Encapsulation of QD Barcodes with Silica Shells", Adv.
Func. Mat., 2010, Accepted.
3. Kuan-Ting Kuo, Shang-Hsiu Hu, Dean-Mo Liu, and San-Yuan Chen. “Magnetically-induced Synthesis of Highly-Crystalline Ternary Semiconductor Chalcopyrite Nanocrystals via a Magnetic Doping at Ambient Conditions”, Journal of Chemistry Materials, 2010, 20, 1744-1750.
4. Shang-Hsiu Hu, Kuan-Ting Kuo, Wei-Lin Tung, Dean-Mo Liu, and San-Yuan Chen. “Synthesis of Drug Delivery Nano-device capable of Imagining, Targeting, and Self-Monitoring of Drug Release in Cancerous Cells”, Adv. Func. Mat., 2009, 19, 3396.
5. Wei-Chen Huang, Shang-Hsiu Hu, Kun-Ho Liu, San-Yuan Chen and Dean-Mo Liu. “A Flexible Drug Delivery Chip for Magnetically-Controlled Release of Anti-Epileptic Drug”, Journal of Controlled Drug Release, 2009, 139, 221-228.
6. Ting-Yu Liu, Shang-Hsiu Hu, Dean-Mo Liu, San-Yuan Chen, and I-Wei Chen, Biomedical
165
Nanoparticle Carriers with Combined Thermal and Magnetic Responses, NanoToday, 2009, 4, 52-69 ( invited review).
7. Shang-Hsiu Hu, Ting-Yu Liu, Hsin-Yang Huang, Dean-Mo Liu, and San-Yuan Chen,
“Stimuli-Responsive Controlled Drug Release from Magnetic-Sensitive Silica Nanospheres”, J.
Nanosci. Nanotechnol., 2009, 9, 866-870.
8. Shang-Hsiu Hu, Chia-Hui Tsai, Chen-Fu Liao, Dean-Mo Liu and San-Yuan Chen, “Controlled Rupture of Magnetic Polyelectrolyte Microcapsules for Drug Delivery”, Langmuir, 2008, 24, 11811–11818.
9. Shang-Hsiu Hu, Wei-Lin Tung, Chen-Fu Liao, Dean-Mo Liu and San-Yuan Chen, Surfactant-free,
“Self-Assemble PVA-Iron Oxide /Silica Core-Shell Nanocarriers for High-Sensitive Magnetically Controlled Drug Release and Ultra-high Cancer Cell Uptake Efficiency”, Adv. Func. Mat., 2008, 18, 2946-2955.
10. Shang-Hsiu Hu, San-Yuan Chen, Chi-Sheng Hsiao and Dean-Mo Liu, “Core/Single-Crystal-Shell Nanospheres for Controlled Drug Release via a Magnetically Triggered Rupturing Mechanism”, Adv. Mat., 2008, 20, 2690-2695.
11. Ting-Yu Liu, Shang-Hsiu Hu, Kun-Ho Liu, Dean-Mo Liu and San-Yuan Chen, Instantaneous Drug Delivery of Magnetic/Thermal Sensitive Nanospheres by a High Frequency Magnetic Field, Langmuir, 2008, 24, 13306-13311.
12. Ting-Yu Liu, Shang-Hsiu Hu, Kun-Ho Liu, Dean-Mo Liu and San-Yuan Chen, “Study on controlled drug permeation of magnetic-sensitive ferrogels: Effect of Fe3O4 and PVA ”, Journal of Controlled Drug Release, 2008, 126, 228-236.
13. Shang-Hsiu Hu, Ting-Yu Liu, Hsin-Yang Huang, Dean-Mo Liu and San-Yuan Chen,
“Magnetic-Sensitive Silica Nanospheres for Controlled Drug Release”, Langmuir, 2008, 23, 239.
14. Ting-Yu Liu, Li-Ying Huang, Shang-Hsiu Hu, Ming-Chien Yang and San-Yuan Chen, Core-shell magnetic nanoparticles of heparin conjugate as recycling anticoagulants, J. Biomed.
Nanotechnol., 2007, in press.
15. Shang-Hsiu Hu, Ting-Yu Liu, Dean-Mo Liu and San-Yuan Chen, “Controlled Pulsatile Drug Release from a Ferrogel by a High-Frequency Magnetic Field”, Macromolecules, 2007, 40(19), 6786-6788.
16. Shang-Hsiu Hu, Ting-Yu Liu, Dean-Mo Liu and San-Yuan Chen, “Nano- Ferrosponges For Controlled Drug Release”, Journal of Controlled Drug Release, 2007, 121 (3), 181-189.
17. Shang-Hsiu Hu, Ting-Yu Liu, Chia-Hui Tsai, Dean-Mo Liu and San-Yuan Chen, “Preparation and Characterization of magnetic ferroscaffolds for tissue engineering”, Journal of Magnetism and Magnetic Materials, 2007, 310(2), 2871-2873.
18. Ting-Yu Liu, Shang-Hsiu Hu, Sheng-Hsiang Hu, Szu-Ping Tsai and San-Yuan Chen, “Preparation and characterization of thermal-sensitive ferrofluids for drug delivery application ”, Journal of Magnetism and Magnetic Materials, 2007, 310 (2), 2850-2852.
19. Ting-Yu Liu, Shang-Hsiu Hu, Tse-Ying Liu, Dean-Mo Liu and San-Yuan Chen,” Magnetic-sensitive
166
behavior of intelligent ferrogels for controlled release of drug,” Langmuir, 2006; 22(14);
5974-5978.
20. Ting-Yu Liu, Hung-Chou Liao, Chin-Ching Lin, Shang-Hsiu Hu, and San-Yuan Chen, ” Bio-functional ZnO nanorods arrays grown on flexible substrates,” Langmuir; 2006; 22(13);
5804-5809.
21. Ting-Yu Liu, Shang-Hsiu Hu, Kun-Ho Liu, Dean-Mo Liu, San-Yuan Chen, “Preparation and characterization of smart magnetic hydrogels and its use for drug release,” Journal of Magnetism and Magnetic Materials, 304, 2006, e397-e399.
22. Jiang-Jen Lin, Shi-Min Chen, Shang-Hsiu Hu, ” Poly(oxyethylene) diamine- Derived Hydrophilic Copolymers for Emulsifying Diglycidylether of Bisphenol-A, ”Journal of Applied Polymer Science, Vol. 94, 1797–1802 (2004).
Conference Papers
1. Shang-Hsiu Hu, Ting-Yu Liu, Hsin-Yang Huang, Dean-Mo Liu, and San-Yuan Chen*,
“Stimuli-Responsive Controlled Drug Release from Magnetic-Sensitive Silica Nanospheres,”
International Conference on Nanoscience & Technology, China 2007, June 4-6, Beijing, China.
2. Shang-Hsiu Hu, Chi-Sheng Hsiao, Dean-Mo Liu and San-Yuan Chen, A Novel Core-Shell PVP-silica/Fe3O4 nanosphere as Cancer Targeted and Drug Delivery System, 8th World Biomaterial Congress, 28 May-1 June, 2008, Amsterdam, Nertherlands.
3. Chen-Fu Liao, Shang-Hsiu Hu, Chia-Hui Tsai, Dean-Mo Liu and San-Yuan Chen*, “Controlled Rupture of Magnetic Polyelectrolyte Microcapsules for Drug Delivery,” 8th World Biomaterial Congress, 28 May-1 June, 2008, Amsterdam, Nertherlands.
4. Shang-Hsiu Hu, Ting-Yu Liu, Chia-Hui Tsai and San-Yuan Chen*,”Preparation and
characterization of magnetic ferroscaffolds for tissue engineering.” The 17th International Conference on Magnetism (ICM) , Aug, 20-25, 2006, Kyoto, Japan.
5. Ting-Yu Liu, Shang-Hsiu Hu, Kun-Ho Liu, Sheng-Hsiang Hu, Dean-Mo Liu and San-Yuan Chen*,”
Magnetic-sensitive characterization of the ferrogels and its use for drug release,” 94 年度生 醫材料暨藥物制放研討會，2005，新竹，清華大學。
6. Shang-Hsiu Hu, Ting-Yu Liu, Sheng-Hsiang Hu, Dean-Mo Liu and San-Yuan Chen*,”Preparation of characterization of smart magnetic bio-membrane and its use for drug
release,”International Symposium on Spintronics and Advanced Mangnetic Technologies and International Symposium on Magnetic Materials and Applications (2005) .