Characteristics and Prescription Patterns of Traditional Chinese Medicine in Endometriosis Patients: Ten-year Experiences at a Medical Center in Taiwan

12th Meeting of Consortium for Globalization of Chinese Medicine (CGCM)

Austria, August 27 - 29, 2013

ABSTRACT SUBMISSION FORM

Guidelines for Submission of Abstracts

1.

You are invited to submit abstracts to the 12th CGCM Meeting.

2.

To support postgraduates to attend the 12th CGCM Meeting, Travel Grants are now open for application.

3.

Abstract submission deadline: May 31, 2013 (Friday)

4.

Abstract can be submitted to centraloffice@tcmedicine.org with the abstract submission form.

5.

All abstracts must be submitted in ENGLISH (including the title, abstract text, authors' names, affiliations, figures and graphs).

6.

The selected abstracts will be invited for poster presentation and published in the meeting abstract book.

7.

Word limit: 300 words including acknowledgement with no more than 2 tables / graphs / figures.

8.

Submission of abstracts does NOT constitute registration for the Meeting. All presenters are required to make registration for the Meeting separately.

Abstracts will be divided into the designated categories for program purpose.

Please choose one category only.

1. Acupuncture

2. Bioinformatics and Database

3. Bioinformatics: Application of "Omics" in TCM Research 4. Clinical Investigation (please select one of the following)

Cancer, Liver Disease and Inflammation ■ Other Diseases and Safety

5. Education

6. Herbal Resources (please select one of the following)

Cultivation and Herbal Quality

Identification, Formulation and Manufacturing

7. Interregional Collaborations in Industry and Academia 8. Natural Products (please select one of the following)

Biological Activity

Cancer, Virus and Inflammation

Identification, Bio-transformation and Metabolism

Travel Grant

Travel grants will be given to selected postgraduates to attend the 12th CGCM Meeting. Awardees will receive up to USD 500, free accommodation (shared room) and waiver of registration fee.

Apply for the Travel Grant

* Please provide proof of student status and endorsement from supervisors.

9. Polychemical Activities and Mechanism Study (please select one of the following)

Cancer, Immunomodulation inflammation

Metabolic, Neural Diseases, Aging Process and Others Metabolism, Drug Interaction and Toxicity

Corresponding Author 1

Title: ■Prof ■Dr Mr Mrs Ms Others:

First name :

_{Hung-Rong Yen}

Last name:

_Yen

Position :

_{Assistant Professor & Attending Physician}

Department:

_{Department of Traditional Chinese Medicine}

Institution /

Company:

Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital

Mailing address:

_{123 Ding-hu Road, Kweishan, Taoyuan 333, Taiwan}

Telephone: (country/area code)

+886-3-319-6200 ext 2611

Fax: (country/area code)

+886-3-329-8995

E-mail: hungrongyen@gmail.com

Name and contact details (phone, fax, e-mail) of your assistant

Corresponding Author 2

Title: ■Prof Dr Mr Mrs Ms Others:

First name :

_Pi-Hua

Last name:

_Liu

Position :

_{Assistant Professor}

Department:

_{Clinical Informatics and Medical Statistics Research Center, College of Medicine}

Institution /

Company:

Chang Gung University

Mailing address:

_{259 Wen-Hwa 1st Road, Kweishan Taoyuan 333, Taiwan}

Telephone: (country/area code)

+886-3-211-8800 ext.3758

Fax: (country/area code)

+886-3-211-8453

E-mail:

phliu@mail.cgu.edu.tw

Name and contact details (phone, fax, e-mail) of your assistant

Other Author 1

Title: Prof ■Dr Mr Mrs Ms Others:

First name :

_Chin-Hui

Last name:

_Yu

Position :

_R

_esident

_Physician

Department:

_{Department of Traditional Chinese Medicine}

Institution /

Company:

Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital

Mailing address:

_{123 Ding-hu Road, Kweishan, Taoyuan 333, Taiwan}

Telephone: (country/area code)

+886-3-319-6200 ext 2611

Fax: (country/area code)

+886-3-329-8995

E-mail:

connieyu39@hotmail.com

Other Author 2

Title: Prof Dr Mr Mrs ■Ms Others:

First name :

_{Angela Shin-Yu}

Last name:

_Lien

Position :

_Lectures

Department:

_{School of Nursing, College of Medicine}

Institution /

Company:

Chang Gung University

Mailing address:

_{259 Wen-Hwa 1st Road, Kweishan Taoyuan 333, Taiwan}

Telephone: (country/area code)

+886-3-211-8800 ext.5186

Fax: (country/area code)

+886-3-327-9372

E-mail:

angela@mail.cgu.edu.tw

Name and contact details (phone, fax, e-mail) of your assistant

Other Author 3

Title: ■Prof ■Dr Mr Mrs Ms Others:

First name :

_Shu-Ling

Last name:

_Yang

Position :

_{Assistant Professor & Attending Physician}

Department:

_{School of Traditional Chinese Medicine, College of Medicine}

Institution /

Company:

Chang Gung University

Mailing address:

_{259 Wen-Hwa 1st Road, Kweishan Taoyuan 333, Taiwan}

Telephone: (country/area code)

+886-3-211-8800 ext.5101

Fax: (country/area code)

+886-3-211-8421

E-mail: gniluhsy@mail.cgu.edu.tw

Name and contact details (phone, fax, e-mail) of your assistant

Other Author 4

Title: ■Prof ■Dr Mr Mrs Ms Others:

First name :

_Hsien-Ming

Last name:

_Wu

Position :

_{Assistant Professor & Attending Physician}

Department:

_{Department of Obstetrics and Gynecology}

Institution /

Company:

Chang Gung Memorial Hospital

Mailing address:

_{5 Fu-Hsing Street, Kweishan, Taoyuan 333, Taiwan}

Telephone: (country/area code)

+886-3-328-1200 ext 2709

Fax: (country/area code)

+886-3-328-8252

E-mail: danielwu@cgmh.org.tw

Name and contact details (phone, fax, e-mail) of your assistant

Other Author 5

Title: Prof ■Dr Mr Mrs Ms Others:

First name :

_Ming-Chen

Last name:

_Kao

Position :

_{Attending Physician}

Company:

Mailing address:

_{123 Ding-hu Road, Kweishan, Taoyuan 333, Taiwan}

Telephone: (country/area code)

+886-3-319-6200 ext 2611

Fax: (country/area code)

+886-3-329-8995

E-mail: small401@adm.cgmh.org.tw

Name and contact details (phone, fax, e-mail) of your assistant

Other Author 6

Title: Prof ■Dr Mr Mrs Ms Others:

First name :

_Wan-Jung

Last name:

_Chiang

Position :

_{Attending Physician}

Department:

_{Department of Traditional Chinese Medicine}

Institution /

Company:

Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital

Mailing address:

_{123 Ding-hu Road, Kweishan, Taoyuan 333, Taiwan}

Telephone: (country/area code)

+886-3-319-6200 ext 2611

Fax: (country/area code)

+886-3-329-8995

E-mail: jungor@adm.cgmh.org.tw

Name and contact details (phone, fax, e-mail) of your assistant

Other Author 7

Title: Prof ■Dr Mr Mrs Ms Others:

First name :

_Tzu-Ping

Last name:

_Huang

Position :

_{Attending Physician}

Department:

_{Department of Traditional Chinese Medicine}

Institution /

Company:

Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital

Mailing address:

_{123 Ding-hu Road, Kweishan, Taoyuan 333, Taiwan}

Telephone: (country/area code)

+886-3-319-6200 ext 2611

+886-3-319-6200 ext 2611

+886-3-319-6200 ext 2611

E-mail: vialactea713@gmail.com

Name and contact details (phone, fax, e-mail) of your assistant

Other Author 8

Title: ■Prof ■Dr Mr Mrs Ms Others:

First name :

_Sien-Hung

Last name:

_Yang

Position :

_{Associate Professor & Attending Physician}

Department:

_{Department of Traditional Chinese Medicine}

Institution /

Company:

Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital

Mailing address:

_{123 Ding-hu Road, Kweishan, Taoyuan 333, Taiwan}

Telephone: (country/area code)

+886-3-319-6200 ext 2611

Fax: (country/area code)

+886-3-329-8995

E-mail: dryang@adm.cgmh.org.tw

Other Author 9

Title: ■Prof ■Dr Mr Mrs Ms Others:

First name :

_Heng-Hong

Last name:

_Chang

Position :

_{Professor & Attending Physician}

Department:

_{Department of Traditional Chinese Medicine}

Institution /

Company:

Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital

Mailing address:

_{123 Ding-hu Road, Kweishan, Taoyuan 333, Taiwan}

Telephone: (country/area code)

+886-3-319-6200 ext 2611

Fax: (country/area code)

+886-3-329-8995

E-mail:

tcmchh@adm.cgmh.org.tw

Name and contact details (phone, fax, e-mail) of your assistant

Abstract (300 words including acknowledgement with no more than 2 tables / graphs / figures)

Title:

Characteristics and Prescription Patterns of Traditional Chinese Medicine in Endometriosis Patients: Ten-year

Experiences at a Medical Center in Taiwan

Authors:

Chin-Hui Yu, Angela Shin-Yu Lien, Shu-Ling Yang, Hsien-Ming Wu, Ming-Chen Kao, Wan-Jung Chiang,

Tzu-Ping Huang, Sien-Hung Yang, Heng-Hong Chang, Pi-Hua Liu, Hung-Rong Yen

Content:

Background: Endometriosis is a common and chronic illness in women of reproductive age. Complementary

and alternative therapies such as traditional Chinese medicine have become popular and acceptable. However,

substantial scientific evidence and consensus on treating endometriosis is lacking.The aim of this study is to

investigate the characteristics and utilization of traditional Chinese medicine among women with

endometriosis in a medical center.

Methods: We retrospectively collected endometriosis patients at the Chang Gung Memorial Hospital between

2002 and 2011. Patients’ demographic data, duration and frequency of treatment, serum cancer antigen 125

levels, and traditional Chinese medicine treatment principles and prescriptions were analyzed.

Results: Overall,

1242 subjects

(6.8% of all patients with endometriosis) visited traditional Chinese medical

clinics between 2002 and 2011.

Among them,

38.5% (n=478)

with older age, longer treatment duration, and

higher levels of cancer antigen 125 chose to receive western medicinal therapy at the same time. Among the

2,176 prescriptions written for Chinese medicine,

Gui-

Zhi-Fu-Ling-Wan (Cinnamon Twig and Poria Pill)

(20.67%) and Xiang-Fu (Cyperi Rhizoma )(5.28%) were the most frequently prescribed herbal formula and

single herb, respectively. Gui-Zhi-Fu-Ling-Wan plus Long-Dan-Xie-Gan-Tang was the most frequent

combination of herbal formulae (16.77%). Commonly used therapeutic principles included tonification,

regulating blood, and clearing

heat.

Conclusion: Our data represents the consensus of experts’ knowledge and experience in regards to herbal

selection for the treatment of endometriosis. Further well-designed, randomized, double-blinded,

placebo-controlled clinical trials are warranted to evaluate the efficacy and safety of these drug lists.

Characteristics

P Value

No. of visits

No. of cases

Age at first clinic (year)

＜0.001

< 20

0 (0.00)

1 (0.21)

20-29

60 (7.85)

11 (2.30)

30-39

280 (36.65)

159 (33.26)

40-49

342 (44.76)

252 (52.72)

50-59

80 (10.47)

55 (11.51)

60-69

2 (0.26)

0 (0.00)

Times of visit

0.002

1

599 (78.40)

306 (64.02)

2-9

159 (20.81)

159 (33.26)

10-19

5 (0.65)

9 (1.88)

20-29

0 (0.00)

3 (0.63)

≧30

1 (0.13)

1 (0.21)

Duration of treatment (day)

＜0.001

≦30

627 (82.07)

332 (69.46)

31-90

27 (3.53)

28 (5.86)

91-180

31 (4.06)

26 (5.44)

181-270

15 (1.96)

15 (3.14)

271-360

14 (1.83)

13 (2.72)

361-450

13 (1.70)

9 (1.88)

451-540

6 (0.79)

8 (1.67)

541-630

3 (0.39)

5 (1.05)

631-720

4 (0.52)

4 (0.84)

≧721

24 (3.14)

38 (7.95)

Level of CA125 (U/mL)

At the beginning of treatment

P=0.008

At the end of treatment

P=0.006

Difference

P=0.766

Categorial data were presented as absolute numbers and percentages (in parentheses),

and continuous data were summerized as means ± standard deviations

(n=16)

(n=39)

2.58 ± 21.50

5.26 ± 44.71

(n=16)

(n=39)

Table 1 Demographics and characteristics of patients receiving only TCM (TCM-only users)

and both TCM and WM (combination therapy)

TCM-only

combination therapy

1197

764

979

478

40.41 ± 7.38

42 ± 6.50

1.57 ± 1.89

2.05 ± 2.98

67.82 ± 210.36

153.69 ± 371.66

43.66 ± 51.59

65.51 ± 59.06

(n=145)

(n=63)

45.59 ± 25.78

81.44 ± 66.39

For inquiries, please contact Miss Joanna Law at CGCM Central Office,

via email: centraloffice@tcmedicine.org, telephone: +852-2816-0847 or fax: +852-2819-3950

- End of Form -

Herbal formulae English name

Gui-Zhi-Fu-Ling-Wan Cinnamon Twig and Poria Pill 805 (20.67%)

Long-Dan-Xie-Gan-Tang Gentiana Combination 642 (16.48%)

Jia-Wei-Xiao-Yao-San Augmented Rambling Powder 301 (7.73%)

Zuo-Gui-Wan Restore the Left (Kidney) Pill 254 (6.52%)

Liu-Jun-Zi-Tang Six Gentleman Decoction 151 (3.88%)

Xiang-Sha-Liu-Jun-Zi-Tang Six Gentlemen Decoction with Aucklandia and Amomum 134 (3.44%)

Zhi-Bo-Di-Huang-Wan Rehmannia Pills Plus Anemarrhena and Cypress Bark 118 (3.03%)

Xue-Fu-Zhu-Yu-Tang Persica and Carthamus Combination 92 (2.36%)

Bu-Zhong-Yi-Qi-Tang Tonify the Middle and Augment the Qi Decoction 89 (2.28%)

Dang-Gui-Shao-Yao-San Tangkuei and Peony Powder 89 (2.28%)

*Total number of herbal formulae = 3895

Times of prescription (%)