Author(s): Chen, HY (Chen, Huey-Yi); Chung, YW (Chung, Ya-Wen); Lin, WY (Lin, Wei- Yong); Chen, WC (Chen, Wen-Chi); Tsai, FJ (Tsai, Fuu-Jen); Tsai, CH (Tsai, Chang-Hai) Title: Progesterone receptor polymorphism is associated with pelvic organ prolapse risk Source: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 88 (7): 835-838 2009 Language: English
Document Type: Article
Author Keywords: Pelvic organ prolapse; progesterone receptor gene polymorphism;
genotype
KeyWords Plus: B-ISOFORM; LIGAMENTS; GENE
Abstract: Progesterone and progesterone receptors (PGR) are known to play important roles in the pathophysiology of pelvic organ prolapse (POP). We investigated whether the PGR gene polymorphisms were associated with POP by conducting a case-control association study in 87 women with POP and 150 women without POP. Genotypes of the PGR gene polymorphisms (rs500760 and rs484389) were determined by polymerase chain reaction, followed by restriction fragment length polymorphism analysis. There was significant difference between women with and those without POP in the distribution of the PGR rs484389 genotypes evaluated. Using multivariable logistic regression, older age, increased body mass index, menopausal status, and PGR rs484389 genotype CT were significantly associated with POP. The present study shows that PGR genotype may be associated with POP.
Addresses: [Chen, Huey-Yi] China Med Univ, Dept Obstet & Gynecol, Taichung, Taiwan;
[Chen, Huey-Yi; Lin, Wei-Yong; Chen, Wen-Chi] China Med Univ, Grad Inst Integrated Med, Taichung, Taiwan; [Chung, Ya-Wen] Natl Chung Hsing Univ, Coll Life Sci, Taichung 40227, Taiwan; China Med Univ, Dept Med Genet, Taichung, Taiwan; [Chen, Wen-Chi] China Med Univ Hosp, Dept Urol, Taichung 404, Taiwan; [Tsai, Fuu-Jen] China Med Univ, Coll Chinese Med, Taichung, Taiwan; [Tsai, Chang-Hai] Asia Univ, Taichung, Taiwan
Reprint Address: Tsai, FJ, China Med Univ Hosp, Dept Med Genet, 2 Yu Der Rd, Taichung 404, Taiwan.
E-mail Address: [email protected] Funding Acknowledgement:
Funding Agency Grant Number
National Science Council of the Republic of China China Medical University
China Medical University Hospital NSC 96-2815-C-039-035B CMU96-035
DMR-97-076
The authors would like to thank the National Science Council of the Republic of China, the China Medical University, and the China Medical University Hospital for financially supporting this research under Contract NSC 96-2815-C-039-035B, CMU96-035, and DMR-97-076.
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Publisher: TAYLOR & FRANCIS AS
Publisher Address: KARL JOHANS GATE 5, NO-0154 OSLO, NORWAY ISSN: 0001-6349
DOI: 10.1080/00016340902822073
29-char Source Abbrev.: ACTA OBSTET GYNECOL SCAND ISO Source Abbrev.: Acta Obstet. Gynecol. Scand.
Source Item Page Count: 4
Subject Category: Obstetrics & Gynecology ISI Document Delivery No.: 460QN
