[PDF] Top 20 Mechansims involved in the antiplatelet activity of midazolam in human platelets

... midazolam in platelet aggregation were explored by means of analysis of the platelet glycoprotein IIb-IIIa complex, phosphoinositide breakdown, intracellular Ca+2 mobilization, ... See full document

... mobilization in human platelets stimulated by collagen. Midazolam (6-26 mum) significantly inhibited thromboxane A2 formation stimulated by collagen in human ...Moreover, ... See full document

... Conclusions: These results indicate that the antiplatelet activity of midazolam may be involved in the following pathways: the effects of midazolam may initially be caused by induction[r] ... See full document

... In this study, ketamine concentration-dependently (100-350 microM) inhibited platelet aggregation both in washed human platelet suspensions and platelet-rich plasma stimulated by agoni[r] ... See full document

... Abstract In this study, magnesium sulphate dose-dependently ...aggregation in human platelets stimulated by ...with the binding of fluorescein isothiocanate-triflavin to ... See full document

... Abstract In this study, naloxone was tested for its antiplatelet activity in human platelet ...suspensions. In platelet suspensions ...inhibited the intracellular free ... See full document

... It is concluded that the antiplatelet activity of naloxone may possibly be due to the induction of conformational changes in the platelet membrane and the inhibition of the intracellula[r] ... See full document

... (1) Magnesium sulphate may initially induce membrane fluidity changes with resulting interference of fibrinogen binding to the GPIIb/IIIa complex, followed by inhibition of phosphoinos[r] ... See full document

... seizures in pregnant women with hypertension (Lucas et al, 1995). The principal objective of this study was to describe the detailed mechanisms involved in the inhibition ... See full document

... inhibited the intracellular free Ca2+ rise of Fura 2-AM loaded platelets stimulated by collagen (5 ...influence the binding of FITC-triflavin to platelet glycoprotein IIb/IIIa ... See full document

... At a higher concentration (1.0 mM), tetramethylpyrazine has also been shown to influence the binding of FITC-triflavin to platelet glycoprotein IIb/IIIa complex. Triflavin, a specific [r] ... See full document

... These results indicate that the antiplatelet activity of LTA may be involved in the following pathways: LTA's effects may initially be due to induction of conformational changes in th[r] ... See full document

... These results indicate that the antiplatelet activity of LTA may be involved in the following pathways: LTA's effects may initially be due to induction of conformational changes in the[r] ... See full document

... is in accord with the concept that intracellular Ca 2+ release is responsible for platelet aggregation ...Although the action mechanisms of various platelet aggrega- tion agonists, such as ... See full document

... In conclusion, these results indicate that the antiplatelet activity of rutin may involve the following pathways: rutin inhibited the activation of phospholipase C, followed by inhibit[r] ... See full document

... increase the formations of cyclic AMP and nitric oxide/cyclic GMP in ...platelets. In conclusion, these results indicate that the antiplatelet activity of ... See full document

... Abstract Midazolam is widely used as a sedative and anesthetic induction ...agent. The aim of this study was to systematically examine the inhibitory mechanisms of midazolam ... See full document

... Abstract Midazolam is widely used as a sedative and anesthetic induction ...agent. The aim of this study was to systematically examine the inhibitory mechanisms of midazolam ... See full document

... delay human ageing, but also has been convinced for it’s effects on cancer ...decrease the risks of prostate cancer, breast cancer, lung cancer, and so ...During the process of platelet ... See full document

... The present study reports a novel and potent antiplatelet agent, CAPE, which involved in the following inhibitory pathways: CAPE increases cyclic GMP/VASP Ser157 phosphorylation, and s[r] ... See full document