Accession number:20080411053716
Title:Reverse iontophoresis: A non-invasive technique for measuring blood lactate level
Authors:Ching, C.T.S. (1); Connolly, P. (2)
Author affiliation:(1) Department of Computer and Communication Engineering, Asia University, Taichung County 41354, Taiwan; (2) Bioengineering Unit, University of Strathclyde, Glasgow, G40NW, United Kingdom
Corresponding author:Ching, C.T.S.
Source title:Sensors and Actuators, B: Chemical Abbreviated source title:Sens Actuators, B Chem Volume:129
Issue:1
Issue date:January 29, 2008 Publication year:2008
Pages:352-358 Language:English ISSN:09254005 CODEN:SABCEB
Document type:Journal article (JA)
Publisher:Elsevier, P.O. Box 211, Amsterdam, 1000 AE, Netherlands Abstract:Blood lactate monitoring is beneficial to many patients, e.g.
critical care patients. However, there are very few non-invasive or continuous monitoring systems for this parameter and significant clinical benefit could be achieved if such systems were readily
available. Therefore, the aim of the current study was to investigate the possibility of non-invasively extracting lactate from blood
through skin using reverse iontophoresis to monitor blood lactate levels in humans. In vitro reverse iontophoresis studies have indicated that the optimum switching mode for reverse
iontophoresis of lactate is continuous direct current but application of current combined with electrode polarity reversal every 15 min was suggested to be used in humans. The reverse iontophoresis technique was applied to 10 healthy volunteers and lactate was successfully extracted through their skin into the methylcellulose gel of the electrodes. A moderate correlation (r<sup>2</sup> =
0.6) between lactate concentrations in collection gels and lactate levels in the blood was observed after an outlier was removed from the regression equation. The result suggests that it may be possible to non-invasively monitor the blood lactate levels using reverse iontophoresis technique. © 2007 Elsevier B.V. All rights reserved.
Number of references:65 Main heading:Blood
Controlled terms:Electrodes - Gels - Medical applications - Patient treatment - Skin
Uncontrolled terms:Lactate - Reverse iontophoresis
Classification code:461.1 Biomedical Engineering - 461.2 Biological Materials and Tissue Engineering - 461.6 Medicine and
Pharmacology - 704.1 Electric Components - 801.3 Colloid Chemistry - 804 Chemical Products Generally
DOI:10.1016/j.snb.2007.08.031 Database:Compendex
Compilation and indexing terms, Copyright 2009 Elsevier Inc.
