PA-42 誘導人類口腔癌鱗狀細胞（HSC-3）細胞凋亡與抑制細胞轉移之分子機轉; The molecular mechanisms of apoptosis and cell metastasis by PA-42 in human oral squamous cancer cells (HSC-3)
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(492) /"1DB975<ʤÐ53D?>93;9>C?> . / aʼkǽʞLJŞƀ 'M!
(493) M''M1
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(495) M ' E=1>?B1<CAE1=?EC31B39>?=131>35B35<<C<9>5 ./9??1D3E<DEB5C<945ʤÐ1<3?>(" ./ [ƌïˋ . 20.
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(504) 1231= . 21.
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(506) / LJŞƞɾɱ ʤÐ#E19B5 . / LJŞƞɾ¬ ʤÐ!$# ./ LJŞƞɾɮ ʤÐ!$# ./ LJŞŤɥʃ 15=?3ID?=5D5BOʤÐ?53? ./ Ů¯ÇȾÖŹˉȟ ʻ @81C53?>DB1CD =93B?C3?@5O ʤ Ð $<I=@EC ./ ÝŲɎ ʤÐ(%% ./ ʵʊ ʤÐ53;=1> ./9C@5>C?BʤÐ(%% . / ȟȎʵɎ ʤÐęƮ . /%9@5D=5>DʤÐ?CD1B .
(507) / ɬĨ ʤÐ!12!9>5 . / ɛ Ɗ Ü Ŗ y ĩ ɟ 1>D8?C
(508)
(509) O ʤ Ð >D8?C !12D53 ECDB1<91 . / ȟȎ &
(510). OʤÐ . / ʵmɗǕʊ ʤÐ"9>9@?B5 . / Ɨƅɨ "?45< . OʤÐ?5;5< . / Ƚȩćʗʃ ʤÐ=5BC81= . / ɜˎŭǮĚŤ OʤÐ?>C?BD . 22.
(511) . /%*=5=2B1>5ʤÐ"9>9@?B5 .
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(514)
(515) /(B1>C65B5<<C<?DŵLj ʤÐ9?&14 .
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(519) / Ɩǔʵʊ
(520) ʤÐ 5B=<5OF5>D5 ("ʤÐ53;=1> .
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(522) /I5<1# B?D1BIF13EE=5F1@?B1D. . 23.
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(524) N ß ¨ ȟ Ȏ Ē %
(525) Ŧ Ȏ =7 L ģ ȱ Ĥ ȟ Ȏ ʵ Ɏ 5@@5>4?B6 rL·b "'$ =< LƔÈʋł . Z7 =< LÅģ Ĥ
(526) V ¸ɱrNɂˊż·ƢĒȨȴńL "'$ ǶˀÈɂˊĞ ɞIJʋłNȰ©§İʚĚĬ 91CC1I £ÌɂˊǜljʋłyÞŔ. M M M M
(527) M
(528) Z7 =<N. ǃ`ȕ aʼkǽʞLJŞƞɾ ÝŲLJŞœ} ŴƼÝŲLJŞœ}ŴļŔíǔȴŲLÄÍʦܸǥŦȣǹǥ ÏɄLJŞǕÈȚŶLʅşLJŞÎjNLJŞȰ©ȴŲńƞɾɥ Lĝʿ [Ñ`LŃLJŞŅǡŴËœĜLĆLJާķĝčƇĜŅǡ¥ƣż . 24.
(529) pÚŔLJŞɂˊIJɦ£N ÷ˍƢʈÚʝɀ~LJŞĞɞsƞɾƝȬǛéǼńLăƢƞɾƝ ÑĤ V IJƅɨr¿ȫL¿ȫńɡ U ƓɐńLʘņăǂb ǰȁʈÚvNÐƗ¸ŸʃĝƴɅǬrĒÝŲnɎLŪ´ʚōɕm ŊãƭɑL©ĤɬǾÝʡIJȺǵLÍżɕmŸĥʹNJNǂÝŲnɎ ńLāǔǂb V IJƅɨríǔȴŲLʑ}ńL Ɠɐʘ ņÝŲnɎǗLăƢǂbǰȁʈÚvNĒȴŲsLJŞʾƄƴL ɵɆbæËƞɾƝsƞɾŸʃv ǶˀĈŔ K Lƶ½ ç{Lģb $
(530) ƞɾɱƞɾNăÁȴŲńÌ õǣƞɾƝN
(531) LJŞÝŲĺÅ ŴƼƢƙƥLJŞʿńÅģĤƴɅǬrćʗɂˊĞɞsLJ ŞNƲÝŲĺÅsLJŞɞŔ§ķþÃÅœƺŜŔ K U sı ɅNÝŲĺ˂ʂ "'$ ʗŔȵʂƌǷƌLǰȁǰÒ
(532)
(533) =93B? !% (5<6<?> ȺʯĝŊijƫʤȉǰȁƿľ NÝŲĺÅsLJŞʋł KR 35<<C =<N ÷ˍÝŲĻ[ õǣȎĝµȎIJƞɾƝLˏɃLJާķƩ ìNƔɗÝŲĺÅȨƴ ƨĻƔɗƢ "'$ bȣʫIJƞɾƝ rLǜńʋłŔ ULƶ½ç{LȱĤŀȫgѨNĒȎLJŞʾƄ ƴ Ŝ =< ŤɏLJŞʋł~ÝŲĻÅœƺNʵńLĄLJŞɥIJɥ . 25.
(534) ȎbɻȎIJÝŲĺÅƴLĆLJŞʋłŔ KR 35<<C =<Lƶ½ç {LyȳĤɧ®ƵȦsÝŲĺÅɎrL =< F91<NÝŲĺÅĬÝŲ ɎȱĤ V r yˁLʴÑ
(535) V r yˁLʴÑ Vr K nż ĝȼĘ LǜńƴǬɨķǧʔÅN aʼkǽʞLJŞƞɾ ǰȁʈÚƨĻ´ˌčĠƁȸʴ yˁL· U Ɠɐʘ ņʈÚũNĞËȍbǰȁʈÚIJʃİçɞ´ɡ˅ U ƓɐLË ɕŸʃƭȐƾɕĻçɞȺLƞɾƝšĆ¨ȎLļɌȎȱĤŀȫg ¿ȫLʦÜ @ ŭˈ}N ' LJŞŔĈLƞɾÁ U '""
(536) ƞɾƝr æ U 65D1<2?F9>5C5BE=M. E>9DC =<@5>939<<9>M. Z7 =< CDB5@D?=I39>M
(537) ="!7<ED1=9>5 LȱĤ VMU $
(538) IJ ( ìƞɾǁĤƞɾɱrƞɾN ȮLJŞƠłķÑ K ɋżļȍÔyɮLŪ´ƢʰƞɾƝå ƗƸLƫȀ =< R%' ɵɸƴ @ T ƵŒċÌLƵŒéń b DBI@C9>( K
(539) =< Ŝ
(540) yˁL·b =< U '""
(541) rʮ DBI@C9> Ú¨LƢƞɾƝvLJŞǂȱʵɎr ʴǔ . B@= ʵ yˁLƢLJŞʵńƕhƵƴLbɻȎ IJƞɾƝLăĒǗ²ß¨ÓƻŤɥɮ 85=?3ID?=5D5B ŤɥLJŞɥ . 26.
(542) LǝɿLJŞȍÔyɮƞɾN ĵfMɂˊrĞʒ¨IJaʼkǽʞLJŞƀ¹ĵ. Ȇ(=5B931>(I@5E<DEB5?<<53D9?> & 1@1>5C5?<<53D9?>?6&5C51B389?B5C?EB35C LJŞŤɥðǎ ŴƼŤɏɥŊߨŊ¨ÓƻŤɥɮLÓƻŤɥɮ[ƑËċŰ 381=25B LøŰ 381=25B rLJĎÈ^Ű ==
(543) l¥ìčr^ŷſ ĕǟIJ¥ì·LJĎ nſLƷłçŔ == NȮ 381=25B h ɕhŕńLø»l¥ìˋʏŔ ==
(544) R ==T R =<N ƨżLŤɥø»l¥ìvsLJŞɥLūǶˀŬɥL·ū L âŔø =< rIJLJŞɥLÄgȿ[N . ȿ`MLJŞŤɥɮ. . 27.
(545) ÷ˍĒǶˀńæËLJŞIJƞɾƝŜ Z<LÐÓƻŤɥɮ381=25B hɨbLɕhɕŕLƫȀÁ . ŬŮ¯ÇˉȟʻgˏɃ~Ť ɥNÁŤɥsżLLJŞšÖĤɴhLļŤhŧɔɴ ĝŤgɴɔ ɴsLJŞ LÄĞæLJŞƠłȺƖLļɏIJLJŞɥɘŹȶl ø[ lſȋȺ ŰLJŞ Lɞţ·bõÂIJƞɾƝǶˀN. ǃ fȕ "((LJŞœĜyĩ
(546). ŴƼ"(( 49=5D8I<D891J?<5
(547) I<
(548) 49@85>I<D5DB1J?<9E= 2B?=945 äÒĬŊĄʆ "?C=1>> ĞdzĵĬL¾ "(( £ĀŊ[ ɍȗÒIJ D5DB1J?<9E=C1<DLȮ "(( ǏDŽɴˋræËIJ CE339>1D5 458I4B?75>1C5 ʧŴńļʴˈŔʱǺÒs 6?B=1J1> LÁ >= g ČËå³ŭN¾ÍĬƕ_ƚǮDŽɴˋsʧŴƐdLiĵLJŞ ÅœɥLʼnȮå³ŭȊƖĵ®LJŞœĜȊƦN ÷ˍƢ ' LJŞLƫɍĤ
(549) ƞɾɮrLčøĞæLJŞ ɥŔ R ŰLLJŞƞɾĤ V M $
(550) ƞɾɱrƞɾ
(551) n żL·yÞǻtqºʋłs %
(552) K
(553) Z7 =< LȰqºƞɾ żȑčʺİƞɾżȑŔ
(554) nżM nż~
(555) nżLƞɾńƢƞ ɾƝåL¨ ,%' ŒċÌLʦ³ʈƘøb
(556). Z<"(( =7 =<Lģȱ VM $
(557) sƞɾɱʗ nżńLƢ "(( å . 28.
(558) Lø·b . Z<"'$ L ģȱ C81;5B yˁńLøå
(559). Z<"'$ ǂÑ ƞɾɮrL ! 'B5145B ǮĚÁ >= IJå³ŭN. ǃȕ Ů¯ÇÖŗŹˉȟʻʚǮLJŞìɅ ÷ˍkǽʞ ' LJŞɍb
(560) ƞɾɮLøkǽʞLJŞɥ Ŕ R ŰLģȱȼLòt K
(561) Z7 =<%
(562) LÁ VM $
(563) IJƞɾɱȍÔ
(564) nżƞɾńLĤŮ¯ÇȾÖŹˉȟʻgȭ ŗyĩN. ǃuȕ ŐÇLJŞɟyĩLJŞȌǧ~LJŞųj . ŴƼ%B?@949E=9?4945% ŊŽɜIJʐ³ŌʂLČơ[ĜɔŽ ɜʩǹN¥ƣƩĭgLJŞɶäƽéʉLĞ% ŌʂŊǰĬŚǖLJŞ ɶLÏȮߨƓɐėĚLJŞɶńLƤË¥ȽNjIJ % ȍbLJŞɶǠ b # hLȰ©ŐÇLJŞɟƚǮ % ʌdzsʐ³LļʗLJŞv # ıɅ~ȍÔLJŞȌǧyĩN ÷ˍkǽʞLJŞɍb
(565) ƞɾɮLøLJŞɥŔ R ŰL ģȱȼǻt K
(566) Z7 =<%
(567) LIJkǽʞLJŞɍb
(568) ƞ ɾɮLʭȍ VM$
(569) IJƞɾɱȍÔƞɾLÁƞɾ
(570) nżńL ƓɐȍÔLJŞėĚLȱĤ
(571) V ¸ɱȼĘÅģN ȼLÉĒLJŞÑ =< IJŐÇLJŞɟơ¨ɎLƶ½ç{ńLâ . 29.
(572) ȍÔŐÇLJŞɟyĩLb . Z< IJ % ŌʂLʦ³ʗ y ˁLǜńŐÇLJŞɟ <?G3ID?=5DBI ȍÔɦľyĩL[řLJŞɥ qȋȺ . ʪLJŞLøÌÉȔ . ʪLJŞLʚǮLJŞȌǧôˈIJ ƩìNɥʆ "?469D!( ǓˋȍÔnjƼyĩN ĵM ,%8?C@81D52E665BC1<9>5 ,%' Lj È. Ŧ Ȏ 7. #1<. . <.
(573) . #1
(574) %$. .
(575) %$.
(576) + Đʢˋʏ . =<. ĵuM%B?@949E=9?4945% ŌʂƔɗ Lj È. ǜljʋł. Ĵʋł. ˋʏ =<. %B?@949E=9?4945% . =7 4<.
(577) =7 4<. . (B9D?>. . . . C5. =7 =<.
(578) =7 =<.
(579) . ,%'. . . . ʢˋʏ.
(580) =<. ǃwȕ ŐÇLJŞɟyĩDŽɴˋɶȽÖ. . ŴƼ9$ 4985HI<?H131B2?3I1>9>59?4945 ŔȓʵmƏȨĜ ŌʂLĥǠbƤťȽNjsDŽɴˋvɶLȮDŽɴˋēďʌȧ}Ï vɶsťȽNjżLvɶǏɧĚ 9$ ȥǭL¾Íʐ³ƦłȥŨÛL . 30.
(581) ÚŔʚǮDŽɴˋɶȽÖ ""% sňɧN ÷ˍkǽʞLJŞɍb ƞɾɮLøLJŞɥŔ R ŰLģ ȱȼńLǻt M
(582) Z7 =<%
(583) LyÞƞɾ M M M
(584) ~
(585) nżńÉĒLJŞLĒLJŞÑ =< IJŐÇLJŞɟơ¨ɎL 9$ Z7 =< =<LÏ 2<1>; =<%' LǂĐLJŞƞɾ ɱ VM$
(586) L ʦ³ yˁńLŐÇLJŞɟyĩN. ǃ ]ȕ ŐÇLJŞɟyĩLJŞvȏʵmʋł . ŴƼ >4? " Ŕʐ³ŌʂLɔȏʵmƇǀĜǹ½Lɫ½ȏʵ mLɫ½ȏʵmsʐ³Ōʂȥ˳ʄƇĜhIJôˈLăʓȀLJŞv ȏʵmʋłIJôˈLÏdzǤqºƦłIJʐ³LĉƚǮLJŞvȏʵm ʋłIJˈ}N ÷ˍkǽʞLJŞɍbƞɾɮLøLJŞɥŔ R ŰLģȱ ȼńLǻt M
(587) Z7 =<%
(588) LyÞƞɾ M M M
(589) M ~
(590) nżńÉĒLJŞLĒLJŞÑ =< IJŐÇLJŞɟơ¨ ɎL >4? " Z7 =< =< LÏ 2<1>; =<%' LǂĐ LJŞƞɾɱ VM $
(591) Lʦ³ yˁńL . B@= ʵ y ˁL %' ƵŒ·ʵ`ÌL . Z<%'LŐÇLJŞɟyĩN. . 31.
(592) ǃ cȕ % LJŞʐ³ŌÒyĩ. . ŴƼ% 491=949>?
(593) @85>I<9>4?<5 Ŋ[ɍŽɜʐ³ŌʂL ȥơ[ĜIJǹ½Á # ʷʣƭsnȪhIJ ( ƜLȮLJŞƿ§ų jżLȥËŌÒɺɭʡM # ʮȄƽȈO¾ÍȮųjƽȈȊʽŦL # ʮȄȊÂLÍżnȪhIJ ( Ɯiĝɖ˃ȊÂLĆõÂIJ % Ōʂǹ½hLÁʐ³ˉȟʻgˏɃLˏɃĐųjLJŞĞƿ§ IJʐ³Ʀłȥ¥ƣLJŞĉIJƦN ÷ˍkǽʞLJŞɍb ƞɾɮLøLJŞɥŔ R ŰLģ ȱȼLb M M M M
(594) ~
(595) Z7 =< %
(596) Lƞɾ
(597) nżńLǂƕhɣƞɾƝLb %' ŒfÌL ?B=1458I45 ėĚ yˁL·b (B9D?>,. %' Ú¨ yˁLǂƕń %' Œ`ÌńL % Ōʂ 7 =<. <L ȱĤ V LJŞƞɾɱʦ³ yˁLǜń· %' ŒfÌLƨ ʐ³ˉȟʻ
(598). , ȭŗˏɃN. ǃ^ȕ # ȄȴȽīyĩ. . ŴƼȮLJŞųjƿ§żLȥË # ȄȴŎIJƿ§LLJŞŽv IJ # ȥȄȴÈ K
(599). 2@Lʲ©ƢLJŞrIJ # ĠLÁǺ. . 32.
(600) ʍgˏɃŏȂʨɷˋȽīńŊãË # ȄȴŎÏʅşȒƯı ƽȈƿ§N ÷ˍƢ R ŰLJŞɍĤ xyƞɾ¬hLĤ V ƞɾȼ ĘńLbĞɞʺİÚ¨
(601) nżLƨ (9CCE535<<75>?=93# @EB96I931D9?>;9D Ƣ # ĠńLȍÔ
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