中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/32420

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(1)ύ!୯!ᙴ!ᛰ!ε!Ꮲ! ! ᅺγፕЎ! ጓဦǺJFI.2:17! ! ௖૸Ոિ)UH‫ک‬IEM.D*ᐚࡋϷᖌ‫ڰ‬ᎇ✊ᙯ౽ೈқ )DFUQ*୷Ӣӭࠠ‫܄‬ᆶ࣬ᜢӢηϐᜢೱ‫!܄‬ Study on the association between high triglyceride, low high-density lipoprotein, and CETP gene polymorphism. ! ! ‫܌‬ձǺᕉნᙴᏢࣴ‫!܌ز‬ ࡰᏤ௲௤Ǻֆ‫ޱ‬ᓤ! ௲௤! ! ! ! ! ! Цྷ࿰! ୋ௲௤! ᏢғǺ‫ࡾ׵‬ᓄ!!Chuen-Lin Lee ᏢဦǺ:776117! ύ๮҇୯!!!ΐΜΐ!!ԃ!!Ϥ!!Д.

(2) ᇞᖴ ! ! ӣᏫ᏾ঁࣴ‫ز‬ғғఱǴ‫׏‬۵ǴࢄВωখ຾Εࣴ‫࠻ز‬΋૓Ǵ΋ၡຳຳና ና‫ٰوޑ‬ǴགྷΑ೚ӭǴΨᏢ‫ډ‬Α೚ӭǴགྷགᖴ‫ޑ‬Γ‫׳‬ӭǶ! ! ! ! ! ! २Ӄाགᖴ‫ࡰޑך‬Ꮴ௲௤ֆ‫ޱ‬ᓤԴৣϷЦྷ࿰ԴৣǴচҁჹᏢୢό‫؃‬ ࣗှ‫ךޑ‬Ǵӧ‫ٿ‬ՏࡰᏤԴৣ‫ޑ‬࿎ߦΠǴ‫ډפ‬Α၀߻຾‫ޑ‬БӛǶֆ‫ޱ‬ᓤԴৣ όѝӧᏢୢ΢ǴΨӧΓғ‫ޑ‬ೕჄᗋԖВத‫ࣁޑ‬ΓೀШ΢Ǵ௲ᏤΑ‫ך‬೚ӭϐ ߻όමགྷၸୢᚒϷှ،Б‫ݤ‬ǴΨӧ‫ך‬໾Ј‫ݪ‬഼ਔǴ๏ᆶ໼᠋‫ک‬ႴᓰǶԶЦ ྷ࿰ԴৣᕴࢂόჇ‫ޑྠځ‬Αှ٠ᔅշ‫ँך‬ઇΑ೚ӭᜤᜢǶ੿‫ࡐޑ‬ᖴᖴ‫ٿ‬Տ ԴৣǴόѝࢂӧᏢ཰΢ǴΨӧ΋૓ೀ٣΢ǴЇᏤ‫ࡐך‬ӭόӕ‫ࡘޑ‬ԵБӛǶ ΨགᖴӧፕЎα၂྽ϺǴόᜏٌമ‫ޑ‬Ц࠮ΏԴৣ‫ک‬ֆߪᑉԴৣǴ๏ϒΑ೚ ӭᝊ຦‫ޑ‬ཀ‫ـ‬Զ٬ளፕЎ‫׳‬у‫ֹޑ‬᏾Ƕ! ! ! ! ! ! ᖴᖴࣴ‫܌ز‬Ꮲߏ‫ۆޑ‬ՙၲǵ߷൛ǵ࠶ቺǵӓቼǵһٍᏢ‫ۆ‬Ǵ๏Α‫ߚך‬ தӭ‫ࡌޑ‬᝼‫ک‬ႴᓰǴᗋԖ΋ଆᏟର‫ޑ‬ӕᏢ஀ᓉǵ߷‫ق‬ǵ‫ے‬ᓄǵ߾ԋǵችཁǴ གᖴεუ‫ޑ‬Ѻ਻ၟу‫ݨ‬ǹࣴ‫ޑ࠻ز‬Ꮲ‫୸ਁۂ׌‬ǵॕ๭ǵ٫ዝǵ⯳ྼǵ☰ҏ ฻฻ߚதགᖴεৎ‫ޑ‬ᔅԆၟЍ࡭Ǵᡣ‫ך‬Ԗ‫׳‬ӭ‫୏ޑ‬ΚǶ! ! ! ! നࡕᗋाགᖴ‫ޑך‬ৎΓǴόᆅ‫ך‬໒ЈᜤၸǴᕴࢂӧङࡕᓨᓨ‫ޑ‬Ѝ࡭‫ך‬Ǵᡣ‫ך‬ ૈ໩ճֹԋፕЎǶ! ! ! ! གᖴεৎǼߚதᖴᖴεৎǼ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ࡾᓄ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! 3121/18/22!. i.

(3) ᄔा ङඳ;! ၸଯ‫ޑ‬ΟለҒ‫ݨ‬િ)UH*Ϸၸե‫ޑ‬ଯஏࡋિೈқᖌ‫ڰ‬ᎇ)IEM.D*ࣁ߷‫ે୏ރ‬Ј᠌ੰ ‫ޑ‬ӒᓀӢηǴΨ৒ܰӝ‫ٳ‬ᑗֿੰǵଯՈᓸ฻ੰੱǶচՐ҇ΟለҒ‫ݨ‬િᆶ IEM.D ౦த‫ޑ‬౰Չ౗ၨߚচՐ҇ाଯǴҁࣴ‫ز‬аᐉᘐԄࣴ‫ز‬௖૸চՐ҇ᆶߚচՐ҇. DFUQ ୷Ӣϐ UbrJC Ϸ J516W ୷Ӣࠠ‫ک‬ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶᕉნӢη ϐ࣬ᜢ‫܄‬Ƕ! ! ‫׷‬਑ᆶБ‫ݤ‬Ǻ! ҁࣴ‫ز‬ჹຝࣁ3118.3119ԃࠄ‫׫‬ᑜߞကໂϷѠύѱύՋ୔ௗ‫ڙ‬Ȩӄ଼҇நߥᓀԋ Γ଼ᔠȩ‫ޣ‬Ӆ916Γ)ѠύѱύՋ୔449Γࠄ‫׫‬ᑜߞကໂ578Γѳ֡ԃសࣁ72/1² 22/7ྃ*Ǵ‫ځ‬ύচՐ҇391ΓǴߚচՐ҇636ΓǶԏ໣ୢ‫ڔ‬ၗ਑Ϸෳ‫ۓ‬ғ౛ғϯॶǴ аᆫӝ䁙᜘ᙹϸᔈ.ज़‫ڋ‬Тࢤߏࡋ୷Ӣӭࠠ‫܄‬၂ᡍ)QDS.SGMQ*຾ՉDFUQ୷Ӣϐ UbrJCϷJ516W୷Ӣࠠ᠘‫ۓ‬Ƕ! ! ่݀Ǻ! ҁࣴ‫ز‬ว౜চՐ҇КߚচՐ҇Ԗၨଯ‫ޑ‬К౗‫ܜ‬๨ǵ໯ଚǵᝅ१ᘓ཯‫ک‬ၨե‫ޑ‬സ‫ڜ‬ ଢ଼ϷസૡಞᄍǶচՐ҇ΟለҒ‫ݨ‬િ౦தӝ‫ٳ‬Ԗၨଯ‫ޑ‬ᖌ‫ڰ‬ᎇ౦த‫ک‬ᑗֿੰǴߚচ Ր҇ IEM.D ౦தܰӝ‫ٳ‬ᑗֿੰ‫ک‬ଯֿለՈੱǴԶӧፓ᏾υᘋӢηࡕǴҁࣴ‫ز‬٠҂ ว౜ DFUQ ୷Ӣϐ UbrJC Ϸ J516W ୷Ӣࠠᆶ೭٤੯ੰ‫ޑ‬ᜢᖄ‫܄‬Ƕ௓‫ڋ‬υᘋӢηࡕǴ চ Ր ҇ Ԗ ໯ ଚ ಞ ᄍ ϐ Ο ለ Ғ ‫ ݨ‬િ ౦ த ‫ ޑ‬॥ ᓀ К ଆ ؒ Ԗ ‫ ࣁ ޣ‬5/6 ७ ):6&! DJ>2/:3ȉ21/5:*ǴԖᝅ१ᘓ཯ಞᄍ‫ޑ‬ΓΟለҒ‫ݨ‬િ౦த‫ޑ‬॥ᓀКଆؒԖ‫ࣁޑ‬ 3/5 ७):6&!DJ>2/31ȉ5/:1*ǶচՐ҇஥Ԗ DFUQ ϐ UbrJC ୷Ӣࠠ C2C3 ၨ C2C2 ϐ ΟለҒ‫ݨ‬િ౦த‫ޑ‬॥ᓀࣁ 1/5 ७):6&!DJ>1/2:ȉ1/:6*Ƕ! !! ่ፕǺ! চՐ҇Ԗ໯ଚϷᝅ१ᘓ཯ಞᄍࣁΟለҒ‫ݨ‬િ౦த‫ޑ‬ӒᓀӢηǴԶ DFUQ ୷Ӣϐ UbrJC!C3 ჹଽ୷ӢࣁΟለҒ‫ݨ‬િ౦த‫ߥޑ‬ៈӢηǴฅԶ٠҂ว౜ DFUQ ϐ UbrJC ᆶ J516W ୷Ӣࠠ‫ঁک‬Γ੯ੰўϐᜢᖄ‫܄‬Ƕ!. ! ! ! ii.

(4) Abstract BackgroundΚ High triglyceride(TG) and low high-density lipoprotein(HDL) are independent risk factors of coronary artery disease(CAD). The prevalence rates of high triglyceride and low high-density lipoprotein in a small population of Taiwanese aborigines were higher than those found in non-aboriginal. In this study, we examined the associations among high triglyceride, low high-density lipoprotein, CETP gene polymorphism and related factors. ! MethodsΚ! This study recruited 805 subjects (280 aborigines and 525 non-aborigines) who lived in the Hsin-Yi area of Nantou County and Taichung County in 2007-2008. Blood samples were collected from these participatants, and used for measuring biochemical markers. The CETP genotypes TaqIB and I405V were performed using the PCR-restriction fragment length polymorphism assay. ResultsΚ! Aborigines were more prevalent than non-aborigines for health-risk habits such as: smoking, drinking and chewing betel nuts, and had lower rate of drinking tea and coffee, and exercise as well as. We found that aboriginals with high TG had high cholesterol and diabetes. Non-aborigines with low HDL were easily acquire diabetes and hyperuricemia, but we found no significant association between gene polymorphism and these diseases. Using multiple logistic regression analysis to adjuste confounding factors, we found that drinking and areca chewing habits significantly associated with high triglyceride in aboriginals (drinking : OR=4.5; 95% CI=1.92-10.49, areca chewing : OR=2.4; 95% CI=1.20-4.90). The aboriginal people with TaqIB B1B2 genotype, compare to those with B1B1, had significantly decreased risk for high triglyceride(OR=0.4; 95% CI=0.19-0.95). ConclusionΚ This study suggestes that drinking and areca chewing are risk factors for high triglyceride, while the CETP TaqIB B2 allele is the protective factor for high triglyceride among aborigines. However, we still don’t have strong evidence to demonstrate the association between TaqIB, I405V gene and CVDs in this study.. ! iii.

(5) ‫ؾ‬ᙕ ᇞᖴ ............................................................................................................................................ i ᄔा ............................................................................................................................................ii Abstract .....................................................................................................................................iii ಃ΋ക. ᆣፕ................................................................................................................. 1. ಃ΋࿯. ࣴ‫ز‬ङඳᆶ୏ᐒ............................................................................................. 1. ಃΒ࿯. ࣴ‫ز‬Ҟ‫ޑ‬......................................................................................................... 3. ಃΒക. Ў᝘௖૸......................................................................................................... 4. ಃ΋࿯. ΟለҒ‫ݨ‬િϷ IEM.D ౦தϐ౰Չ౗ ............................................................. 4. ಃΒ࿯. ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶ੯ੰᜢ߯ ................................................. 5. ಃΟ࿯. ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶᕉნӢη ................................................. 6. ಃѤ࿯. ᖌ‫ڰ‬ᎇ✊ᙯ౽ೈқ......................................................................................... 7. ಃϖ࿯. DFUQ!୷Ӣӭࠠ‫܄‬........................................................................................... 8. ಃΟക. ‫׷‬਑ᆶБ‫ݤ‬................................................................................................... 10. ಃ΋࿯. ࣴ‫ࢎز‬ᄬ....................................................................................................... 10. ಃΒ࿯. ࣴ‫ز‬ჹຝ....................................................................................................... 11. ಃΟ࿯. ΟለҒ‫ݨ‬િ౦தϷ IEM.D ౦த‫ۓ‬က ........................................................... 11. ಃѤ࿯. ୢ‫ڔ‬ፓࢗϣ৒............................................................................................... 11. ಃϖ࿯. ᔠᡏԏ໣ᆶೀ౛........................................................................................... 12. ಃϤ࿯. ӄՈ‫ ܜ‬EOB ϐБ‫ݤ‬....................................................................................... 12. ಃΎ࿯. ᖌ‫ڰ‬ᎇ✊ᙯ౽ೈқȐDFUQ*୷Ӣϐӭࠠ‫܄‬᠘‫ ۓ‬......................................... 12. ಃΖ࿯. ၗ਑಍ीᆶϩ‫݋‬........................................................................................... 14. ಃѤക. ࣴ‫่݀ز‬....................................................................................................... 16. ಃ΋࿯. ࣴ‫ز‬ჹຝ‫୷ޑ‬ҁ੝ቻ................................................................................... 16. ಃΒ࿯. DFUQ ϐ UbrJC Ϸ J516W ୷ӢࠠϷғ౛ғϯࡰ኱ϐ໔‫࣬ޑ‬ᜢ‫ ܄‬.............. 19. ಃΟ࿯. ΓαᏢϷᕉნӢηჹΟለҒ‫ݨ‬િϷ IEM.D ౦த‫ޑ‬ቹៜ ........................... 19. iv.

(6) ಃѤ࿯ ಃϖക. UbrJC Ϸ J516W ୷Ӣӭࠠ‫܄‬ჹ‫ܭ‬ΟለҒ‫ݨ‬િၸଯ‫ ک‬IEM.D ၸե‫ޑ‬ቹៜ 20 ૸ፕ............................................................................................................... 21. ಃ΋࿯. ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶΓαᏢ੝‫܄‬ϐᜢ߯ ............................... 21. ಃΒ࿯. ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶӅੰੱ ................................................... 21. ಃΟ࿯. ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶᕉნӢηϐᜢ߯ ................................... 22. ಃѤ࿯. ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶ DFUQ ୷Ӣ ............................................. 23. ಃϖ࿯. ࣴ‫ز‬ज़‫ڋ‬....................................................................................................... 25. ಃϤക. Ў᝘௖૸....................................................................................................... 26. v.

(7) ߄Ҟᒵ! ߄΋;ࣴ‫ز‬ჹຝϐ୷ҁ੝ቻ ................................................................................................... 30 ߄Β;ࣴ‫ز‬ჹຝ‫ޑ‬ғ౛ғϯॶ ............................................................................................... 31 ߄Ο;ࣴ‫ز‬ჹຝ DFUQ ϐ UbrJC Ϸ J516W ୷Ӣࠠϩթ ......................................................... 32 ߄Ѥ;ࣴ‫ز‬ჹຝ‫ঁޑ‬Γ੯ੰў ............................................................................................... 33 ߄ϖ;চՐ҇‫୷ޑ‬ҁၗ਑ᆶғࢲಞᄍ‫ ک‬UH Ϸ IEM.D ϐᜢ߯ ............................................. 34 ߄Ϥ;ߚচՐ҇‫୷ޑ‬ҁၗ਑ᆶғࢲಞᄍ‫ ک‬UH Ϸ IEM.D ϐᜢ߯ ......................................... 35 ߄Ύ;চՐ҇ᆶߚচՐ҇‫ޑ‬ғ౛ғϯॶ‫ ک‬UH Ϸ IEM.D ϐКၨ ......................................... 36 ߄Ζ;চՐ҇ঁΓ੯ੰў ....................................................................................................... 37 ߄ΐ;ߚচՐ҇ঁΓ੯ੰўϩթ ........................................................................................... 38 ߄Μ;UbrJC ୷Ӣࠠϩթᆶғ౛ғϯࡰ኱ϐᜢ߯ ................................................................ 39 ߄Μ΋;J516W ୷Ӣࠠϩթᆶғ౛ғϯࡰ኱ϐᜢ߯ ............................................................ 40 ߄ΜΒ;চՐ҇ᆶߚচՐ҇ϐғࢲࠠᄊჹ UH ၸଯϐ॥ᓀ ................................................. 41 ߄ΜΟ;চՐ҇ᆶߚচՐ҇ϐғࢲࠠᄊჹ IEM.D ၸեϐ॥ᓀ ........................................... 42 ߄ΜѤ;DFUQ ϐ UbrJC Ϸ J516W ୷Ӣӭ‫܄׎‬ჹ‫ ܭ‬UH ၸଯϐയᆉК ................................ 43 ߄Μϖ;DFUQ ϐ UbrJC Ϸ J516W ୷Ӣӭ‫܄׎‬ჹ‫ ܭ‬IEM ၸեϐയᆉК .............................. 44. ! ! ! ! ! !. vi.

(8) ಃ΋കʳ ᆣፕ! ಃ΋࿯ʳ !ࣴ‫ز‬ङඳᆶ୏ᐒ ၸଯ‫ޑ‬ΟለҒ‫ݨ‬િ!)usjhmzdfsjef<!UH*!‫ک‬ၸե‫ޑ‬ଯஏࡋિೈ қᖌ‫ڰ‬ᎇ!)ijhi!efotjuz!mjqpqspufjo.dipmftufspm<!IEM.D*!Ǵନ Α཮ቚу߷‫ે୏ރ‬Ј᠌ੰ!)dpspobsz!ifbsu!ejtfbtf<!DBE*!‫ޑ‬ᑡ஻ 2. 3. ᐒ౗Ѧ ǴΨ৒ܰӝ‫ٳ‬ᑗֿੰǵଯՈᓸ฻ੱ‫ ރ‬Ƕ !!!!চՐ҇ΟለҒ‫ݨ‬િᆶ IEM.D ‫ޑ‬ᐚࡋ‫ڀ‬Ԗ‫ځ‬੝ਸ‫܄‬ǴਥᏵလ฻Γ )3112*‫ࡰزࣴޑ‬рǴচՐ҇ΟለҒ‫ݨ‬િၸଯ‫ޑ‬ΓαǴ51 ྃа΢౰Չ 4. ౗ऊࣁ 31.61&ǴѲၭ௼‫׳‬ଯၲ 61&а΢ Ǵ஭฻Γ)3114*Ϸֆ฻Γ)3112* 5.6. ‫زࣴޑ‬ᡉҢচՐ҇ΟለҒ‫ݨ‬િ‫ޑ‬ᐚࡋᡉ๱ଯ‫ߚܭ‬চՐ҇௼ဂ ǹ٩ྣ Ȩ3116.3119 ୯҇ᔼᎦ‫ݩރ‬ᡂᎂፓࢗȩ!!)Ovusjujpo!Boe!Ifbmui! Tvswfz!jo!Ubjxbo<!OBITJU*!‫ޑ‬ၗ਑‫ک‬ዐ฻Γ)3111*‫่݀زࣴޑ‬ว౜ Ѡ᡼ξӦচՐ҇ໂΟለҒ‫ݨ‬િ‫ ک‬IEM.D ౦த‫ޑ‬౰Չ౗ᇻଯ‫ܭ‬Ѡ᡼‫ځ‬ 7.8. дӦ୔ Ƕ! ! ! ೷ԋΟለҒ‫ݨ‬િ‫ ک‬IEM.D ᐚࡋ౦த‫ޑ‬চӢፄᚇǴନΑᅿ௼ѦǴԃ សᆶ‫܄‬ձ. 7-!9.:. ǵᕉნǵ୷Ӣǵᕉნ‫୷ک‬Ӣ໔‫ޑ‬ҬϕբҔ฻ࣣࢂ‫ځ‬ቹៜ. Ӣન‫ځ‬ύᕉნӢηх֖‫ܜ‬๨ǵ໯ଚǵၮ୏฻ғࢲಞᄍǴUftijnb ฻Γ )3112*‫زࣴޑ‬ว౜‫ܜ‬๨཮ගଯΟለҒ‫ݨ‬િᐚࡋ‫ک‬फ़ե IEM.D ‫ޑ‬ᐚࡋ 21. 22. ǴFmmjtpo ฻Γ)3115*ࣴ‫ࡰز‬р໯ଚໆᆶ IEM.D ᐚࡋԋ҅࣬ᜢ ǴDipv 1.

(9) ฻Γ)2::4*ӧ঵ٚ‫زࣴޑ‬ว౜Ԗၮ୏ಞᄍ‫ޣ‬ǵؒԖ‫ܜ‬๨Ϸ໯ଚಞᄍ‫ޣ‬ 23. ᏱԖၨե‫ޑ‬ΟለҒ‫ݨ‬િၸଯ॥ᓀ ǴLjoh ฻Γ)2::6*ჹ 61.76 ྃԴΓ 24. ‫ࡰ߾زࣴޑ‬рǴၮ୏Ԗշ‫ܭ‬ቚу IEM.D ‫ޑ‬ᐚࡋ Ƕ! !!!!ᖌ‫ڰ‬ᎇ ✊ ᙯ౽ೈқ!)dipmftufszm!ftufs!usbotgfs!qspufjo<! DFUQ*! ࣁ IEM.D ຾ Չ ᖌ ‫ ڰ‬ᎇ ଍ ᙯ ၮ ! )sfwfstf! dipmftufspm! usbotqpsu*!ၸำύ‫ޑ‬ख़ाӢηǶቅ฻Γ)3114*ӧύ୯‫زࣴޑ‬ว౜Ǵ 25. DFUQ ᆶΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեԖ࣬ᜢ ǶUbrJC ‫ޑ‬ᡂ౦ࢂᖌ‫ڰ‬ 26. ᎇ✊ᙯ౽ೈқ୷Ӣ΢ၨத೏௖૸ᆶ IEM.D ᐚࡋ࣬ᜢ‫ޑ‬ᡂ౦ ǴSvbo ฻ Γ)311:*߾ว౜ UbrJC ୷ӢࠠᆶΟለҒ‫ݨ‬િჹ IEM.D ᐚࡋԖҬϕբҔ ‫ޑ‬ቹៜ. 27. ǹԶӧৎ௼‫܄‬ଯᖌ‫ڰ‬ᎇՈੱ‫زࣴޑ‬ύว౜Ǵ஥Ԗ UbrJC!C3 28. ჹଽ୷Ӣ‫ޣ‬ၨ஥Ԗ C2!‫ޣ‬Ԗၨե‫ޑ‬໭ࡕΟለҒ‫ݨ‬િᐚࡋ ǹԜѦǴќ ΋ၨத೏ࣴ‫ ࣁز‬J516W ୷Ӣࠠ!WW ࠠᆶ IEM.D ᐚࡋ‫࣬ޑ‬ᜢ‫܄‬. 27-!29. ǹӧ. ΟለҒ‫ݨ‬િၨଯ‫܄تޑ‬ϐύǴWW ୷Ӣࠠᆶ WJ Ϸ JJ ୷ӢࠠКၨଆٰǴ 2:. ᏱԖၨଯ‫ ޑ‬IEM.D ᐚࡋ Ƕ! ! ! ҁࣴ‫ز‬ԏ໣ࠄ‫׫‬ᑜߞကໂ578ΓϷѠύѱύՋ୔449Γௗ‫ڙ‬Ȩӄ҇ ଼நߥᓀԋΓ଼ᔠȩ‫ޣ‬Ӆ916ΓǴ௖૸ΟለҒ‫ݨ‬િၸଯϷIEM.Dၸեᆶ DFUQ୷ӢϐUbrJCǵJ516W୷Ӣࠠ‫ک‬ᕉნӢη࣬ᜢ‫܄‬Ƕ! ! ! 2.

(10) ಃΒ࿯ʳ ࣴ‫ز‬Ҟ‫ޑ‬ ҁࣴ‫ز‬аࠄ‫׫‬ᑜߞကໂϷѠύѱύՋ୔ௗ‫ڙ‬Ȩӄ଼҇நߥᓀԋΓ଼ ᔠȩࣁࣴ‫ز‬ჹຝǴ!аᐉᘐԄࣴ‫)ز‬dsptt.tfdujpobm!tuvez*௖૸ DFUQ ୷Ӣϐ UbrJC Ϸ J516W ୷Ӣࠠ‫ک‬ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶᕉნ Ӣηϐ࣬ᜢ‫܄‬Ƕ!. 3.

(11) ಃΒകʳ Ў᝘௖૸! ಃ΋࿯ʳ ΟለҒ‫ݨ‬િϷ IEM.D ౦தϐ౰Չ౗ ! ! Gpse ฻Γ)311:*வ 2:::.3115 ԃऍ୯୯ৎ଼நᆶᔼᎦᔠᡍፓࢗ )Obujpobm!Ifbmui!boe!Ovusjujpo!Fybnjobujpo!Tvswfz<!OIBOFT*!‫ޑ‬ ၗ਑ว౜Ǵ31 ྃа΢ऍ୯қΓǵ໵ΓǵᏀဴऍᝤΓΟለҒ‫ݨ‬િၸଯ 31. )UHɪ311!nh0eM*‫ޑ‬౰Չ౗Ǵϩձࣁ 2:/5&ǵ:/1&Ϸ 31/:& ǶӧВҁ ‫ޑ‬ፓࢗ߾ࡰрǴΟለҒ‫ݨ‬િၸଯ)UHɪ261!nh0eM*‫ޑ‬౰Չ౗‫܄ت‬Ϸζ ‫܄‬ϩձࣁ 41/9&Ϸ 46/8&ǴԶଯஏࡋિೈқᖌ‫ڰ‬ၸե)IEMɦ51!nh0eM* 32. ‫ޑ‬౰Չ౗‫܄ت‬Ϸζ‫܄‬ϩձࣁ 36/:&Ϸ 29/7& Ƕ! ! ! ୯ϣѠ୯҇ᔼᎦ଼ந‫ݩރ‬ᡂᎂፓࢗᡉҢǴIEM.D ၸե)IEMɦ46! nh0eM*‫ޑ‬౰Չ౗‫ ࣁ܄ت‬22/6&ζ‫ ࣁ܄‬2/9&ǹԶΟለҒ‫ݨ‬િၸଯ)UHɪ 311!nh0eM*‫ޑ‬౰Չ౗‫܄ت‬வ 2::4.2::7 ‫ ޑ‬24/5&ቚуԿ 3116.3119 ‫ޑ‬ 31/9&Ǵζ‫߾܄‬җ 7/2&ቚу‫ ډ‬8/:&ǹऩ٩ྣԃសϩቫٰ࣮Ǵஒԃសቫ ϩԋ 42.55 ྃǵ56.75 ྃǵ76 ྃа΢ΟቫǴ‫܄ت‬Ϸζ‫܄‬ΟለҒ‫ݨ‬િၸ ଯ౰Չ౗ϩձࣁ 37/5&ǵ34&ǵ2:/2&Ϸ 4/:&ǵ22/9&ǵ32/9&Ǵё࣮р ӧ 75 ྃϐ߻‫܄ت‬ΟለҒ‫ݨ‬િၸଯ౰Չ౗ଯၸζ‫܄‬ǴԶӧ 76 ྃϐࡕǴ ζ‫߾܄‬ଯ‫܄تܭ‬ǹԶӧ IEM.D Бय़ǴΟঁԃសቫ‫܄ت‬Ϸζ‫܄‬౰Չ౗ϩ ձࣁ 26/3&ǵ21/2&ǵ21/8&Ϸ 2/1&ǵ3/:&ǵ5/5&Ǵ‫܄ت‬όፕԃសቫ೿ 7. ၨζ‫ٰ܄‬ளाଯ Ƕ! 4.

(12) ! ! လ฻Γ)3112*ჹচՐ҇ੀ໡௼ǵѲၭ௼ǵ௨᡼௼‫ޑ‬ፓࢗว౜Ǵ51 ྃа΢চՐ҇ΟለҒ‫ݨ‬િၸଯ)UHɪ311!nh0eM*౰Չ౗ऊ 31.61&ǴΟ ௼ύаѲၭ௼നଯǴ‫ ܄ت‬64&ζ‫ ܄‬62&Ǵੀ໡௼ԛϐǴ‫ ܄ت‬41&ζ‫܄‬ 4. 42& Ƕ! ಃΒ࿯ʳ ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶ੯ੰᜢ߯! ! ! Ոనύၸഭ‫ޑ‬ᖌ‫ڰ‬ᎇ࿶ၸࢲ‫਼਼܄‬ϯࡕ཮ᡂԋለϯિ፦Ǵ୴ᑈӧ ୏ે‫ޑ‬ՈᆅᏛǶӆу΢Ոనύ‫ޑ‬ᖌ‫ڰ‬ᎇϷΟለҒ‫ݨ‬િߕ๱ࡕǴՈᆅ཮ ᡂள੟ઞǵฯЪૄ১Ǵ഼Ѩচҁ‫ࢋޑ‬೬‫܄‬Զ‫׎‬ԋଯՈᓸǶϐࡕऩࢂౢ ғՈਵǴ߾৒ܰЇଆ୏ેฯϯǴӄ‫ي‬ՈᆅࣣࢂԖёૈวғǴऩ‫ٮܭ‬ᔈ Ј᠌Ոࢬ‫ે୏ރ߷ޑ‬Ǵ߾཮Їଆ߫ᆀȨ߷Јੰȩ‫ે୏ރ߷ޑ‬Ј᠌ੰ 33. )dpspobsz!ifbsu!ejtfbtf<!DBE* Ƕ! !!!!ΟለҒ‫ݨ‬િჹ‫ܭ‬ЈՈᆅ੯ੰࢂցࣁᐱҥ‫ޑ‬ӒᓀӢη΋‫ޔ‬Ԗ‫ݾ܌‬ ᝼ǴЬӢࢂ྽ΟለҒ‫ݨ‬િၸଯਔǴ৒ܰӝ‫ ٳ‬IEM.D ၸե‫ک‬եஏࡋિೈ 34. қᖌ‫ڰ‬ᎇၸଯ‫ޑ‬௃‫ ׎‬ǶBTTNBO ฻Γ)2::3*‫زࣴޑ‬ᇡࣁǴ྽ၸଯ‫ޑ‬Ο ለҒ‫ݨ‬િᆶଯКॶ‫ ޑ‬MEM0IEM ӕਔวғਔǴჹ߷‫ે୏ރ‬Ј᠌ੰԶ‫ࢂق‬ 35. ႣෳӢη Ƕՠ Npssjtpo ฻Γ)311:*߾ࡰрǴΟለҒ‫ݨ‬િࢂ߷‫୏ރ‬ 36. ેЈ᠌ੰ‫ޑ‬ᐱҥႣෳӢη Ƕჹ‫ ܭ‬IEM.D Զ‫ق‬ǴCvsdigjfm ฻Γ)2::6* 37. ‫زࣴޑ‬ᇡࣁЈՈᆅ੯ੰวғ౗ᆶ‫ځ‬ԋॄ࣬ᜢ Ƕჹတύ॥ٰᇥǴ Mbcsfvdif ฻Γ)311:*‫ࡰزࣴޑ‬рǴΟለҒ‫ݨ‬િᐚࡋᆶတύ॥࣬ᜢǴ 5.

(13) 38. ၨե‫ޑ‬ΟለҒ‫ݨ‬િᐚࡋёаႣٛတύ॥ ǶόၸǴE{jfe{jd ฻Γ)3115* ‫߾زࣴޑ‬ว౜࣬ϸ‫่݀ޑ‬Ǵࣴ‫ࡰ่݀ز‬рե‫ޑ‬ΟለҒ‫ݨ‬િᐚࡋǴԖၨ 39. ଯ‫ޑ‬တύ॥॥ᓀ Ƕၸѐ‫زࣴޑ‬ΨࡰрǴIEM.D ‫ޑ‬ᐚࡋᆶတύ॥࣬ᜢ 3:. Ƕ୯ϣ٩ྣՉࡹଣȨѠ᡼Ӧ୔Οଯଓᙫፓࢗൔ֋ȩ ǴՈિ౦த‫ޑ‬୯Γ. ᆶ҅த‫࣬ޣ‬КǴวғύ॥‫ޑ‬ᐒ౗ࣁ 3/5 ७ǹวғ๝᠌ੰ‫ޑ‬ᐒ౗ࣁ 2/7 41. ७ǴวғЈ᠌ੰ‫ޑ‬ᐒ౗߾ࣁ 2/9 ७ Ƕ! ! ! Ujspti ฻Γ)3119*‫زࣴޑ‬ว౜ǴΟለҒ‫ݨ‬િࣁᑗֿੰ‫ޑ‬΋ঁӒ 42. ᓀӢη ǶᑗֿੰᆶΟለҒ‫ݨ‬િ‫ ک‬IEM.D ᐚࡋ‫ޑ‬ᜢ߯Ǵёૈᆶ௓‫ڋ‬Ո ᑗ‫ޑ‬ລᅟᆾી৞નԖᜢǴᑗֿੰΓӢࣁી৞નϩ‫ݜ‬ό‫ى‬ǴᏤठಒझค ‫֎ݤ‬ԏᗐᜪǴ٬ဟ๻ᑗᅉ੮ӧՈనύǴ೷ԋՈᑗᐚࡋϲଯǶಒझόૈ ճҔᗐᜪǴϿΑૈໆٰྍǴ‫ي‬ᡏࣁΑံᓭ೭ঁཞѨǴѝӳуೲϩှᡏ ϣ‫ޑ‬િެǴаග‫׳ٮ‬ӭ‫ૈޑ‬ໆǴԶિެуೲϩှǴ൩཮ᏤठΟለҒ‫ݨ‬ 33. િᐚࡋϲଯ‫ ک‬IEM.D ᐚࡋ‫ޑ‬फ़ե Ƕ!! ಃΟ࿯ʳ ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶᕉნӢη! !!!!ᕉნӢη཮ჹΟለҒ‫ݨ‬િ‫ ک‬IEM.D ᐚࡋౢғቹៜǶа‫ܜ‬๨ಞᄍٰ ᇥǴ३๨৒ܰफ़եռᕗ፦ᖌ‫ڰ‬ᎇㄽ୷ᙯϯ䁙Ȑmfdjuijo;dipmftufspm! bdzmusbotgfsbtfǹMDBUȑ!ࢲ‫܄‬. 43.44. ǴӢԶ‫ ڋ׭‬IEM.D ‫ޑ‬ԋዕǶJnbnvsb 44. ฻Γ)3113*‫زࣴޑ‬ว౜‫ܜ‬๨ಞᄍᆶ IEM.D ‫ޑ‬ᐚࡋԖ࣬ᜢ‫ ܄‬ǴUftijnb ฻Γ)3112*‫ޑ‬ӧВҁჹ 31.4: ྃ‫ࡰ߾زࣴޑ܄ت‬р‫ܜ‬๨ಞᄍ཮फ़ե 6.

(14) 21. ଯஏࡋિೈқ‫ޑ‬ᐚࡋ‫ک‬ගϲΟለҒ‫ݨ‬િ‫ޑ‬ᐚࡋ Ƕၸໆ‫ޑ‬໯ଚ཮٬‫ط‬ 3. ᠌εໆӝԋΟለҒ‫ݨ‬િǴԶ٬Ոనύ‫ޑ‬ΟለҒ‫ݨ‬િໆቚу Ƕ Dipveivsz ฻Γ)2::5*ࣴ‫ز‬ᡉҢ໯ଚ‫ޣ‬ၨค໯ଚ‫ޣ‬КၨଆٰǴ཮ቚу IEM.D ‫ޑ‬ᐚࡋ. 34. 46. ǴKpttb ฻Γ)2::2*‫زࣴޑ‬ΨԖ࣬ӕ‫ ่݀ޑ‬ǶDipj. ฻Γ)3118*ჹऍ୯‫ڜ‬ଢ଼Ϸૡ‫ޑ‬٬Ҕࣴ‫ࡰز‬рǴ‫ڜ‬ଢ଼‫ޑ‬٬ҔᆶեՈિԖ 47. ࣬ᜢ‫܄‬Ǵόၸૡယ‫ޑ‬٬Ҕ߾ց ǶLp ฻Γ)3116*‫زࣴޑ‬ᡉҢǴԖᝅ१ 48. ᘓ཯ಞᄍ‫ޣ‬ǴΟለҒ‫ݨ‬િၸଯ‫ޑ‬॥ᓀࣁ 3/5 ७ Ƕόၸӧ୏‫ނ‬ჴᡍύǴ 49. ᗯ१ᘓ཯๧‫ڗ‬ԋϩ‫ޑ‬εႵ཮ܴᡉ‫ޑ‬फ़եᖌ‫ڰ‬ᎇ‫ک‬ΟለҒ‫ݨ‬િ Ƕၮ୏ 24. ёа‫ڈ‬ᐟ IEM.D ‫ޑ‬ౢғ‫ک‬ᖌ‫ڰ‬ᎇ‫ޑ‬଍ᙯၮ Ǵ‫ڬ‬฻Γӧ঵ٚ‫زࣴޑ‬ว ౜ǴԖၮ୏ಞᄍၨؒԖၮ୏ಞᄍ‫ޣ‬ΟለҒ‫ݨ‬િ౦த‫ޑ‬യᆉКࣁ 1/72 23. ७ Ƕ! ಃѤ࿯ʳ ᖌ‫ڰ‬ᎇ✊ᙯ౽ೈқ! !!!!ᖌ‫ڰ‬ᎇ‫ޑ‬଍ᙯၮ!)sfwfstf!dipmftufspm!usbotqpsu*!ࣁIEM.D ஒ‫ڬ‬ᜐಔᙃౢғ‫ޑ‬ӭ‫ܭ‬ᖌ‫ڰ‬ᎇ‫ک‬િެ஥ӣ‫ࢬޑ᠌ط‬ำǶᖌ‫ڰ‬ᎇ✊ᙯ౽ ೈқࣁ೭ঁၸำύख़ा‫ޑ‬ӢηǴIEM.DᗭಈճҔᖌ‫ڰ‬ᎇ✊ᙯ౽ೈқஒ ᖌ‫ڰ‬ᎇ✊ᆶWMEMύ‫ޑ‬ΟለҒ‫ݨ‬િ຾ՉҬඤǴԶWMEM࿶ၸિೈқિှ䁙! ȐMjqpqspufjo!Mjqbtf<!MQMȑ!ᆶ‫ط‬િှሇન)ifqbujd!mjqbtf*բҔ ࡕǴԋࣁJEMϷMEMࡕǴӆஒᖌ‫ڰ‬ᎇ✊җMEM!sfdfqupsଌӣ‫᠌ط‬Ǵӵკ 4:. ΋‫܌‬Ң Ƕ 7.

(15) ! !!!!!!!!!!!!!!კ΋;ᖌ‫ڰ‬ᎇ‫ޑ‬଍ᙯၮ! ಃϖ࿯ʳ DFUQ!୷Ӣӭࠠ‫!܄‬ ! ! UbrJC ࣁᖌ‫ڰ‬ᎇ✊ᙯ౽ೈқၨத೏௖૸‫୷ޑ‬ӢࠠǴ‫ځ‬ჹଽ୷Ӣᓎ ౗Ӣᅿ௼Ԗ‫܌‬ৡ౦Ǵύ୯Γ)Dijoftf*UbrJC ‫ ޑ‬C2!bmmfmf ᆶ C3!bmmfmf 51. ϩձࣁ 63/3&Ϸ 58/9&ǹቺ୯Γ)Hfsnbo*ࣁ 82/8&ᆶ 39/4& ǹऍ୯Γ 52. ‫ޑ‬ᓎ౗Ӛࣁ 69/4&‫ ک‬52/8& ǹВҁΓ‫ ޑ‬C2C2ǵC2C3ǵC3C3 ୷Ӣᓎ౗ 26. ߾ϩձࣁ 46/9&ǵ59/5&Ϸ 26/9& ǶCpflipmeu)3116*‫ࡰزࣴޑ‬рǴ 53. UbrJC ᆶ IEM.D Ԗᜢ ǶKfotfo ‫߾زࣴޑ‬ᡉҢǴଚᆒᆶ IEM.D ϐ໔‫ޑ‬ ࣬ᜢ‫ڗ܄‬،‫ ܭ‬UbrJC3 ୷Ӣ 43ΖJ516W ࣁќ΋ᖌ‫ڰ‬ᎇ✊ᙯ౽ೈқ୷Ӣ 55. ࠠǴ‫ ځ‬WWǵJWǵJJ ୷Ӣࠠᓎ౗ӧύ୯Γࣁ 2:&ǵ61&ǵ42& ǹЃՋࣁ 56. 29&ǵ65&ǵ39& Ƕၸѐࣴ‫ز‬ว౜ J516W ୷Ӣࠠ཮ቹៜᖌ‫ڰ‬ᎇિᙯ౽ೈ 8.

(16) 2:. қ‫܄ࢲޑ‬Ǵ຾Զቹៜ IEM.D ǶCsvdf ฻Γ)2::9*‫زࣴޑ‬ว౜ΟለҒ‫ݨ‬ િᆶ J516W ୷ӢࠠϐҬϕբҔ཮ჹ IEM.D ೷ԋቹៜǴ྽ΟለҒ‫ݨ‬િᐚ ࡋၸଯਔǴ஥Ԗ J516W ୷Ӣϐ WW ᡂ౦ࠠ‫཮ޣ‬К JW ‫ ک‬JJ ‫ޣ‬Ԗ‫׳‬ଯ‫ޑ‬ 2:. IEM.D Ƕ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! 9.

(17) ಃΟകʳ ‫׷‬਑ᆶБ‫!ݤ‬ ಃ΋࿯ʳ ࣴ‫ࢎز‬ᄬ! !. ӄ଼҇நߥᓀԋΓ଼ᔠ! চՐ҇ 391 ΓߚচՐ҇ 636 ΓӅ 916 Γ!. ! ! ୷Ӣࠠ᠘‫!ۓ‬. !. DFUQ ୷Ӣ! ϐ UbrJC Ϸ J516W ୷Ӣࠠ!. ! ୢ‫ڔ‬ፓࢗ! 2/ ΓαᏢၗ਑!. ! Ȑԃសǵ‫܄‬ձǵ௲‫ػ‬ำࡋ฻ȑ!. ғ౛ғϯࡰ኱!. 3/ ғࢲಞᄍ!. ‫ي‬ଯ!. ! Ȑ‫ܜ‬๨ǵ໯ଚǵᝅ१ᘓ཯ǵૡϷ‫ڜ‬ଢ଼. ᡏख़!. ‫ޑ‬٬Ҕǵၮ୏ಞᄍ฻ȑ! 4/ ੯ੰў!. ဈൎ!. !. Ոᓸ!. ȐЈ᠌੯ੰǵတύ॥ǵᑗֿੰǵଯՈ ᓸ฻ȑ!. ‫ޜ‬ဎՈᑗ!. !. ᕴᖌ‫ڰ‬ᎇ! ΟለҒ‫ݨ‬િ!. !. IEM.D!. ! !. ຑ՗ DFUQ ୷Ӣϐ UbrJC Ϸ J516W ୷Ӣࠠ‫ک‬ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶᕉ ნӢηϐᜢ߯Ƕ!. ! ! ! ! ! 10.

(18) ಃΒ࿯ʳ ࣴ‫ز‬ჹຝ! !!!!ҁࣴ‫ز‬ଞჹჹຝࣁ 3118.3119 ԃࠄ‫׫‬ᑜߞကໂϷѠύѱύՋ୔ ௗ‫ڙ‬Ȩӄ଼҇நߥᓀԋΓ଼ᔠȩԃសε‫ ܭ‬51 ྃ‫ޣ‬Ӆ 916 Γ)Ѡύѱύ Ջ୔ 449 Γࠄ‫׫‬ᑜߞကໂ 578 Γѳ֡ԃសࣁ 72/1²22/7 ྃ*Ǵ‫ځ‬ύচ Ր҇ 391 ΓߚচՐ҇ 636 ΓǶ‫܌‬Ԗࣴ‫ز‬ჹຝࣣ೸ၸय़ჹय़‫ޑ‬ୢ‫ڔ‬ೖ ຎǴғ౛ᔠࢗϷ௦໣Ոనኬҁ຾Չғϯϩ‫݋‬ᆶ୷Ӣࠠ᠘‫ۓ‬Ƕ‫܌‬Ԗၸำ ࣣቻளࣴ‫ز‬ჹຝᒃԾᛝ࿿ୖу‫ޣ‬ӕཀਜࡕ຾ՉǶ! ಃΟ࿯ʳ ΟለҒ‫ݨ‬િ౦தϷ IEM.D ౦த‫ۓ‬က! ! ! ҁࣴ‫ز‬аѠ᡼ᔼᎦ଼ந‫ݩރ‬ᡂᎂፓࢗ‫ࡌ܌‬᝼Ǵ‫ۓ‬ကΟለҒ‫ݨ‬િɪ 311!nh0eM ࣁΟለҒ‫ݨ‬િ౦தǴ‫ۓ‬က IEM.Dɦ46!nh0eM ࣁ IEM.D ౦தǶ! ಃѤ࿯ʳ ୢ‫ڔ‬ፓࢗϣ৒! !!!!ࣴ‫ز‬ჹຝаय़ჹय़‫ޑ‬ୢ‫ڔ‬ೖຎ‫܌‬ԏ໣Ƕ่ᄬԄୢ‫ޑڔ‬ϣ৒х֖Α ΓαᏢᡂ໨)‫܄‬ձǵԃសǵ௲‫ػ‬ำࡋǵᅿ௼฻*ǵғࢲࠠᄊ)֎๨Չࣁǵ ໯ଚಞᄍǵസ‫ڜ‬ଢ଼ಞᄍǵᝅ१ᘓ཯ಞᄍǵၮ୏ಞᄍ฻*ǵ੯ੰў)ภ॥ǵ ଯՈᓸǵတύ॥ǵᑗֿੰǵ߷Јੰ฻*Ƕࣴ‫ز‬ჹຝ‫ܜޑ‬๨Չࣁх֖‫؂‬ ‫ޑڬ‬Ѝኧ‫ک‬๨សǴಞᄍ‫܄‬໯ଚ‫ۓ‬ကࣁ‫ڬ؂‬ԿϿ΋ԛǴ٠࡭ុϤঁДа ΢Ƕಞᄍ‫܄‬സૡϷಞᄍ‫܄‬໯Ҕ‫ڜ‬ଢ଼ǴΨ‫ۓ‬ကࣁ‫ڬ؂‬ԿϿ΋ԛǴ࡭ុϤ ঁДа΢Ƕೕࡓၮ୏‫ۓޣ‬ကࣁԾ‫ך‬ൔ֋‫ຼ؂‬ѝϿவ٣΋ԛ 41 ϩដа ΢ၮ୏ਔ໔ǶঁΓ੯ੰўБय़Ǵ߷Јੰǵတύ॥ǵଯՈᓸǵᖌ‫ڰ‬ᎇၸ 11.

(19) ଯϷଯֿለՈੱࣣҗ‫ڙ‬ೖჹຝԾ‫ך‬ൔ֋Ƕ! ಃϖ࿯ʳ ᔠᡏԏ໣ᆶೀ౛! !!!!଼நᔠࢗ྽В௦໣‫ڙ‬ᔠ‫ޣ‬࿣१ΜΒλਔং‫ޑ‬ՈనǴ٠ϩձԏ໣ӧ ֖Ԗ FEUB ‫ל‬ᏉՈᏊ‫ޑ‬௦ՈᆅύǴ຾΋‫؁‬ஒՈనኬҁϩᚆ cvggz!dpbu ࡕᓯӸ‫ܭ‬.91 ࡋа΢аഢ EOB ๧‫ڗ‬Ƕ٠‫ૼہ‬ᏱԖፁғЬᜢᐒᜢਡว໒ ཰୺ྣϐᔠᡍ‫܌‬຾Չෳ‫ۓ‬х֖‫ޜ‬ဎՈᑗ)gbtujoh!qmbtnb!hmvdptf*ǵ ᕴᖌ‫ڰ‬ᎇǵΟለҒ‫ݨ‬િǵIEM.Dǵեஏࡋિೈқᖌ‫ڰ‬ᎇᆶֿለ)vsjdbdje* ฻ғϯࡰ኱Ƕ! ಃϤ࿯ʳ ӄՈ‫ ܜ‬EOB ϐБ‫!ݤ‬ !!!!ஒ֖ FEUB ϐ၂ᆅϣ‫ั҃ޑ‬ՈనᚆЈ 2-411sqn!21 ϩដǴ‫ڗ‬рқ Ոౚ 1/6nm!Ƕ!уΕ 2/6nm!2Y!SCD!mztjt!cvggfsǴ࿼‫ܭ‬Ӈ΢ 26 ϩដǶ ᚆЈ!3-111sqn!21njoǴѐନ΢మనࡕǴуΕ 2!nm!HfopNblfs!sfbhfouǶ ӧ࠻ྕΠᓉ࿼ 6 ϩដǶϐࡕуΕ 1/6nm!dimpspgpsnǴᚆЈ 23-111sqnǴ 5ʚǴ6 ϩដǶ‫ڗ‬р΢మన‫ܫ‬Εཥ‫ ޑ‬2/6nm!༾ໆᚆЈᆅϣǴуΕ 1/6nm! jtpqspqbopmǴӧ 5ʚΠа 7-111sqnǴᚆЈ 3 ϩដǴ౽ନ΢మనǴу Ε 2nm!81&!fuibopmǴа 7-111sqnǴᚆЈ 3 ϩដǴନѐ΢మనǴԜ‫؁‬ ᡯӆख़ፄ΋ԛǶӆ౽ନ΢మనǴEOB ྋ‫ ܭ‬211vm!UF!cvggfsǶ࿼‫!ܭ‬.91 ʚߥӸǴаഢ୷Ӣࠠϩ‫݋‬Ƕ! ಃΎ࿯ʳ ᖌ‫ڰ‬ᎇ✊ᙯ౽ೈқȐDFUQ*୷Ӣϐӭࠠ‫܄‬᠘‫!ۓ‬ 12.

(20) !!!!DFUQ ୷ӢՏ‫ܭ‬ಃ 27 ဦࢉՅᡏ΢Ǵх֖ 27 ঁѦᡉη)fypo*ᆶ 26 ঁϣ֖η)jouspo*Ǵऊ 36lcǹUbrJC!)st819383*ᡂ౦Տ࿼Տ‫ܭ‬ DFUQ!jouspo!2 ಃ 388 ঁਡҒለȐovdmfpujefȑ΢Ǵёҗ UbrJ ज़‫ڋ‬ ሇન᠘ձǴࢂҞ߻ၨத௖૸ϐᡂ౦ǹJ516W)st6993*ᡂ౦Տ࿼߾Տ ‫ ܭ‬fypo25 ಃ 533 ঁữ୷ለ΢Ǵёҗ Uui222J ज़‫ڋ‬ሇન᠘ձǶDFUQ ϐ UbrJCǵJ516W ‫ ঁٿ‬TOQ ୷Ӣࠠ᠘‫ۓ‬Ǻ೿ࢂճҔ QDS.SGMQ ‫ޑ‬Б‫!ݤ‬ 2/ UbrJC ୷Ӣࠠ᠘‫!ۓ‬ DFUQ!ϐ UbrJC ୷Ӣࠠ‫ޑ‬Їη!)qsjnfs*!೛ीӵΠ;! !!gpsxbse;!6ȷ.DBDUB!HDDDB!HB!HB!HB!H.HB!HUHD.4ȷ! !!sfwfstf;!6ȷ.BBB!HDB!BBH!BDB!HHD!BUB!BBB!B.4ȷ!! ϸᔈచҹࣁଆ‫ ࡋྕۈ‬:5ʚ!6 ϩដǹௗ๱ :5ʚ!41 ࣾ٬ᚈި EOB ᡂ‫܄‬ )efobuvsbujpo*Ǵफ़ྕԿ 71ʚ!41 ࣾ٬Їηᗹӝ!)boofbmjoh*Ǵӆቚ ྕ‫ ډ‬83ʚ!2 ϩដ٬ EOB ‫)ߏۯ‬fyufotjpo*Ǵൻᕉϸᔈ 42 ԛǹനࡕӆ ೛‫ ࣁۓ‬83ʚ!6 ϩដǶԜ QDS ϐТࢤߏࡋࣁ 646 ᡵ୷ჹ!)cbtf!qbjs-! cq*Ƕ! ஒ 646 ᡵ୷ჹϐ QDS ౢ‫ނ‬уΕ UbrJ!ज़‫ڋ‬ሇનೀ౛ 76ʚǴϸᔈѤλਔ ٬ϐ੃ϯǴ੃ϯࡕౢ‫ނ‬ճҔ 4&!֖ྜྷϯΌᒭ!)fuijejvn!cspnjef-!FuCs*! ϐᛏિᗐጤ!)bhbsptf!hfm*຾Չႝ‫ݚ‬Ƕႝ‫่݀ޑࡕݚ‬ղ᠐Ǻ྽ QDS Т ࢤѝԖ 646 ᡵ୷Тࢤߏࡋਔ᠘‫ ࣁۓ‬C30C3 ୷ӢࠠǹԶౢғ 472 ᆶ 285 13.

(21) ᡵ୷ჹ‫ٿ‬Тࢤߏࡋ‫ ࣁޣ‬C20C2 ୷Ӣࠠǹ྽ӕਔхࡴ 646ǵ472 ᆶ 285 Οᅿᡵ୷ჹТࢤߏࡋਔ߾ឦ‫ ܭ‬C20C3 ୷ӢࠠǶ! 3/ J516W ୷Ӣࠠ᠘‫!ۓ‬ 2:. DFUQ!!J516W ୷Ӣࠠ‫ޑ‬Їη!)qsjnfs*!೛ीӵΠ ;! gpsxbse;6ȷ.!DUDBDDBUHHHDBUUUHBUUHDBHBHDBHDUDDHBDUDD!.4ȷ! !sfwfstf;!6ȷ.!BBB!HHU!HBB!BUH!HHB!BHD!UDU!HUD!BHD!DUD!HH!.4ȷ!! ϸᔈచҹࣁଆ‫ ࡋྕۈ‬:5ʚ!6 ϩដǹௗ๱ :5ʚ!2 ϩដ٬ᚈި EOB ᡂ‫܄‬ )efobuvsbujpo*Ǵफ़ྕԿྕࡋ 74ʚ!2 ϩដ٬Їηᗹӝ! )boofbmjoh*Ǵӆቚྕ‫ ډ‬83ʚ!56 ࣾ٬ EOB ‫)ߏۯ‬fyufotjpo*Ǵൻᕉϸ ᔈ 41 ԛǹനࡕӆ೛‫ ࣁۓ‬83ʚ!6 ϩដǶԜ QDS ϐТࢤߏࡋࣁ 26: ᡵ୷ ჹ!)cbtf!qbjs-!cq*Ƕ! !!!!ஒ 26: ᡵ୷ჹϐ QDS ౢ‫ނ‬уΕ Uui222J!ज़‫ڋ‬ሇનೀ౛ 76ʚǴϸ ᔈѤλਔ٬ϐ੃ϯǴ੃ϯࡕౢ‫ނ‬ճҔ 4&!֖ྜྷϯΌᒭ!)fuijejvn! cspnjef-!FuCs*!ϐᛏિᗐጤ!)bhbsptf!hfm*຾Չႝ‫ݚ‬Ƕႝ‫่ޑࡕݚ‬ ݀ղ᠐Ǻ྽ QDS ТࢤѝԖ 26: ᡵ୷Тࢤߏࡋਔ᠘‫ ࣁۓ‬JJ ୷ӢࠠǹԶ ౢғ 233 ᆶ 48 ᡵ୷Тࢤߏࡋ‫ ࣁޣ‬WW ୷Ӣࠠǹ྽ౢғ 26:ǵ233 ᆶ 48 Οᅿᡵ୷ჹТࢤߏࡋਔ߾ឦ‫ ܭ‬JW ୷ӢࠠǶ! ಃΖ࿯ʳ ၗ਑಍ीᆶϩ‫!݋‬ !!!!٬Ҕ u.uftu ᔠ‫ۓ‬ԃសᆶғ౛ғϯॶ฻ೱុᡂ໨ࢂցԖᡉ๱ৡ 14.

(22) ౦Ƕ྽ϩ‫݋‬ᜪձᡂ໨ӵᅿ௼ǵ‫܄‬ձǵ௲‫ػ‬ำࡋ฻ᡂ໨ᆶ௼ဂǵΟለҒ ˟. ‫ݨ‬િϷ IEM.D ౦தճҔьБᔠ‫ ͞)!ۓ‬.uftu*!ᔠᡍǴӕਔीᆉ‫ځ‬യᆉ К!)peet!sbujp<!PS*Ƕ! !!!!ճҔ፾ӝࡋᔠ‫)!ۓ‬hppeoftt!pg!gju!uftu*!ղᘐԜ‫ٿ‬ᡂ౦ӧόӕ ௼ဂࢂց಄ӝࠖྕѳᑽ!)Ibsez.Xfjocfsh!frvjmjcsjvn*ǶќѦǴճ ҔьБᔠ‫ ۓ‬UHǵIEM.D ҅தᆶ౦தಔԜ‫୷کঁٿ‬Ӣᡂ౦ࢂցԖ࣬ᜢǴ ຾΋‫؁‬ճҔᛥӓථ଑ᘜኳԄ!)mphjtujd!sfhsfttjpo!npefm*!ፓ᏾வ ൂᡂ໨ϩ‫݋‬ύள‫ޑډ‬υᘋӢηࡕᢀჸ୷ӢࠠǵᕉნӢηᆶΟለҒ‫ݨ‬િ Ϸଯஏࡋિೈқᐚࡋ‫࣬ޑ‬ᜢ‫܄‬Ƕ! !!!!‫܌‬Ԗၗ਑֡а Njdsptpgu!pggjdf!Fydfm!3118 ࡌᔞߥӸǴ٠ճҔ TQTT!28/1/1 ຾Չၗ਑᏾౛ᆶϩ‫݋‬Ƕ! ! ! ! ! ! ! ! ! 15.

(23) ಃѤകʳ ࣴ‫!่݀ز‬ ಃ΋࿯ʳ ࣴ‫ز‬ჹຝ‫୷ޑ‬ҁ੝ቻ! !!!!ӧ916Տࣴ‫ز‬ჹຝύচՐ҇Ԗ391Γ)45/9&*ǴߚচՐ҇Ԗ636Γ )76/3&*Ƕ߄΋և౜ࣴ‫ز‬ჹຝϐ୷ҁၗ਑Ǵࣴ‫ز‬ჹຝѳ֡ԃសࣁ72/1 ²22/7ྃǴচՐ҇ၨߚচՐ҇ѳ֡ԃសࣁե)6:/3²23/2ྃwt!73/1² 22/4<!q>1/112*Ƕ௲‫ػ‬ำࡋԶ‫ق‬চՐ҇ၟߚচՐ҇և౜಍ी΢‫ޑ‬ৡ౦ )q=1/112*ǶӧғࢲࠠᄊБय़Ǵ‫ܜ‬๨ǵ໯ଚǵᝅ१ᘓ཯ǵസ‫ڜ‬ଢ଼ǵസ ૡϷၮ୏ಞᄍӧচՐ҇‫ߚک‬চՐ҇ϐ໔Ψ೿և౜಍ी΢‫ޑ‬ৡ౦)‫ܜ‬๨ q>1/122Ǵ‫ځ‬Ꭹq=1/112*Ƕ߄Βև౜ࣴ‫ز‬ჹຝ‫ޑ‬ғ౛ғϯॶǶচՐ҇ ၨߚচՐ҇ǴԖၨଯ‫ޑ‬ԏᕭᓸϷ๤஭ᓸ)ԏᕭᓸ249/5²29/1!nnIh!wt/! 23:/9²29/1!nnIh-๤஭ᓸ!97/7²22/9!nn!Ih!wt/!88/:²22/2!nnIh<! q=1/112*ǵၨଯ‫ޑ‬Ոᑗ)219/6²65/9!nh0eM!wt/!:7/8²42/9!nh0eM<! q=1/112*ǵၨե‫ޑ‬ᕴᖌ‫ڰ‬ᎇ)29:/8²63/:!nh0eM!wt/!312/8²48/2!nh0eM<! q=1/112*ǵၨଯ‫ޑ‬ΟለҒ‫ݨ‬િ)281/6²236/9!nh0eM!wt/!231/7²81/8! nh0eM<!q=1/112*ǵၨե‫ޑ‬IEM.D)54/8²21/9!nh0eM!wt/!63/7²24/6! nh0eM<!q=1/112*ǵၨଯ‫ޑ‬CNJ)39/5²5/6!lh0n³!!wt/!35/3²4/5!lh0n ³<!q=1/112*ǵၨե‫ޑ‬եஏࡋિೈқᖌ‫ڰ‬ᎇ)222/:²64/9!nh0eM!wt/! 236/2²43/2!nh0eM<!q=1/112*ǵၨଯ‫ֿޑ‬ለ)7/3²1/9!nh0eM!wt/!7/2 ²1/8!nh0eM<!q>1/153*Ϸၨଯ‫ޑ‬ဈൎ):2/2²22/3!dn!wt/!92/3²:/9!dn<! 16.

(24) q=1/112*Ƕ߄Οև౜DFUQ୷ӢϐUbrJCϷJ516W୷ӢࠠӧচՐ҇Ϸߚচ Ր҇ϐ໔‫ޑ‬ϩթǴ‫ځ‬ύUbrJC୷ӢࠠϩթԖ಍ी΢‫ޑ‬ৡ౦)q=1/112*Ǵ ԶJ516W୷Ӣࠠӧ‫ٿ‬ಔ໔‫ޑ‬ϩթ߾҂ၲ಍ीৡ౦Ƕ߄Ѥև౜ࣴ‫ز‬ჹຝ ‫ঁޑ‬Γ੯ੰўϩթǴচՐ҇ၨߚচՐ҇Ԗၨଯ‫ޑ‬ଯՈᓸК౗)65/7&! wt/37/4&<!q=1/112*ǵၨଯ‫ޑ‬ΟለҒ‫ݨ‬િ౦தК౗)38/:&!wt/22/1&<! q=1/112*ǵၨե‫ޑ‬ᖌ‫ڰ‬ᎇၸଯК౗)7/9&!wt/!27/7&<!q=1/112*ǵၨ ଯ‫ޑ‬IEM.D౦தК౗)31/1&!wt/6/:&<!q=1/112*Ϸၨଯ‫ޑ‬ᑗֿੰК౗ )26/5&!wt/!21/2&<!q>1/14*ǴԶ߷Јੰ‫ک‬တύ॥ӧ‫ٿ‬ಔ໔߾҂ၲ಍ ीৡ౦Ƕӧፓ᏾υᘋӢηࡕǴҁࣴ‫ز‬٠҂ว౜DFUQ୷ӢϐUbrJCϷ J516W୷ӢࠠᆶঁΓ੯ੰўϐᜢᖄ‫)܄‬ၗ਑҂ᡉҢ*Ƕ! !!!!߄ϖᆶ߄Ϥϩձ٩ᅿ௼ϩቫࡕǴஒΟለҒ‫ݨ‬િ‫ ک‬IEM.D ᐚࡋ҅த Ϸ౦தϩಔǴࣴ‫ز‬ჹຝ‫୷ޑ‬ҁၗ਑Ƕа߄ϖচՐ҇‫୷ޑ‬ҁၗ਑ᆶғࢲ ಞᄍ‫ ک‬UH Ϸ IEM.D ϐᜢ߯ǴΟለҒ‫ݨ‬િᐚࡋ҅தಔၨ౦தಔѳ֡ԃ សᡉ๱ၨଯ)71/6²23/6 ྃ!wt/!66/:²21/5 ྃ<!q>1/115*ǹ‫ٿ‬ಔ໔‫܄‬ ձϷ௲‫ػ‬ำࡋ҂ၲ‫ډ‬಍ी΢‫ޑ‬ৡ౦ǹӧғࢲࠠᄊБय़ǴΟለҒ‫ݨ‬િᐚ ࡋ౦தಔၨ҅தಔԖၨଯ‫ܜޑ‬๨ಞᄍ)45/7&!wt/!33/9&<!q>1/153*ǵ ၨଯ‫ޑ‬໯ଚಞᄍ)96/:&!wt/!76/4&<!q>1/112*ǵၨଯ‫ޑ‬ᝅ१ᘓ཯ಞᄍ )78/:&!wt/!55/7&<!q>1/112*ǵၨե‫ޑ‬സ‫ڜ‬ଢ଼ಞᄍ)1/1&!wt/!8/:&<! q>1/119*ǴՠӧസૡϷၮ୏ಞᄍ߾҂ၲ಍ी΢‫ޑ‬ᡉ๱ৡ౦ǶӧКၨ 17.

(25) IEM.D ౦தϷ҅தಔǴӧচՐ҇௼ဂόፕ୷ҁ੝ቻϷғࢲࠠᄊ֡ค಍ ी΢‫ޑ‬ৡ౦Ƕ! !!!!߄ΎࣁচՐ҇ᆶߚচՐ҇‫ޑ‬ғ౛ғϯॶ‫ ک‬UH Ϸ IEM.D ϐКၨǶ аচՐ҇ၗ਑Զ‫ق‬ǴΟለҒ‫ݨ‬િᐚࡋ౦தಔၨ҅தಔԖၨଯ‫ޑ‬๤஭ᓸ )9:/8²22/1!nnIh!wt/!96/4²22/:!nnIh<!q>1/117*ǵၨଯ‫ ޑ‬CNJ)3:/: ²5/3!lh0n³!wt/!38/9²5/6!lh0n³<!q=1/112*ǵၨଯ‫ޑ‬ဈൎ):6/2²21/:! dn!wt/!9:/6²21/:dn<!q=1/112*ǵၨଯ‫ޑ‬Ոᑗ)235/9²7:/1!nh0eM!wt/! 213/3²57/:!nh0eM<!q>1/113*ǵၨե‫ޑ‬եஏࡋિೈқᖌ‫ڰ‬ᎇᐚࡋ):2/6 ²87/6!nh0eM!wt/!22:/9²4:/4!nh0eM<!q=1/112*ǴՠԏᕭᓸϷֿለϷ ҂ၲ಍ी΢ᡉ๱ৡ౦Ƕ! !!!!߄ΖϷ߄ΐϩচՐ҇ᆶߚচՐ҇ϐঁΓ੯ੰўϩթᆶ UH Ϸ IEM.D ϐᜢ߯Ǵа߄ΖচՐ҇ၗ਑Զ‫ق‬ǴΟለҒ‫ݨ‬િᐚࡋ౦தಔၨ҅ தಔǴᏱԖၨଯ‫ޑ‬ᖌ‫ڰ‬ᎇᐚࡋ౦த)25/2&!wt/!5/1&<!q>1/117*Ϸၨ ଯ‫ޑ‬ᑗֿੰК౗)35/5&!wt/22/:&<!q>1/126*ǹIEM.D ౦தಔၨ҅த ಔǴᏱԖၨଯ‫ޑ‬တύ॥К౗)21/:&!wt/!2/4&<!q>1/114*Ϸၨଯ‫ޑ‬ᑗ ֿੰ)46/8&!wt/21/4&<!q>=1/112*ǶԶ߄ΐ‫ߚޑ‬চՐ҇ၗ਑ᡉҢΟለ Ғ ‫ ݨ‬િ ᐚ ࡋ ౦ த ಔ ၨ ҅ த ಔ Ԗ ၨ ଯ ‫ ޑ‬ଯ ֿ ለ Ո ੱ К ౗ )26/6&! wt/8/6&<!q>1/157*<!IEM.D ౦தಔၨ҅தಔԖၨଯ‫ޑ‬ᑗֿੰК౗ )3:/1&! wt/9/:&<! q>1/113* Ϸ ଯ ֿ ለ Ո ੱ К ౗ )2:/5&! wt/8/8&<! 18.

(26) q>1/147*Ƕ! ಃΒ࿯ʳ DFUQ ϐ UbrJC Ϸ J516W ୷ӢࠠϷғ౛ғϯࡰ኱ϐ໔‫࣬ޑ‬ᜢ‫܄‬ ! ! ߄ΜϷ߄Μ΋և౜ࣴ‫ز‬ჹຝғ౛ғϯࡰ኱ϐ୷ӢࠠϩթǶа UbrJC ୷ӢࠠԶ‫ق‬ǴC2C2 ӕ፦୷Ӣࠠၨ C2C3 ౦፦୷Ӣࠠ‫ޣ‬Ԗၨଯ‫ޑ‬ ΟለҒ‫ݨ‬િ)25:/2²217/2!nh0eM!wt/!236/2²94/8!nh0eM<!q>1/114*ǵ ၨ ե ‫ ޑ‬IEM.D ᐚ ࡋ )59/3 ² 23/7! nh0eM! wt/! 61/9 ² 24/8! nh0eM<! q>1/142* ǵ ၨ ଯ ‫ ޑ‬CNJ)37/4 ² 5/8! lh0n ³ ! wt/! 36/3 ² 4/:! lh0n ³ <! q>1/113*<C2C2 ୷ӢࠠΨၨ C3C3 ୷ӢࠠԖၨଯ‫ ޑ‬CNJ ॶ)37/4²5/8! lh0n³!wt/!35/9²4/5!lh0n³<!q>1/119*Ƕ! ಃΟ࿯ʳ ΓαᏢϷᕉნӢηჹΟለҒ‫ݨ‬િϷ IEM.D ౦த‫ޑ‬ቹៜ ӧፓ᏾υᘋӢηࡕғࢲࠠᄊϩձჹΟለҒ‫ݨ‬િ౦தϷ IEM.D ౦ த‫ޑ‬യᆉК၁‫߄ـ‬ΜΒϷ߄ΜΟǶԖၮ୏ಞᄍ‫ޑ‬চՐ҇ၨؒԖၮ୏ಞ ᄍ ‫ ޣ‬Ԗ ၨ ե ‫ ޑ‬Ο ለ Ғ ‫ ݨ‬િ ၸ ଯ ॥ ᓀ )Dsvef! PS>1/4<! :6&DJ>1/25.1/9:*ǴԖസ‫ڜ‬ଢ଼ಞᄍ‫ߚޑ‬চՐ҇ᆶؒԖസ‫ڜ‬ଢ଼ಞᄍ‫ޣ‬Ԗ ၨଯ‫ޑ‬ΟለҒ‫ݨ‬િ౦த॥ᓀ)Dsvef!PS>2/8<!:6&DJ>2/14.3/83*Ƕӧ ፓ᏾‫܄‬ձǵԃសǵ๤஭ᓸǵ‫ي‬ᡏ፦ໆࡰኧǵՈᑗǵIEM.Dǵեஏࡋિ ೈқᖌ‫ڰ‬ᎇࡕǴচՐ҇ύԖ໯ଚಞᄍ‫ޣ‬КؒԖ໯ଚಞᄍ‫ޣ‬Ԗၨଯ‫ޑ‬Ο ለҒ‫ݨ‬િ౦த॥ᓀ)PS>5/6<!:6&DJ>2/:3.21/5:*ǵԖᝅ१ᘓ཯ಞᄍ‫ޣ‬ К ଆ ؒ Ԗ ಞ ᄍ ‫ ޣ‬Ψ Ԗ ၨ ଯ ‫ ޑ‬Ο ለ Ғ ‫ ݨ‬િ ౦ த ॥ ᓀ )PS>3/5<! 19.

(27) :6&DJ>2/31.5/:1*ǶԶӧߚচՐ҇ύǴፓ᏾‫܄‬ձǵԃសǵ๤஭ᓸǵᕴ ᖌ‫ڰ‬ᎇǵဈൎǵIEM.D ࡕǴ٠҂࣮‫ډ‬ғࢲࠠᄊჹΟለҒ‫ݨ‬િ౦தၲᡉ ๱ቹៜǶ! ಃѤ࿯ʳ UbrJC Ϸ J516W ୷Ӣӭࠠ‫܄‬ჹ‫ܭ‬ΟለҒ‫ݨ‬િၸଯ‫ ک‬IEM.D ၸ ե‫ޑ‬ቹៜ! ! ! ߄ΜѤϷ߄Μϖև౜চՐ҇ᆶߚচՐ҇ፓ᏾υᘋӢηࡕǴUbrJC Ϸ J516W ୷Ӣࠠჹࣴ‫ز‬ჹຝΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեϐቹៜǶӧ চՐ҇Бय़ǴUbrJC ϐ C2C3 ୷Ӣࠠၨ C2C2 ୷ӢࠠԖၨե‫ޑ‬ΟለҒ‫ݨ‬ િᐚࡋ౦தയᆉК)Dsve!PS>1/5<:6&DJ>1/34.1/95*ǶԶӧߚচՐ҇ Бय़ǴUbrJC ϐ C3C3 ୷Ӣࠠၨ C2C2 ୷ӢࠠԖၨଯ‫ ޑ‬IEM.D ౦தയᆉ К)Dsve!PS>6/5<:6&DJ>2/89.27/46*Ƕӧፓ᏾‫܄‬ձǵԃសǵԏᕭᓸǵ ‫ي‬ᡏ፦ໆࡰኧǵՈᑗǵIEM.Dǵեஏࡋિೈқᖌ‫ڰ‬ᎇǵ໯ଚಞᄍࡕǴ চՐ҇ UbrJC ϐ C2C3 ୷Ӣࠠၨ C2C2 ୷ӢࠠǴϝԖၨե‫ޑ‬ΟለҒ‫ݨ‬િ ၸଯ॥ᓀ)PS>1/5<:6&DJ>1/2:.1/:6*ǹԶӧߚচՐ҇Бय़Ǵፓ᏾Α‫܄‬ ձǵԃសǵՈᑗǵᖌ‫ڰ‬ᎇǵΟለҒ‫ݨ‬િࡕǴUbrJC ϐ C3C3 ୷Ӣࠠϝ ၨ. C2C2. ୷ Ӣ ࠠ Ԗ ၨ ଯ ‫ޑ‬. )PS>4/7<:6&DJ>2/15.23/79*Ƕ! ! ! 20. IEM.D. ౦ த ॥ ᓀ.

(28) ಃϖകʳ ૸ፕ! ಃ΋࿯ʳ ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶΓαᏢ੝‫܄‬ϐᜢ߯ ! ! ΟለҒ‫ݨ‬િᆶ IEM.D ‫ޑ‬ᐚࡋ٠ߚҗൂ΋Ӣન‫܌‬ቹៜǴԶࢂᆶ୷ ӢǵжᖴϷᕉნ฻ाનԖᜢǶഋ฻Γ)3113*‫ࡰزࣴޑ‬рǴ୯Γ IEM.D ၸե‫ޑ‬ᐚࡋόፕԃសቫ‫ࣣ܄ت‬ଯ‫ܭ‬ζ‫܄‬. 57. Ƕҁࣴ‫ز‬ว౜ǴߚচՐ҇. IEM.D ౦த‫ޑ‬౰Չ౗‫܄ت‬ᡉ๱‫ޑ‬ၨζ‫܄‬ଯǴᆶၸѐ‫่݀زࣴޑ‬΋ठǶ ќѦǴOBITJU ‫ޑ‬ፓࢗว౜Ѡ᡼Ӧ୔ξӦচՐ҇ໂ‫ޑ‬ΟለҒ‫ݨ‬િၸଯ )UHɪ311!nh0eM*‫ت‬ζ‫܄‬౰Չ౗ϩձࣁ 45/:&ᆶ 35/6&ǴIEM.D ၸե 7. )IEM=46!nh0em*‫ت‬ζ‫܄‬౰Չ౗ϩձࣁ 35/6&ᆶ 23/2&ࣁӄѠϐ߷ Ƕҁ ࣴ‫่݀ز‬ǴᡉҢচՐ҇ΟለҒ‫ݨ‬િၸϷ IEM.D ၸե‫ޑ‬౰Չ౗ࣁ 38/:& Ϸ 31&ǴߚচՐ҇ࣁ 22&Ϸ 7&ǹচՐ҇КߚচՐ҇໯ଚǵᝅ१ᘓ཯‫ޑ‬ ಞᄍၨଯ)82/2&!wt/!32/2&-!62/2&!wt/!23/7&<!q=1/112*ǴԖ‫ܜ‬๨ ಞᄍΨКߚচՐ҇ӭ)37/2&!wt/!29/2&<!q>1/122*ǴԶԖၮ୏ಞᄍǵ സ‫ڜ‬ଢ଼Ϸസૡಞᄍ‫߾ޣ‬ၨߚচՐ҇ե)6/8&!wt/!38/1&-!7/9&!wt/! 4:/7&-!23/6&!wt/61/8&<!q=1/112*ǴচՐ҇‫ޑ‬ғࢲಞᄍόӕёૈ཮ ჹΟለҒ‫ݨ‬િϷ IEM.D ೷ԋቹៜǶ ಃΒ࿯ʳ ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶӅੰੱ ! ! Mbcsfvdif ฻Γ)311:*‫ࡰزࣴޑ‬рΟለҒ‫ݨ‬િଯեᆶတύ॥Ԗ 38. ᜢǴၨե‫ޑ‬ΟለҒ‫ݨ‬િёаႣٛတύ॥ Ƕόၸ E{jfe{jd ฻Γ)3115* 21.

(29) ‫߾زࣴޑ‬ว౜࣬ϸ‫่݀ޑ‬ǴᇡࣁեΟለҒ‫ݨ‬િܰԖ‫׳‬ଯ‫ޑ‬တύ॥॥ᓀ 39. 3:. ǶBnbsfodp ฻Γ)3119*‫زࣴޑ‬Ψࡰр IEM.D ‫ޑ‬ᐚࡋᆶတύ॥Ԗᜢ Ƕ. ҁࣴ‫ز‬ว౜চՐ҇ IEM.D ౦தၨ҅த‫࣬ޣ‬КǴ཮Ԗၨଯ‫ޑ‬တύ॥౰Չ 3:. ౗)21/:&!wt/!2/4&<! q>1/114*Ǵᆶ Bnbsfop ฻Γ)3119*่݀΋ठ Ǵ ՠӧΟለҒ‫ݨ‬િ౦த‫ޣ‬ϷߚচՐ҇ࣴ‫ز‬ჹຝᆶတύ॥٠ค࣬ᜢǶ! ! ! Ujspti ฻Γ)3119*ଓᙫϖԃ‫زࣴޑ‬ว౜ΟለҒ‫ݨ‬િёૈࣁᑗֿ 42. ੰ‫ޑ‬ӒᓀӢηϐ΋ Ǵҁࣴ‫ز‬ว౜চՐ҇ΟለҒ‫ݨ‬િᆶ IEM.D ౦த‫ޣ‬ Кଆ҅த‫ޣ‬ǴࣣԖၨଯ‫ޑ‬ᑗֿੰ౰Չ౗)35/5&!wt/!22/:&<!q>1/13-! 46/8&!wt/!21/4&<!q=1/112*ǴՠӧߚচՐ҇‫ي‬΢߾ѝԖӧ IEM.D ಔ Ԗว౜ᜪ՟่݀!)3:/1&!wt/!9/:&<!q>1/13*Ǵ೭ёૈࢂচՐ҇‫ޑ‬ғ ࢲಞᄍᆶΟለҒ‫ݨ‬િԖᜢǴ‫ځ‬ύ໯ଚಞᄍᆶΟለҒ‫ݨ‬િԖᜢǶ ಃΟ࿯ʳ ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶᕉნӢηϐᜢ߯ ! ! ၸໆ‫ޑ‬໯ଚ཮٬‫᠌ط‬εໆӝԋΟለҒ‫ݨ‬િǴԶ٬Ոనύ‫ޑ‬ΟለҒ 3. ‫ݨ‬િໆቚу ǶDipveivsz ฻Γ)2::5*ࣴ‫ز‬ᡉҢǴ໯ଚ‫ޣ‬ၨค໯ଚ‫ޣ‬ 45. ཮ቚу IEM.D ‫ޑ‬ᐚࡋϷΟለҒ‫ݨ‬િ ΖKpttb ฻Γ)2::2*‫߾زࣴޑ‬ᡉ 46. Ң IEM.D ᆶ໯ଚໆԖ҅࣬ᜢ‫ ܄‬Ƕҁࣴ‫่݀ز‬ᡉҢǴӧፓ᏾υᘋӢη ࡕǴচՐ҇ύԖ໯ଚ‫ޣ‬ΟለҒ‫ݨ‬િၸଯ‫ޑ‬॥ᓀКଆค໯ଚ‫ ࣁޣ‬5/6 45. ७Ǵᆶၸѐࣴ‫่݀ز‬΋ठ ǹՠӧߚচՐ҇٠҂ว౜໯ଚᆶΟለҒ‫ݨ‬ િ‫ ک‬IEM.D ԖᜢǶ! 22.

(30) !!!!LP ฻Γ)3116*‫زࣴޑ‬ᡉҢǴԖᝅ१ᘓ཯ಞᄍ‫ޣ‬ǴΟለҒ‫ݨ‬િၸ 48. ଯ‫ޑ‬॥ᓀࣁ 3/5 ७ Ƕҁࣴ‫ز‬Ψว౜ǴচՐ҇Ԗᝅ१ᘓ཯ಞᄍ‫ޣ‬Οለ 48. Ғ‫ݨ‬િ౦த‫ޑ‬॥ᓀၨؒԖ‫ ࣁޣ‬3/5 ७Ǵᆶၸѐࣴ‫่݀ز‬΋ठ Ƕ೭ё 58. ૈᆶᘓ཯཮೷ԋߚી৞ન٩ᒘࠠᑗֿੰ Ǵ຾ԶቹៜΟለҒ‫ݨ‬િ‫ޑ‬ᐚ ࡋǶ! ಃѤ࿯ʳ ΟለҒ‫ݨ‬િၸଯϷ IEM.D ၸեᆶ DFUQ ୷Ӣ ! ! DFUQ ‫୷ޑ‬Ӣࠠᡂ౦Ǵ!UbrJC ࣁၨத೏௖૸‫୷ޑ‬ӢࠠǴӧύ୯Γ )Dijoftf*UbrJC ‫ ޑ‬C2!bmmfmf ၟ C3!bmmfmmf ᓎ౗ϩձࣁ 63/3&Ϸ 51. 58/9&ǹቺ୯Γ)Hfsnbo*ࣁ 82/8&ၟ 39/4& ǹऍ୯Γ‫ޑ‬ᓎ౗Ӛࣁ 69/4& 52. ‫ ک‬52/8& ǴВҁΓ‫ ޑ‬C2C2ǵC2C3ǵC3C3 ୷Ӣᓎ౗߾ϩձࣁ 46/9&ǵ 26. 59/5&Ϸ 26/9& Ƕҁࣴ‫ز‬ว౜ǴߚচՐ҇‫ ޑ‬UbrJC ᓎ౗εठᆶऍ୯қ Γ࣬ӕǴԶচՐ҇߾Ԗ‫܌‬ৡ౦Ǵ೭ёૈࢂҗ‫ܭ‬ᅿ௼όӕ‫܈‬ኬҁኧό‫ى‬ ‫܌‬೷ԋ‫่݀ޑ‬Ǵሡा‫׳‬຾΋‫زࣴޑ؁‬Ƕ!! ! ! ၸѐӧқΓύ‫زࣴޑ‬ǴၨϿว౜ UbrJC ୷ӢࠠᆶΟለҒ‫ݨ‬િϐᜢ 59. ߯ǴԶၨத‫ܭـ‬ύ୯Ϸӑࡋ ‫زࣴޑ‬྽ύǴᡉҢΑ UbrJC ୷ӢࠠᆶΟ ለҒ‫ݨ‬િϐ໔‫ޑ‬ᜢ߯ᆶᅿ௼ԖᜢǶҁࣴ‫ز‬Ψว౜Αӧፓ᏾ΑυᘋӢη ϐࡕǴচՐ҇྽ύ஥Ԗ C2C3 ၨ C2C2 ୷ӢࠠǴ‫ځ‬ΟለҒ‫ݨ‬િ౦த॥ᓀ ၨեǹC3 ჹଽ୷ӢჹচՐ҇ΟለҒ‫ݨ‬િ౦த‫܈‬೚ࣁ΋ߥៈӢηǴό ၸӧߚচՐ҇‫ي‬΢Ǵ߾҂ว౜ UbrJC ୷ӢࠠᆶΟለҒ‫ݨ‬િϐ࣬ᜢǴ೭ 23.

(31) Ψёૈᆶᅿ௼ԖᜢǶќѦΨёૈ UbrJC ୷Ӣࠠᆶৎ௼‫܄‬ᒪ໺੯ੰӸӧ ҬϕբҔǴԶቹៜΟለҒ‫ݨ‬િᐚࡋǴӵၸѐӧৎ௼‫܄‬ଯᖌ‫ڰ‬ᎇՈੱ‫ޑ‬ ࣴ‫ز‬ύว౜Ǵ஥Ԗ UbrJC!C3 ჹଽ୷Ӣ‫ޣ‬ၨ஥ C2 ჹଽ୷Ӣ‫ޣ‬Ԗၨե‫ޑ‬ 28. ໭ࡕΟለҒ‫ݨ‬િᐚࡋ Ƕҁࣴ‫ز‬Ψว౜ǴߚচՐ҇ C3C3 ၨ C2C2 ୷Ӣ ࠠǴԖၨଯ‫ ޑ‬IEM.D ౦த॥ᓀǴ೭ᆶၸѐࣴ‫܌ز‬ගрǴC3 ჹଽ୷Ӣ 5:. ཮फ़ե DFUQ ࢲ‫܄‬Զගଯ IEM.D ่݀࣬ϸǴ೭ёૈࢂҗ‫ ܭ‬UbrJC ٠ό ࢂ΋ঁԖфૈ‫୷ޑ܄‬ӢࠠǴ‫ځ‬ჹ IEM.D ‫ޑ‬ቹៜࢂᆶќ΋ঁ୷Ӣࠠೱ่ ‫่݀ޑ‬Ǵќ΋ঁёૈࢂߚচՐ҇ IEM.D ౦த‫ޑ‬ΓኧၨϿ‫܌‬೷ԋǴሡा ‫׳‬εࠠኬҁኧ‫زࣴޑ‬຾΋‫؁‬௖૸Ƕ! ! ! ၸѐ‫زࣴޑ‬ว౜ǴJ516W ୷Ӣ! Wbm0Wbm ᡂ౦ࠠёૈ཮फ़եᖌ‫ڰ‬ 2:. ᎇિᙯ౽ೈқ‫܄ࢲޑ‬Զቹៜ IEM.D ‫ޑ‬ᐚࡋ ǶόፕࢂӧচՐ҇‫ߚ܈‬চ Ր҇‫ي‬΢Ǵ‫زࣴޑॺך‬೿ؒԖว౜ J516W ୷Ӣࠠᆶ IEM.D ‫࣬ޑ‬ᜢ‫܄‬ǹ ೭ёૈࢂᅿ௼‫܌‬೷ԋ‫ޑ‬ቹៜǴԜѦΨёૈӵ Csvdf ฻Γ)2::9*‫܌‬ว౜ 2:. ǴӧΟለҒ‫ݨ‬િၸଯ‫܄تޑ‬஥Ԗ WW ୷Ӣࠠ‫ޣ‬ၨ WJ Ϸ JJ ‫ޣ‬Ԗၨଯ‫ޑ‬. IEM.D ՠӧၨե߾ցǶ௢ෳ౛җࢂǴ྽ΟለҒ‫ݨ‬િଯਔǴᖌ‫ڰ‬ᎇિᙯ ౽ೈқ‫ޑ‬ᒪ໺‫ف‬Յ཮ᡂளКၨख़ाǹ‫܈‬ёૈࢂ J516W ᆶ‫ځ‬д୷ӢԖҬ ϕբҔ‫ޑ‬ӸӧǴӵ Lbllp ‫܌‬ว౜‫ ޑ‬J516W ᆶ S562R ໔ೱᙹόѳᑽ‫ޑ‬ਏ 61. ᔈ Ƕ! ! ! ҁ ࣴ ‫ ز‬٠ ҂ ว ౜ UbrJC ᆶ J516W ୷ Ӣ ࠠ ໔ Ԗ Ҭ ϕ բ Ҕ Ǵ ೭ ᆶ 24.

(32) Hveobtpo฻Γ‫܌‬ගр‫ޑ‬UbrJCᆶJ516W୷Ӣࠠ‫܄‬ӚԾж߄‫ٿ‬ಔфૈ΢ 62. ϕ࣬ᐱҥ཮ቹៜᖌ‫ڰ‬ᎇ✊౽ᙯೈқࢲ‫ޑ܄‬ᒪ໺ᡂ౦ ࣬֍ӝǶ!. ಃϖ࿯ʳ ࣴ‫ز‬ज़‫ڋ‬ ! ! ҁࣴ‫ࢂز‬΋ঁᐉᘐࣴ‫ز‬Ǵ‫܌‬аᜤаᙶమΟለҒ‫ݨ‬િၸଯ‫ک‬ଯࡋિ ೈқᖌ‫ڰ‬ᎇၸեᆶ࣬ᜢ੯ੰ‫ޑ‬ਔ‫܄ׇ‬ǴԶค‫ݤ‬ள‫ډ‬Ӣ݀ᜢ߯ǶЪҗ‫ܭ‬ ࣴ‫ز‬ԏ໣ঁਢٰԾ‫ܭ‬ԋΓ଼ᔠǴёૈ཮Ԗ࣬ӕ੝፦‫ޑ‬Ӹӧ)ӵКၨӧ ཀԾ‫଼ي‬ந‫҇ޑ‬౲฻*Ǵ‫܌‬аࣴ‫่݀ز‬௢՗‫ځډ‬д௼ဂሡӭуᙣ཈Ƕ ୢ‫ڔ‬ϣ৒٤೚ၗ਑ࢂаԾ‫ך‬༤เ‫ޑ‬БԄᕇளǴёૈ཮Ԗᒱᇤϩಔ‫ޑ‬௃ ‫׎‬Ƕ ! ! ! ! ! ! ! ! ! ! 25.

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(35) 29. Amarenco P, Labreuche J, Touboul PJ. High-density lipoprotein-cholesterol and risk of stroke and carotid atherosclerosis: a systematic review. Atherosclerosis 2008;196(2):489-96. 30. ຫ৬ո. 97 ‫؀ڣ‬᨜‫چ‬೴Կ೏ಳ᠋ᓳ਷໴‫ܫ‬. ۩ਙೃᓡ‫س‬ᆟഏ‫ا‬೜ൈ‫ ݝ‬2009. 31. Tirosh A, Shai I, Bitzur R, et al. Changes in triglyceride levels over time and risk of type 2 diabetes in young men. Diabetes Care 2008;31(10):2032-7. 32. Mero N, Van Tol A, Scheek LM, et al. Decreased postprandial high density lipoprotein cholesterol and apolipoproteins A-I and E in normolipidemic smoking men: relations with lipid transfer proteins and LCAT activities. J Lipid Res 1998;39(7):1493-502. 33. Imamura H, Teshima K, Miyamoto N, Shirota T. Cigarette smoking, high-density lipoprotein cholesterol subfractions, and lecithin: cholesterol acyltransferase in young women. Metabolism 2002;51(10):1313-6. 34. Choudhury SR, Ueshima H, Kita Y, et al. Alcohol intake and serum lipids in a Japanese population. Int J Epidemiol 1994;23(5):940-7. 35. Jossa F, Trevisan M, Krogh V, et al. Correlates of high-density lipoprotein cholesterol in a sample of healthy workers. Prev Med 1991;20(6):700-12. 36. Choi HK, Curhan G. Coffee, tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey. Arthritis Rheum 2007;57(5):816-21. 37. Ko YC, Huang MC, Wang TN, Chang SJ, Tsai LY, Tu HP. Prevalence and risk factors associated with dyslipidaemia in children and adolescents among ethnic groups in Taiwan. Public Health 2005;119(6):489-97. 38. Jeon SM, Kim HS, Lee TG, et al. Lower absorption of cholesteryl oleate in rats supplemented with Areca catechu L. extract. Ann Nutr Metab 2000;44(4):170-6. 39. Yamashita S, Maruyama T, Hirano K, Sakai N, Nakajima N, Matsuzawa Y. Molecular mechanisms, lipoprotein abnormalities and atherogenicity of hyperalphalipoproteinemia. Atherosclerosis 2000;152(2):271-85. 40. Xu K, Lichtermann D, Lipsky RH, et al. Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch Gen Psychiatry 2004;61(6):597-606. 41. Liu S, Schmitz C, Stampfer MJ, et al. A prospective study of TaqIB polymorphism in the gene coding for cholesteryl ester transfer protein and risk of myocardial infarction in middle-aged men. Atherosclerosis 2002;161(2):469-74. 42. Boekholdt SM, Sacks FM, Jukema JW, et al. Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects. Circulation 2005;111(3):278-87. 28.

(36) 43. Jensen MK, Mukamal KJ, Overvad K, Rimm EB. Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women. Eur Heart J 2008;29(1):104-12. 44. Zheng KQ, Zhang SZ, He Y, et al. Association between cholesteryl ester transfer protein gene polymorphisms and variations in lipid levels in patients with coronary heart disease. Chin Med J (Engl) 2004;117(9):1288-92. 45. Lottenberg AM, Nunes VS, Nakandakare ER, et al. The human cholesteryl ester transfer protein I405V polymorphism is associated with plasma cholesterol concentration and its reduction by dietary phytosterol esters. J Nutr 2003;133(6):1800-5. 46. ຫ৬ո. ‫؀‬᨜‫چ‬೴೏ۨᚘΕ೏ۨᗷΕ೏ۨ౟ฐ۩෷ᓳ਷໴‫ܫ‬. ۩ਙೃᓡ‫س‬ᆟ. ഏ‫ا‬೜ൈ‫ ݝ‬2002. 47. Boucher BJ, Ewen SW, Stowers JM. Betel nut (Areca catechu) consumption and the induction of glucose intolerance in adult CD1 mice and in their F1 and F2 offspring. Diabetologia 1994;37(1):49-55. 48. Padmaja N, Ravindra Kumar M, Soya SS, Adithan C. Common variants of Cholesteryl ester transfer protein gene and their association with lipid parameters in healthy volunteers of Tamilian population. Clin Chim Acta 2007;375(1-2):140-6. 49. Ordovas JM, Cupples LA, Corella D, et al. Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study. Arterioscler Thromb Vasc Biol 2000;20(5):1323-9. 50. Kakko S, Tamminen M, Paivansalo M, et al. Cholesteryl ester transfer protein gene polymorphisms are associated with carotid atherosclerosis in men. Eur J Clin Invest 2000;30(1):18-25. 51. Gudnason V, Kakko S, Nicaud V, et al. Cholesteryl ester transfer protein gene effect on CETP activity and plasma high-density lipoprotein in European populations. The EARS Group. Eur J Clin Invest 1999;29(2):116-28.. 29.

(37) ߄΋;ࣴ‫ز‬ჹຝϐ୷ҁ੝ቻ!. !. !. !. !. ᡂ໨!. !. চՐ҇ಔ!. ߚচՐ҇ಔ!. !. ! !. !. n=280. n=525. ʳ. ԃស)ԃ*!. !. 59.2±12.1. 62.0±11.3. 0.001. ‫܄‬ձ! !!‫!܄ت‬ !!ζ‫!܄‬ ௲‫ػ‬ำࡋ! !!୯ύаΠ! !!ଯύ! !!εᏢа΢! ‫ܜ‬๨ಞᄍ! !!ց! !!ࢂ! ໯ଚಞᄍ! !!ց! !!ࢂ! ᝅ१ᘓ཯ಞᄍ! !!ց! !!ࢂ! സ‫ڜ‬ଢ଼ಞᄍ! !!=2 ԛ0ຼ! !!ɪ2 ԛ0ຼ! സૡಞᄍ¨!. ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! !. 130(46.4%) 150(53.6%). 185(35.2%) 340(64.8%). 0.002. 247(88.2%) 30(10.7%) 3(1.1%). 265(50.5%) 186(35.4%) 74(14.1%). <.0001. 207(73.9%) 73(26.1%). 430(81.9%) 95(18.1%). 0.011. 81(28.9%) 199(71.1%). 414(78.9%) 111(21.1%). <.0001. 137(48.9%) 143(51.1%). 459(87.4%) 66(12.6%). <.0001. 264(94.3%) 16(5.7%). 383(73.0%) 142(27.0%). <.0001. 316(60.3%) 208(39.7%). <.0001. 257(49.1%) 266(50.9%). <.0001. !!=2 ԛ0ຼ! !!ɪ2 ԛ0ຼ! ၮ୏ԛኧ¨! !!=2 ԛ0ຼ! !!ɪ2 ԛ0ຼ! ¨. ! ! 259(93.2%) ! 19(6.8%) ʳ ʳ 242(87.4%) ʳ 35(12.6%). Ӛᡂ໨ύΓኧό‫ࣁޣى‬લᅅॶ. ʳ. ʳ. 30. ʳ ʳ. ! ! pॶ. ʳ ʳ.

(38) ߄Β;ࣴ‫ز‬ჹຝ‫ޑ‬ғ౛ғϯॶ! ᡂ໨!. !. ! !. ! !. চՐ҇ಔ!. ߚচՐ҇ಔ!. !. n=280. n=525. ʳ. ԏᕭᓸ(mmHg)!!. 138.4±18.0. 129.8±18.0. <0.001. ๤஭ᓸ(mmHg)!! ‫ي‬ᡏ፦ໆࡰኧ(kg/m²)!!. 86.6±11.8. 77.9±11.1. <0.001. 28.4±4.5 91.1±11.2. 24.2±3.4 81.2±9.8. <0.001 <0.001. 108.5±54.8 189.7±52.9 170.5±125.8 43.7±10.8. 96.7±31.8 201.7±37.1 120.6±70.7 52.6±13.5. <0.001 <0.001 <0.001 <0.001. 111.9±53.8. 125.1±32.1. <0.001. 6.2±0.8. 6.1±0.7. ! !. ဈൎ)dn*! Ոᑗ(mg/dL)!! ᕴᖌ‫ڰ‬ᎇ(mg/dL)!! ΟለҒ‫ݨ‬િ(mg/dL)!! ଯஏࡋિೈқᖌ‫ڰ‬ᎇ(mg/dL)!! եஏࡋિೈқᖌ‫ڰ‬ᎇ(mg/dL)!! ֿለ(mg/dL)!!. 31. ʳ. ! ! pॶ. 0.042.

(39) ߄Ο;ࣴ‫ز‬ჹຝ DFUQ ϐ UbrJC Ϸ J516W ୷Ӣࠠϩթ! ᡂ໨! ! ! UbrJC!. !. চՐ҇ಔ!. ߚচՐ҇ಔ!. n=280 !. n=525 !. ! 1/92! 1/2:!. ʳ ! ! ʳ q ॶ! ʳ !. ʳ. ! 1/72! 1/4:!. ! ! !. ʳ ʳ ʳ. +Jmf! +Wbm!. ! 294)77/4&*! 91)3:/1&*! 24)5/8&*! ! ! 1/7! 1/5!. ! 2:5)48/3&*! 359)58/6&*! 91)26/4&*! ! ! 1/66! 1/56!. ! =1/112! ! ! ! ! ! !. ʳ ʳ ʳ ʳ ʳ ʳ ʳ ʳ. Jmf0Jmf! Jmf0Wbm! Wbm0Wbm! ! !. ! ::)46/5&*! 251)61/1&*! 52)25/7&*! ! !. ! ! ʳ 266)3:/8&*! 1/23! ʳ 376)61/9&*! ʳ ʳ 213)2:/6&*! ! ʳ ! ! ! ! ʳ. !ჹଽ୷Ӣᓎ౗! +C2! +C3! !୷Ӣࠠձ̗! C20C2! C20C3! C30C3! J516W! !ჹଽ୷Ӣᓎ౗!. !୷Ӣࠠձ̘!. ̗. 8 Γค‫ݤ‬ᒣ᛽୷Ӣࠠ! 4 Γค‫ݤ‬ᒣ᛽୷Ӣࠠ!. !. ̘. 32. !. !. ʳ.

(40) ߄Ѥ;ࣴ‫ز‬ჹຝ‫ঁޑ‬Γ੯ੰў! ! ᡂ໨! ! ! ߷Јੰ! !!ค! !!Ԗ! တύ॥! !!ค! !!Ԗ! ଯՈᓸ! !!ค! !!Ԗ! ΟለҒ‫ݨ‬િၸଯɁ! !!ค! !!Ԗ! ᖌ‫ڰ‬ᎇၸଯ! !!ค! !!Ԗ! ଯஏࡋિೈқᖌ‫ڰ‬ᎇၸեɁ! !!ค! !!Ԗ! ᑗֿੰ! !!ค! !!Ԗ! ଯֿለՈੱ! !!ค! !!Ԗ!. !. !. !. !. চՐ҇ಔ!. ߚচՐ҇ಔ!. ! !. ! !. o>391!. o>636!. ! !. q ॶ!. !. !. !. !. !. 347)95/4&* 55)26/8&*! ! 382):7/9&* :)4/3&*! ! 238)56/5&* 264)65/7&*. ! ! ! ! ! ! ! !. 557)96/1&*! 8:)26/1&*! ! 627):9/4&*! :)2/8&*! ! 498)84/8&*! 249)37/4&*!. ! ! ! ! ! ! ! !. 1/948! ! ! 1/322! ! ! =/1112! !. ! 313)83/2&* 89)38/:&*! ! 372):4/3&* 2:)7/9&*!. ! ! ! ! ! !. ! 578)9:/1&*! 69)22/1&*! ! 549)94/5&*! 98)27/7&*!. ! ! ! ! ! !. ! =/1112! ! ! =/1112! !. ! 335)91/1&* 67)31/1&*! ! 348)95/7&* 54)26/5&*! ! 333)8:/4&* 69)31/8&*!. ! ! ! ! ! ! ! !. ! 5:5):5/2&*! 42)6/:&*! ! 583)9:/:&*! 64)21/2&*! ! 592):2/7&*! 55):/5&*!. ! ! ! ! ! ! ! ! ! !. ! =/1112! ! ! 1/14! ! ! =/1112! ! !. Ɂ. ағ౛ғϯॶຬၸ኱ྗ‫ۓ‬က!. 33.

(41) ߄ϖ;চՐ҇‫୷ޑ‬ҁၗ਑ᆶғࢲಞᄍ‫ ک‬UH Ϸ IEM.D ϐᜢ߯! ᡂ໨! ! ! ! ԃស)ԃ*! ‫܄‬ձ! !!‫!܄ت‬ !!ζ‫!܄‬ ௲‫ػ‬ำࡋ! !!୯ύаΠ! !!ଯύ! !!εᏢа΢! ‫ܜ‬๨ಞᄍ! !!ց! !!ࢂ! ໯ଚಞᄍ! !!ց! !!ࢂ! ᝅ१ᘓ཯ಞᄍ! !!ց! !!ࢂ! സ‫ڜ‬ଢ଼ಞᄍ! !!=2 ԛ0ຼ! !!ɪ2 ԛ0ຼ! സૡಞᄍ¨! !!=2 ԛ0ຼ! !!ɪ2 ԛ0ຼ! ၮ୏ԛኧ¨!. ΟለҒ‫ݨ‬િ!. !. ҅த!. ౦த!. n=202. ʳʳ. ʳ. ଯஏࡋિೈқᖌ‫ڰ‬ᎇ!. ʳ ʳ. ҅த!. !. ౦த!. n=78. ! pॶ. n=224. ʳ. n=56. ! pॶ. 60.5±12.5. 55.9±10.4. 0.004. 59.4±12.2. 58.5±11.7. 0.62. 95(47.0%) 107(53.0%). 35(44.9%) 43(55.1%). 0.79. 107(47.8%) 117(52.2%). 23(41.1%) 33(58.9%). 0.45. 180(89.1%) 19(9.4%) 3(1.5%). 67(85.9%) 11(14.1%) 0(0.0%). 0.304. 198(88.4%) 23(10.3%) 3(1.3%). 49(87.5%) 7(12.5%) 0(0.0%). 0.62. 156(77.2%) 46(22.8%). 51(65.4%) 27(34.6%). 0.049. 166(74.1%) 58(25.9%). 41(73.2%) 15(26.8%). 0.88. 70(34.7%) 132(65.3%). 11(14.1%) 67(85.9%). 0.001. 64(28.6%) 160(71.4%). 17(30.4%) 39(69.6%). 0.87. 112(55.4%) 90(44.6%). 25(32.1%) 53(67.9%). 0.001. 115(51.3%) 109(48.7%). 22(39.3%) 34(60.7%). 0.135. 186(92.1%) 16(7.9%). 78(100.0%) 0(0.0%). 0.008. 209(93.3%) 15(6.7%). 55(98.2%) 1(1.8%). 0.21. 185(92.0%) 16(8.0%). 74(96.1%) 3(3.9%). 0.295. 207(93.2%) 15(6.8%). 52(92.9%) 4(7.1%). 0.92. 0.069 193(87.3%) 49(87.5%) ʳ 28(12.7%) ʳ 7(12.5%) ʳ ʳ ʳʳ. 0.97. !!=2 ԛ0ຼ! !!ɪ2 ԛ0ຼ!. 169(84.9%) 73(93.6%) 30(15.1%) 5(6.4%) ¨ Ӛᡂ໨ύΓኧό‫ࣁޣى‬લᅅॶ!. 34. ʳ ʳ.

(42) ߄Ϥ;ߚচՐ҇‫୷ޑ‬ҁၗ਑ᆶғࢲಞᄍ‫ ک‬UH Ϸ IEM.D ϐᜢ߯! ᡂ໨! ! ! !. ΟለҒ‫ݨ‬િ!. !. ʳ ʳ. !. ౦த!. n=58. n=494. ʳ. n=31. ! pॶ. 61.8±11.3. 63.4±11.1. 0.32. 59.4±12.2. 58.5±11.7. 0.62. 163(34.9%) 304(64.1%). 22(37.9%) 36(62.1%). 0.66. 165(33.4%) 329(66.6%). 20(64.5%) 11(35.5%). 0.001. 234(50.1%) 169(36.2%) 64(13.7%). 31(53.4%) 17(29.3%) 10(17.2%). 0.53. 249(50.4%) 174(35.2%) 11(14.4%). 16(51.6%) 12(38.7%) 3(9.7%). 0.75. 385(82.4%) 82(17.6%). 45(77.6%) 13(22.4%). 0.37. 407(82.4%) 87(17.6%). 23(74.2%) 8(25.8%). 0.24. 370(79.2%) 97(20.8%). 44(75.9%) 14(24.1%). 0.61. 391(79.1%) 103(20.9%). 23(74.2%) 8(25.8%). 0.5. 409(87.6%) 58(12.4%). 50(86.2%) 8(13.8%). 0.833. 435(88.1%) 59(11.9%). 24(77.4%) 7(22.6%). 0.093. 340(72.8%) 127(27.2%). 43(74.1%) 15(25.9%). 0.88. 360(72.9%) 134(27.1%). 23(74.2%) 8(25.8%). 0.87. 281(60.3%) 185(39.7%). 35(60.3%) 23(39.7%). 1. 298(60.4%) 195(39.6%). 18(58.1%) 13(41.9%). 0.85. 227(48.8%) 30(51.7%) 0.68 242(49.2%) 15(48.4%) 238(51.2%) 28(48.3%) ʳ 250(50.8%) ʳ 16(51.6%) ¨ Ӛᡂ໨ύΓኧό‫ࣁޣى‬લᅅॶ! ʳ ʳ ʳʳ. 0.93. !!=2 ԛ0ຼ! !!ɪ2 ԛ0ຼ! ၮ୏ԛኧ¨!. n=467. IEM.D! ҅த!. ‫܄‬ձ! !!‫!܄ت‬ !!ζ‫!܄‬ ௲‫ػ‬ำࡋ! !!୯ύаΠ! !!ଯύ! !!εᏢа΢! ‫ܜ‬๨ಞᄍ! !!ց! !!ࢂ! ໯ଚಞᄍ! !!ց! !!ࢂ! ᝅ१ᘓ཯ಞᄍ! !!ց! !!ࢂ! സ‫ڜ‬ଢ଼ಞᄍ! !!=2 ԛ0ຼ! !!ɪ2 ԛ0ຼ! സૡಞᄍ¨!. ౦த!. ʳ. ! pॶ. ԃស)ԃ*!. ҅த!. ʳʳ. !!=2 ԛ0ຼ! !!ɪ2 ԛ0ຼ!. 35. ʳ ʳ.

(43) ߄Ύ;চՐ҇ᆶߚচՐ҇‫ޑ‬ғ౛ғϯॶ‫ ک‬UH Ϸ IEM.D ϐКၨ ! ʳ ʳ. !. চՐ҇!. !. ԏᕭᓸ(mmHg)!! ๤஭ᓸ(mmHg)!! ‫ي‬ᡏ፦ໆࡰኧ(kg/m²)!!. ΟለҒ‫ݨ‬િ!. ! !. ౦த!. q!. ! 138.0±18.3. 139.4±17.4. 0.543. ! 85.3±11.9 ! 27.8±4.5 ! 89.5±10.9. 89.7±11.0. 0.006. 29.9±4.2 95.1±10.9. <0.001 <0.001. ᕴᖌ‫ڰ‬ᎇ(mg/dL)!! եஏࡋિೈқᖌ‫ڰ‬ᎇ(mg/dL)!! ֿለ(mg/dL)!!. ! 102.2±46.9 ! 187.4±42.9 ! 119.8±39.3 ! 6.2±0.8. ߚচՐ҇!. !. 124.8±69.0 195.8±72.8 91.5±76.5 6.3±0.8 ! !. ԏᕭᓸ(mmHg)!!. ! 129.4±18.1. ๤஭ᓸ(mmHg)!! ‫ي‬ᡏ፦ໆࡰኧ(kg/m²)!! ဈൎ)dn*! Ոᑗ(mg/dL)!! ᕴᖌ‫ڰ‬ᎇ(mg/dL)!!. ! ! ! !. ဈൎ)dn*! Ոᑗ(mg/dL)!!. եஏࡋિೈқᖌ‫ڰ‬ᎇ(mg/dL)!! ֿለ(mg/dL)!!. ҅த!. ʳ. ʳʳ. ʳ. ଯஏࡋિೈқᖌ‫ڰ‬ᎇ! ҅த!. !. ౦த!. 138.9±18.1 ʳ 136.4±17.9 86.9±11.6 ʳ 85.3±12.7. q! 0.344 0.394. 0.002 0.231 <0.001 0.377 ! !. 28.2±4.6 ʳ 29.0±4.1 90.3±11.5 ʳ 94.2±9.2 101.4±44.2 ʳ 136.8±79.2 192.9±42.4 ʳ 177.1±82.1 114.1±42.8 ʳ 103.2±84.5 6.2±0.8 ʳ 6.3±0.7 ! ! ! ! !. <0.001 0.045 0.174 0.484 ! !. 133.9±16.6. 0.076. 129.6±18.1. 134.3±14.5. 0.163. 77.6±11.2 24.0±3.5 80.5±9.7. 80.8±10.4 24.7±5.8 86.6±9.1. 0.043 0.195 <0.001. 77.77±11.2 24.0±3.7 80.7±9.7. 81.0±8.5 25.8±5.7 88.1±8.7. 0.117 0.011 <0.001. 96.2±31.7. 100.4±32.2. 0.353. 95.7±28.3. 112.6±65.2. 0.005. ! 199.9±34.9 ! 124.5±33.1. 215.4±49.6 116.5±44.4. 0.003 0.097. 203.4±36.1 124.8±34.1. 173.7±42.0 105.1±37.6. <0.001 0.002. 6.2±0.6. 0.135. 6.1±0.7. 6.2±0.8. 0.531. ! !. ! 6.1±0.7. 36. ʳ. 0.256 0.02.

(44) ߄Ζ;চՐ҇ঁΓ੯ੰў!. ʳ. চՐ҇!. !. ΟለҒ‫ݨ‬િ!. ! !. !. ҅த!. !. ౦த!. p ॶ!. ߷Јੰ!. !. !. !. !. !. !!ค! !!Ԗ! တύ॥! !!ค! !!Ԗ! ଯՈᓸ! !!ค! !!Ԗ! ᖌ‫ڰ‬ᎇၸଯ! !!ค! !!Ԗ! ᑗֿੰ! !!ค! !!Ԗ! ଯֿለՈੱ! !!ค! !!Ԗ!. ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! !. ʳ. !. 285)97/2&*! ! 73)8:/6&* 39)24/:&*! ! 27)31/6&* ! ! ! 2:8):8/6&*! ! 85):5/:&* 6)3/6&*! ! 5)6/2&*! ! ! ! ::)5:/1&*! ! 39)46/:&* 214)62/1&*! ! 61)75/2&* ! ! ! 2:5):7/1&*! ! 78)96/:&* 9)5/1&*! ! 22)25/2&* ! ! ! 289)99/2&*! ! 6:)86/7&* 35)22/:&*! ! 2:)35/5&* ! ! ! 26:)89/8&*! ! 74)91/9&* 54)32/4&*! ! 26)2:/3&*. 1/3! ! ! 1/38 ! ! 1/172 ! ! 1/117 ! ! 1/126 ! ! 1/856 !. 37. ʳ ʳ. IEM.D! ҅த! ʳ 29:)95/5&* 46)26/7&* ! 332):9/8&* 4)2/4&*! ! 215)57/5&* 231)64/7&* ! 321):4/9&* 25)7/4&*! ! 312)9:/8&* 34)21/4&* ! 28:)8:/:&* 56)31/2&*. ʳ ʳ ʳ ౦த!. ʳ. !. p ॶ!. ʳ ʳ 58)94/:&*!ʳ :)27/2&*! ʳ ! ʳ 61)9:/4&*!ʳ 7)21/:&*! ʳ ! ʳ 34)52/2&*!ʳ 44)69/:&*!ʳ ! ʳ 62):2/2&*!ʳ 6)9/:&*! ʳ ! ʳ 47)75/4&*!ʳ 31)46/8&*!ʳ ! ʳ 54)87/9&*!ʳ 24)34/3&*!ʳ. 2! ! ! 1/114! ! ! 1/65:! ! ! 1/662! ! ! =1/112! ! ! 1/696! ! !.

(45) ߄ΐ;ߚচՐ҇ঁΓ੯ੰўϩթ!. !. ʳ. ᡂ໨!. !. ΟለҒ‫ݨ‬િ!. ! !. !. ҅த!. !. ౦த!. p ॶ!. ߷Јੰ!. !. !. !. !. !. !!ค! !!Ԗ! တύ॥! !!ค! !!Ԗ! ଯՈᓸ! !!ค! !!Ԗ! ᖌ‫ڰ‬ᎇၸଯ! !!ค! !!Ԗ! ᑗֿੰ! !!ค! !!Ԗ! ଯֿለՈੱ! !!ค! !!Ԗ!. ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! !. 513)97/2&*! 76)24/:&*! ! 569):9/2&*! :)2/:&*! ! 45:)85/8&*! 229)36/4&*! ! 4:6)95/7&*! 83)26/5&*! ! 533):1/5&*! 56):/7&*! ! 543):3/6&*! 46)8/6&*!. ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! !. 55)86/:&*! 25)35/2&*! ! 69)211/1&*! 1)1/1&*! ! 49)76/6&*! 31)45/6&*! ! 54)85/2&*! 26)36/:&*! ! 61)97/3&*! 9)24/9&*! ! 5:)95/6&*! :)26/6&*!. 1/162 ! ! 1/718 ! ! 1/265 ! ! 1/16: ! ! 1/464 ! ! 1/157 ! !. ʳ ʳ. ! !. 38. ʳ ʳ. IEM.D! ҅த! ʳ 533)96/5&* 83)25/7&* ! 596):9/8&* :)2/4&*! ! 476)84/:&* 23:)37/2&* ! 522)94/3&* 94)27/9&* ! 561):2/2&* 55)9/:&*! ! 576):3/4&* 49)8/8&*!. ʳ ʳ ʳ ౦த!. ʳ ʳ. p ॶ! ʳ ʳ. 35)88/5&*!ʳ 8)33/7&*! ʳ ! ʳ 42)9:/4&*!ʳ 1)21/:&*! ʳ ! ʳ 33)82/1&*!ʳ :)3:/1&*! ʳ ! ʳ 38)98/2&*!ʳ 5)23/:&*! ʳ ! ʳ 33)82/1&*!ʳ :)3:/1&*! ʳ ! ʳ 36)91/7&*!ʳ 7)2:/5&*! ʳ. 1/3:6! ! ! 2! ! ! 1/78:! ! ! 1/914! ! ! 1/113! ! ! 1/147! ! !.

(46) ߄Μ;UbrJC ୷Ӣࠠϩթᆶғ౛ғϯࡰ኱ϐᜢ߯! ! ! Upubm! ԏᕭᓸ)nnIh*!! ๤஭ᓸ)nnIh*!! ‫ي‬ᡏ፦ໆࡰኧ)lh0n³*!! ဈൎ)dn*! Ոᑗ)nh0eM*!! ᕴᖌ‫ڰ‬ᎇ)nh0eM*!! ΟለҒ‫ݨ‬િ)nh0eM*!! ଯஏࡋિೈқᖌ‫ڰ‬ᎇ)nh0eM*!! եஏࡋિೈқᖌ‫ڰ‬ᎇ)nh0eM*!! ֿለ)nh0eM*!! চՐ҇! ԏᕭᓸ)nnIh*!! ๤஭ᓸ)nnIh*!! ‫ي‬ᡏ፦ໆࡰኧ)lh0n³*!! ဈൎ)dn*! Ոᑗ)nh0eM*!! ᕴᖌ‫ڰ‬ᎇ)nh0eM*!! ΟለҒ‫ݨ‬િ)nh0eM*!! ଯஏࡋિೈқᖌ‫ڰ‬ᎇ)nh0eM*!! եஏࡋિೈқᖌ‫ڰ‬ᎇ)nh0eM*!! ֿለ)nh0eM*!! ߚচՐ҇! ԏᕭᓸ)nnIh*!! ๤஭ᓸ)nnIh*!! ‫ي‬ᡏ፦ໆࡰኧ)lh0n³*!! ဈൎ)dn*! Ոᑗ)nh0eM*!! ᕴᖌ‫ڰ‬ᎇ)nh0eM*!! ΟለҒ‫ݨ‬િ)nh0eM*!! ଯஏࡋિೈқᖌ‫ڰ‬ᎇ)nh0eM*!! եஏࡋિೈқᖌ‫ڰ‬ᎇ)nh0eM*!! ֿለ)nh0eM*!!. ʳ. ʳʳ ʳ C20C2!!. ʳʳ. UbrJC ୷Ӣࠠ!. ʳʳ ʳ. C20C3!. C30C3!!. q ॶ!. 244/8!²!2:/6! 92/7!²!23/6!. 242/6!²!28/4! 91/4!²!22/9!. 245/4!²!29/1! 91/3!²!22/8!. 1/333!! 1/395!!. 37/4!²!5/8! 97/3!²!23/3! 214/3!²!55/1!. 36/3!²!4/:! 94/2!²!21/5! 211/5!²!53/2!. 35/9!²!4/5! 97/3!²!21/1! :4/8!²!3:/5!. =1/112! 1/112!! 1/258!!. 2:8/6!²!58/6! 25:/2!²!217/2 59/3!²!23/7!. 2:8/2!²!52/4! 236/2!²!94/8! 61/9!²!24/8!. 2:9/4!²!46/9! 247/8!²!:5/7! 61/4!²!25/6!. 1/:87!! 1/115!! 1/143!!. 22:/5!²!57/7!. 232/4!²!48/9!. 231/:!²!42/6!. 1/935!!. 7/3!²!1/9!. 7/2!²!1/8!. 7/2!²!1/9!. 1/252!!. ! !. ! !. ! !. 251/2!²!28/7! 98/6!²!22/1! 39/8!²!5/7! :3/3!²!22/4!. 245/4!²!27/8! 96/4!²!24/4! 38/9!²!5/4! 99/6!²!22/3!. 257/3!²!34/7! 93/6!²!23/9! 38/7!²!4/2! :1/:!²!8/2!. 1/126!! 1/26:!! 1/385!! 1/156!!. 21:/5!²!66/1! 2:2/:!²!68/4!. 218/6!²!65/9! 297/3!²!57/6!. 219/9!²!74/2! 289/9!²!39/5!. 1/:81!! 1/658!!. 295/6!²!23:/2 53/9!²!:/:! 223/3!²!69/4!. 256/6!²!233/8! 56/7!²!23/:! 222/5!²!68/6!. 229/2!²!73/1! 56/3!²!:/9! 21:/:!²!33/4!. 1/133!! 1/255!! 1/:97!!. 7/3!²!1/9!. 7/2!²!1/8!. 7/6!²!1/8!. 1/3:6!!. ! !. ! !. ! !. 238/7!²!2:/4!. 241/8!²!28/6!. 243/4!²!27/4!. 1/1:1!!. 87/2!²!22/3!. 89/8!²!21/9!. 8:/9!²!22/7!. 1/123!!. 34/:!²!4/:! 91/5!²!21/1! :8/3!²!39/:!. 35/5!²!4/4! 92/5!²!:/6! :9/2!²!47/:!. 34/8!²!6/1! 93/5!²!:/:! :2/3!²!29/6!. 1/422!! 1/427!! 1/353!!. 313/8!²!46/4! 226/8!²!73/5! 64/5!²!23/9! 234/9!²!45/8!. 311/8!²!4:/1! 229/6!²!76/5! 63/6!²!24/7! 235/6!²!44/7!. 312/5!²!47/1! 24:/8!²!:9/9! 62/3!²!26/2! 22:/8!²!48/6!. 1/962!! 1/141!! 1/55:!! 1/664!!. 7/3!²!1/8!. 7/2!²!1/8!. 7/2!²!1/8!. 1/472!!. ! !. ! !. 39.

(47) ߄Μ΋;J516W ୷Ӣࠠϩթᆶғ౛ғϯࡰ኱ϐᜢ߯. ʳ. ! !. ʳʳ ʳ. J516W ୷Ӣࠠ!. Upubm!. JJ!. JW!. ԏᕭᓸ)nnIh*!! ๤஭ᓸ)nnIh*!! ‫ي‬ᡏ፦ໆࡰኧ)lh0n³*!! ဈൎ)dn*! Ոᑗ)nh0eM*!! ᕴᖌ‫ڰ‬ᎇ)nh0eM*!! ΟለҒ‫ݨ‬િ)nh0eM*!! ଯஏࡋિೈқᖌ‫ڰ‬ᎇ)nh0eM*!! եஏࡋિೈқᖌ‫ڰ‬ᎇ)nh0eM*!! ֿለ)nh0eM*!! চՐ҇!. ʳʳ ʳʳ ʳ WW!. q ॶ!. 244/3!²!29/:!. 243/:!²!29/3!. 243/1!²!29/3!. 1/927!!. 92/:!²!23/4!. 91/6!²!23/1!. 91/6!²!22/:!. 1/415!!. 36/:!²!5/6! 96/2!²!23/2!. 36/9!²!5/4! 95/9!²!22/1!. 35/:!²!4/9! 94/6!²!21/8!. 1/183!! 1/483!!. :9/5!²!4:/7! 2:9/2!²!61/3! 254/:!²!221/7 5:/6!²!24/:!. 212/9!²!53/1! 2:7/9!²!49/4! 245/5!²!9:/5! 5:/5!²!23/7!. 213/9!²!55/9! 2:9/5!²!56/2! 249/3!²!9:/8! 5:/9!²!25/6!. 1/624!! 1/:15!! 1/585!! 1/:45!!. 22:/9!²!59/9!. 231/7!²!47/2!. 232/3!²!52/6!. 1/:59!!. 7/3!²!1/8!. 7/2!²!1/9!. 7/2!²!1/8!. 1/516!!. ! !. ! !. ! !. ! !. ԏᕭᓸ)nnIh*!! ๤஭ᓸ)nnIh*!! ‫ي‬ᡏ፦ໆࡰኧ)lh0n³*!! ဈൎ)dn*! Ոᑗ)nh0eM*!!. 251/1!²!28/:! 98/7!²!23/3! 39/7!²!5/7! :2/6!²!23/5!. 248/4!²!28/9! 96/8!²!22/8! 39/5!²!5/8! :2/1!²!22/1!. 249/2!²!2:/3! 98/1!²!22/4! 38/5!²!4/8! :1/7!²!9/2!. 1/627!! 1/578!! 1/454!! 1/:15!!. 213/3!²!58/:!. 221/:!²!66/6!. 226/6!²!77/:!. 1/441!!. ᕴᖌ‫ڰ‬ᎇ)nh0eM*!!. 2:2/8!²!76/8! 298/9!²!257/8 53/8!²!:/:!. 29:/1!²!51/6! 277/6!²!22:/7! 55/6!²!22/2!. 298/5!²!67/:! 253/8!²!8:/8! 54/5!²!22/9!. 1/997!! 1/246!! 1/523!!. 222/6!²!77/8! 7/4!²!1/9!. 222/3!²!52/5! 7/2!²!1/9!. 226/6!²!68/4! 7/4!²!1/8!. 1/:13!! 1/1:7!!. ! !. ! !. ! !. 239/:!²!29/5! 89/5!²!22/2! 35/2!²!4/6! 92/1!²!:/:!. 241/7!²!29/1! 88/9!²!22/3! 35/3!²!4/:! 92/7!²!:/6!. 23:/6!²!28/3! 88/:!²!22/2! 34/8!²!5/2! 91/7!²!21/4!. 1/746!! 1/976!! 1/577!! 1/789!!. :7/1!²!44/4! 313/3!²!47/9!. :7/:!²!42/8! 312/1!²!47/6!. :8/6!²!41/3! 313/:!²!49/9!. 1/:45!! 1/9:3!!. 226/9!²!77/2! 64/9!²!25/5! 236/3!²!42/:!. 228/6!²!73/4! 62/:!²!23/7! 235/3!²!45/5!. 247/5!²!:4/8! 63/6!²!25/9! 231/1!²!49/8!. 1/154!! 1/4:1!! 1/57:!!. 7/2!²!1/7!. 7/2!²!1/9!. 7/2!²!1/8!. 1/::2!!. ΟለҒ‫ݨ‬િ)nh0eM*!! ଯஏࡋિೈқᖌ‫ڰ‬ᎇ)nh0eM*!! եஏࡋિೈқᖌ‫ڰ‬ᎇ)nh0eM*!! ֿለ)nh0eM*!! ߚচՐ҇! ԏᕭᓸ)nnIh*!! ๤஭ᓸ)nnIh*!! ‫ي‬ᡏ፦ໆࡰኧ)lh0n³*!! ဈൎ)dn*! Ոᑗ)nh0eM*!! ᕴᖌ‫ڰ‬ᎇ)nh0eM*!! ΟለҒ‫ݨ‬િ)nh0eM*!! ଯஏࡋિೈқᖌ‫ڰ‬ᎇ)nh0eM*!! եஏࡋિೈқᖌ‫ڰ‬ᎇ)nh0eM*!! ֿለ)nh0eM*!!. ! !. 40.

(48) ߄ΜΒ;চՐ҇ᆶߚচՐ҇ϐғࢲࠠᄊჹ UH ၸଯϐ॥ᓀ! ᡂ໨!. !. !. !Crude OR. ԃស)ԃ*!. !. !!=6:073! ! !!ɪ6:073! ! ‫܄‬ձ! ! !!‫!܄ت‬ ! !!ζ‫!܄‬ ! ‫ܜ‬๨ಞᄍ! ! !!ց! ! !!ࢂ! ! ໯ଚಞᄍ! ! !!ց! ! !!ࢂ! ! ᝅ१ᘓ཯ಞᄍ!! !!ց! ! !!ࢂ! ! സ‫ڜ‬ଢ଼ಞᄍ! ! !!=2 ԛ0ຼ! ! !!ɪ2 ԛ0ຼ! ! സૡಞᄍ! ! !!=2 ԛ0ຼ! ! !!ɪ2 ԛ0ຼ! ! ၮ୏ԛኧ! ʳ !!=2 ԛ0ຼ! ʳ !!ɪ2 ԛ0ຼ! ʳ. !. !. চՐ҇!. 1 0.8 1 1.3 1 1.1 1 1.5 1 1.7 1 0.4 1 1.6 1. 95%CI. Adjust ORa. ! ߚচՐ҇!. 95%CI. Crude OR. Adjust ORb. 95%CI. (0.83-3.35). 1 1.3. (0.57-3.14). (0.66-2.30). 1 1.3. (0.57-3.02). (0.33-1.69). 1 1. (0.37-2.76). (1.03-2.72). 1 0.8. (0.40-1.65). (0.60-1.49). 1 1. (0.54-1.94). 95%CI. (0.45-1.30). 1 1.3. (0.80-2.00). (0.71-2.44). 1 0.8. (0.45-1.28). (0.55-2.25). 1 2.2. (0.76-3.15). 1 4.5. (0.87-3.22). 1 2.4. (0.10-1.50). 1 0.3. (0.52-4.80). 1 0.6. ʳ. (0.95-4.97). 1 1.7. (1.92-10.49). 1 1.2. (1.20-4.90). 1 0.7. (0.8-1.1). 1 1.7. (0.15-2.72). 1 0.9. 1. 1. 1. 0.3 (0.14-0.89) 0.6 (0.20-2.02) 0.8 (0.53-1.29) 0.9 (0.49-1.65) ፓ᏾Α‫܄‬ձǵԃសǵ๤஭ᓸǵ‫ي‬ᡏ፦ໆࡰኧǵՈᑗǵଯஏࡋિೈқᖌ‫ڰ‬ᎇǵեஏࡋિೈқᖌ‫ڰ‬ᎇ! c ፓ᏾Α‫܄‬ձǵԃសǵ๤஭ᓸǵᕴᖌ‫ڰ‬ᎇǵဈൎǵଯஏࡋિೈқᖌ‫ڰ‬ᎇ ! ! ! b. 41.