Author(s): Tsai, CH (Tsai, Chung-Huang); Li, TC (Li, Tsai-Chung); Lin, CC (Lin, Cheng- Chieh)
Title: Metabolic syndrome as a risk factor for nonalcoholic fatty liver disease Source: SOUTHERN MEDICAL JOURNAL, 101 (9): 900-905 SEP 2008 Language: English
Document Type: Article
Author Keywords: metabolic syndrome; nonalcoholic fatty liver disease; screening health examination; waist circumference
KeyWords Plus: INSULIN-RESISTANCE SYNDROME; BRIGHT LIVER;
STEATOHEPATITIS; PREVALENCE; CHOLESTEROL; PANEL
Abstract: Background: Metabolic syndrome has been linked to nonalcoholic fatty liver disease (NAFLD).
Objectives: The purpose of the current study was to evaluate metabolic syndrome as a risk factor for NAFLD in Taiwanese adults.
Methods: A cross-sectional study was conducted in which 876 subjects were enrolled. The diagnosis of NAFLD was made by abdominal ultrasonography. The Asia-Pacific modification of the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III guideline was used to establish the diagnosis of metabolic syndrome.
Results: NAFLD was diagnosed in 373 (42.6%) of the study population. Metabolic syndrome was diagnosed in 202 (23.1%) of the study population, and it was independently associated with NAFLD (odds ratio [OR] = 2.37; P < 0.001). Among the components of metabolic syndrome, hypertriglyceridemia (OR = 2.24; P < 0.001), hyperglycemia (OR = 2.23; P = 0.001), increased waist circumference (OR = 1.76; P = 0.013), and the diagnostic components of metabolic syndrome were independently associated with NAFLD.
Conclusion: Metabolic syndrome and some of its diagnostic components are independent risk factors for NAFLD.
Addresses: [Tsai, Chung-Huang] Cheng Ching Hosp, Dept Family Med, Taichung 407, Taiwan; Asia Univ, Coll Hlth Sci, Inst Hlth Care Adm, Taichung, Taiwan; China Med Univ, Coll Publ Hlth, Sch & Grad Inst Hlth Care Adm, Taichung, Taiwan; China Med Univ Hosp, Dept Family Med, Taichung, Taiwan; China Med Univ, Ctr Biostat, Coll Chinese Med, Grad Inst Chinese Med Sci, Taichung, Taiwan; Chaoyang Univ Technol, Grad Inst Biochem Sci &
Technol, Taichung, Taiwan
Reprint Address: Tsai, CH, Cheng Ching Hosp, Dept Family Med, 118 Sec 3,Chung Kang RD, Taichung 407, Taiwan.
E-mail Address: [email protected]
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Publisher: LIPPINCOTT WILLIAMS & WILKINS
Publisher Address: 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA ISSN: 0038-4348
29-char Source Abbrev.: SOUTHERN MED J ISO Source Abbrev.: South.Med.J.
Source Item Page Count: 6
Subject Category: Medicine, General & Internal ISI Document Delivery No.: 353QL
