試題第 1 頁
高雄醫學大學 101 學年度 研究所 招生考試
考試科目: 英文
I. Vocabulary: Choose the answer that best matches the meaning of each bold word or phrase (20%) 1. Fungal spores, lighter and smaller than all plant seeds, are mainly dispersed from their parent by wind.A. spread widely B. delivered C. made more stable D. collected
2. The devastating earthquake and tsunami in Fukushima ruined most of the buildings there and killed thousands of lives. A. foreboding B. damaging and harmful C. bitter D. intimidating
3. The philosophy of Barack Obama’s foreign policy has been postulated as “The Obama Doctrine” for the principles it advocates.
A. disputed B. dismissed C. assumed D. scorned
4. Debates have been stirred on whether inmates should become the integral part of the social workforce. A. constituent B. honest C. extrinsic D. outward
5. A mistake that was inadvertently made by the clerk has cost him his job. A. intentionally B. deliberately C. carefully D. accidentally
6. It is mandatory that all students, regardless of degree program, take at least five core courses offered by the university. A. compulsory B. optional C. elective D. voluntarily
7. The Bumrungrad Hospital, one of the leading international hospitals in the world, is known for treating patients with state-of-the-art technology.
A. very expensive B. the most advanced C. fashionable D. national treasure
8. Clinicians argue that rigorous scientific research is not necessary on alternative medicine, but researchers think otherwise. A. powerful and forceful B. scrupulously accurate C. lenient D. strenuous
9. Under optimal temperature and growth conditions, certain bacteria can have a generation of 15-20 minutes. A. unfavorable B. adverse C. ideal D. disagreeable
10. The word “Linsanity” is now in most NBA fan’s vernacular as a result of Jeremy Lin’s stunning breakout performance in these past few weeks.
A. collection B. everyday language C. souvenir D. password
II. Sentence Completion: Choose the word that best completes the sentence (10%) 11. Mary is ______ and would never want to be closed in a small room or space.
A. xenophobic B. homophobic C. acrophobic D. claustrophobic
12. Studies show that ______ children are at high risk for a number of conditions, including overweight, high blood pressure and high cholesterol.
A. slim B. anorexic C. obese D. malnourished
13. The ways web-based social media impact our lives are rather different from the ways traditional media do, the most notable being that social media allow communication to become more ______.
A. interactive B. hyperactive C. stagnant D. torpid
14. According to the International Labor Organization, the recent economic decline is likely to increase the unemployment rate for women as well as to make gender _______ in economic policies more visible.
A. equality B. discrepancy C. disparity D. similarity
15. Children with disabilities are discriminated against and treated as burden mainly due to ______ understanding by society and a lack of social supports.
A. sufficient B. ample C. disinterested D. inadequate
III. Written Expression: Identify the underlined word or phrase that must be changed in order for the sentence to be correct (14%)
16. My (A) strong experience, (B) good training, and (C) am a hard worker (D) qualify me for this position.
17. In (A) recent years, some educators argue that it is better for undergraduate students (B) to focus on only one or two subjects than to study a (C) diversified range of different (D) subject.
18. The furniture and refrigerator were (A) delivered (B) promptly to my home, but they were not the style I (C) ordered, and the (D) price was not right either.
試題第 2 頁
19. The saltwater (A) crocodile, the largest of all living (B) reptiles, can travel long (C) distances at sea and is capable of killing any animal that (D) enter its territory.
20. If you are (A) assigned a specific topic for a research paper, you can begin (B) by going to the library to look for (C)informations that (D) is relevant to the topic.
21. According to scientists, if a woman’s waist is 70 percent as wide as her (A) hips, she (B) viewed as attractive by most men because the evolution of the brain (C) associates this body figure (D) with fertility.
22. Even though some companies view bribery (A) as illegal, (B) other tolerate it because it is a good way to speed up the (C) completion of a deal and (D) prevent harassment.
IV. Cloze Test: Choose the best answer for each missing word or phrase in the following passages (20%)
On the day of Taiwan's presidential election, hundreds of millions of ethnic Chinese worldwide watched the ballot count on TV and the Internet. Taiwan is the sole ethnic Chinese society (23) a second democratic turnover of power. Ethnic Chinese communities around the world (24) their hopes on this crucial political experiment. By succeeding, we can make
unparalleled contributions to the democratic development of all ethnic Chinese communities. This responsibility is (25) to fulfill. The new administration's most urgent task is to lead Taiwan through the daunting challenges from globalization. The world economy (26) profoundly, and newly emerging countries are arising rapidly. We must upgrade Taiwan's international (27) and recover lost opportunities. The uncertainty of the current global economy poses as the main challenge to the
revitalization of Taiwan's economy. Yet, we firmly believe that, with right policies and steadfast determination, our goals are (28) our grasp. (Source: President Ma's Inaugural Address in 2008)
23. A. to complete B. has completed C. completed D. to completing 24. A. laid B. is laying C. have laid D. will be laying 25. A. yours B. ours C. theirs D. them
26. A. change B. is changing C. had changed D. changed 27. A. competition B. competitiveness C. competitive D. competitor 28. A. beyond B. under C. next to D. within
The cinema offers a number of possible pleasures. One is scopophilia (a pleasure in looking). There are circumstances in which looking (29) is a source of pleasure, just as, in the reverse formation, there is pleasure in being looked at...[Freud] associated scopophilia with taking other people as objects, (30) them to a controlling and curious gaze... The camera satisfies a primordial wish (31) pleasurable looking, but it also goes further: developing scopophilia (32) its narcissistic aspect. (source: excerpt from “Visual Pleasure and Narrative Cinema” by Luara Mulvey)
29. A. itself B. at it C. forward to D. after 30. A. is subjecting B. subjecting C. subjects D. subjected 31. A. in B. at C. to D. for
32. A. in B. at C. to D. for
V. Reading Comprehension: Choose the best answers to the following questions (36%)
In a recent experiment, scientists asked a group of prescreened people to look at a set of gray patterns and try to visualize color. Eleven members of the group had been identified as highly susceptible to hypnosis while seven of the subjects were not
susceptible. Hypnosis is a trance-like state characterized by heightened focus, concentration, and inner absorption, according to the Mayo Clinic. About 10 percent of people worldwide are highly susceptible to hypnosis while 10 percent are not influenced at all. The remaining 80 percent—the majority of the population—are moderately susceptible, said study co-author William McGeown, a neuroscientist at the U.K.'s Hull University. The new study found that all the subjects who were easily hypnotized reported seeing a range of colors even while not under hypnosis, McGeown said. The scientists didn't just take their word for it—MRI scans showed that the parts of the subjects' brains linked to color perception lit up when they saw the imaginary hues. "We can see changes in these color-sensitive regions of their brains, which they have no way of faking," said McGeown, who published the study with colleagues in the December issue of the journal Consciousness and Cognition.
The new study also found that being under hypnosis enhanced color hallucination in susceptible subjects. But those who were not susceptible to hypnosis could not hallucinate color with or without hypnosis. Stephen Kosslyn, a psychologist at Stanford
試題第 3 頁
University, said the results reinforce his team's earlier research. In 2000, Kosslyn and colleagues published one of the first studies on hallucinating color. Their experiment asked highly susceptible people under hypnosis to imagine gray squares as being in color. That study, which used PET scans of the subjects' brains, also found that the subjects activated parts of their brains associated with color perception. The new study confirms a similar finding with MRI scans, which are more often favored in today's experiments because they provide better spatial resolution, co-author McGeown said.
Ultimately, the hallucination research may help medical professionals who use hypnosis to treat a range of conditions, from phobias to pain, McGeown noted. That's because, despite its medical use, many people are fearful of the procedure. The new research shows that suggestion can be almost as powerful a tool, which means there may be a less intimidating alternative for people fearful of hypnosis, he said. "Psychological therapies which consist of making suggestions to a patient—even in the absence of hypnosis—may help with their problem substantially."
(Source: “People Can Hallucinate Color at Will” by Christine Dell'Amore in National Geographic News, published December 7, 2011)
33. The word “susceptible” in this passage is closest in meaning to A. unresistant
B. invulnerable C. unexposed D. doubtful
34. Which of the following is NOT one of the characteristics of hypnosis? A. The subject is put into a sleeplike state
B. Hypnosis is a state of mental concentration C. A hypnotized mind is judging and critiquing. D. None of the above
35. Which of the following statements is NOT true?
A. Subjects who are susceptible to hypnosis can hallucinate color.
B. Subjects who are unsusceptible to hypnosis can visualize color when being under hypnosis. C. Only MRI scans were used in the experiment conducted by William McGeown and his partner.
D. The parts of the brain that respond to color perception are activated when the subjects are hallucinating color. 36. According to McGreown, the findings of hallucination research may be of help to people with
A. irrational fear of a specific object or activity B. migraine
C. fever
D. A and B only
37. Which of the following statements best summarizes the central idea of this article? A. Hypnosis can help people with their problems.
B. Some people are fearful of hypnosis
C. Only a portion of people are susceptible to hypnosis.
D. People can hallucinate color just with the power of suggestion.
“Green” has become a popular English phrase. It means that something is good for the environment. Customers are looking for products that are “natural,” “pure,” and “made from recycled materials.” They feel good about helping the Earth and about buying food and cosmetics that are healthier for their bodies. Anita Roddick sensed this when she founded The Body Shop in 1976. She advertised cosmetics that were “100 percent pure” and boasted that The Body Shop’s products were not tested on animals. Also, she said The Body Shop did not take unfair advantage of the workers in poor countries.
For some people, this sounded too good to be true. In 1994, reporter Jon Entine wrote a famous magazine article disputing Roddick’s claims. He said that The Body Shop cosmetics were actually only one percent pure. Entine also pointed out that most of the ingredients in The Body Shop’s product were, indeed, tested on animals. This prompted Roddick to change the phrase on her cosmetics labels. Instead of “not tested on animals,” it became “against animal testing.” Later, other critics joined in. The London chapter of Greenpeace accused The Body Shop of exploiting poor workers.
試題第 4 頁
do producers simply claim that they are so they can make more money? It’s a tough question. Thanks to writers such as Entine, however, one thing is certain: They are less likely to trust the manufacturer’s word.
(Source: “The Green Myth” in Reading for the Real World, Campus Publishing, 2009)
38. According to the passage, the word “green” has become associated with products A. that are not greasy and look fresh
B. that are friendly to the environment C. that can be easily absorbed by the body D. All of the above
39. Which of the following claims of The Body Shop was NOT disputed by Jon Entine? A. The Body Shop cosmetics did not exploit workers in poor countries.
B. The Body Shop cosmetics were not tested on animals. C. The Body Shop cosmetics were 100% pure.
D. None of the above
40. Which of the following statements best summarizes the main idea of the article? A. Customers should never trust the manufacturers because they are dishonest. B. Green advertising claims could be misleading.
C. “Green” is a good marketing strategy to sell products. D. False advertising should be punished.
41. Which of the following statement would the writer of this passage probably agree with? A. We should stop buying “green” products because none of them is really “green.” B. Anita Roddick has abused the trust of her customers.
C. Writers such as Jon Entine work to ruin manufactures’ reputation. D. All products are bad for environment.
About a year ago I was diagnosed with cancer. I had a scan at 7:30 in the morning, and it clearly showed a tumor on my pancreas. I didn't even know what a pancreas was. The doctors told me this was almost certainly a type of cancer that is incurable, and that I should expect to live no longer than three to six months. My doctor advised me to go home and get my affairs in order, which is doctor's code for prepare to die. It means to try to tell your kids everything you thought you'd have the next 10 years to tell them in just a few months. It means to make sure everything is buttoned up so that it will be as easy as possible for your family. It means to say your goodbyes. I lived with that diagnosis all day. Later that evening I had a biopsy, where they stuck an endoscope down my throat, through my stomach and into my intestines, put a needle into my pancreas and got a few cells from the tumor. I was sedated, but my wife, who was there, told me that when they viewed the cells under a microscope the doctors started crying because it turned out to be a very rare form of pancreatic cancer that is curable with surgery. I had the surgery and I'm fine now.
This was the closest I've been to facing death, and I hope it's the closest I get for a few more decades. Having lived through it, I can now say this to you with a bit more certainty than when death was a useful but purely intellectual concept:
Your time is limited, so don't waste it living someone else's life. Don't be trapped by dogma — which is living with the results of other people's thinking. Don't let the noise of others' opinions drown out your own inner voice. And most important, have the courage to follow your heart and intuition. They somehow already know what you truly want to become. Everything else is secondary.
When I was young, there was an amazing publication called The Whole Earth Catalog, which was one of the bibles of my generation. It was created by a fellow named Stewart Brand not far from here in Menlo Park, and he brought it to life with his poetic touch. This was in the late 1960's, before personal computers and desktop publishing, so it was all made with typewriters, scissors, and polaroid cameras. It was sort of like Google in paperback form, 35 years before Google came along: it was
idealistic, and overflowing with neat tools and great notions.
Stewart and his team put out several issues of The Whole Earth Catalog, and then when it had run its course, they put out a final issue. It was the mid-1970s, and I was your age. On the back cover of their final issue was a photograph of an early morning country road, the kind you might find yourself hitchhiking on if you were so adventurous. Beneath it were the words:
試題第 5 頁
"Stay Hungry. Stay Foolish." It was their farewell message as they signed off. Stay Hungry. Stay Foolish. And I have always wished that for myself. And now, as you graduate to begin anew, I wish that for you.
Stay Hungry. Stay Foolish.
(Source: Stanford commencement address delivered by Steve Jobs on June 12, 2005)
42. Which of the following statements is/are true about Steve Jobs?
A. He did not seem to be familiar with some body organs before his illness. B. He was told that he would be dead in less than a year.
C. The tumor he got could be removed with surgery D. All of the above
43. The phrase “buttoned up” is closest in meaning to A. kept silence
B. finished C. loosened up D. tied down
44. Why did Steve Jobs’ doctors react so strongly to the fact that Jobs’ cancer was actually curable? A. They were upset over the misdiagnosis they had made.
B. They were worried that Job would sue them for medical malpractice. C. They were surprised that they could keep their patient alive.
D. None of the above
45. In his speech, what advice did Jobs give to Stanford students? A. Do not try to live up to others’ expectation
B. Do not let other people speak louder than you do C. Always put yourself in others’ shoes
D. It is a waste of time to live with others
46. What did Jobs probably mean by “Stay Hungry. Stay Foolish”? A. He meant that it is good to eat less and study less.
B. He meant that it is important to always have the curiosity for knowledge. C. He meant that without enough food one can never be smart.
D. He meant that it is foolish to stay hungry.
Tonight is a particular honor for me because, let's face it, my presence on this stage is pretty unlikely.
My father was a foreign student, born and raised in a small village in Kenya. He grew up herding goats, went to school in a tin- roof shack. His father, my grandfather, was a cook, a domestic servant to the British. But my grandfather had larger dreams for his son. Through hard work and perseverance my father got a scholarship to study in a magical place, America, that's shown as a beacon of freedom and opportunity to so many who had come before him. While studying here my father met my mother. She was born in a town on the other side of the world, in Kansas.
My parents shared not only an improbable love; they shared an abiding faith in the possibilities of this nation. They would give me an African name, Barack, or "blessed," believing that in a tolerant America, your name is no barrier to success.
They imagined me going to the best schools in the land, even though they weren't rich, because in a generous America you don't have to be rich to achieve your potential.
They're both passed away now. And yet I know that, on this night, they look down on me with great pride. And I stand here today grateful for the diversity of my heritage, aware that my parents' dreams live on in my two precious daughters. I stand here knowing that my story is part of the larger American story, that I owe a debt to all of those who came before me, and that in no other country on Earth is my story even possible.
試題第 6 頁
Tonight, we gather to affirm the greatness of our nation not because of the height of our skyscrapers, or the power of our military, or the size of our economy; our pride is based on a very simple premise, summed up in a declaration made over two hundred years ago: "We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain inalienable rights, that among these are life, liberty and the pursuit of happiness."
That is the true genius of America, a faith in simple dreams, an insistence on small miracles; that we can tuck in our children at night and know that they are fed and clothed and safe from harm; that we can say what we think, write what we think, without hearing a sudden knock on the door; that we can have an idea and start our own business without paying a bribe; that we can participate in the political process without fear of retribution; and that our votes will be counted -- or at least, most of the time.
And fellow Americans, Democrats, Republicans, independents, I say to you, tonight, we have more work to do... more work to do, for the workers I met in Galesburg, Illinois, who are losing their union jobs at the Maytag plant that's moving to Mexico, and now they're having to compete with their own children for jobs that pay 7 bucks an hour; more to do for the father I met who was losing his job and choking back the tears wondering how he would pay $4,500 a month for the drugs his son needs without the health benefits that he counted on; more to do for the young woman in East St. Louis, and thousands more like her who have the grades, have the drive, have the will, but don't have the money to go to college.
People don't expect -- people don't expect government to solve all their problems. But they sense, deep in their bones, that with just a slight change in priorities, we can make sure that every child in America has a decent shot at life and that the doors of opportunity remain open to all.
(Source: Excerpt from Barack Obama’s Democratic Convention Speech delivered on July 27, 2004)
47. Which of the following is/are mentioned in Obama’s speech? A. Interracial heritage
B. Education C. Opportunity D. All of the above
48. Obama’s parents thought their son’s African name would not hinder his success because A. they believed he could go to the best school.
B. America is a racially tolerant country C. Obama is blessed by his name
D. one of his parents was born in America
49. Which of the following statements would Obama probably have faith in? A. All men are created equal
B. One does not have to be rich to achieve one’s dream in America C. There is no poverty in America
D. A and B only E. B and C only
50. What are some of the social causes that Obama would most probably support according to the passaget? A. Encouraging interracial marriage
B. Offering financial aids to low income students C. Lowering the unemployment rate
D. A and B only E. B and C only
試題第 1 頁
系所：藥學系碩士班乙組-有機藥物化學組
高雄醫學大學 101 學年度研究所招生考試
科目：藥物化學
A. Single choice questions: (40%)1. What drug could form complexes with iron ions? These complexes generate reactive oxygen species that cleave the strands of DNA. (A) Dactinomycin (B) Mitoxantrone (C) Amsacrine (D) Bleomycin
2. What drug is a naturally occurring cytotoxic alkaloid extracted from a Chinese bush? (A) Etoposide (B) Camptothecin (C) Melphalan (D) Doxorubicin
3. What drug has an indirect effect on thymidylate synthase by lowering the amount of N5,N10-methylene FH4 cofactor required? (A) Methotrexate (B) Pentostatin (C) Gemitabine (D) Prednisone
4. What drug is an analogue of ganciclovir where a methylene group has replaced the oxygen in the acylic ‘sugar’ moiety? It is metabolized to the active triphosphate in the same way as acyclovir. (A) Desciclovir (B) Penciclovir (C)
Valaciclovir (D) Valganciclovir
5. What drug is an orally active diaminopyrimidine structure which has proved to be a highly selective antibacterial and antimalarial agent? It could act against dihydrofolate reductase. (A) Trimethoprim (B) Sulfamethoxazole (C) Proflavine (D) Sulfanilamide
6. What description of 5-fluorouracil is wrong? (A) acting as a prodrug for a suicide substrate (B) is converted in the body to the fluorinated analogue of 2’-deoxyuridylic acid monophosphate (C) could inhibit ribonucleotide reductase (D) is a particular useful drug for the treatment of skin cancer
7. What description of physostigmine is wrong? (A) an anticholinesterase drug (B) an alkaloid (C) still used clinically to treat glaucoma (D) the carbamate group of its structure is not essential to activity
8. What description of alkylating agents is wrong? (A) are highly nucleophilic compounds that react with electrophiles to form strong covalent bonds (B) drugs with two alkylating groups can react with a quanine on each chain and cross-link the strands (C) chlormethine was the first alkylating agent to be used medicinally (D) have poor selectivity
9. What description of cimetidine is wrong? (A) inhibits H2 receptors (B) inhibits pentagastrin from stimulating release of gastric acid (C) the only metabolites that have been identified are due to oxidation of the sulfur link or oxidation of the ring methyl group (D) may not inhibit the cytochrome P450 enzymes in the liver
10. What drug is a proton pump inhibitor? (A) Omeprazole (B) Famotidine (C) Burimamide (D) Prednisolone 11. What structure is a 5-membered ring? (A) Pyrazine (B) Pyrrole (C) Pyrimidine (D) Piperidine
12. What is the parent nucleus for
N S
N Cl
? (A) Diazepin (B) Phenothiazine (C) Benzothiazole (D) Thiazepine
13. What drug is a third-generation cephalosporin? (A) Cefoxitin (B) Ceftazidine (C) Cefepime (D) Cefalexin 14. What drug could inhibit DNA polymerases? (A) Cytarabine (B) 6-mercaptopurine (C) Dihydrotestosterone (D)
Diethylstilbestrol
15. What drug could inhibit tubulin depolymerization? (A) Phyllanthoside (B)Mitosane (C) Cryptophycins (D) Taxol 16. What description of vancomycin is wrong? (A) a narrow-spectrum glycopeptide antibiotic (B) inhibits the production of
a sugar component of the bacterial cell wall (C) is derived from a linear heptapeptide containing six aromatic residues (D) is given orally to treat gut infections due to a microorganism called Clostridium difficile
B. What structures were intercalating drugs contain which can slide between the base pairs of the DNA double helix? (4%) C. Please explain LD50 and ED50. (4%)
D. Please explain the phenonmenon of synergy. (4%) E. Please explain ‘me too’ drug. (4%)
F. Please write three compounds which are thought to be neurotransmitters or neurohormones in the brain and operate as the body’s natural painkillers? (6%)
試題第 2 頁 G. Please number the following fused-ring systems. (6%)
(A) N N (B) N O O H2N
H. Please describe the five main mechanisms by which antibacterial agents act. (10%) I. Please explain the specificity and selectivity of target and its importance? (10%) J. Please explain four phases of clinical trials? (12%)
試題第 1 頁
系所：藥學系碩士班甲組-藥物分析學組
高雄醫學大學 101 學年度研究所招生考試
科目：藥物分析學
簡答及計算題：
1.質譜法中不同 Ionization Sources 適用藥物分析之不同用途，請舉出 5 種質譜法常用之 Ionization Sources。(英文作 答，10%)
2.請描述如何由 1.0 M acetic acid solution 與 sodium acetate 配製出 500.0 mL pH 4.5 之 buffer solution？Ka of CH3COOH is 1.75×10-5 (5%)
3.請描述 Thin Layer Chromatography (TLC)如何操作及其於藥物分析上之應用。(10%) 4.請比較 Liquid Chromatography (LC)及 Gas Chromatography (GC)異同之處。(10%) 5.測量中草藥內重金屬含量時，可用哪些分析方法？(5%)
申論題 (請詳細作答說明)：
1.利用 LC/ESI-Q-TOF mass spectrometry 可對藥物分子進行分子量分析，並可利用 MS/MS 進行結構鑑定。請敘述 Quadrupole(Q)及 Time-of-Flight (TOF) Mass Analyser 原理。(10%)
2.請敘述 Molecular Fluorescence Spectrometry 之原理並繪出儀器配置圖。(10%) 3.請介紹 Liquid Chromatography 常見之 detectors，並詳加說明。(10%)
4.請敘述 Micellar Electrokinetic Chromatography (MEKC)之原理。(10%)
5.藥物分析之樣品前處理常用 Solid Phase Extraction (SPE)，請敘述其原理及操作流程。(10%) 6.請說明影響 UV Spectrometry 吸收值之因素。(10%)
試題第 1 頁
系所：藥學系碩士班丙組-藥劑學組
高雄醫學大學 101 學年度研究所招生考試
科目：藥劑學
一、 解釋下列名詞: (每小題 4 分，共 20 分)
1. Accelerated stability tests
2. Effervescent granules
3. Gastrointestinal therapeutic system
4. IVIVC
5. HLB system
二、 簡述可做為測定粒子大小的方法及其特性？(10 分)
三、 試述乳劑(emulsion)與微乳劑(microemulsion)之異同及其優缺點為何？(10 分)
四、 藥品在劑型配方設計與製備前進行之配方前研究(preformulation studies)，主要評估藥品的那些
性質？請簡要說明其重點內容。(12 分)
五、 簡述製備錠劑的三種主要方法為何，各有何優缺點？(12 分)
六、 口服劑型基於那些原因或理由需在體內具有延遲釋放(delayed-release)之特性？製備時可藉由那
些方法達到此目的？(12 分)
七、 對藥用製劑產品而言所謂「滅菌(sterilization)」之意為何？並簡述中華藥典所載之滅菌方法。
(12 分)
八、 簡述下列二項生物技術產品之特性為何？(12 分)
1. Epoetin Alfa (Epogen)
試題第 1 頁
