題名:Progressive remodeling of the atrial substrate--a novel finding from consecutive voltage mapping in patients with recurrence of atrial fibrillation after catheter ablation. 作者:陳亦仁
Lo LW; Tai CT; Lin YJ; Chang SL; Wongcharoen W; Chang SH; Hsieh MH; Tuan TC; Udyavar AR; Chen YJ; Tsao HM; Chen SA.
貢獻者:臨床醫學研究所
上傳時間:2009-08-21T08:58:52Z
摘要:BACKGROUND: Atrial substrate properties have been
demonstrated to be related to atrial arrhythmias. This study investigated whether the atrial substrate exhibits progressive remodeling in patients with recurrence of atrial fibrillation (AF) after catheter ablation.
METHODS AND RESULTS: Fifteen consecutive AF patients (52 +/- 12 years old, 12 males) underwent the same mapping technique (NavX, St. Jude Medical, Minnetonka, MN, USA) and same ablation technique for primary AF and
recurrence of AF (170 +/- 66 days after the first
procedure). The bipolar mean peak-to-peak voltage (PPV) of the global left atrium during sinus rhythm
significantly decreased in the second procedure (2.25 +/- 0.62 vs. 1.79 +/- 0.60 mV, P = 0.008). Also, the percentage of the surface area of the low voltage zone (LVZ; less than 0.5 mV) in the left atrium increased from 6 +/- 4% to 13 +/- 6% (P = 0.001) in the second procedure. There was no significant change in the right atrial bipolar mean PPV or surface area of the LVZ in the second procedure. CONCLUSION: Atrial substrate remodeling with a progressive decrease in the left atrial voltage was demonstrated in patients with recurrent AF.
