未來如果能將去模糊技術實際應用到本研究上,就能大幅降低影像在加速後 所產生的模糊指標程度。本研究中,目前證明 SCWB DTI 技術已經能降低傳統 DTI 造影的掃描時間,達到至少兩倍加速的效果,未來如果能在增加更多加速倍率,
不管是 2D 或者 3D 的 DTI 造影,將能夠改善傳統 DTI 掃描耗時太長的問題,也 能夠提升本研究的應用範圍取得大鼠全腦的 DTI 影像。而在未來也能與本研究室 所研發的高溫超導表面線圈技術[61],搭配多通道相位陣列線圈和低溫裝置,將能 夠結合寬頻磁振造影技術來取得大鼠脊神經的 DWI 影像和研究脊神經相關的疾病。
而且不僅是使用在神經相關疾病的研究,也希望能為在高時間解析度的前提下,
觀察像是心臟、胸腔等,容易產生假影的動態器官影像,利用更快的掃瞄速度來 觀察動態器官在隨時間快速變化狀態下的結構和生理變化也會是寬頻磁振造影技 術未來邁進的目標。最後,寬頻磁振造影技術應用在現今臨床的擴散磁振造影上,
還可以再結合常用的 EPI 技術實際應用在大腦臨床科學研究上。最後,寬頻磁振 造影技術應用到擴散磁振造影將會是未來的發展趨勢,不僅能加速掃描 DWI 影像 還能增加影像空間解析度,在臨床醫學疾病和大腦神經科學研究等都將會是一大 貢獻。
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參考文獻
[1] P. B. Kingsley, "Introduction to diffusion tensor imaging mathematics: Part III.
Tensor calculation, noise, simulations, and optimization," Concepts in Magnetic Resonance Part A, vol. 28, pp. 155-179, 2006.
[2] K. M. Hasan, D. L. Parker, and A. L. Alexander, "Comparison of gradient encoding schemes for diffusion‐tensor MRI," Journal of Magnetic Resonance Imaging, vol. 13, pp. 769-780, 2001.
[3] P. B. Kingsley, "Introduction to diffusion tensor imaging mathematics: Part II.
Anisotropy, diffusion ‐ weighting factors, and gradient encoding schemes,"
Concepts in Magnetic Resonance Part A, vol. 28, pp. 123-154, 2006.
[4] S. Hunsche, M. E. Moseley, P. Stoeter, and M. Hedehus, "Diffusion-Tensor MR Imaging at 1.5 and 3.0 T: Initial Observations 1," Radiology, vol. 221, pp.
550-556, 2001.
[5] S. Choi, D. T. Cunningham, F. Aguila, J. D. Corrigan, J. Bogner, W. J. Mysiw, et al., "DTI at 7 and 3 T: systematic comparison of SNR and its influence on quantitative metrics," Magnetic resonance imaging, vol. 29, pp. 739-751, 2011.
[6] I.-T. Lin, H.-C. Yang, and J.-H. Chen, "Using high-Tc superconducting resonator for enhancement of diffusion tensor imaging," Journal of Applied Physics, vol.
109, p. 116103, 2011.
[7] M. Laakso, K. Partanen, P. Riekkinen, M. Lehtovirta, E.-L. Helkala, M.
Hallikainen, et al., "Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia An MRI study,"
Neurology, vol. 46, pp. 678-681, 1996.
[8] A. Saleh, M. Schroeter, C. Jonkmanns, H. P. Hartung, U. Mödder, and S. Jander,
"In vivo MRI of brain inflammation in human ischaemic stroke," Brain, vol. 127, pp. 1670-1677, 2004.
[9] P. Hagmann, M. Kurant, X. Gigandet, P. Thiran, V. J. Wedeen, R. Meuli, et al.,
"Mapping human whole-brain structural networks with diffusion MRI," PloS one, vol. 2, p. e597, 2007.
[10] J. Achterberg, K. Cooke, T. Richards, L. J. Standish, L. Kozak, and J. Lake,
"Evidence for correlations between distant intentionality and brain function in recipients: a functional magnetic resonance imaging analysis," Journal of Alternative & Complementary Medicine: Research on Paradigm, Practice, and Policy, vol. 11, pp. 965-971, 2005.
[11] D. Le Bihan, "Looking into the functional architecture of the brain with diffusion MRI," Nature Reviews Neuroscience, vol. 4, pp. 469-480, 2003.
[12] K. Setsompop and L. L. Wald, "Method for simultaneous multi-slice magnetic resonance imaging," ed: Google Patents, 2010.
63
[13] K. Lee, J. Wild, P. Griffiths, and M. Paley, "Simultaneous multislice imaging with slice‐multiplexed RF pulses," Magnetic resonance in medicine, vol. 54, pp.
755-760, 2005.
[14] P. J. Basser, J. Mattiello, and D. LeBihan, "MR diffusion tensor spectroscopy and imaging," Biophysical journal, vol. 66, pp. 259-267, 1994.
[15] H. C. Torrey, "Bloch equations with diffusion terms," Physical Review, vol. 104, p. 563, 1956.
[16] P. J. Basser and D. K. Jones, "Diffusion‐tensor MRI: theory, experimental design and data analysis–a technical review," NMR in Biomedicine, vol. 15, pp.
456-467, 2002.
[17] C.-P. Lin, V. J. Wedeen, J.-H. Chen, C. Yao, and W.-Y. I. Tseng, "Validation of diffusion spectrum magnetic resonance imaging with manganese-enhanced rat optic tracts and ex vivo phantoms," Neuroimage, vol. 19, pp. 482-495, 2003.
[18] V. J. Wedeen, R. Wang, J. D. Schmahmann, T. Benner, W. Tseng, G. Dai, et al.,
"Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers," Neuroimage, vol. 41, pp. 1267-1277, 2008.
[19] D. S. Tuch, "Q‐ball imaging," Magnetic Resonance in Medicine, vol. 52, pp.
1358-1372, 2004.
[20] A. W. Anderson, "Measurement of fiber orientation distributions using high angular resolution diffusion imaging," Magnetic Resonance in Medicine, vol. 54, pp. 1194-1206, 2005.
[21] P. J. Basser and C. Pierpaoli, "A simplified method to measure the diffusion tensor from seven MR images," Magnetic resonance in medicine, vol. 39, pp.
928-934, 1998.
[22] C.-F. Westin, S. E. Maier, H. Mamata, A. Nabavi, F. A. Jolesz, and R. Kikinis,
"Processing and visualization for diffusion tensor MRI," Medical image analysis, vol. 6, pp. 93-108, 2002.
[23] P. F. Góra, "The theory of Brownian Motion: A Hundred Years’ Anniversary,"
Marian Smoluchowski Institute of Physics, pp. 52-57, 2006.
[24] E. L. Hahn, "Spin echoes," Physical Review, vol. 80, p. 580, 1950.
[25] H. Y. Carr and E. M. Purcell, "Effects of diffusion on free precession in nuclear magnetic resonance experiments," Physical Review, vol. 94, p. 630, 1954.
[26] F. Bloch, "Nuclear induction," Physical review, vol. 70, p. 460, 1946.
[27] E. Stejskal and J. Tanner, "Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient," The journal of chemical physics, vol. 42, p. 288, 1965.
[28] D. Le Bihan and E. Breton, "Imagerie de diffusion in-vivo par resonance magnetique nucleaire," Comptes-Rendus de l'Académie des Sciences, vol. 93, pp.
27-34, 1985.
64
[29] D. Taylor and M. Bushell, "The spatial mapping of translational diffusion coefficients by the NMR imaging technique," Physics in Medicine and Biology, vol. 30, p. 345, 1985.
[30] D. Le Bihan, E. Breton, D. Lallemand, P. Grenier, E. Cabanis, and M.
Laval-Jeantet, "MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders," Radiology, vol. 161, pp.
401-407, 1986.
[31] S. Warach, D. Chien, W. Li, M. Ronthal, and R. Edelman, "Fast magnetic resonance diffusion‐weighted imaging of acute human stroke," Neurology, vol.
42, pp. 1717-1717, 1992.
[32] G. Cleveland, D. Chang, C. Hazlewood, and H. Rorschach, "Nuclear magnetic resonance measurement of skeletal muscle: anisotrophy of the diffusion coefficient of the intracellular water," Biophysical journal, vol. 16, pp.
1043-1053, 1976.
[33] P. Douek, R. Turner, J. Pekar, N. Patronas, and D. Le Bihan, "MR color mapping of myelin fiber orientation," Journal of Computer Assisted Tomography/Journal of Computer-Assisted Tomography, vol. 15, pp. 923-9, 1991.
[34] S. Mori, Introduction to diffusion tensor imaging: Elsevier, 2007.
[35] A. T. Van, C. Granziera, and R. Bammer, "An Introduction to Model-Independent Diffusion MRI," Topics in magnetic resonance imaging:
TMRI, vol. 21, p. 339, 2010.
[36] D. Jones, M. Horsfield, and A. Simmons, "Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging," Magn Reson Med, vol. 42, 1999.
[37] C. Pierpaoli and P. J. Basser, "Toward a quantitative assessment of diffusion anisotropy," Magnetic resonance in medicine, vol. 36, pp. 893-906, 1996.
[38] J. Mattiello, P. J. Basser, and D. LeBihan, "Analytical Expressions for the< i>
b</i> Matrix in NMR Diffusion Imaging and Spectroscopy," Journal of magnetic resonance, Series A, vol. 108, pp. 131-141, 1994.
[39] J. Mattiello, P. J. Basser, and D. Le Bihan, "The b matrix in diffusion tensor echo‐planar imaging," Magnetic Resonance in Medicine, vol. 37, pp. 292-300, 1997.
[40] M. Neeman, J. P. Freyer, and L. O. Sillerud, "A simple method for obtaining cross‐term‐free images for diffusion anisotropy studies in NMR microimaging,"
Magnetic Resonance in Medicine, vol. 21, pp. 138-143, 1991.
[41] M. Neeman, J. P. Freyer, and L. O. Sillerud, "Pulsed-gradient spin-echo diffusion studies in NMR imaging. Effects of the imaging gradients on the determination of diffusion coefficients," Journal of Magnetic Resonance (1969), vol. 90, pp. 303-312, 1990.
65
[42] P. Hagmann, L. Jonasson, P. Maeder, J.-P. Thiran, V. J. Wedeen, and R. Meuli,
"Understanding Diffusion MR Imaging Techniques: From Scalar Diffusion-weighted Imaging to Diffusion Tensor Imaging and Beyond1,"
Radiographics, vol. 26, pp. S205-S223, 2006.
[43] D. S. Tuch, T. G. Reese, M. R. Wiegell, N. Makris, J. W. Belliveau, and V. J.
Wedeen, "High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity," Magnetic Resonance in Medicine, vol. 48, pp.
577-582, 2002.
[44] V. J. Wedeen, P. Hagmann, W. Y. I. Tseng, T. G. Reese, and R. M. Weisskoff,
"Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging," Magnetic Resonance in Medicine, vol. 54, pp. 1377-1386, 2005.
[45] S. Mori and P. van Zijl, "Fiber tracking: principles and strategies–a technical review," NMR in Biomedicine, vol. 15, pp. 468-480, 2002.
[46] M. Lazar, D. M. Weinstein, J. S. Tsuruda, K. M. Hasan, K. Arfanakis, M. E.
Meyerand, et al., "White matter tractography using diffusion tensor deflection,"
Human brain mapping, vol. 18, pp. 306-321, 2003.
[47] G. J. Parker, C. A. Wheeler-Kingshott, and G. J. Barker, "Estimating distributed anatomical connectivity using fast marching methods and diffusion tensor imaging," Medical Imaging, IEEE Transactions on, vol. 21, pp. 505-512, 2002.
[48] Y.-A. Huang, E. L. Wu, T.-D. Chiueh, and J.-H. Chen, "W= 2 Acceleration Single carrier Wideband MRI Technique and Blur Mitigation Method."
[49] E. Wu, J. Chen, and T. Chiueh, "Wideband MRI: a new dimension of MR image acceleration," in Proceedings of the 17th annual meeting of ISMRM, Hawaii, USA, 2009, p. 2678.
[50] E. Wu, J.-H. Chen, and T.-D. Chiueh, "Wideband MRI: Theoretical analysis and its applications," in Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE, 2010, pp. 5681-5684.
[51] E. L. Wu, L.-W. Kuo, F.-H. Wu, C.-F. Hsu, C.-W. Hsieh, J.-H. Chen, et al.,
"Ultra-fast brain MR imaging using simultaneous multi-slice acquisition (SMA) technique," in Engineering in Medicine and Biology Society, 2007. EMBS 2007.
29th Annual International Conference of the IEEE, 2007, pp. 2618-2621.
[52] E. Wu, J. Chen, and T. Chiueh, "A study of Wideband MR imaging: SNR and CNR."
[53] E. Wu, J. Chen, and T. Chiueh, "Wideband MRI: A new dimension of MR image acceleration," in Proceedings of the 17th Annual Meeting of ISMRM, 2009, p.
2678.
[54] F. Wu, E. Wu, L. Kuo, J. Chen, and T. Chiueh, "Wideband parallel imaging," in Proceedings of the 17th Annual Meeting of ISMRM, Hawaii (ISMRM, Berkeley,
66
CA, 2009), p. 2677.
[55] E. Wu, K. Cho, T. Chiueh, and J. Chen, "Reduction of Diffusion Tensor Imaging Acquisition Time with Wideband MR Imaging."
[56] J.-h. Chen, T.-d. Chiueh, E. L. Wu, and L.-w. Kuo, "Method and apparatus for simultaneously acquiring multiple slices/slabs in a magnetic resonance imaging system," ed: EP Patent 2,116,859, 2009.
[57] C.-P. Lin, W.-Y. I. Tseng, H.-C. Cheng, and J.-H. Chen, "Validation of diffusion tensor magnetic resonance axonal fiber imaging with registered manganese-enhanced optic tracts," Neuroimage, vol. 14, pp. 1035-1047, 2001.
[58] S. Brockstedt, C. Thomsen, R. Wirestam, S. Holtås, and F. Ståhlberg,
"Quantitative diffusion coefficient maps using fast spin-echo MRI," Magnetic resonance imaging, vol. 16, pp. 877-886, 1998.
[59] T. M. Shepherd, E. Ö zarslan, M. A. King, T. H. Mareci, and S. J. Blackband,
"Structural insights from high-resolution diffusion tensor imaging and tractography of the isolated rat hippocampus," Neuroimage, vol. 32, pp.
1499-1509, 2006.
[60] J. Zhang, P. van Zijl, and S. Mori, "Three-dimensional diffusion tensor magnetic resonance microimaging of adult mouse brain and hippocampus," Neuroimage, vol. 15, pp. 892-901, 2002.
[61] I.-T. Lin, H.-C. Yang, L.-W. Kuo, C.-W. Hsieh, C. Yao, W.-H. Chang, et al.,
"Non-invasive fiber tracking on diffusion tensor MRI using high-temperature superconducting tape RF coil," in Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the, 2006, pp.
2329-2332.
[62] Paulson, O. B., Hertz, M. M., Bolwig, T. G. and Lassen, N. A. “Filtration and diffusion of water across the blood-brain-barrier in man. Microvasc Res 13, 113-124, 1997.
[63] Nicholson, C. and Phillips, J. M. Ion diffusion modified by tortuosity and volume fractional in the extracellular microenvironment of the rat cerebellum.
Journal Physiol. 321, 225-257. 1981.