Could traditional Chinese medicine used for curing erectile dysfunction?

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Accession number:20100312643678

Title: Could traditional Chinese medicine used for curing erectile dysfunction?

Authors: Chen, Chien-Yu (1); Bau, Da-Tian (1); Tsai, Ming-Hsui (3);

Hsu, Yuan-Man (1); Ho, Tin-Yun (2); Huang, Hung-Jin (1); Chang, Yea- Huey (1); Tsai, Fuu-Jen (4); Tsai, Chang-Hai (6); Chen, Calvin Yu- Chian (1)

Author affiliation:(1) Laboratory of Pharmacoinformatics and

Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, 40402, Taiwan; (2) Graduate Institute of Chinese Medical Science, China Medical University, Taichung, 40402, Taiwan; (3) Terry Fox Cancer Research Lab., China Medical University Hospital, Taichung, 40402, Taiwan; (4)

Department of Medical Genetics, Pediatrics and Medical Research, China Medical University Hospital, College of Chinese Medicine, Taichung, 40402, Taiwan; (5) Department of Bioinformatics, Asia University, Taichung, 41354, Taiwan; (6) Department of Healthcare Administration, Asia University, Taichung, 41354, Taiwan

Corresponding author:Bau, D.-T.

Source title: Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009

Abbreviated source title:Proc. Int. Conf. Biomed. Eng. Informatics, BMEI

Monograph title:Proceedings of the 2009 2nd International

Conference on Biomedical Engineering and Informatics, BMEI 2009 Issue date:2009

Publication year:2009 Article number:5304967 Language:English

ISBN-13:9781424441341

Document type:Conference article (CA)

Conference name:2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009

Conference date:October 17, 2009 - October 19, 2009 Conference location:Tianjin, China

Conference code:78840

Sponsor:IEEE Engineering in Medicine and Biology Society

Publisher:IEEE Computer Society, 445 Hoes Lane - P.O.Box 1331,

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Piscataway, NJ 08855-1331, United States

Abstract:This study could show that the potent inhibitor of PDE5 from Epimedium sagittatum components. The PDE 5 inhibitors of data set from Xia's study were calculated their properties. Multiple linear regression analysis was used to build the QSAR model. Those properties were associated to drug activities by the QSAR model.

This result showed high correlation (R2 = 0.848) with drug activities in this QSAR model. The weights of those properties were -5.359, 6.434, -3.959, 5.149, and 8.689. In the result of prediction, the correlation was employed to predict pIC50 of the ES series (Cialis = 7.988, ES02 = 6.31, ES03a = 9.78, ES03b = 10.03). The docking protocol was used to prove the trend of prediction. This result showed the same trend in docking scores (Cialis = 53.271, ES02 = 57.864, ES03a = 64.260, ES03b = 76.915). According to those results, ES03b was elevated to be a potent inhibitor of PDE5.

Number of references:14 Main heading:Medicine

Controlled terms: Docking - Linear regression - Molecular graphics Uncontrolled terms: Data sets - Docking score - Epimedium - Erectile dysfunction - Multiple linear regression analysis - PDE-5 inhibitor - Potent inhibitor - QSAR model - Traditional Chinese Medicine

Classification code:922.2 Mathematical Statistics - 801.4 Physical Chemistry - 723.5 Computer Applications - 931.3 Atomic and Molecular Physics - 674.1 Small Marine Craft - 655.1 Spacecraft, General - 461.6 Medicine and Pharmacology - 672 Naval Vessels DOI:10.1109/BMEI.2009.5304967

Database:Compendex