Body weight versus time in rabbits fed various diets on 4th and 8th week.
All values are the means±SE(n = 3) .In the normal group were fed rabbit chow;
the control group were fed rabbit chow plus 10﹪corn oil and 0.5﹪cholesterol;
and the western-medicine groups were fed the same diet as control group plus 200mg/kg probucol or 6 mg/kg lovastatin,respectively. There was no significant difference between control（n =3）and the western-medicine（n =3）groups.
2、血液生化值
Plasma cholesterol levels versus time in rabbits fed various diets 4th and 8th week.
All values are the means±SE(n = 3) .In the normal group were fed rabbit chow; the control group were fed rabbit chow plus 10﹪corn oil and 0.5﹪cholesterol; and the western-medicine groups were fed the same diet as control group plus 200mg/kg probucol or 6 mg/kg lovastatin,respectively.
*P＜0.05,vs control group.# P＜0.05,vs normal group.
GPT cholesterol組相比 P＜0.05，西藥組之 probucol 具有統計學上明顯差異。
Plasma GPT levels versus time in rabbits fed various diets on 4th and 8th week.
All values are the means±SE(n = 3) .In the normal group were fed rabbit chow;
the control group were fed rabbit chow plus 10﹪corn oil and 0.5﹪cholesterol;
and the western-medicine groups were fed the same diet as control group plus 200mg/kg probucol or 6 mg/kg lovastatin,respectively.
*P＜0.05,vs control group. # P＜0.05,vs normal group.
# #
* *
*
LDL-C 週以 Cobas Mira plus（Roche）測量血液中低密度脂蛋白含量，數值為
平均數 ± 標準誤（n = 3）。＃表示與 normal 組相比 P＜0.05；＊代表與 cholesterol組相比 P＜0.05，西藥組具有統計學上明顯差異。
Plasma LDL-C levels versus time in rabbits fed various diets on 4th and 8th week.
All values are the means±SE(n = 3) .In the normal group were fed rabbit chow; the control group were fed rabbit chow plus 10﹪corn oil and 0.5﹪cholesterol; and the western-medicine groups were fed the same diet as control group plus 200mg/kg probucol or 6 mg/kg lovastatin,respectively.
*P＜0.05,vs control group. # P＜0.05,vs normal group.
#
#
* *
*
*
Triglyceride cholesterol組相比 P＜0.05，8 週時西藥組具有統計學上明顯差異。
Plasma TG levels versus time in rabbits fed various diets on 4th and 8th week.
All values are the means±SE(n = 3) .In the normal group were fed rabbit chow;
the control group were fed rabbit chow plus 10﹪corn oil and 0.5﹪cholesterol;
and the western-medicine groups were fed the same diet as control group plus 200mg/kg probucol or 6 mg/kg lovastatin,respectively.
*P＜0.05,vs control group. # P＜0.05,vs normal group.
*
#
*
*
3、MDA 4、 8 週以 CuSO4誘導血液中脂質過氧化，以 thiobarbituric acide-reactive substances(TBARS)之含量評估脂質過氧化程度。數值為平均數 ±標準誤
（n = 3）。＃表示與 normal 組相比 P＜0.05；＊代表與 cholesterol 組相比 P
＜0.05，西藥組具有統計學上明顯差異。
Plasma MDA levels versus time in rabbits fed various diets on 4th and 8th week.
All values are the means±SE(n = 3) .In the normal group were fed rabbit chow;
the control group were fed rabbit chow plus 10﹪corn oil and 0.5﹪cholesterol;
and the western-medicine groups were fed the same diet as control group plus 200mg/kg probucol or 6 mg/kg lovastatin,respectively.
*P＜0.05,vs control group.# P＜0.05,vs normal group.
4、血液自由基
4、8 週以 chemiluminescence CLD-110（Tohoku），利用 luminol 測量其血液中 過氧化氫自由基，數值為平均數 ±標準誤（n = 3）。＃表示與 normal 組相比 P
＜0.05；＊代表與 cholesterol 組相比 P＜0.05，8 週時西藥組具有統計學上明 顯差異。
Whole blood luminol-CL counts of rabbits fed various diets on 4th and 8th week.
All values are the means±SE (n =3) . In the normal group were fed rabbit chow；
the control group were fed rabbit chow plus 10% corn oil and 0.5% cholesterol ; and the western-medicine groups rabbits were fed the same diet as the control group plus 200mg/kg probucol or 6 mg/kg lovastatin, respectively.
*P<0.05, vs control group. # P＜0.05,vs normal group.
#
* *
blood free radical-lucigenin
Fig 8兔子給予 200mg/kg probucol 或 6 mg/kg lovastatin 治療後，分別在 4、8 週以 chemiluminescence CLD-110（Tohoku），利用 lucigenin 測量其血液中超 氧自由基，數值為平均數±標準誤（n = 3）。＃表示與 normal 組相比 P＜0.05；
＊代表與 cholesterol 組相比 P＜0.05，8 週時西藥組具有統計學上明顯差異。
Whole blood lucigenin-CL counts of rabbits fed various diets on 4th and 8th week.
All values are the means±SE (n =3) . In the normal group were fed rabbit chow；
the control group were fed rabbit chow plus 10% corn oil and 0.5% cholesterol ; and the western-medicine groups rabbits were fed the same diet as the control group plus 200mg/kg probucol or 6 mg/kg lovastatin, respectively.
*P<0.05, vs control group. # P＜0.05,vs normal group.
#
* *
5、組織自由基
tissue free radical
0 100 200 300 400 500 600
normal cho probucol lovastatin
time
count/ protein (g)
Fig 9兔子給予 200mg/kg probucol 或 6 mg/kg lovastatin 治療後，在 8 週時以 chemiluminescence CLD-110（Tohoku），利用 luminol 測量其肝臟中超氧自由 基，數值為平均數 ±標準誤（n = 3）。＃表示與 normal 組相比 P＜0.05；＊
代表與 cholesterol 組相比 P＜0.05，西藥組具有統計學上明顯差異。
Liver tissues luminol-CL counts of rabbits fed various diets on 8th week.
All values are the means±SE (n =3) . In the normal group were fed rabbit chow；the control group were fed rabbit chow plus 10% corn oil and 0.5% cholesterol ; and the western-medicine groups rabbits were fed the same diet as the control group plus 200mg/kg probucol or 6 mg/kg lovastatin, respectively.
*P<0.05, vs control group. # P＜0.05,vs normal group.
#
*
*
6、Sudan IV 染色
normal cho probucol lovastatin
group
% surface lipid lesions
Fig 10 兔子給予 200mg/kg probucol 或 6 mg/kg lovastatin 治療後，在 8 週時以
Sudan IV作胸主動脈血管染色，觀察其血管脂質斑塊堆積之情形，數值為
平均數 ±標準誤（n = 3）。＃表示與 normal 組相比 P＜0.05；＊代表與 cholesterol組相比 P＜0.05，西藥組具有統計學上明顯差異。
#
* *
The extent of the development of lipid lesions on 8th week.
(A) (double magnification 2 x , one of three) and densitometric analysis of the relative area of lipid lesions.
(B) in the aorta after feeding with the experimental diet.
Results are expressed as the means±SE(n = 3). In the normal group were fed rabbit chow; the control group were fed rabbit chow plus 10% corn oil and 0.5﹪
cholesterol ; and the western-medicine groups rabbits were fed the same diet as the control group plus 200mg/kg probucol or 6 mg/kg lovastatin, respectively.
*P<0.05, vs control group, # P<0.05, vs normal group.
7、Western blot Fas-ligand
N C P L
Fig 11 兔子給予 200mg/kg probucol 或 6 mg/kg lovastatin 治療後，以 Western blot分析其主動脈血管 Fas-ligand 之表現情形。數值為平均數 ±標準誤
（n = 3）。西藥組無統計學上明顯差異。
normal（N）組 cholesterol（C）組 probucol（P）組 lovastatin（L）組
In the normal group were fed rabbit chow; the control group were fed rabbit chow plus 10﹪corn oil and 0.5﹪cholesterol; and the western-medicine groups were fed the same diet as control group plus 200mg/kg probucol or 6 mg/kg lovastatin , respectively.Results of an density analysis（Fas-ligand）performed on rabbits 0.5
﹪cholesterol（as control）and the western-medicines groups after 8 weeks.
Error is expressed as standard error of the mean.There was no significant
difference between control（n =3）and the western-medicine（n =3） groups.
0 500000 1000000 1500000
N C P L
第四節、中藥組－川芎
Body weight versus time in rabbits fed various diets on 4th and 8th week.
All values are the means±SE(n = 3) .In the normal group were fed rabbit chow;
the control group were fed rabbit chow plus 10﹪corn oil and 0.5﹪cholesterol;
the lovastatin group were fed the same diet as the control group plus 6 mg/kg lovastatin, and the herbal-medicine groups were fed the same diet as control group plus 1﹪Ligusticuum chuanxiong, respectively. There was no significant difference between control（n =3）and Ligusticuum chuanxiong（n =3）groups.