Author(s): Yeh, YH (Yeh, Yen-Hung); Chen, MH (Chen, Ming-Hsiung); Lee, YT (Lee, Ya- Ting); Hsieh, HS (Hsieh, Hung-Sheng); Hwang, DF (Hwang, Deng-Fwu)
Title: Effect of taurine on toxicity of oxidized cholesterol in rats
Source: JOURNAL OF FOOD AND DRUG ANALYSIS, 16 (3): 74-82 JUN 2008 Language: English
Document Type: Article
Author Keywords: taurine; oxidized cholesterol; toxic effect; rats; liver function KeyWords Plus: LIPID-PEROXIDATION; DIETARY TAURINE; INDUCED
NEPHROTOXICITY; GLUTATHIONE; INJURY; SUPPLEMENTATION; HEPATOTOXICITY;
HYPOTAURINE; METABOLISM; PROTECTION
Abstract: This research was aimed to study the effect of dietary taurine on the toxicity of oxidized cholesterol in male Wistar rats. The rats were divided into eight groups and fed different diets with or without supplement of 5% taurine and 3% oxidized cholesterol for 8 weeks. To evaluate effects of taurine at the same time, before diets and after diets in the food, after feeding diet with 3% oxidized cholesterol and 5% taurine at the same time, taurine could improve the decrease of body weight and the glutathione (GSH) level in the liver, and the increase of relative ratio of liver or kidney weight to body weight and thiobarbituric acid- reactive substances (TBARS) level in the liver of rats caused by oxidized cholesterol (P <
0.05). It also could inhibit the activities of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) in the plasma of rats caused by oxidized cholesterol (P
< 0.05). It was also found that taurine possessed a good recovering effect and a short-term preventing effect the toxicity of oxidized cholesterol in rats. Judging from these data, on taurine may play an important role in diminishing the toxic effect of oxidized cholesterol in rats.
Addresses: [Yeh, Yen-Hung] Toko Univ, Dept Nutr & Hlth Sci, Chiayi, Taiwan; [Chen, Ming- Hsiung; Hwang, Deng-Fwu] Natl Taiwan Ocean Univ, Dept Food Sci, Chilung, Taiwan; [Lee, Ya-Ting] Chien Kuo Technol Univ, Dept Beauty Sci, Changhua, Taiwan; [Hsieh, Hung-Sheng]
Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan
Reprint Address: Yeh, YH, Toko Univ, Dept Nutr & Hlth Sci, Chiayi, Taiwan.
E-mail Address: [email protected]
Cited References: *AM I NUTR, 1977, J NUTR, V107, P1340.
ALKHADER A, 1996, TRANSPLANTATION, V62, P427.
ALVAREZ JG, 1983, BIOL REPROD, V29, P548.
BANKS MA, 1992, ADV EXP MED BIOL, V315, P341.
BOSINGER S, 1993, INT DAIRY J, V3, P1.
CASINI AF, 1985, AM J PATHOL, V118, P225.
CHEN YX, 1993, CHIN MED J, V73, P276.
CHIUEH CC, 1999, FREE RADICAL RES, V31, P641.
CHOW CK, 1992, FATTY ACIDS FOODS TH, P689.
DAWSON R, 1999, MECH AGEING DEV, V107, P73.
DOGRUABBASOGLU S, 2001, HUM EXP TOXICOL, V20, P23.
ERDEM A, 2000, NEPHROL DIAL TRANSPL, V15, P1175.
FINOCCHIARO ET, 1983, J FOOD PROTECT, V46, P917.
GANDHI VM, 1992, INDIAN J EXP BIOL, V30, P413.
GHADERMARZI M, 1996, J ENZYM INHIB, V10, P167.
GRIFFITH OW, 1980, ANAL BIOCHEM, V106, P207.
GUTTERIDG JMC, 1995, CLIN CHEM, V14, P1819.
HAUMANN BF, 1993, INFORM, V4, P800.
HELRICH K, 1990, OFFICIAL METHODS ANA, P242.
HUXTABLE RJ, 1992, PHYSIOL REV, V72, P101.
HWANG DF, 1998, FOOD CHEM TOXICOL, V36, P239.
KIM SK, 2002, FOOD CHEM TOXICOL, V40, P545.
KONOSU S, 1982, CHEM BIOCH MARINE FO, P367.
KUBOW S, 1993, NUTR REV, V51, P33.
KURIYAMA K, 1980, FED PROC, V39, P2680.
MAELLARO E, 1990, BIOCHEM PHARMACOL, V39, P1513.
MAERKER G, 1987, J AM OIL CHEM SOC, V64, P388.
MEISTER A, 1983, ANNU REV BIOCHEM, V52, P711.
MEISTER A, 1983, SCIENCE, V220, P472.
MILEI J, 1992, AM HEART J, V123, P339.
MOCHIZUKI H, 1999, BIOSCI BIOTECH BIOCH, V63, P1984.
MORIN RJ, 1991, BIOL EFFECTS CHOLEST, P89.
MORIN RJ, 1992, BIOL EFFECTS CHOLEST, P191.
NAKAMURA T, 1993, BIOL PHARM BULL, V16, P970.
OSADA K, 1995, LIPIDS, V30, P405.
PANIANGVAIT P, 1995, J FOOD SCI, V52, P57.
PASANTESMORALES H, 1985, BIOCHEM PHARMACOL, V34, P2205.
PENG SK, 1984, WORLD REV NUTR DIET, V34, P653.
PURI SC, 1980, APPL STAT FOOD AGR S, P146.
RONALD L, 1992, CHRONIC HEPATITIS SC.
SAAD SY, 2002, CHEMOTHERAPY, V48, P42.
SCHULLERLEVIS G, 1994, ADV EXP MED BIOL, V359, P31.
STURMAN JA, 1986, ANN NY ACAD SCI, V477, P196.
TADOLINI B, 1995, BIOCHEM BIOPH RES CO, V213, P820.
TATUM VL, 1990, LIPIDS, V25, P226.
THURSTON JH, 1980, LIFE SCI, V26, P1561.
TRACHTMAN H, 1992, AM J PHYSIOL, V262, F117.
WANG JH, 1996, SHOCK, V6, P331.
WANG LC, 1997, J CHIN AGR CHEM SOC, V35, P612.
WATERS E, 2001, AM J PHYSIOL-GASTR L, V280, G1274.
WRIGHT CE, 1986, ANNU REV BIOCHEM, V55, P427.
YAMANAKA Y, 1986, J NUTR SCI VITAMINOL, V32, P287.
YEH YH, 2008, FOOD CHEM, V106, P260, DOI 10.1016/j.foodchem.2007.05.084.
YOKOGOSHI H, 1999, J NUTR, V129, P1705.
Cited Reference Count: 54 Times Cited: 1
Publisher: BUREAU FOOD DRUG ANALYSIS
Publisher Address: 161-2 KUNYANG STREET, NANGANG, TAIPEI, 00000, TAIWAN ISSN: 1021-9498
29-char Source Abbrev.: J FOOD DRUG ANAL ISO Source Abbrev.: J. Food Drug Anal.
Source Item Page Count: 9
Subject Category: Food Science & Technology; Pharmacology & Pharmacy ISI Document Delivery No.: 322CI
