利用超音波技術探討動脈硬化
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(7) . KXYZ [\]'^_`RKLMN B-Mode GHIS45a6789:&bUV cdeGHIfdW6778gh; i67jklS45bOm. ABSTRACT. nop&'23`RGHISfqrW 67789:sCDbE . Atherosclerosis is one of the major disease entities causing significant mortality and mobility of human beings. This complications resulted from atheroscl erosis such as hypertension, cerebral vascula r diseases and corona ry arte ry diseases are the major caus e of deaths for adults. The physicians should try to realiz e the cause of atheroscle rosis and how to observe the changes of blood wall resulted from atheroscl erosis will be crucial for the ea rlier detection and e arlie r tre atment. B-mode ultrasound has the advantage that it is noninvasive, can be used in nonsymptomatic subjects. Carotid artery is near the body surfa ce and easily to be used for noninvasive ultrasound investigation the artery wall charact eristics. Carotid artery wall thickness measured by ultrasound has recently been demonstrated to be significantly gre ater in patients with angiographyc ally de fined corona ry art ery disease than in patients with normal coronary angiogram. There for e, how to quantify the carotid artery wall changes becomes an. t&uvwxyzR B-Mode{|W6 7k}~k}f-ghT sCD &JfF . b&W. GHIk}yS0 @ by'a ¡¢S £UV¤¥&¦UV§`Rk }¨©ªlS«¬WGHIi o&`Rk}¨©ªlSf®W 678-gh¯Wq°v 10 mm ¨±²gh³-´µ gh³677¶;·0 67¸¹º h&UVF 6 »¼X -gh ´µ¯ 0.45±0.05mmƊ12 »wx -gh½s 0.79±0.14 mm¼X . 1.
(8) important tool for athe rosclerosis study. Currently, the clinicians use the longitudinal ultrasound image of c arotid art ery, then measure the intima-media thickness for the diagnosis re ference of atheros clerotic lesions. However, the measurement results will depend on the interobserve r vari ation. Actually, it is difficult to measure the intima-medi a thickness from the carotid ultrasound image when then the atheroscl erotic lesions in ea rly stage. To find a more sensitive way to quantify the atheroscl erotic lesions is a good rese ar ch topic. In this study, some image processing techniques are employed to investigate the arthe rosclerosis through the common carotid artery ultrasound image. The mean intima-media thickness, artery chamber di ameter changes and the embolism rate are obtained from the locations of 10 mm be for e the bifurcation of common carotid artery. The results show that the mean intima-media thickness of 6 normal subjects are 0.45±0.05 mm and those of 12 patients with stroke are 0.79±0.14 mm. In general, the intima-media thickness of normal subjects ar e less than 0.6 mm, and those of the patients with stroke are greate r than 0.6 mm. The intima-media thickness is a good parameter to diffe rentiate the normal subjects from the patients with stoke. Finally, embolism rate is another parameter using to separ ate the normal group(13.25±1.77 %) and the patient group(22.38±4.26 %). Keywords atherosclerosis, ultrasound, intima-madia.. ;á¢+/þ£678;&uve ¿GHIªl~GHI ¯wx y¿ X ùsCD t&2 Ú B-Mode GHIS45W67 8S
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(21) )vF&Diameter = 6.92 mmƋIMC Thickness = 0.97 mmƋE.R = 27.85%. Bà C|WGHIw67¶w)v F Bë #1 -!fähq´ B. . . ¯fÌw-!fÈ hÈ\å\a7³ºh\. ¼X Wk}¤. aæÉÊbçèäåãç& #2 Wk}¤. Diameter = 5.55 mm IMC Thickness = 0.43 mm E.R = 14.34%. Diameter = 5.28 mm IMC Thickness = 0.76 mm E.R = 28.67%. Bà ¼X Wk}-w)v FDiameter = 5.55 mmƋIMC Thickness= 0.43. mmƋE.R = 14.34%. Bú #2 Wk}-w )vF&Diameter = 5.28 mmƋIMC Thickness. #1 Wk}¤. = 0.76 mmƋE.R = 28.67%. Diameter = 6.92 mm IMC Thickness = 0.97 mm E.R = 27.85%. Bû #2 -!fähq´. Bê #1 Wk}-w. B 6.
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(35) ³¸¹ºhâ. ¤s¯fW«Gõ. ! c;aA¿wxy. O>67 zà67yð·0. ÅWW6. 9ÂebwST=ÈÑw ·0wå\.¯k}y67Ñ. 778ºhbÕÖ9e¿v[. wç7·0wÙ. [1GHI/rhzà B-Mode k}á. p&. ¢¯?@ãä0 :}ᢠ=>?@ãä?@ABEF&uB-mode WGHIk}y?f³f . . A¿wxytbÙÐÏb"¿CD& . ¯QRUV6 »¼X -. . gh´µ¯ 0.45±0.05 mmƊ12 »wx. . -gh½s 0.79±0.14 mm ¼X -gh´µ¾¿ 0.6mm. [1] D.H. O’Leary, et al “Use of sonography to Daniel H. O’Leary, Joseph F. Polak, Sidney K. Wol fs on Jr., “Use o f s o no g r a p h y t o e v a l u a t e c a r o t i d atherosclerosis in elderly the cardiovascul ar health study,” Stroke, vol. 2 2, p p . 1 1 5 5 - 1 1 6 3 , 1 9 9 1. [2] E. Grobbee and M. L. Bots, “Carotid artery intima -m edi a thi ckne ss a s indi c ator of gene ra liz ed a ther osc le rosi s,” Journal of internal M ed i cin e 2 36, p p. 3 41 -3 6 0, 1994. [3] P. Pignoli, E. Tremoli, A. Poli, P. Oreste a n d P a o l e tt i, “I n ti m a t e pl u s m e d i a l thi c kne s s o f a r t e r i a l w al l : a d i r e c t measur em ent with ultr asound imagi ng,” Circulation 74, no. 6, pp. 1399-1406, 1986 .. -ghÀÁ¿ 0.6 mm -gh OÃÄqÅd¼XÆ Ç p &¸ ¹ È É Ê¼ X 13.25±1.77 %Ƌ 22.38±4.26 %Ɗ!Ë OÃÄÌqd¼XÆ Çp&e ¿m=£ 67íy:b=8; : b; Á¾ í - çghS D67;Ùp 4¯QRUVM=£¸¹È -ghy¸¹ÈS
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(37) [4] J. R. Course, G. H. Harplod, E. R. Kahl, J. F. Toole and W. M. Mckinner, “Evaluation of a scoring system for extrac ranial carotid atherosclerosis extent with B-Mode ultrasound,” Strok e, vol. 17, no. 2, pp. 270-275, 1986. [5] J. R. Course, “Risk factors for extr ac ranial carotid artery Atheroscle rosis,” Stroke, vol. 18, pp. 990-996, 1987. [6] Suzan D. J. M. Kanters and Al e Algr a, “Reproducibility of in vivo carotid intima-media thickness measurement,” Stroke, vol. 28, pp. 782-787, 1997. [7] J . W i k s t r a n d a n d I . W e n d e l h a g , “Methodologic al consid er ations o f ultrasound investigation of intima-me dia thickness and lumen diameter,” Journal of Internal Medicine 236, pp. 555-559, 1994. [8] R. C. Gonzalez and R. E. Woods, Digital Image Proc essing, Addison Wesley, New York, 1993. [9] R. K. Shepard, G. James. and A. Samuel, “Quanti fi c ation of a the roscl e roti c plaque composition in cholesterol- fed r abbits with 50-MHz acoustic microscopy,” Athe rios cl e ros is an d Thromb osi s, vol. 12, no 10, pp.1227-1234, 1992. [10] # $ %, »k}¨©, &'B() *+l, ,-., pp. 419-427,1996. [11] Nobuyuki Ots u, “A threshold s el ect ion method from gray-l evel histograms,” IEEE T r a ns a c ti o ns on syst e m, vol. MSC - 9, n o . 1 , p p. 6 2 - 6 6 , J a n u a r y 1 9 7 9.. 10.
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