中 華 民 國 急 救 加 護 醫 學 會 1 0 1 年 年 會 暨 學 術 研 討 會
年會徵求論文摘要
Aims/Introduction: Antihypertensive drugs have been linked to new-onset diabetes (NOD); however, data on the effect of these drugs on the development of NOD in hypertensive patients has not been well determined in a real-world setting. The aim was to investigate the association between antihypertensive drugs and NOD in a real-world setting.
Materials and Methods: We conducted a retrospective study of hypertensive Taiwanese patients receiving antihypertensive drugs treatment between January 2006 and December 2011. Clinical information and laboratory parameters were collected by reviewing the medical records. We estimated the odds ratios (ORs) of NOD associated with antihypertensive drug use; non-diabetic subjects served as the reference group.
Results: A total of 120 NOD cases were identified in 1001 hypertensive patients during the study period. The risk of NOD after adjusting sex, age, baseline characteristics and lipid profiles was higher among users of diuretics (OR, 1.65; 95% confidence interval (CI), 1.12-2.45), and Non-dihydropyridine (non-DHP) calcium channel blockers (OR, 1.96; 95% CI, 1.01-3.75) than among non-users.
Beta-blockers (OR, 1.39; 95% CI, 0.94-2.06), Dihydropyridine (DHP) calcium channel blockers (OR, 1.24; 95% CI, 0.84-1.82), angiotensin converting enzyme (ACE) inhibitors (OR, 1.53; 95% CI, 0.90-2.64), angiotensin receptor blockers (ARBs) (OR, 1.16; 95% CI, 0.77-1.75), alpha-blockers (OR, 0.71; 95% CI, 0.31-1.68), and vasodilators (OR, 0.92; 95% CI, 0.53-1.60) were not associated with risk of NOD. Conclusions: The results of this study suggest that hypertensive patients who take diuretics and non-DHP calcium channel blockers were associated with a significant increase in the risk of NOD in a real-world setting.
KEY WORDS: Antihypertensive drugs, New-onset diabetes, Real-world 下資料為必填
本文性質(請勾選)：■臨床 □基礎
中文題目：現今醫療體系下高血壓用藥與新發生糖尿病之回朔性世代研究
英文題目：A Retrospective Longitudinal Cohort Study of Antihypertensive Drug Use and New-onset Diabetes in a Real-World Setting
作者中文姓名(依序)：謝佩玲1△, 黃靖雅2 ,馬作鏹3 ,田麗雲4 ,謝右文2 ,陳鴻儀1 ,鍾國屏5 作者單位中文書寫(依序)：1中國醫藥大學藥學系 ２ 中國醫藥大學附設醫院藥劑部 ３ 中國醫藥大學公共衛生學院醫務管理學系 ４ 中央健保局中區分局 ５ 國軍台中總醫院內科部 注意事項：請註明演講者(△記號)，並以 1，2，3 表明不同單位 本論文研究負責人(會員)姓名： 鍾國屏 (請簽名) 日期：2012/07/18 現在服務單位及職稱： 國軍台中總醫院內科部 心臟內科主治醫師 電話：04-23934191 # 525342 聯絡地址：台中市太平區中山路二段３４８號 傳真：04-23928070 E-mail：cgp8009@yahoo.com.tw
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