Primary surgery versus primary
radiation therapy for FIGO stages I-II
small cell carcinoma of the uterine
cervix: A retrospective Taiwanese
Gynecologic Oncology Group study
Contribution to journal › ArticleTze Chien Chen ; Huei Jean Huang ; Tao Yeuan Wang ; Lan Yan Yang ; Chi Hau Chen ; Ya Min Cheng ; Wen Hsiung Liou ; Shih Tien Hsu ; Kuo
Chang Wen ; Yu Che Ou ; Yao Ching Hung ; Hung Cheng Lai ; Chih
Ming Ho ; Ting Chang Chang
Obstetrics & Gynecology
Objective: To evaluate the role of surgery, radiation therapy and chemotherapy in the management of small cell carcinoma of the uterine cervix (SCCC) through a retrospective study of Taiwanese Gynecologic Oncology Group. Methods: We reviewed the medical records and histological files of 144 patients with FIGO stages IA-IIB SCCC treated in 11 main hospitals in Taiwan from 1987 to 2009. Results: There were 110 patients receiving primary surgery and 34 primary radiation therapy. Most patients in each group also received chemotherapy as part of primary treatment. A lower loco-regional failure rate was observed in patients who received primary radiation therapy than in those who had primary surgery (6% vs. 27%; P = 0.009). The 5-year overall survival (OS) was 89% for 13 surgically treated patients with cervical tumor â‰2 cm and no
lymphovascular space involvement (LVSI) in whom recurrence was noted in 2 of 4 patients without receiving adjuvant chemotherapy and none in the 9 patients who had chemotherapy. Excluding these 13 patients, primary radiation therapy with at least 5 cycles of platinum-based chemotherapy (n = 14, including 12 stages IB2-IIB) resulted in a 5-year OS of 78%, better than that of 46% by primary surgery (n = 97, including 40 stages IB2-IIB) (P = 0.046).
Conclusions: None of the 9 patients with cervical tumor 2 cm and no LVSI showed disease recurrence after primary surgery and adjuvant chemotherapy. For most patients with stages I-II, primary radiation therapy with aggressive chemotherapy was associated with better survival than surgery.
Original
language English (US)
Pages
(from-to) 468-473
Number of
pages 6
Journal Gynecologic Oncology
Volume 137 Issue number 3 DOIs http://dx.doi.org/10.1016/j.ygyn o.2015.03.015
State Published - Jun 1 2015
Link to publication in Scopus
Link to citation list in Scopus
PMID: 25797082 Fingerprint
Carcinoma, Small Cell Cervix Uteri Radiation Drug TherapyAdjuvant Chemotherapy Survival Recurrence Platinum Taiwan Medical Records
Cite this
Standard
Primary surgery versus primary radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix : A retrospective Taiwanese Gynecologic Oncology Group
Lan Yan; Chen, Chi Hau; Cheng, Ya Min; Liou, Wen Hsiung; Hsu, Shih Tien; Wen, Kuo Chang; Ou, Yu Che; Hung, Yao Ching; Lai, Hung Cheng; Ho, Chih Ming; Chang, Ting Chang.
In: Gynecologic Oncology, Vol. 137, No. 3, 01.06.2015, p. 468-473. Research output: Contribution to journal › Article
Harvard
Chen, TC, Huang, HJ, Wang, TY, Yang, LY, Chen, CH, Cheng, YM, Liou, WH, Hsu, ST, Wen, KC, Ou, YC, Hung, YC, Lai, HC, Ho, CM & Chang, TC 2015, 'Primary surgery versus primary radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix: A retrospective Taiwanese Gynecologic Oncology Group study' Gynecologic
Oncology, vol 137, no. 3, pp.
468-473., 10.1016/j.ygyno.2015.03.015
APA
Chen, T. C., Huang, H. J., Wang, T. Y., Yang, L. Y., Chen, C. H., Cheng, Y. M., ... Chang, T. C. (2015). Primary surgery versus primary
radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix: A retrospective Taiwanese Gynecologic Oncology Group study. Gynecologic Oncology, 137(3),
468-473. 10.1016/j.ygyno.2015.03.015
Vancouver
Chen TC, Huang HJ, Wang TY, Yang LY, Chen CH, Cheng YM et
al. Primary surgery versus primary radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix: A retrospective
Taiwanese Gynecologic Oncology Group study. Gynecologic Oncology. 2015 Jun 1;137(3):468-473. Available
from: 10.1016/j.ygyno.2015.03.015
Author
Chen, Tze Chien; Huang, Huei Jean; Wang, Tao Yeuan; Yang, Lan Yan; Chen, Chi Hau; Cheng, Ya Min; Liou, Wen Hsiung; Hsu, Shih Tien; Wen, Kuo Chang; Ou, Yu Che; Hung, Yao Ching; Lai, Hung Cheng; Ho, Chih Ming; Chang, Ting Chang / Primary surgery versus primary
radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix : A retrospective Taiwanese Gynecologic Oncology Group study.
In: Gynecologic Oncology, Vol. 137, No. 3, 01.06.2015, p. 468-473. Research output: Contribution to journal › Article
N2 - <p>Objective: To evaluate the role of surgery, radiation therapy and chemotherapy in the management of small cell carcinoma of the uterine cervix (SCCC) through a retrospective study of Taiwanese Gynecologic Oncology Group. Methods: We reviewed the medical records and histological files of 144 patients with FIGO stages IA-IIB SCCC treated in 11 main hospitals in Taiwan from 1987 to 2009. Results: There were 110 patients receiving
primary surgery and 34 primary radiation therapy. Most patients in each group also received chemotherapy as part of primary treatment. A lower loco-regional failure rate was observed in patients who received primary radiation therapy than in those who had primary surgery (6% vs. 27%; P = 0.009). The 5-year overall survival (OS) was 89% for 13 surgically treated patients with cervical tumor â ‰2 cm and no lymphovascular space involvement (LVSI) in whom recurrence was noted in 2 of 4 patients without receiving adjuvant chemotherapy and none in the 9 patients who had chemotherapy. Excluding these 13 patients, primary radiation therapy with at least 5
cycles of platinum-based chemotherapy (n = 14, including 12 stages IB2-IIB) resulted in a 5-year OS of 78%, better than that of 46% by primary surgery (n = 97, including 40 stages IB2-IIB) (P = 0.046). Conclusions: None of the 9 patients with cervical tumor 2 cm and no LVSI showed disease recurrence after primary surgery and adjuvant chemotherapy. For most patients with stages I-II, primary radiation therapy with aggressive chemotherapy was
associated with better survival than surgery.</p> AB - <p>Objective: To evaluate the role of surgery, radiation therapy and chemotherapy in the management of small cell carcinoma of the uterine cervix (SCCC) through a retrospective study of Taiwanese Gynecologic Oncology Group. Methods: We reviewed the medical records and histological files of 144 patients with FIGO stages
IA-IIB SCCC treated in 11 main hospitals in Taiwan from 1987 to 2009. Results: There were 110 patients receiving
primary surgery and 34 primary radiation therapy. Most patients in each group also received chemotherapy as part of primary treatment. A lower loco-regional failure rate was observed in patients who received primary radiation therapy than in those who had primary surgery (6% vs. 27%; P = 0.009). The 5-year overall survival (OS) was 89% for 13 surgically treated patients with cervical tumor â ‰2 cm and no lymphovascular space involvement (LVSI) in whom recurrence was noted in 2 of 4 patients without receiving adjuvant chemotherapy and none in the 9 patients who had chemotherapy. Excluding these 13 patients, primary radiation therapy with at least 5
cycles of platinum-based chemotherapy (n = 14, including 12 stages IB2-IIB) resulted in a 5-year OS of 78%, better than that of 46% by primary surgery (n = 97, including 40 stages IB2-IIB) (P = 0.046). Conclusions: None of the 9 patients with cervical tumor 2 cm and no LVSI showed disease recurrence after primary surgery and adjuvant chemotherapy. For most patients with stages I-II, primary radiation therapy with aggressive chemotherapy was
associated with better survival than surgery.</p> KW - Cervical cancer
KW - Platinum-based chemotherapy KW - Radiation therapy
KW - Radical hysterectomy KW - Small cell carcinoma
UR - http://www.scopus.com/inward/record.url? scp=84930046571&partnerID=8YFLogxK UR - http://www.scopus.com/inward/citedby.url? scp=84930046571&partnerID=8YFLogxK U2 - 10.1016/j.ygyno.2015.03.015 DO - 10.1016/j.ygyno.2015.03.015 M3 - Article VL - 137 SP - 468 EP - 473
JO - Gynecologic Oncology JF - Gynecologic Oncology SN - 0090-8258 IS - 3 ER -Show less
Similar Research Outputs
1. Treatment of small cell carcinoma of the cervix with cisplatin,
doxorubicin, and etoposide
Morris, M., Gershenson, D. M., Eifel, P., Silva, E. G., Mitchell, M. F., Burke, T. W. & Wharton, J. T. 1992 In : Gynecologic Oncology. 47, 1, p. 62-65 4 p.
Contribution to journal › Article
ID: 16748852
Powered by Pure and the Elsevier Fingerprint Engine™
U.S. National Library of Medicine is the source of the 2012 MeSH thesaurus used in this solution | National Agricultural Library is the source of the 2012 NAL thesaurus used in this solution. | NASA is the source of the NASA thesaurus used in this solution
Cookies are set by this site. To decline them or learn more, visit our Cookies page.
About Pure | Elsevier Fingerprint Engine™ | Terms and conditions | Privacy statement | Contact
© 2013 Elsevier B.V All rights reserved.
