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自體吞噬的介紹及其應用

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自體吞噬的介紹及其應用

資料整理學生:王文鴻 指導老師:林美惠

自體吞噬是細胞在缺乏營養或面臨壓力時的保命機制,主要是利用細胞質內 的胞器或蛋白質,在必要時使之降解,提供細胞能量以利於存活。自體吞噬也是 一種利用代謝物質進行回收,以維持細胞內部穩定的保護機制。自體吞噬已被證 實與多種疾病的形成有關,尤其是在腫瘤的形成過程中,扮演相當重要的角色。

本文首先介紹自體吞噬的機制,包括自體吞噬的作用過程、參與自體吞噬作用的 相關基因與自體吞噬的分類,接下來再進一步了解自體吞噬與神經性退化疾病、

糖尿病、腫瘤形成的關聯性,最後再討論透過自體吞噬的活化與抑制在醫療上可 能的治療策略。

文獻來源:

1. White E, DiPaola RS. The Double-edged sword of autophagy modulation in cancer. Clin Cancer Res. 2009,15:5308-5316.

2. Kuma A, Mizushima N. Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism. Semin Cell Dev Biol. 2010;21: 683-690.

3. Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell. 2004;6:463–477.

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