Vancomycin 的 SAR
1. 化學式 C66 H75 Cl2 N9 O24 2. 完整學名及別名
(1) 22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H, 16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetrac osine, vancomycin deriv.
(2) 22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H, 16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetrac osine-26-carboxylic acid, 3-(2-amino-2-oxoethyl)-44-[[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-Fa-L-lyx o-hexopyranosyl)-β-D-glucopyranosyl]oxy]-10,19-dichloro-2,3,4,5,6,7,23,24,2 5,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-[[(2R)-4-me thyl-2-(methylamino)-1-oxopentyl]amino]-2,5,24,38,39-pentaoxo-, (3S,6R,7R,22R,23S,26S,36R,38aR)- (3) 22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H, 16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetrac osine-26-carboxylic acid, 3-(2-amino-2-oxoethyl)-44-[[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy]-10,19-dichloro-2,3,4,5,6,7,23,24,25,2 6,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-[[(2R)-4-methyl -2-(methylamino)-1-oxopentyl]amino]-2,5,24,38,39-pentaoxo-, (3S,6R,7R,22R,23S,26S,36R,38aR)- (4) 22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H, 16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetrac osine-26-carboxylic acid, 3-(2-amino-2-oxoethyl)-44-[[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy]-10,19-dichloro-2,3,4,5,6,7,23,24,25,2 6,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-[[4-methyl-2-( methylamino)-1-oxopentyl]amino]-2,5,24,38,39-pentaoxo-,[3S-[3R*,6S*(S*),7 S*,22S*,23R*,26R*,36S*,38aS*]]- (5) Diatracin
藥學科技二
(Scifinder&Thomson Innovation 學習成果)
(6) Vancocin (7) Vancocin CP (8) Vancocine (9) Vancoled (10) Vancoplus 3. 結構式
4. 相關合成方法 1. 單步驟
3. 多步驟 11 步驟
5. 相關文獻
The interaction of vancomycin with DNA
Vancomycin is the store antibiotic, used only in the grave infections treatments (endocarditis, septicemias, pneumonias,meningitis) with the resistance pathogens of other antibiotics. The interaction of vancomycin with calf thymus DNA was studied by the absorbance measurements. The vancomycin self-assocn. has been investigated in terms of Tipping andSchwarz methods. The binding of vancomycin to DNA has been investigated in terms of Benesi-Hildebrand, Scott andScatchard methods, supposing a 1:1 binding ratio and do not account explicitly for either the dimerization of the drug or cooperativity effects on the binding.
在上這兩堂藥學科技之前，我從未接觸過這兩個軟體的相關資訊，甚至沒聽過， 使用過後覺得相當值得學習，尤其是 scifinder，不但會有新的研究資料，資料比 起 google 或 yahoo 等搜尋引擎所得較具準確性也比較有參考價值，不過 Thomson innovation 學校買的版本有許多功能無法使用無法做練習，是滿可惜的地方。 然而，scifinder 為英文版本，搜尋所得資料也較為專業，要使用它成為平時搜尋 工具，我認為自己也需培養好相當程度的專業知識，如此一來才足以利用他並從 其中學習到新的知識。
