Dengue immunopathology research and teaching

國立成功大學「邁向頂尖大學計畫」

  延攬優秀人才工作報告表

NCKU’s “Aim for the Top University Project”

Work Report Form for Distinguished Scholars

▓續聘

□離職

100 年 7 月 13 日更新

Name of the Employee

Robert

Anderson 男 女Male Female

聘　期 Period of Employment from 2012 年(y)　4 月(m)　 15 日(d) to 2012 年(y) 12 月(m)　31 日(d) 研究或教學或科技研發與 管理計畫名稱 The project title of research,

teaching, technology development and management

Dengue immunopathology

research and teaching （申請單位主管）計畫主持人

Project Investigator (Head of Department/Center)

Dr Yee-Shin Lin

補助延聘編號

Grant Number

HUA101-21T-22-456

一、

（由受聘人填寫）

Please summarize the entire research, teaching, or science and technology R&D and management work process (To be completed

by the employee)

1. Summary

Over a three month period in 2012, I continued my highly productive research and teaching collaboration with the Department of Microbiology & Immunology at NCKU. Working primarily with Dr Yee-Shin Lin and colleagues, I was able to contribute to several manuscripts on dengue immunopathogenesis and related topics. I also coordinated a new funding proposal which promises to expand the international scope of our research. Furthermore, I made major contributions to teaching at NCKU, with numerous lectures in courses given by the Department of Microbiology & Immunology. Finally, my close interactions with faculty colleagues and students include extensive contributions to editing of manuscripts and enhancing English writing and speaking skills. 2, Time period of attendance at NCKU

April 15 - 29 2012 July 17 - Aug 5 2012 Oct 1 - 28 2012 Dec 3 - 31 2012 3. Research

Our main area of research, dengue virus pathogenesis, has been considerably advanced by the publication of several manuscripts, one international conference presentation, graduate student co-supervision and a new funding initiative. By joining forces with Dr Yee-Shin Lin and colleagues we have enhanced both our research programs and have built a strong international collaboration which capitalizes on our individual strengths. Within the scope of the newly established International Institute of Biomedical Sciences and Technology (IIBMST) I coordinated a new funding proposal which will facilitate closer interaction between NCKU and SUNY Upstate Medical University in the area of global dengue disease research. Specific collaborative highlights achieved this past year include the following:

3.1. Publications:

Fang, Y.T., Lin, C.F., Wang, C.Y., Anderson, R. and Lin, Y.S. (2012) Interferon- stimulates p11-dependent surface expression of annexin A2 in lung epithelial cells to enhance phagocytosis. J. Cell Physiol. 227, 2775-2787.

Wan, S.-W., Lin, C.-F., Lu, Y.-T., Lei, H.-Y., Anderson, R. and Lin, Y.-S. (2012) Endothelial cell surface expression of protein disulfide isomerase activates 1 and 3 integrins and facilitates dengue virus infection. J Cell. Biochem. 113, 1681-1691.

Wan, S.-W., Lin, C.-F., Yeh, T.-M., Liu, C.-C., Liu, H.-S., Wang, S.-Y., Ling, P., Anderson, R., Lei, H.-Y., and Lin, Y.-S. Autoimmunity in dengue pathogenesis. J. Formosa Med. Assoc. (in press).

Ho, T.-S., Wang, S.-M., Anderson, R., and Liu, C.-C. Antibodies in dengue immunopathogenesis. J. Formosa Med. Assoc. (in press).

Chen, C.-L., Lin, C.-F., Wan, S.-W., Wei, L.-S., Chen, M.-C., Yeh, T.-M., Liu, H.-S., Anderson, R. and Lin, Y.-S. Anti-dengue virus nonstructural protein 1 antibodies cause NO-mediated endothelial cell apoptosis via ceramide-regulated GSK-3 and NF-B activation. J. Immunol. (in revision).

3.2. International Conference presentation:

Lin, Y.-S., Fang, Y.-T., Lu, Y.-T., Lin, C.-F and Anderson, R. Autophagy facilitates antibody-enhanced dengue virus infection of human mast cells. Sixth International Symposium on Autophagy, Okinawa, Japan, Oct 28-Nov 1 2012.

4. Teaching and student mentoring

I have made major teaching contributions at NCKU by giving lectures in several graduate-level courses in Microbiology & Immunology. These are high-profile, "showcase" courses in the Department in which I am honored to be involved. Students are taught in English and respond well to the intellectual and linguistic challenges. In addition, my regular attendance at graduate student presentations and research meetings has provided great opportunities for advising on research projects and improving English language skills.

4.1. Lectures:

Scientific writing course

Oct 16 2012 Scientific writing (2 hour lecture) Graduate Immunology course

Dec 3 2012 "Dynamics of Adaptive Immunity" (3 hour lecture) Dec 10 2012 "Mucosal Immunity" (3 hour lecture)

Dec 17 2012 "Failures of Host Defense Mechanisms" (3 hour lecture) Dec 24 2012 "Allergy and Allergic Diseases" (3 hour lecture)

Advanced Immunology course

Dec 18 2012 "Antibody engineering" (3 hour class: lecture and student presentations) Dec 25 2012 "Vaccines" (3 hour class: lecture and student presentations)

Infectious Diseases course

Dec 26 2012 "HIV Immunity" (3 hour class: lecture and student presentations) 4.2. Seminar Presentations:

April 16 2012 "Cellular reprogramming by dengue virus", Dept Microbiology & Immunology, NCKU Dec 14 2012 "Flavivirus capsid protein interactomics", Dept Microbiology & Immunology, NCKU 4.3. Graduate Student co-supervision:

Working closely with primary graduate student Supervisor, Dr Yee-Shin Lin, I am providing ongoing research advice and collaborative assistance on the MSc project of Ms Ya-Ting Chu on the role of mast cells in dengue virus infection. This is one of several hot-topic areas in dengue research in which we are making significant contributions to new knowledge.

4.4. Graduate Student Thesis Defense Examinations: MSc thesis defense Chang Yu-Chang, July 26 2012 MSc thesis defense Yang Yi-Wan, July 26 2012

二、

由計畫主持人或單位主管填寫

Please evaluate the performance of research, teaching or science and technology R&D and management Work: ( To be completed

by Project Investigator or Head of Department/Center)

(1)是否達到延攬預期目標？

Has the expected goal of recruitment been achieved?

是的，無論在研究和教學上的成效都符合預期目標。

(2)研究或教學或科技研發與管理的方法、專業知識及進度如何？

What are the methods, professional knowledge, and progress of the research, teaching, or R&D and management work?

在研究上，共同研究主題為登革病毒之致病機制，著重於登革病毒感染時 mast cells 扮演的角

色。本年度已發表四篇期刊論文，另有在投稿中的 manuscripts。在教學上，負責 Graduate

Immunology 四週課程，Advanced Immunology 兩次課程，Infectious Diseases 一次課程，和英

文寫作課程，並且參與研究生每週之專題討論。在 EV71-dengue co-meeting 報告研究結果，並

且在 Journal Club 演講。

(3)受延攬人之研究或教學或科技研發與管理成果對該計畫(或貴單位)助益如何？

How have the research, teaching, or R&D and management results of the employed person given benefit to the project (or your unit)?

此密切的國際合作在傳染性疾病及訊息研究中心的登革病毒及訊息傳遞研究有很大的助益，

參加研究進度報告，並且共同發表論文。對於博士班和碩士班研究生，無論在教學和研究上

以及英文能力的增強都提供極大助益。

(4)受延攬人於補助期間對貴單位或國內相關學術科技領域助益如何？

How has the employed person, during his or her term of employment, benefited your unit or the relevant domestic academic field?

Dr. Robert Anderson 對於成大碩博士班研究生在學術研究上提供貢獻，擔任研究生的論文指

導委員，並且參加本中心定期舉行的進度報告會議。

(5)具體工作績效或研究或教學或科技研發與管理成果：

Please describe the specific work performance, or the results of research, teaching, or R&D and management work:

1. 共同合作探討登革病毒之致病機制，對於疫苗研發提供策略

2. 共同發表四篇期刊論文，並有 manuscripts 在送審或撰寫中

3. 與感染與免疫相關的授課計 7 次

4. 英文論文寫作的課程與輔導

5. 參與研究生每週之專題討論，以及免疫和感染症書報討論

6. 參加傳染性疾病及訊息研究中心定期舉行的進度報告會議

(6)

是否續聘受聘人?

▓續聘

□不續聘

※此報告表篇幅以三～四頁為原則。This report form should be limited to 3-4 pages in principle. ※此表格可上延攬優秀人才成果報告繳交說明網頁下載。

This report form can be downloaded in http://scholar.lib.ncku.edu.tw/explain/