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Published 2011. Accessed August 26, 2016.
附錄一、 兒童脫水症狀之臨床表現(取自 NICE clinical guideline 84, 2009)
Increasing severity of dehydration
No clinically detectable dehydration
Clinical dehydration Clinical shock
Symptoms (remote and face-to-face assessments)
Appears well Appears to be unwell or deteriorating
–
Alert and responsive Altered responsiveness (for example, irritable, lethargic)
Decreased level of consciousness
Normal urine output Decreased urine output – Skin colour
unchanged
Skin colour unchanged Pale or mottled skin
Warm extremities Warm extremities Cold extremities
Signs (face-to-face assessments)
Alert and responsive Altered responsiveness (for example, irritable, lethargic)
Decreased level of consciousness
Skin colour unchanged
Skin colour unchanged Pale or mottled skin
Warm extremities Warm extremities Cold extremities Eyes not sunken Sunken eyes –
Moist mucous membranes (except after a drink)
Dry mucous membranes (except for ‘mouth breather')
–
Normal heart rate Tachycardia Tachycardia Normal breathing
pattern
Tachypnoea Tachypnoea
Normal peripheral pulses
Normal peripheral pulses Weak peripheral pulses
Normal capillary refill time
Normal capillary refill time Prolonged capillary refill time
Normal skin turgor Reduced skin turgor – Normal blood
pressure
Normal blood pressure Hypotension
(decompensated shock)
附錄二、搜尋文獻策略
資料庫 查詢日期 搜尋條件 篇數
Pubmed 2016.08.18 #1 ("racecadotril"[Supplementary
Concept] OR "racecadotril"[All Fields]) AND ("child"[MeSH Terms] OR
"child"[All Fields] OR "children"[All Fields])
48
#2 #1 AND (Randomized Controlled Trial[ptyp])
6
#3 #1 AND (systematic[sb])AND (meta-analysis)
11
#4 selected 5
Embase 2016.08.18 #1 'racecadotril'/exp OR racecadotril AND ('children'/exp OR children) AND acute AND ('gastroenteritis'/exp OR
gastroenteritis)
49
#2 #1 AND ('meta analysis'/de OR 'randomized controlled trial'/de OR 'systematic review'/de)
8
#3 selected 3
Cochrane Library
2016.08.18 #1 racecadotril 3
#2 Review OR health technology assessment
1
#3 selected 0
CRD 2016.08.18 #1 Racecadotril 1
#2 selected 1
附錄三、經濟評估文獻搜尋記錄
資料庫 查詢日期 關鍵字 篇數 篩選後篇數
PubMed 2016..08.24 #1 ((acute diarrhoea) OR infant) OR children
#2 (hidrasec) OR racecadotril
#3 (((cost effectiveness) OR cost utility) OR cost benefit) OR cost minimization
#1 and #2 and #3
3 1
EMBASE 2016.08.24 #1 ((acute diarrhoea) OR infant) OR children
#2 (hidrasec) OR racecadotril
#3 (((cost effectiveness) OR cost utility) OR cost benefit) OR cost minimization
#1 and #2 and #3
0 0
Cochrane Library
2016.08.24 #1 ((acute diarrhoea) OR infant) OR children
#2 (hidrasec) OR racecadotril
#3 (((cost effectiveness) OR cost utility) OR cost benefit) OR cost minimization
#1 and #2 and #3
1 0
CDR 2016.08.25 #1 ((acute diarrhoea) OR racecadotril
30 0 Airiti 2016.08.25 #1 racecadotril
#2 cost
#1 and #2
2 1