2012/9/11
1
CPAP Therapy Improves
CPAP Therapy Improves
Stage 1 Sleep
Stage 1 Sleep Nocturia
Nocturia in
in
Patient with Obstructive
Patient with Obstructive
Sleep Apnea
Sleep Apnea
EricEric ChiehChieh--LungLung ChouChou11
Shin
Shin--ChiehChieh LiangLiang22
China
China MedicalMedical UniversityUniversity 1
1DepartmentDepartment ofof Urology Urology 22SleepSleep
Center,
Center, DepartmentDepartment ofof InternalInternal Medicine Medicine
Introduction
Introduction
ICS (2002)ICS (2002)Nocturia is the complaint that the individual Nocturia is the complaint that the individual has to wake at night one or more times to has to wake at night one or more times to void void EpidemiologyEpidemiology 5050––59 59 years years 58% in women 58% in women 66% in men 66% in men > 80 years > 80 years 72% in women and 72% in women and 91% in men 91% in men
Middlekoop HA et al.Gerontol Biol Sci Med Sci 1996;
Introduction
Introduction
Obstructive sleep apnea is (OSA) a Obstructive sleep apnea is (OSA) a widespread medical problem widespread medical problem prevalence of up to 20 prevalence of up to 20--50% 50%
OSA and nocturia are two of the common OSA and nocturia are two of the common causes of sleep disturbance and have causes of sleep disturbance and have been shown to impair the function, been shown to impair the function, cognition and quality of life
cognition and quality of life
Ancoli-Israel S, Sleep 1991
Introduction
Introduction
Continuous positive airway pressure Continuous positive airway pressure (CPAP) improve the symptoms of nocturia (CPAP) improve the symptoms of nocturia in patients with OSA.
in patients with OSA.
However, the relationship between However, the relationship between
nocturia and sleep architecture in the OSA nocturia and sleep architecture in the OSA patients under CPAP treatment are patients under CPAP treatment are scarce.
scarce.
Purpose
Purpose
The objective of this study is to evaluate The objective of this study is to evaluate the efficacy of treatment and the difference the efficacy of treatment and the difference of nocturia during sleep stage under the of nocturia during sleep stage under the CPAP therapy in patients with OSA. CPAP therapy in patients with OSA.
Materials and Methods
Materials and Methods
Prospectively study from Feb 2010 to Prospectively study from Feb 2010 to January 2011
January 2011
Enrolled from GU clinic, Age 48Enrolled from GU clinic, Age 48--70, male70, male
Definition of frequently nocturia: nocturia Definition of frequently nocturia: nocturia at least 2/ per night, lasting over 3 months at least 2/ per night, lasting over 3 months
Exclusion:Exclusion:
Prostate> 30 gm, history of GU malignancy,Prostate> 30 gm, history of GU malignancy,
residual urine>100 ml, history of CVA, DM, residual urine>100 ml, history of CVA, DM, CHF, depression, taking medications like CHF, depression, taking medications like corticosteroid or diuretic treatment corticosteroid or diuretic treatment
