本研究包含二階段:COWMEM 發展及初步心理計量特性驗證。本研究第一 階段研究者參考Baddeley 之多系統 WM 模式設計 COWMEM,以完整地評量思 覺失調症患者之6 個 WM 向度能力,包含視空間系統、語音系統、訊息整合系統 及中央執行系統之3 種注意力:集中性注意力、轉換性注意力及分配性注意力。
COWMEM 之測驗流程包含 2 階段:施測篩檢題及施測適當難度測驗組,
COWMEM 先藉由 1 組篩檢題(6 題,各 WM 向度 1 題)初步估計受測者之 6 個 WM 向度能力,再於各 WM 向度中依據受測者之能力高低選擇 1 組高或低難度測 驗組(15 題),以更精準地評量受測者之 6 個 WM 向度能力。透過 2 階段之評估 流程,COWMEM 之總題數雖高達 186 題,然而每位受測者僅須作答 96 題(約 50%題數)。
本研究第二階段研究者初步驗證COWMEM 於思覺失調症患者之能力估計信 度、同時效度、收斂效度及已知族群效度,結果發現COWMEM 中 6 個 WM 向 度分數之信度可接受、收斂效度良好、已知族群效度中度至良好。同時效度驗證 結果發現,COWMEM 之視空間系統、語音系統及訊息整合系統測驗具可接受之 同時效度,但中央執行系統中3 種注意力測驗之同時效度尚不明確。
COWMEM 適用於思覺失調症患者團體層級之各 WM 向度能力比較,如研究 中實驗組及對照組於各WM 向度能力比較,或臨床上不同嚴重程度或病程之患者 族群於各WM 向度能力比較。此外,由於 COWMEM 之 6 個 WM 向度分數將於 所有WM 向度測驗完成後一起估計,因此未來使用者無法僅評估 COWMEM 之 單一或部分WM 向度。
參考文獻
American Psychiatric Association. (2013). Desk Reference to the Diagnostic Criteria From DSM-5. Arlington, VA: American Psychiatric Association.
Atkinson, R. C., & Shiffrin, R. M. (1968). Human memory: A proposed system and its control processes. Psychology of Learning and Motivation, 2, 89-195.
Baddeley, A. D. (1996). Exploring the central executive. The Quarterly Journal of Experimental Psychology: Section A, 49, 5-28.
Baddeley, A. D. (2012). Working memory: Theories, models, and controversies. Annual Review of Psychology, 63, 1-29.
Baddeley, A. D., & Hitch, G. (1974). Working memory. Psychology of Learning and Motivation, 8, 47-89.
Bengson, J. J., & Luck, S. J. (2016). Effects of strategy on visual working memory capacity. Psychonomic Bulletin and Review, 23, 265-270.
Bond, T. G., & Fox, C. M. (2001). Applying the Rasch model: Fundamental measurement in the human sciences. Mahwah, NJ: Lawrence Erlbaum Associates.
Bowie, C. R., & Harvey, P. D. (2005). Cognition in schizophrenia: Impairments, determinants, and functional importance. Psychiatric Clinics of North America, 28, 613-633.
Brekke, J., Kay, D. D., Lee, K. S., & Green, M. F. (2005). Biosocial pathways to functional outcome in schizophrenia. Schizophrenia Research, 80, 213-225.
Briggs, D. C., & Wilson, M. (2003). An introduction to multidimensional measurement using Rasch models. Journal of Applied Measurement, 4, 87-100.
Burton, C. Z., Vella, L., Harvey, P. D., Patterson, T. L., Heaton, R. K., & Twamley, E.
W. (2013). Factor structure of the MATRICS Consensus Cognitive Battery (MCCB) in schizophrenia. Schizophrenia Research, 146, 244-248.
Cheke, L. G., & Clayton, N. S. (2013). Do different tests of episodic memory produce consistent results in human adults? Learning and Memory, 20, 491-498.
Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.).
Hillsdale, NJ: Lawrence Erlbaum Associates.
Conklin, H. M., Curtis, C. E., Katsanis, J., & Iacono, W. G. (2000). Verbal working memory impairment in schizophrenia patients and their first-degree relatives:
Evidence from the digit span task. American Journal of Psychiatry, 157, 275-277.
Conway, A. R., Kane, M. J., Bunting, M. F., Hambrick, D. Z., Wilhelm, O., & Engle, R.
W. (2005). Working memory span tasks: A methodological review and user's guide. Psychonomic Bulletin and Review, 12, 769-786.
Cowan, N. (1984). On short and long auditory stores. Psychological Bulletin, 96, 341-370.
Cowan, N. (1993). Activation, attention, and short-term memory. Memory and Cognition, 21, 162-167.
Dodrill, C. B., & Troupin, A. S. (1975). Effects of repeated administrations of a
comprehensive neuropsychological battery among chronic epileptics. Journal of Nervous and Mental Disease, 161, 185-190.
Embretson, S. E., & Reise, S. P. (2013). Item response theory for Psychologists.
Mahwah, NJ: Psychology Press.
Ericsson, K. A., & Kintsch, W. (1995). Long-term working memory. Psychological Review, 102, 211-245.
Faget-Agius, C., Boyer, L., Lançon, C., Richieri, R., Fassio, E., Soulier, E., . . . Guye, M. (2013). Structural and functional reorganization of working memory system during the first decade in schizophrenia. A cross-sectional study. Schizophrenia Research, 151, 48-60.
Fisekovic, S., Memic, A., & Pasalic, A. (2012). Correlation between MoCA and MMSE for the assessment of cognition in schizophrenia. Acta Informatica Medica, 20, 186-189.
Fonseca, A. O., Berberian, A. A., de Meneses-Gaya, C., Gadelha, A., Vicente, M. d. O., Nuechterlein, K. H., . . . Lacerda, A. L. (2017). The Brazilian standardization of the MATRICS consensus cognitive battery (MCCB): Psychometric study.
Schizophrenia Research, 185, 148-153.
Forbes, N., Carrick, L., McIntosh, A., & Lawrie, S. (2009). Working memory in schizophrenia: A meta-analysis. Psychological Medicine, 39, 889-905.
Fujii, D. E., Wylie, A. M., & Nathan, J. H. (2004). Neurocognition and long-term prediction of quality of life in outpatients with severe and persistent mental illness. Schizophrenia Research, 69, 67-73.
Georgiades, A., Davis, V. G., Atkins, A. S., Khan, A., Walker, T. W., Loebel, A., . . .
Umbricht, D. (2017). Psychometric characteristics of the MATRICS Consensus Cognitive Battery in a large pooled cohort of stable schizophrenia patients.
Schizophrenia Research, 190, 172-179.
Graf, P., & Schacter, D. L. (1985). Implicit and explicit memory for new associations in normal and amnesic subjects. Journal of Experimental Psychology: Learning, Memory, and Cognition, 11, 501-518.
Green, M. F., Nuechterlein, K. H., Gold, J. M., Barch, D. M., Cohen, J., Essock, S., . . . Heaton, R. K. (2004). Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria. Biological Psychiatry, 56, 301-307.
Greenberger, C., & Serper, M. R. (2010). Examination of clinical and cognitive insight in acute schizophrenia patients. Journal of Nervous and Mental Disease, 198, 465-469.
Guy, W. (1976). ECDEU Assessment Manual for Psychopharmacology. Rockville, MD:
US Department of Heath, Education, and Welfare Public Health Service Alcohol, Drug Abuse, and Mental Health Administration.
Haatveit, B. C., Sundet, K., Hugdahl, K., Ueland, T., Melle, I., & Andreassen, O. A.
(2010). The validity of d prime as a working memory index: Results from the
"Bergen n-back task". Journal of Clinical and Experimental Neuropsychology, 32, 871-880.
Haley, S. M., Andres, P. L., Coster, W. J., Kosinski, M., Ni, P., & Jette, A. M. (2004).
Short-form activity measure for post-acute care. Archives of Physical Medicine and Rehabilitation, 85, 649-660.
Harrow, M., Jobe, T., & Faull, R. (2012). Do all schizophrenia patients need antipsychotic treatment continuously throughout their lifetime? A 20-year longitudinal study. Psychological Medicine, 42, 2145-2155.
Hays, R. D., Morales, L. S., & Reise, S. P. (2000). Item response theory and health outcomes measurement in the 21st century. Medical Care, 38, II28-II42.
Heeramun-Aubeeluck, A., Liu, N., Fischer, F., Huang, N., Chen, F., He, L., . . . Lu, Z.
(2015). Effect of time and duration of untreated psychosis on cognitive and social functioning in Chinese patients with first-episode schizophrenia: A 1-year study. Nordic Journal of Psychiatry, 69, 254-261.
Hobart, J. C., Cano, S. J., & Thompson, A. J. (2010). Effect sizes can be misleading: Is
it time to change the way we measure change? Journal of Neurology, Neurosurgery and Psychiatry, 81, 1044-1048.
Hobart, J. C., Lamping, D. L., & Thompson, A. J. (1996). Evaluating neurological outcome measures: The bare essentials. Journal of Neurology, Neurosurgery and Psychiatry, 60, 127-130.
Hoonakker, M., Doignon-Camus, N., & Bonnefond, A. (2017). Sustaining attention to simple visual tasks: A central deficit in schizophrenia? A systematic review.
Annals of the New York Academy of Sciences, 1408, 32-45.
Hou, W. H., Chen, J. H., Wang, Y. H., Wang, C. H., Lin, J. H., Hsueh, I. P., . . . Hsieh, C.
L. (2011). Development of a set of functional hierarchical balance short forms for patients with stroke. Archives of Physical Medicine and Rehabilitation, 92, 1119-1125.
Huang, H. Y., Wang, W. C., Chen, P. H., & Su, C. M. (2013). Higher-order item response models for hierarchical latent traits. Applied Psychological Measurement, 37, 619-637.
Jablensky, A., Kirkbride, J. B., & Jones, P. B. (2011). Schizophrenia: The epidemiological horizon. Oxford, UK: Wiley-Blackwell.
Jaeger, J., Czobor, P., & Berns, S. M. (2003). Basic neuropsychological dimensions in schizophrenia. Schizophrenia Research, 65, 105-116.
Jeon, S. Y., & Han, S. J. (2012). Improvement of the working memory and naming by transcranial direct current stimulation. Annals of Rehabilitation Medicine, 36, 585-595.
Jiang, S., Wang, C., & Weiss, D. J. (2016). Sample size requirements for estimation of item parameters in the multidimensional graded response model. Frontiers in Psychology, 7, 109.
Kaneda, Y., Sumiyoshi, T., Keefe, R., Ishimoto, Y., Numata, S., & Ohmori, T. (2007).
Brief assessment of cognition in schizophrenia: Validation of the Japanese version. Psychiatry and Clinical Neurosciences, 61, 602-609.
Kim, H. S., An, Y. M., Kwon, J. S., & Shin, M. S. (2014). A preliminary validity study of the cambridge neuropsychological test automated battery for the assessment of executive function in schizophrenia and bipolar disorder. Psychiatry
Investigation, 11, 394-401.
Kirshner, B., & Guyatt, G. (1985). A methodological framework for assessing health
indices. Journal of Chronic Diseases, 38, 27-36.
Kline, P. (1998). The new psychometrics: Science, psychology, and measurement.
Abingdon, Oxon: Routledge.
Kucharska-Pietura, K., Tylec, A., Czernikiewicz, A., & Mortimer, A. (2012). Attentional and emotional functioning in schizophrenia patients treated with conventional and atypical antipsychotic drugs. Medical Science Monitor, 18, CR44-CR49.
Lees, J., Applegate, E., Emsley, R., Lewis, S., Michalopoulou, P., Collier, T., . . . Drake, R. J. (2015). Calibration and cross-validation of MCCB and CogState in
schizophrenia. Psychopharmacology, 232, 3873-3882.
Lohr, K. N. (2002). Assessing health status and quality-of-life instruments: Attributes and review criteria. Quality of Life Research, 11, 193-205.
Luciana, M., Conklin, H. M., Hooper, C. J., & Yarger, R. S. (2005). The development of nonverbal working memory and executive control processes in adolescents.
Child Development, 76, 697-712.
McCarthy, M. L., Silberstein, C. E., Atkins, E. A., Harryman, S. E., Sponseller, P. D., &
Hadley-Miller, N. A. (2002). Comparing reliability and validity of pediatric instruments for measuring health and well-being of children with spastic cerebral palsy. Developmental Medicine and Child Neurology, 44, 468-476.
Milanzi, E., Molenberghs, G., Alonso, A., Verbeke, G., & De Boeck, P. (2015).
Reliability measures in item response theory: Manifest versus latent correlation functions. British Journal of Mathematical and Statistical Psychology, 68, 43-64.
Mokkink, L. B., Prinsen, C. A., Bouter, L. M., Vet, H. C., & Terwee, C. B. (2016). The COnsensus-based Standards for the selection of health Measurement
INstruments (COSMIN) and how to select an outcome measurement instrument.
Brazilian Journal of Physical Therapy, 20, 105-113.
Mokkink, L. B., Terwee, C. B., Patrick, D. L., Alonso, J., Stratford, P. W., Knol, D.
L., . . . de Vet, H. C. (2010). The COSMIN study reached international
consensus on taxonomy, terminology, and definitions of measurement properties for health-related patient-reported outcomes. Journal of Clinical Epidemiology, 63, 737-745.
Nobre, A. d. P., Rodrigues, J. d. C., Sbicigo, J. B., Piccolo, L. d. R., Zortea, M., Junior, S. D., & de Salles, J. F. (2013). Tasks for assessment of the episodic buffer: A
systematic review. Psychology & Neuroscience, 6, 331-343.
Noh, J., Kim, J.-H., Hong, K. S., Kim, N., Nam, H. J., Lee, D., & Yoon, S. C. (2010).
Factor structure of the neurocognitive tests: An application of the confirmative factor analysis in stabilized schizophrenia patients. Journal of Korean Medical Science, 25, 276-282.
Owen, A. M., Doyon, J., Petrides, M., & Evans, A. C. (1996). Planning and spatial working memory: A positron emission tomography study in humans. European Journal of Neuroscience, 8, 353-364.
Owen, A. M., McMillan, K. M., Laird, A. R., & Bullmore, E. (2005). N‐back working memory paradigm: A meta‐analysis of normative functional neuroimaging studies. Human Brain Mapping, 25, 46-59.
Pietrzak, R. H., Olver, J., Norman, T., Piskulic, D., Maruff, P., & Snyder, P. J. (2009). A comparison of the CogState Schizophrenia Battery and the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Battery in assessing cognitive impairment in chronic schizophrenia. Journal of Clinical and Experimental Neuropsychology, 31, 848-859.
Pinna, F., Deriu, L., Diana, E., Perra, V., Randaccio, R. P., Sanna, L., . . . Cagliari Recovery Study, G. (2015). Clinical Global Impression-severity score as a reliable measure for routine evaluation of remission in schizophrenia and schizoaffective disorders. Annals of General Psychiatry, 14, 6.
Piskulic, D., Olver, J. S., Norman, T. R., & Maruff, P. (2007). Behavioural studies of spatial working memory dysfunction in schizophrenia: A quantitative literature review. Psychiatry Research, 150, 111-121.
Portney, L. G., & Watkins, M. P. (2000). Foundations of clinical research: Applications to practice. (2nd ed.). Upper Saddle River, NJ: Prentice Hall.
Pukrop, R., Matuschek, E., Ruhrmann, S., Brockhaus-Dumke, A., Tendolkar, I., Bertsch, A., & Klosterkotter, J. (2003). Dimensions of working memory dysfunction in schizophrenia. Schizophrenia Research, 62, 259-268.
Rössler, W., Salize, H. J., van Os, J., & Riecher-Rössler, A. (2005). Size of burden of schizophrenia and psychotic disorders. European Neuropsychopharmacology, 15, 399-409.
Raffard, S., Gutierrez, L. A., Yazbek, H., Larue, A., Boulenger, J. P., Lançon, C., . . .
apathy in schizophrenia: A 1-Year longitudinal study. Schizophrenia Bulletin, 42, 642-651.
Rensink, R. A. (2014). Limits to the usability of iconic memory. Frontiers in Psychology, 5, 971.
Robertson, I. H., Ward, T., Ridgeway, V., & Nimmo-Smith, I. (1996). The structure of normal human attention: The Test of Everyday Attention. Journal of the International Neuropsychological Society, 2, 525-534.
Robinson, D. G., Woerner, M. G., McMeniman, M., Mendelowitz, A., & Bilder, R. M.
(2004). Symptomatic and functional recovery from a first episode of
schizophrenia or schizoaffective disorder. American Journal of Psychiatry, 161, 473-479.
Rund, B. R. (1989). Distractibility and recall capability in schizophrenics: A 4 year longitudinal study of stability in cognitive performance. Schizophrenia Research, 2, 265-275.
Salamé, P., Danion, J.-M., Peretti, S., & Cuervo, C. (1998). The state of functioning of working memory in schizophrenia. Schizophrenia Research, 30, 11-29.
Salthouse, T. A., & Hedden, T. (2002). Interpreting reaction time measures in between-group comparisons. Journal of Clinical and Experimental Neuropsychology, 24, 858-872.
Saperstein, A. M., Fuller, R. L., Avila, M. T., Adami, H., McMahon, R. P., Thaker, G.
K., & Gold, J. M. (2006). Spatial working memory as a cognitive endophenotype of schizophrenia: Assessing risk for pathophysiological dysfunction. Schizophrenia Bulletin, 32, 498-506.
Shrivastava, A., Johnston, M., Shah, N., Thakar, M., & Stitt, L. (2011). Persistent cognitive dysfunction despite clinical improvement in schizophrenia: A 10-year follow-up study. Journal of Psychiatric Practice, 17, 194-199.
Silverstein, S. M., Jaeger, J., Donovan-Lepore, A. M., Wilkniss, S. M., Savitz, A., Malinovsky, I., . . . Marcello, S. (2010). A comparative study of the MATRICS and IntegNeuro cognitive assessment batteries. Journal of Clinical and
Experimental Neuropsychology, 32, 937-952.
Simmering, V. R., & Perone, S. (2013). Working memory capacity as a dynamic process. Frontiers in Psychology, 3, 567.
Stretton, J., Sidhu, M. K., Winston, G. P., Bartlett, P., McEvoy, A. W., Symms, M.
R., . . . Duncan, J. S. (2014). Working memory network plasticity after anterior temporal lobe resection: A longitudinal functional magnetic resonance imaging study. Brain, 137, 1439-1453.
Tesio, L. (2003). Measuring behaviours and perceptions: Rasch analysis as a tool for rehabilitation research. Journal of Rehabilitation Medicine, 35, 105-115.
Tulsky, D., Zhu, J., & Ledbetter, M. (1997). WAIS-III/WMS-III Technical Manual. San Antonio, TX: The Psychological Corporation.
Tyson, P. J., Laws, K. R., Flowers, K. A., Mortimer, A. M., & Schulz, J. (2008).
Attention and executive function in people with schizophrenia: Relationship with social skills and quality of life. International Journal of Psychiatry in Clinical Practice, 12, 112-119.
Vingerhoets, W. A., Bloemen, O. J., Bakker, G., & van Amelsvoort, T. A. (2013).
Pharmacological interventions for the MATRICS cognitive domains in schizophrenia: What's the evidence? Front Psychiatry, 4, 157.
Vlahou, C. H., Kosmidis, M. H., Dardagani, A., Tsotsi, S., Giannakou, M.,
Giazkoulidou, A., . . . Pontikakis, N. (2013). Development of the Greek Verbal Learning Test: Reliability, construct validity, and normative standards. Archives of Clinical Neuropsychology, 28, 52-64.
Wang, W. C., Chen, P. H., & Cheng, Y. Y. (2004). Improving measurement precision of test batteries using multidimensional item response models. Psychological Methods, 9, 116-136.
Wechsler, D. (1997). Wechsler memory scale (WMS-III). San Antonio, TX: The Psychological Corporation.
Wegner, D. M. (1987). Transactive memory: A contemporary analysis of the group mind Theories of group behavior. New York, NY: Springer.
Wright, B. D., & Linacre, J. M. (1989). Observations are always ordinal; Measurements, however, must be interval. Archives of Physical Medicine and Rehabilitation, 70, 857-860.
Wright, B. D., & Linacre, J. M. (1994). Reasonable mean-square fit values. Rasch Measurement Transactions, 8, 370.
Wright, B. D., & Mok, M. (2000). Rasch models overview. Journal of Applied Measurement, 1, 83-106.
Wu, C., Dagg, P., & Molgat, C. (2014). A pilot study to measure cognitive impairment
in patients with severe schizophrenia with the Montreal Cognitive Assessment (MoCA). Schizophrenia Research, 158, 151-155.
Yao, S., Chen, H., Jiang, L., & Tam, W. C. (2007). Replication of factor structure of Wechsler Adult Intelligence Scale‐III Chinese version in Chinese mainland non‐
clinical and schizophrenia samples. Psychiatry and Clinical Neurosciences, 61, 379-384.
Yu, L., Buysse, D. J., Germain, A., Moul, D. E., Stover, A., Dodds, N. E., . . . Pilkonis, P. A. (2012). Development of short forms from the PROMIS™ sleep disturbance and sleep-related impairment item banks. Behavioral Sleep Medicine, 10, 6-24.
Zhong, N., Jiang, H., Wu, J., Chen, H., Lin, S., Zhao, Y., . . . Zhao, M. (2013).
Reliability and validity of the CogState battery Chinese language version in schizophrenia. PloS One, 8, e74258.
圖一:Baddeley 之「多系統 WM 模式」
資料來源:修改自Baddeley (2012)
圖二:Cowan 之「階層性訊息處理模式」
資料來源:修改自Cowan (1988)
圖三:Ericsson 之「長期工作記憶模式」
資料來源:修改自Ericsson (1995)
圖四:電腦化多階段測驗流程
圖五:COWMEM 測驗架構
圖六:語音系統題目施測流程
圖七:視空間系統題目施測流程
記憶時間
圖九:中央執行系統-集中性注意力題目施測流程
測驗作答規則:白色三角形按,其它顏色三角形按X
圖例 COWMEM測驗畫面
測驗畫面說明(測驗中不呈現)
受測者眼睛之凝視點(提醒受測者留意看畫面)
COWMEM中央執行系統之集中性注意力 題目之測驗流程
凝視點1 (1.0 s) 提示
(1.0 s) 請判斷以下圖片
判斷物1範例 答案:
(1.0 s)
凝視點2 (0.5~2.0 s)
判斷物2範例 答案: X (0.5~2.0 s)
圖十:中央執行系統-轉換性注意力題目施測流程
圖十一:中央執行系統-分配性注意力題目施測流程
測驗作答規則:白色或三角形按,其它顏色及形狀按X COWMEM中央執行系統之分配性注意力
題目之測驗流程
圖例 COWMEM測驗畫面
測驗畫面說明(測驗中不呈現)
受測者眼睛之凝視點(提醒受測者留意看畫面)
凝視點 (1.0 s) 提示
(1.0 s) 請判斷以下圖片
判斷物 範例 答案: X (0.5~2.0 s) 判斷物 範例
答案: (0.5~2.0 s)
判斷物 範例 答案: (0.5~2.0 s) 可能的判斷物
圖十二:語音系統之受測者能力與題目難度對應圖
圖十三:視空間系統之受測者能力與題目難度對應圖
圖十四:訊息整合系統之受測者能力與題目難度對應圖
圖十五:中央執行系統-集中性注意力之受測者能力與題目難度對應圖
圖十六:中央執行系統-轉換性注意力之受測者能力與題目難度對應圖
圖十七:中央執行系統-分配性注意力之受測者能力與題目難度對應圖
圖十八:COWMEM 語音系統之個別信度及能力散佈圖
圖十九:COWMEM 視空間系統之個別信度及能力散佈圖
圖二十:COWMEM 訊息整合系統之個別信度及能力散佈圖
圖二十一:COWMEM 中央執行系統-集中性注意力之個別信度及能力散佈圖
圖二十二:COWMEM 中央執行系統-轉換性注意力之個別信度及能力散佈圖
圖二十三:COWMEM 中央執行系統-分配性注意力之個別信度及能力散佈圖