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Genetic diversity of multidrug-resistant Mycobacterium tuberculosis isolates and identification of 11 Novel rpoB alleles in Taiwan

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Genetic diversity of multidrug-resistant

Mycobacterium tuberculosis isolates and

identification of 11 Novel rpoB alleles in

Taiwan

余明治

Jou RJ;Chen HY;Chiang CY;Yu MC;Su IJ

摘要

Abstract

Of 162 multidrug-resistant Mycobacterium tuberculosis isolates from Taiwan, 60.5% were found to belong to the Beijing family on the basis of spoligotyping results. IS6110 restriction fragment length polymorphism fingerprinting showed genetic diversity among the multidrug-resistant isolates. Furthermore, 90.1% of the

multidrug-resistant isolates had mutations in the rpoB gene, and 11 novel alleles were recognized.

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