Author(s): Hsu, WC (Hsu, Wei-Chung); Chung, NN (Chung, Na-Na); Chen, YC (Chen, Yu- Chia); Ting, LL (Ting, Lai-Lei); Wang, PM (Wang, Po-Ming); Hsieh, PC (Hsieh, Pao-Chun);
Chan, SC (Chan, Shu-Ching)
Title: Comparison of surgery or radiotherapy on complications and quality of life in patients with the stage IB and IIA uterine cervical cancer
Source: GYNECOLOGIC ONCOLOGY, 115 (1): 41-45 OCT 2009 Language: English
Document Type: Article
Author Keywords: Quality of life; Complication; Radiotherapy; Surgery; Uterine cervical cancer
KeyWords Plus: SPARING RADICAL HYSTERECTOMY; TAIWAN CHINESE VERSION;
SEXUAL FUNCTION; EORTC QLQ-C30; VAGINAL CHANGES; CARCINOMA; QLQ-H-AND- N35; VALIDATION; MANAGEMENT; SURVIVORS
Abstract: Objectives. To compare the long-term complications and quality of life of patients with stage IB and stage IIA uterine cervical carcinoma treated by surgery or radiotherapy.
Methods. From August 2003 to May 2004, 202 patients with uterine cervical carcinoma were treated with surgery or radiotherapy at two institutions and were enrolled in this study upon follow-up at least 2 years post treatment. All patients completed the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and complications
Questionnaire.
Results. Constipation (P<0.001), flushing (p<0.001), dysuria (p<0.001), urinary incontinence (p<0.01), dysparia (p<0.05) and vaginal dryness (p<0.05) were statistically higher in the surgery treated group, while diarrhea (p<0.001), bloody stools (p<0.001) and abdominal pain (p<0.01) were higher in the radiotherapy group. Using factor analysis and introducing personal conditioned variables, pelvic neural dysfunction was significantly higher in surgery group and intestinal dysfunction was higher in radiotherapy group. There was no difference in sexual dysfunction between these two modalities. Comparison of EORTC QLQ-C30 showed that the majority of issues had minimal differences between these two treatment modalities, except social functioning (p<0.05; higher in radiotherapy group), constipation (p<0.001; higher in surgery group) and diarrhea (p<0.01; higher in radiotherapy group).
Conclusions. In early stage uterine cervical cancer patients, surgery or radiotherapy resulted in different complications, whereas long-term quality of life showed few differences between these two different modalities. These data were helpful for physicians in regards to the changes of patients, and moreover, for rehabilitation and supportive care of the patients after treatment. (C) 2009 Elsevier Inc. All rights reserved.
Addresses: [Chen, Yu-Chia] Natl Dong Hwa Univ, Coll Indigenous Studies, Program
Indigenous Social Work, Shoufeng 97401, Hualien, Taiwan; [Hsu, Wei-Chung; Chung, Na-Na;
Wang, Po-Ming] Cheng Ching Gen Hosp, Dept Radiat Oncol, Taichung, Taiwan; [Ting, Lai- Lei] Natl Taiwan Univ Hosp, Dept Oncol, Div Radiat Oncol, Taipei, Taiwan; [Ting, Lai-Lei] Natl Taiwan Univ, Coll Med, Dept Radiol, Taipei 10764, Taiwan; [Hsieh, Pao-Chun] Cheng Ching Gen Hosp, Dept Obstet & Gynecol, Taichung, Taiwan; [Chan, Shu-Ching] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan
Reprint Address: Chen, YC, Natl Dong Hwa Univ, Coll Indigenous Studies, Program Indigenous Social Work, 1,Sec 2,Hsueh Rd, Shoufeng 97401, Hualien, Taiwan.
E-mail Address: yuchiachenn@yahoo.com.tw Funding Acknowledgement:
Funding Agency Grant Number
Cheng Ching General Hospital Research Fund
We appreciated the financial support from the Cheng Ching General Hospital Research Fund. The resource of the some patients' data was based on Cancer Information Bank, Cheng Ching General Hospital.
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Cited Reference Count: 29 Times Cited: 0
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Publisher Address: 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2009.06.028
29-char Source Abbrev.: GYNECOL ONCOL ISO Source Abbrev.: Gynecol. Oncol.
Source Item Page Count: 5
Subject Category: Oncology; Obstetrics & Gynecology ISI Document Delivery No.: 496IZ
