藥學科技上課心得：游宗龍

Scifinder 學習心得與使用成果報告

指導老師：吳建德老師

班級：

D 班

學號：

B303098167

壹. 正文

65. MDMA: Interactions with other psychoactive drugs

By: Mohamed, Wael M. Y.; Ben Hamida, Sami; Cassel, Jean-Christophe; Pereira de Vasconcelos, Anne; Jones, Byron C.

3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most widely abused illegal drugs. Some users self-report euphoria and an increased perception and feeling of closeness to others. When taken in warm environments, MDMA users may develop acute complications with potential fatal consequences. In rodents, MDMA increases locomotor activity and, depending on ambient temp., may produce a dose-dependent, potentially lethal hyperthermia. Like most other recreational drugs, MDMA is frequently taken in combination with other substances including tobacco, EtOH, marijuana, amphetamines, cocaine and, caffeine. Although polydrug use is very common, the understanding of the effects of this multiple substance use, as well as the anal. of consequences of different drug-drug assocns., received rather little attention. The purpose of this review is to summarize our current knowledge about the changes on MDMA-related behavior, pharmacol., and neurotoxicity assocd. with co-consumption of other drugs of abuse and psychoactive agents.

貳

. 索引

Pharmacology

參. Concepts

Human

3,4-methylenedioxymethamphetamine increased locomotor activity and may develop lethal hyperthermia in rodent while its interaction with other drugs of abuse and psychoactive agents may cause neurotoxic effect in human

Neurotoxicity

3,4-methylenedioxymethamphetamine increased locomotor activity and may develop lethal hyperthermia in rodent while its interaction with other drugs of abuse and psychoactive agents may cause neurotoxicity in human

Behavior

3,4-methylenedioxymethamphetamine increased locomotor activity and may produce dose-dependent potentially lethal hyperthermia depending on ambient temp. in rodent

Substance abuse

3,4-methylenedioxymethamphetamine interaction with drug of abuse including tobacco, ethanol, marijuana, amphetamine, cocaine and caffeine may develop acute complication with potential fatal consequences in human

Combination chemotherapy

3,4-methylenedioxymethamphetamine interaction with psychoactive agents including tobacco, ethanol, marijuana, amphetamine, cocaine and caffeine may develop acute complication with potential fatal consequences in human

Fever and Hyperthermia

3,4-methylenedioxymethamphetamine may produce dose-dependent potentially lethal hyperthermia depending on ambient temp.

Behavior

locomotor; 3,4-methylenedioxymethamphetamine increased locomotor activity and depending on ambient temp. may produce dose-dependent potentially lethal hyperthermia in rodent

Cannabis sativa

marijuana; 3,4-methylenedioxymethamphetamine interaction with psychoactive agents including tobacco, ethanol, marijuana, amphetamine, cocaine and caffeine may develop acute complication with potential fatal consequences in human

肆

. 學習心得

在使用

_{Scifinder 的過程中，並沒有像 Innovation 上在收尋時那樣的方便，我覺得}

是自己在使用上，沒有運用到資料庫內的收尋工具，所以在收尋時才會一直無法

減少收尋目標的數量。

然而，我很喜歡

_{Scifinder 的 concepts 的整理，因為這篇資料經過各領域的專家}

先行閱讀整理，它可以幫助我快速而大略的了解本文，可以知道這篇的內容是不

是我所要的主題。

在使用上，我覺得

_{Scifinder 的學科分類選項的功能很強大，在收尋分類上，我可}

以清楚的區別我要的主題，如果可以加上其他的收尋技巧，在收尋主題上應該會

更得心應手。

伍

. 學習成果

登入後，找到主要的收尋引擎。

於收尋引擎中輸入我想要尋找的內容。

於右方

Analyze by 中，選取 CA section title，並選取 Pharmacology。