第12屆海峽兩岸生物 匴孛孛木材捻舍
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EmergingTransIatiUnaI】
旺
UdeIfUr
NephrUlithiasisResearch
YuΠg一HSiaⅡgCheⅡ
,Wei-YUngLin,Huey-Ⅵ Chen,alldWen-ChiChen
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加 羽Severalanilllal speciesareusedtUstudycalciumUxalateurUlithiasis;hUwever,anideal lllUdelhas yettUbeidenⅡ Πed.WeusedD〞 U∫Up乃′′aasamUdelUrganismandfedtheflies lithUgenicagents such
asethylene叡 ycUl,hydrUxyl-L-prUline,andsUdiumUxalate.Atdifferent tⅡⅡes,theMalpighiantLlbules,
thekidneyequivalentUfinsects,weredissectedandapUlarizedlight rnicrUscUpeuSedtUhighlightthe
bire£Ⅱngentc呼stals. ScanningclectrUnⅡ ⅡcrUscUpyandenergy-diSpersiveX-rayspectrUscUpycUnnrllled
thatthec玓用talCUnlpUsitiUnwas predUΠinatelycalciulnUxalate FuhheΠ nUre,adninistratiUnUfpUtassium
citratesuccessfuIlyreducedthequantityUfandmUdulatedtheintegrityUftheethyleneglycUl-induced
c勺召talS.Thus,theD,.U∫Up乃′′alllUdelUfbiU-IⅡ inefalizatiUn prUducesc〃 Stals in theurinaΓγsyStem tlIUugh manylithUgenicagents,peΠ 【ⅡtsUbservajUnUfcrystalfUmajUn,andisamenabletUgeneticmanipulajUn. This mUdel rnayⅡ ⅡΠictheetiUlUgyandclinical lllanifestatiUnsUfcalciumUxalatestUnefUrlllatiUnand
aidin idenjncatiUnUfthegenejcbasisUfthisdisease Recentl,4lnelalmine-taintedfUUdcan inducerenal StUnes inbUthhumansandan丘 nals.WealsUfUundthatadIuinistra位UnUfIllelaΠlinealUnecausedc〃 Stal
fUma伍Un inadUse-dependent rnanner Thecξ ystalSalSUappearedafter ingesjUnUfrnelaΠ InefUr3、veeks
in theMalp㎏ hiantubulesUfDㄌ ∫Up乃′′a.ThesilllplebutelegantD石 U∫UpJ,′′aisemergingasapUwerft1l
tranSlajUnal rnUdelUfhumandisease,includingnephrUIithiasisandmayprUvideimpUrtant infUΠ natiUn esSentialtUUurunderstandingUfstUnefUrlllajUn TheabilnytUreadⅡ ylllanipulateandquanjn√ stUne fUl11latiUn inDη ∫qp乃〃沙mUdelsUfhumannephrUlithhsk presents tlleurUlU虫 ccUmmuniㄅ witllaunique
