CPAP therapy improves stage 1 sleep noctuira in patient with obstructive sleep apnea

2012/9/11

1

CPAP therapy improves

CPAP therapy improves

stage 1 sleep

stage 1 sleep noctuira

noctuira in

in

patient with obstructive

patient with obstructive

sleep apnea

sleep apnea

Introduction

Introduction

Nocturia is the complaint that the individual Nocturia is the complaint that the individual has to wake at night one or more times to has to wake at night one or more times to void void  EpidemiologyEpidemiology  5050––59 59 years years 58% in women 58% in women 66% in men 66% in men  > 80 years > 80 years 72% in women and 72% in women and 91% in men 91% in men

Middlekoop HA et al.Gerontol Biol Sci Med Sci 1996;

Introduction

Introduction



Obstructive sleep apnea is (OSA) a Obstructive sleep apnea is (OSA) a

widespread medical problem widespread medical problem

prevalence of up to 4% in men and 2% in prevalence of up to 4% in men and 2% in women.

women.



OSA and nocturia are two of the common OSA and nocturia are two of the common causes of sleep disturbance and have causes of sleep disturbance and have been shown to impair the function, been shown to impair the function, cognition and quality of life

cognition and quality of life

Introduction

Introduction



Continuous positive airway pressure Continuous positive airway pressure

(CPAP) improve the symptoms of nocturia (CPAP) improve the symptoms of nocturia in patients with OSA.

in patients with OSA.



However, the relationship between However, the relationship between

nocturia and sleep architecture in the OSA nocturia and sleep architecture in the OSA patients under CPAP treatment are patients under CPAP treatment are scarce.

scarce.

Purpose

Purpose



The objective of this study is to evaluate The objective of this study is to evaluate the efficacy of treatment and the difference the efficacy of treatment and the difference of nocturia during sleep stage under the of nocturia during sleep stage under the CPAP therapy in patients with OSA. CPAP therapy in patients with OSA.

Materials and Methods

Materials and Methods



Prospectively study from Feb 2010 to Prospectively study from Feb 2010 to

January 2011 January 2011



enrolled from GU clinic, Age 48enrolled from GU clinic, Age 48--70, male70, male



definition of frequently nocturia: nocturia at definition of frequently nocturia: nocturia at

least 2/ per night, lasting over 3 months least 2/ per night, lasting over 3 months



 exclusion:exclusion:



Prostate> 30 gm, history of GU malignancy,Prostate> 30 gm, history of GU malignancy,

residual urine>100 ml, history of CVA, DM, residual urine>100 ml, history of CVA, DM, CHF, depression, taking medications like CHF, depression, taking medications like corticosteroid or diuretic treatment corticosteroid or diuretic treatment