TABLE OF CONTENTS
Organizational Chart ...5
Graduate Institutes
Graduate Institute of Medical Sciences ...7
Graduate Institute of Clinical Medicine...9
Master Program in School of Respiratory Therapy ...11
International Master/Ph.D. Program in Medicine...12
International Clinical Training Program...13
Medical Education...14
International Ph.D. Program for Cell Therapy and Regeneration Medicine ...15
Research Centers
Cochrane Taiwan...17
Biostatistics Center ...18
Research Groups
Anesthesiology
Perioperative Medicine Research Team ...20
Cardiovascular Medicine
Arrhythmogenesis Research Team...21
Atherosclerosis and Vascular Biology Research Team ...22
Emergency Medicine
Extreme Exercise Research Team & Medical Informatics Research Team...23
Hyperglycemia research team ...24
Gastroenterology
Magnetic Field Navigated Intelligent Capsule Endoscope Research Team...25
Microbiology & Immunology Research
Infectious Diseases and Inflammation Research Team ...26
Molecular Virology Research Team...27
Neuroscience
Dementia Research Team ...28
Parkinson’s Disease Research Team ...29
Cerebrovascular Research Team ...30
Parkinson’s Disease Research Team ...31
Pain Research Team ...32
Peripheral Polyneuropathy Research Team ...33
Obesity Medicine
Obesity-related Research Team...34
Oncology
Pediatric Brain Cancer Research Team ...35
Breast Cancer Translational Research Team...36
Colon Cancer Translational Research Team ...37
Prostate Cancer Research Team ...38
Tumor Aggressiveness and Stemness Research Team ...39
Orthopedic
Platelet-Rich Plasma Research Team ...40
Bone and Joint Research Team ...41
Spine Research Team ...42
Pediatrics
Pediatric Gastroenterology Research Team ...43
Metabolic Neuromuscular Research Team ...44
Lung Development and Injury Research Team...45
Epilepsy surgery and presurgical evaluation...46
Pulmonary Research
Pulmonary Fibrosis Research Team ...47
Chronic Obstructive Pulmonary Disease Research ...48
Tuberculosis Research Team ...49
Radiology
MR Radiogenomics Research in Glioma ...50
Endovascular Treatment of Cerebrovascular Disease Research Team...51
Osteoporosis, Osteoarthritis and Osteonecrosis Research Team...52
Rehabilitation Medicine
Neurorehabilitation Research Team ...53
International Classification of Functioning Research Team ...54
Renal Medicine
Chronic Kidney Disease Research Team...55
Acute Kidney Injury Research Team...56
Sleep Medicine
Sleep-Related Breathing Disorders Research Team ...57
Sleep Deprivation Research Team...58
Tropical Medicine Research
Neglected Tropical Diseases Research Team or NTDs Research Team ...59
Woman Health
Reproductive Medicine Research...60
Cancer Translational Research Team ...61
TMU Healthcare System ...62
Taipei Medical University Hospital...63
Wan-Fang Hospital...64
Shuang-Ho Hospital...65
Ningbo Medical Center Lihuili Eastern Hospital ...66
Campus Life...67
Han-Pin Kuo, M.D., Ph.D.
Professor and Dean
Department of Internal Medicine
College of Medicine
Taipei Medical University
Founded in 1960, the College of Medicine, Taipei Medical University is now composed of seven
academic units. We currently have close to 600 faculty members, including full-time professors, adjunct
professors, and clinical instructors, and a total of 1600 students comprised of undergraduate students,
Master’s degree and Ph.D. students. We integrate resources from not only 3 JCI-accredited affiliated
hospitals, Taiwan Medical University Hospital, Taipei Medical University Wang-Fang Hospital and Taipei
Medical University Shuang-Ho Hospital, but also Graduate Institutes, and Research Centers to nurture
researchers and students in the field of Basic Medical Sciences, Clinical Medicine and Applied Medicine.
To achieve greater perfection in medical research and education, we have developed several translational
research groups in different research fields. In addition, we hold “Mushan Biomedical Research Seminar”
monthly inviting domestic and oversea distinguished experts to share their research journeys. Several
international symposiums are also held annually to boost the collaboration between TMU and other
renowned universities. Furthermore, we have signed MOUs to establish official relationship with
universities all over the world, and also the Dual Degree/Joint Degree Agreements with America and
Canada; we expect to provide the opportunity for international academic exchange and broaden students’
global vision to cultivate advanced physician scientists.
We will continue on our missions to advance the discovery of disease treatment and improve human
health via providing a high quality and interactive research environment. We believe our researchers and
students will be the very pioneers in medical research fields. In the meanwhile we are committed to
maintaining an academic culture that respects diversity and fosters compassion to change our students
into professionals who will be leaders in healthcare.
Colleg
e
of
Medici
ne
Graduate Institutes
Graduate Institute of Medical Sciences
Graduate Institute of Clinical Medicine
Master Program in School of Respiratory Therapy
International Master/Ph.D. Program in Medicine
International Clinical Training Program
International PhD Program for Cell Therapy and
Regeneration Medicine
Schools
School of Medicine
(including basic and clinical departments)
School of Respiratory Therapy
Research Centers
Research Groups
Graduate Institutes
Graduate Institute of Medical Sciences 7
Graduate Institute of Clinical Medicine 9
Master Program in School of Respiratory Therapy 11
International Master/Ph.D. Program in Medicine 12
International Clinical Training Program 13
Medical Education 14
International Ph.D. Program for Cell Therapy and Regeneration Medicine 15
Graduate Institute of Medical Sciences
About Ruei-Ming Chen Ph.D. Distinguished Professor and Director The research teams in the Graduate Institute of Medical Sciences were established based on disease-orientedmissions. We had four major fields of interest as follows:
1. The neuroscience translational medicine team works active research based on collaboration of basic neuroscientists and clinicians in neurology, neurosurgery, psychiatry and rehabilitation.
2. The inflammation research group provides several research platforms for lung fibrosis research, including molecular mechanics, clinical translational studies, anti-fibrotic drug design, and small molecule drug screening. 3. The breast cancer translational research team integrates basic research and clinical resources to develop novel
tumor markers for targeted anti-cancer drug development.
4. The mission of the stem cell research group is to develop the closely cooperation with experts in basic research and clinical medicine, and to promote translational medicine of cell/stem cell in TMU.
Major achievements The lung inflammatory team
Demonstrated that a disintegrin and metalloproteinases 17(AD AM17) and α-SMA are overexpressed in fibroblasts from patients with COA compared to normal subjects. They also demonstrated that C/EBPβ-mediated hypoxia induced expression of ADAM17 and α-SMA as well as fibroblast differentiation. The main focus of this team is on why ADAM17 is the key mediator in the progression of fibroblast differentiation and pulmonary fibrosis. Delineation of the ADAM17 signaling processes in the lung fibroblast cell types will not only help elucidate the mechanisms underlying the development of pulmonary fibrosis, but facilitate the development of novel therapeutic strategies for curing or alleviating pulmonary fibrosis.
Lung inflammatory research group: The integrative research team.
Staff and contact information
Chien-Huang Lin, Ph.D., Professor/President
Tel: +886-2-2736-1661 ext. 2018 Fax: +886-2-2378-7795 E-mail: chlin@tmu.edu.tw URL: http://goo.gl/gdFYVe The neuroscience research team
TMU has established a University-grade “Center for Neurotrauma and Regeneration Medicine” and a Sleep Center for patients. There are 4 main teams : New diagnosis and treatment for neurological or psychiatric sequelae following traumatic brain injury (TBI); Impact of Sleep Disorders on Metabolic Functions; Impact of BBB / Neurovascular unit / Hypoxia in neurological or psychiatric diseases; New drug development for glioma.
1. The TBI team has established a translational research framework for early detection, therapeutic design from cellular or animal studies, and extended to health care for TBI patients. This team also established International Collaboration with NIH in USA with an ongoing integrated program project led by Dr. Wen-Chang Chang.
2. The team in sleep medicine has established a reliable and valid animal model of maternal early-life sleep deprivation and found
trans-generational impact of sleep deprivation.
3. Neurovascular research team focuses on cerebrovascular studies in hypoxia, ischemia, white matter injury and neurodegenerative diseases.
4. The glioma team has established orthotopic xenofeaft and allograft animal models and identified new biomarkers for glioma and potential new therapeutic approaches.
Staff and contact information
Jia-Yi Wang Ph.D. Professor and Director
Tel: +886-2-27361661 ext. 3412 Fax: +886-2-23778620
E-mail: jywang2010@tmu.edu.tw
URL: http://physiology.tmu.edu.tw/teacher_001-1.php
Major publications
[1] Lin JW, Chen JT, Hong CY, et al. Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic Bax-mitochondrion-cytochrome c-caspase protease pathway. Neuro-Oncology 2012;14:302-314
[2] Jin G, Lee SW, Zhang X, et al. Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1. Mol Cell 2015; 58:989-1000
[3] Yeh PS, Wang W, Chang YA, et al. Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration. Cancer Letters 2016;370(1):66-77
[4] Kuo YC, Au HK, Hsu JL, et al. IGF-1R promotes symmetric self-renewal and migration of alkaline phosphatase+ germ
stem cells through hif-2α–oct4/cxcr4 loop under hypoxia. Stem Cell Rep 2018; 10:524-37.
[5] Chang TS, Wu YC, Ching CC, et al. Activation of IL6/IGF-IR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression. Clin Cancer Res 2015; 21:201-210.
[6] Chang TS, Wu YC, Tung SY, et al. Alpha-fetoprotein measurement benefits hepatocellular carcinoma surveillance in patients with cirrhosis. Am J Gastroenterol 2015; 110:836-44.
[7] Huang ZW, Lien GS, Chen BC, et al. p300 and C/EBPβ-regulated IKKβ expression are involved in thrombin-induced IL-8/CXCL8 expression in human lung epithelial cells. Pharmacol Res. 2017; 121:33-41.
[8] Yang LY, Greig NH, Huang YN, et al. Post-traumatic admini-stration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury. Neurobiol Dis. 2016; 96: 216-26.
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Graduate Institute of Medical Sciences
The breast cancer team
This research team has provide the molecular evidence for smoking-induced breast cancer formation. They focused on three major aims as follows:
1. Develop a therapeutic antibody for the Ƞ9-nAChR. 2. Validate the therapeutic efficacy of the Ƞ9-nAChR-specific
antibody.
3. Evaluate the Ƞ9-nAChR molecule as an early-diagnostic marker for breast cancer patients.
4. Establish the down-stream signaling mechanisms of smoking-induced carcinogenesis.
After nicotine treatment, the protein phosphatase Mg2+/Mn2+ dependent 1F (PPM1F), a Ser/Thr protein phosphatase, triggered the inactivation of both p-p53 and p-BAX by dephosphorylating them at specific sites. These results suggest that PPM1F could be downstream of Ƞ 9-nAChR in nicotine-induced breast cancer formation, and could attenuate p-p53 (Ser-20)- and p-BAX (Ser-184)-induced pro-apoptotic pathways. Thus, PPM1F expression could be used for prognostic diagnosis or inhibited for cancer prevention and therapy.
International Connection
Hui-Kuan Lin, Ph.D. Professor, Cancer Biology, Comprehensive Cancer Center, Office of Women in Medicine and Science, Wake Health University.
URL: http://www.wakehealth.edu/Research/Cancer-Biology/Hui-Kuan-Lin-Lab.htm
Staff and contact information
Yuan-Soon Ho, Ph.D., Distinguished Professor
Tel: +886-2-2736-1661, ext. 3327, 3420 E-mail: hoyuansn@tmu.edu.tw URL: http://gims.tmu.edu.tw/main.php
The stem cell research team
Our main efforts will focus on basic research, drug targeting on cancer stemness and disease-specific induced pluripotent stem cells (disease iPS), and disease-indication of preclinical animal studies. Future cooperation in medicine research, clinical treatment, and product innovation of cell/stem cell will be highlighted. The major aims of the stem cell research team as follows.
1. Pluripotent stem cells, embryonic germ cells and induced pluripotent stem cells (iPS cells).
2. Niche regulation of stemness expression in stem cell and cancer. 3. Homeostasis regulation of pluripotent transcription factor OCT4 in
stem cell and cancer.
4. Preclinical animal studies of small blood cells and mesenchymal stem cells in bone repair and wound healing.
5. Drug screening of disease iPS cells and cancer stem cells.
Schematic of mouse postimplantation germ cell development in symmetric self-renewal proliferation and migration.
IL6 increases the expression of pluripotent gene OCT4 and NANOG through IGFIR activation in human HBV-HCC cells.
Staff and contact information
Rita Yen-Hua Huang, Ph.D., Distinguished Professor and Director
Tel: +886-2-2736-1661 ext. 3150 Fax: +886-2-2735-6689 E-mail: rita1204@tmu.edu.tw URL: http://biochemistry.tmu.edu.tw/teacher-1.asp http://goo.gl/fCZnnI g
Graduate Institute of Clinical Medicine
About
Kuan-Chou Chen M.D., Ph.D. Professor and Director The Graduate Institute of Clinical Medicine was established to enhance the health of the public through prospective
clinical and translational medical research, the exploration and solving of clinical problems, and the development of advanced diagnosis tools and treatments in order to earlier detecting and preventing diseases.
Both the master’s and doctoral programs are designed to train students to the highest standards of this institute.
Our curriculum characteristics are three aspects, including Disease-Oriented Research, Research-Oriented Learning and Dual mentorship. We offer courses in clinical trials, translational medicine, clinical & translational epidemiology, clinical evidenced medicine, cell biology, molecular biology, lab rotation and research techniques, applied statistics, research design, advanced paper writing and genetic medicine. All students are given guidance and counseling by two supervisors who possess backgrounds in clinical medicine and research.
Major achievements Research teams:
Cancer
N-α-acetyltransferase 10 protein (Naa10p) is a poor prognostic factor the expression of which is correlated with metastasis and shorter survival in osteosarcomas. We propose that Naa10p can act as an oncogene by stabilizing MMP-2 protein expression in osteosarcomas. Our findings may provide a possible strategy for targeting Naa10p-MMP-2 regulation to prevent the highly metastatic property of osteosarcomas.
Effects of Naa10p on MMP-2 stabilization. In invasive osteosarcoma cells, Naa10p was highly expressed and formed a complex with Naa15p to acetylate and stabilize the MMP-2 protein thus contributing to cell invasion and metastasis.
Renal Diseases
We used resveratrol-loaded nanoparticles (Res NPs) as a novel method for improving the pharmacokinetic properties of Res and analyzed the effect of Res NPs in chronic kidney disease (CKD)
Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1β secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals. Treatment with KIM-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in murine model of CKD. Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD.
Cardiovascular Diseases
Atrial fibrosis plays a pivotal role in the pathophysiology of heart failure (HF). The left atrium (LA) experiences greater fibrosis than the right atrium (RA) during HF. Study elucidated differences in profibrotic activity between LA and RA fibroblasts may be caused by different responses to mitogen-activated protein kinase signaling.
a. Interstitial fibrosis of left atrium (LA) and right atrium (LA) tissues in healthy and heart failure rats.
b. Illustration of vascular endothelial growth factor (VEGF) on collagen production and interaction between VEGF and MAPK signaling in LA and RA.
Genetic Medicine
Interleukin-6 (IL-6) is an inflammatory cytokines that plays a role in the
9
Graduate Institute of Clinical Medicine
Inflammation & Autoimmune
Possible associations of single-nucleotide polymorphisms (SNPs) of melatonin receptor type 1A (MTNR1A) and 1B (MTNR1B), with autoimmune thyroid disease in an ethnic Chinese (i.e., Taiwanese) population were examined.
Genetic variants of melatonin receptor type 1A and the AT haplotype of the combination of rs2119882 and rs13140012 were associated with GD susceptibility in an ethnic Chinese population.
Evidence-Based Medicine
Background: This study investigated whether incident hypertension,
incident hyperlipidemia, or both, increased the dementia risk in patients with and without prior diabetes mellitus (DM).
Major findings: The dementia risk was higher in the DM cohort
than in the non-DM cohort (adjusted hazard ratio (HR) = 1.47). In the non-DM cohort, patients with both hypertension and hyperlipidemia had a higher dementia risk (adjusted HR = 1.33).
Staff and contact information
Kuan-Chou Chen, M.D., Ph.D., Professor and Director Hermia Ho, Secretary
Tel: +886-2-2736-1661 ext. 3229 Fax: +886-2-2739-0500 E-mail: gicm@tmu.edu.tw URL: gicm.tmu.edu.tw/main.php
development of cancer. The relationships between IL-6 -174G>C polymorphism and bladder cancer risk are still inconclusive. A comprehensive literature search was performed to identify eligible studies regarding IL-6 -174G>C polymorphism and bladder cancer. Finally, five studies were included. In the fixed-effect analysis, significantly higher bladder cancer risks of 1.20 and 1.30 were found for dominant model (C/C+G/C vs. G/G) and recessive model (C/C vs. G/C+G/G), respectively. Especially for the Asian population, significantly greater bladder cancer risks of 1.63 and 1.54 were observed for dominant model and recessive model, respectively. In conclusion, our findings suggest that IL-6 -174G>C polymorphism is significantly associated with bladder cancer in the Asian population. Further studies with a larger sample size are needed to validate the effects of IL-6 polymorphisms on bladder cancer.
Fig. 2 Forest plot for the dominant model (C/C+G/C vs. G/G genotypes).
Fig. 3 Forest plot for the recessive model (C/C vs. G/C+G/G genotypes).
Major publications
[1] Chien MH, Lee WJ, Yang YC, et al. N-α-acetyltransferase 10 protein promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas. Cancer Lett. 2018; 433:86-98.
[2] Y-F Lin, Y-H Lee, Y-H Hsu, Y-J Chen, Y-F Lin, F-Y Cheng and H-W Chiu. Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease.
Nanomedicine 2017; 12:2741-2756.
[3] Chung CC, Kao YH, Yao CJ, et al. A comparison of left and right atrial fibroblasts reveals different collagen production activity and stress-induced mitogen-activated protein kinase signalling in rats. Acta Physiol (Oxf). 2017 Aug;220(4):432-445. doi: 10.1111/apha.12835. Epub 2017 Jan 16.
[4] Zheng JQ, Lai HJ, Wang YH. et al. Association of stroke subtypes with risk of hip fracture: a population-based study in Taiwan. Archives of Osteoporosis. 2017 Nov 22;12(1):104.
[5] Lin JD, Yang SF, Wang YH, et al. Associations of melatonin receptor gene polymorphisms with Graves' disease. PLoS One. 2017; 12(9): e0185529. [6] Fan YC, Hsu JL, Bai CH, et al. Increased dementia risk predominantly
indiabetes mellitus rather than in hypertension or hyperlipidemia: a population-based cohort study. Fan et al. Alzheimer's Research & Therapy (2017) 9:7 DOI 10.1186/s13195-017-0236-z
Master Program in School of Respiratory Therapy
About
Bing-Chang Chen Ph.D. Professor and Director. The School of Respiratory Therapy offers a Master of Science (M.S.) degree, with a specialization in respiratory
therapy, to prepare future experts in the profession as well as advanced clinical practitioners.
Faculties in our programs integrate critical thinking and simulation into teaching and research in order to provide students opportunities to excel their profession. The healthcare systems in Taipei Medical University also provide students more chances to perform translational research.
We also offer a dual M.S. degree with the integrated master program of Respiratory Therapy in Georgia State University (GSU), USA.
This Program is for highly motivated and academically accomplished baccalaureate graduate who wants to:
1. To enhance the ability to perform respiratory care in the clinical site at an advanced level as a respiratory therapy specialist. 2. To develop the ability to examine the scientific basis of respiratory
care procedures and evaluate technology used in respiratory care. 3. To develop professions in respiratory sciences for faculty in
academic institutes.
We have seven core research groups in the Master Program
1. Respiratory pharmacology and lung fibrosis 2. Diagnostics and therapy in critical respiratory care
3. Verification and development of respiratory therapy equipment 4. Long-term respiratory care and rehabilitation
5. Infectious pulmonary disease and tuberculosis 6. Environmental pulmonary disease
7. Inflammation-induced airway hyperreactivity
Program highlights
1. 30 credits program
2. Web-enhanced program designed for the working professionals 3. Interdisciplinary research
Program information
1. Program of study (30 credits) 2. Respiratory therapy Core: 16 credits 3. Specialized Curriculum: 8 credits 4. Thesis: 6 credits
Prospects after graduation
1. Advanced respiratory therapists
2. R&D in respiratory therapy and critical care medicine
Representative figures
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MEKK1/ERK/RSK1 mediates thrombin-induced C/EBPE activation and IL-8/CXCL8 expression in lung epithelial cells.o
CXCR4 mediates CXCL12-stimulated stress fiber formation in lung fibroblastsp
Determination of inflammopathology in mouse using CT(Left) and SPECT(Right)q
Hypothesized mechanisms involved in the TRPA1-TRPV1 interaction in pulmonary sensory neuronsMajor publications
[1] Hsu CC, Lee LY. Role of calcium ions in the positive interaction between TRPA1 and TRPV1 channels in bronchopulmonary sensory neurons. J Appl Physiol 2015; 118:1533-43. [2] Lin LL, Chen FH, Huang LY, et al. Virulence effect from
switching conserved homologous genes responsible for capsular polysaccharide synthesis from klebsiella pneumoniae serotype K1 into serotype K20. Virulence 2016; 26:1-7.
[3] Huang ZW, Lien GS, Lin CH, et al. p300 and C/EBPE-regulated IKKE expression are involved in thrombin-induced
IL-8/CXCL8 expression in human lung epithelial cells. Pharmacol Res 2017; 121:33-41.
[4] Lai CY, Lai CH, Chuang HC, et al. Physicochemistry and cardiovascular toxicity of metal fume PM2.5: a study of human coronary artery endothelial cells and welding workers. Sci Rep 2016; 6:33515.
[5] Hsu CC, Lin YS, Lin RL, Lee LY. Immediate and delayed potentiating effects of tumor necrosis factor-alpha on TRPV1 sensitivity of rat vagal pulmonary sensory neurons. Am J Physiol Lung Cell Mol Physiol 2017; (Accepted)
[6] Weng CM, Chen BC, Wang CH, et al. The endothelin A receptor mediates fibrocyte differentiation in chronic obstructive asthma. The involvement of connective tissue growth factor. Am J Respir Crit Care Med 2013; 188:298-308.
Staff and contact information Bing-Chang Chen, Ph.D., Director
Tel: +886-2-2736-1661 ext. 3511 E-mail: bcchen@tmu.edu.tw
Hui-Ting Yu, Secretary
Tel: +886-2-2736-1661 ext. 3515 E-mail: claire710@tmu.edu.tw URL: http://rt.tmu.edu.tw/main.php
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International Master/Ph.D. Program in Medicine
About
Yen-Chou Chen Ph.D. Professor and Director The International Master/Ph.D. Program in Medicine (IGPM) started recruiting students in the fall of 2016.
This program offers both degree of Master/Ph.D. degree in medical sciences. IGPM provides its students with interdisciplinary research and clinical training opportunities in the world-class laboratories of doctoral faculty located both at campuses of Taipei Medical University (TMU) and at the affiliated hospitals in TMU healthcare system, which include TMU hospital, TMU Wanfang Hospital and TMU Shuang-Ho Hospital. Students will receive a fundamental orientation and training in the current field of biomedical sciences as well as mastery of the knowledge and investigative approaches in his or her chosen areas of specialization.
In addition, International Clinical Training Program (ICTP) is also provided for resident and fellow training. Residents or fellows will receive certifications after finishing this program.
Eligibility
1. Non-citizen of Taiwan
2. Hold a bachelor degree in science related to biomedical fields (for applicants in Master program)
3. Hold a master degree in science or art related to biomedical fields (for applicants in Doctoral program)
4. An MD degree and at least two years of documented clinical training with publication(s) equivalent to a master’s thesis (for applicants in Doctoral program)
Missions
1. To prepare master candidates to have broad range of knowledge in the fields of medical sciences, leading to bolster their preparation for further study or entry into the biomedical workforce
2. To prepare doctoral candidates to become research professionals equipped to teach in university programs and for leadership positions in biotechnology and research
Requirements for Master degree
1. 12 credits in Required Courses (including 6 credits in Thesis)
2. 18 credits in Elective Courses 3. Research Ethics (No credit) 4. Thesis
5. Pass oral thesis defense
Requirements for Ph.D. degree
1. 18 credits in Required Courses (including 12 credits in Dissertation)
2. 12 credits in Elective Courses 3. Research Ethics (No credit)
4. Pass Qualification Examination (QE) to advance doctoral candidate
5. At least one article published in a
SCI/SSCI/A&HCI/EI/THCI Core journal (ranked in top 50%) as the first author
6. Dissertation
7. Pass oral dissertation defense
Major publications
[1] Cheng TC, Tu SH, Chen LC, et al. Down-regulation of L- fucosidase 1 expression confers inferior survival for triple- negative breast cancer patients by modulating the glycosylation status of the tumor cell surface. Oncotarget 2015; 6:21283-21300.
[2] Chang TS, Wu YC, Ching CC, et al. Activation of IL6/IGF-IR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression. Clinical Cancer Res 2015; 21:201-10.
[3] Yang SF, Lee WJ, Tan P, et al.Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas. Oncotarget 2015; 6:2736-53. [4] Guan SS, Chang J, Cheng CC, et al. Afatinib and its encapsulated
polymeric micelles inhibits HER2-overexpressed colorectal tumor cell growth in vitro and in vivo. Oncotarget 2014; 5:4868-80.
Staff and contact information
Shing-Chuan Shen, Ph.D., Professor and Counselor
Tel: +886-2-2736-1661 ext. 3425 E-mail: scshen@tmu.edu.tw
E-mail:igpm@tmu.edu.tw URL: http://igpm.tmu.edu.tw;
International Clinical Training Program
About
Under the umbrella of International Master/Ph.D. Program in Medicine which provides a wide range of master and doctoral degrees, the International Clinical Training Program (ICTP) provides opportunities for foreign clinicians to join the clinical training in three affiliated hospitals of TMU. The trainee includes residents, fellows and visiting scholars. The period may range from 1 month to 2 years depending on the training level and specialty. The trainees of ICTP programs may join the courses of International Master/Ph.D. Program in Medicine at school and participate in the patient care at hospitals. We encourage trainees to apply for International Master/Ph.D. Program in Medicine after finishing ICTP. Courses taken during the ICTP will be credited in the International Master/Ph.D. Program in Medicine. We value the diversity that visiting residents/fellows bring to our program, and they have every opportunity to experience what we have to offer.
Eligibility
1. Non-citizen of Taiwan.
2. Hold either the M.D. degree certificate or the diploma given by College of Medicine.
3. Hold medical doctor license and clinical training experience for at least 1 year.
4. Be able to communicate in English.
Notice
1. ICTP trainee is permitted making clinical decisions, diagnosis or giving advices on any medical issues during the program span under the supervision of mentors.
2. ICTP trainee has to choose from departments for apprenticeship.
3. Training contents, durations and further prerequisites vary from department to department.
4. Housing may be arranged upon request but is subject to availability; fees may apply and are subject to different dormitories.
5. ICTP trainee will receive a clinical training certificate issued by the university after finishing all training courses.
Materials Required for Application
1. Application form. 2. Curriculum Vitae.
3. Copy of M.D. degree certificate or the diploma given by College of Medicine.
4. Copy of medical doctor license.
5. Certificate of clinical training experience.
6. At least one recommendation letter from the head of the department which the applicant belongs to at the hospital or the Dean of the Medical School.
7. Copy of valid passport.
8. Health record, immunization record within the last three months (prior the arrival).
9. Proof of personal health/accident insurance with overseas coverage or proof of national health insurance (prior the arrival).
Training Fees
1. The fees vary according to the policy of the applied affiliation. 2. Students studied in TMU International Master/Ph.D. Program
in Medicine are exempt from the fees. 3. The fees are non-refundable after registration.
Rotation Clinical Departments
1. Breast Cancer Training Program 2. Cardiovascular Medicine 3. Gastroenterology and Hepatology 4. Laparoscopic Surgical Training Program
5. Minimal Invasive Surgery and Epigenetics of Gynecological Oncology
6. Minimally Invasive Thoracic Surgery 7. Minimally Invasive Urologic Surgery 8. Neurology
9. Orthopaedics Surgery and Sports Medicine 10. Physical Medicine and Rehabilitation 11. Plastic and Reconstructive Surgery 12. Pulmonary Medicine
13. Radiology 14. Renal Medicine
Staff and contact information
E-mail: yufenhuang@tmu.edu.tw E-mail: ictp@tmu.edu.tw URL: http://igpm.tmu.edu.tw
Medical Education
Major research aims
Wu, Chien-Chih M.D., Ph.D. Research in medical education aims at examining teaching and learning processes and the human attributes,
interactions, organizations, and institutions that shape outcomes of medical education. Educational research encompasses a broad range of methodologies, and the development of new methods is sometimes used. For instance, we conducted qualitative studies on students’ reflective journals to ensure the reasonableness of our curricular innovations in medical humanities. These innovations included early clinical exposure courses and teaching medical ethics. To find convenient and effective models for teaching, learning and assessing clinical skills, our empirical studies focus on simulation education, technology-enhanced learning and competency-based education.
Major achievements
1. The International Conference of Clinical Competence and Simulation Education in Healthcare (Since 2013).
2. Authenticated training program for IMPROVING SIMULATION INSTRUCTIONAL METHODS (ISIM).
3. The Establishment of ACGME Milestone Project in Acta Anaesthesiologica Taiwanica.
4. The Development of a Situational Judgement Checklist for Collaborative Ethics Teaching.
Representative figures
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This table shows that all ACGME competency indicators declined significantly in Level 5 according to the consensus of 38 local experts.
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149 reflective journals of Year-6 medical students (M/F = 45/12); The local scenarios embodied all CanMEDS key competencies. Only one (0.7%) scenario cannot fit in with the CanMEDS framework. The role expectation for a good Communicator was mostly emphasized. In most scenarios, more than one role was involved.
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An Exploratory Study on Simulated Clinical Skill Learning Satisfaction in the Flipped ApproachSeventy eight fifth grade medical students took flipped nasogastric insertion course and filled learning satisfaction questionnaire. The questionnaire was consisted of three domains satisfaction in learning nasogastric insertion knowledge, nasogastric insertion skill, and affective learning. The result showed that:
1. students have high learning satisfaction in flipped classroom. 2. There was no statistical difference among three domains and overall average of students’ learning satisfaction in flipped classroom. Table 1 Satisfaction on Bloom's taxonomy of learning domains
Domain M SD t-value p-value
Cognitive 4.03 0.72 6.45 < .001 Psychomotor 4.12 0.64 8.44 < .001 Affective 4.10 0.71 7.46 < .001 One-sample t-test, test value: 3.5.
Major publications
[1] Lin CW, Clinciu DL, Swartz MH, et al. An integrative OSCE methodology for enhancing the traditional OSCE program at Taipei medical university hospital-a feasibility study. BMC Med Educ 2013; 13:102.
[2] Tang KP, Kang. YN, Ho JJ, et al. CanMEDS roles as framework for analyzing Taiwanese medical students’ reflective journals: an exploratory research for cross-cultural compatibility. Bulletin of Medical Education - Taichung Veterans General Hospital 2015; 18:21-8.
[3] Tang KP, Kang YN, Wu CC, et al. The Educational Implementation of Duo-Case Method in Teaching Medical Ethics on Ventilator-Dependent Patient Care. Bulletin of Medical Education - Taichung Veterans General Hospital 2017; 20:3-12.
[4] Kang YN, Lin CW, Chen CY, et al. An Exploratory Study on Simulated Clinical Skill Learning Satisfaction in the Flipped Approach. Journal of Taiwan Society for Simulation in Healthcare 2016; 3:23-31.
Staff and contact information
Chien-Chih Wu, M.D., Ph.D., Associate Professor
Tel: +886-2-2736-1661, ext. 3001 E-mail: ccwu@tmu.edu.tw
International Ph.D. Program for Cell Therapy and Regeneration Medicine
About
Rita Yen-Hua Huang Ph.D. Distinguished Professor and Director The International Ph.D. Program for Cell Therapy and Regeneration Medicine (IPCTRM) has begun to recruit
students for the inaugural Fall semester 2017. The mission of this program is to promote translational medicine and clinical trials of cell/stem cell based therapy. Along with TMU’s university-grade Center for Cell Therapy and Regeneration Medicine (TMU-CTRM), IPCTRM aims to cultivate talented young researchers in diverse fields, including immune cell applications in cancer treatment; blood and mesenchymal stem cell therapies for regenerative processes, wound healing, graft-versus-host disease, and multiple sclerosis; and drug screening platform with cancer stem cells and disease-specific induced pluripotent stem cells. IPCTRM brings experts and scientists together to not only facilitate outstanding research in basic studies but also place major emphasis on clinical translational medicine and industrial cell/stem cell product development.
Major Achievements
1. Establishment of university-grade “TMU Center for Cell Therapy and Regeneration Medicine” for integration of cell/stem cell researches between TMU and TMU-affiliated hospitals. X 2. Founding of “TMU Distinguished Stem Cell Translational
Medicine Research Group”.
3. Investigation of safety and efficacy of small blood cells and mesenchymal stem cells in preclinical animal studies. o
4. Investigation of niche hypoxia synergistically cooperates with the symmetric division and cell migration of Germ Stem Cells. p 5. Inauguration of Good Tissue Practice (GTP) Laboratory for
preparation of clinical grade cells/stem cells for clinical use. q 6. Reinforcement of collaboration and transition between laboratory
and patent/industry development.
Program Highlights
1. Cancer immunotherapy
2. Pluripotent stem cells: embryonic germ cells and iPS cells 3. Pluripotent small blood stem cells in clinical trials 4. Mesenchymal stem cells in clinical trials
5. Drug screening platform with disease iPS cells 6. FDA/TFDA regulations on cell therapy 7. CMC/ Pharm-Tox/ clinical trial/ IRB training
Career Opportunities
Our graduates will become leaders in the following areas: 1. Clinical research coordination
2. Regulation development and review 3. Research and development 4. Clinical trial drafting and review 5. Academic research
6. Cell manufacturing process
Representative Figures
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Organization of TMU Center for Cell Therapy and Regeneration Medicine.
o HSA coated-fluorescent nanodiamond (FND)-labeled placenta chorion mesenchymal stem cells (pcMSCs) in pig lung tissues. pProliferation and metastasis of embryonic germline stem cell in a
hypoxic micro-environment during the early embryonic stage.
q
The GTP Laboratory has two class 1,000 cleanrooms with clinical- grade flow cytometry, biological safety cabinet, centrifuge, and incubators.
Major Publications
[1] A phase I study of autologous adult peripheral small blood stem cells for human guided bone regeneration in dental implantation. 2018 (Under Revision)
[2] Lin YH, Chen YH, Chang HY, et al. Chronic niche
inflammation in endometriosis-associated infertility: current understanding and future therapeutic strategies. Int J Mol Sci 2018; 19:2385.
[3] Kuo YC, Au HK, Hsu JL, et al. IGF-1R promotes symmetric self-renewal and migration of alkaline phosphatase+ germ stem
cells through hif-2α–oct4/cxcr4 loop under hypoxia. Stem Cell Rep 2018; 10:524-37.
[4] Su LJ, Wu MS, Hui YY, et al. Fluorescent nanodiamonds enable quantitative tracking of human mesenchymal stem cells in miniature pigs. Sci Rep 2017; 7:45607.
[5] Chang TS, Wu YC, Ching CC, et al. Activation of IL6/IGF-IR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression. Clin Cancer Res 2015; 21:201-10.
[6] Chang TS, Wu YC, Tung SY, et al. Alpha-fetoprotein
measurement benefits hepatocellular carcinoma surveillance in patients with cirrhosis. Am J Gastroenterol 2015; 110:836-44. [7] Wu YC, Ling TY, Lu SH, et al. Chemotherapeutic sensitivity of
testicular germ cell tumors under hypoxic conditions is negatively regulated by SENP1-controlled sumoylation of OCT4. Cancer Res 2012; 72:4963-73.
[8] Huang YH, Chin CC, Ho HN, et al. Pluripotency of mouse spermatogonial stem cells maintained by IGF-1 dependent signaling pathway. FASEB J 2009; 23:2076-87.
Staff and contact information
Dr. Heng-Yu Chang, Assistant Professor Dr. Yu-Chu Chang, Assistant Professor
Tel: +886-2-2736-1661, ext. 3082 or 3179 Fax: +886-2-2735-6689
E-mail: hychang@tmu.edu.tw and yuchuc@tmu.edu.tw URL: http://ipctrm.tmu.edu.tw/members/teacher.php?class=110 http://cctrm.tmu.edu.tw/main.php
Research Centers
Cochrane Taiwan 17
Biostatistics Center 18
Major research aims
Chiehfeng Chen M.D. M.P.H. Ph.D. Director Cochrane Taiwan is one of the official Cochrane societies supporting the global work of Cochrane and maximizing
the use and the impact of Cochrane Reviews for Taiwan and East Asian region. Funded and based at Taipei Medical University, we support the education and the production of Cochrane Systematic Reviews. It is our goal to maximize the impact of Cochrane Reviews by disseminating and implementing the findings to health professionals, researchers, decision makers and the public. Research fields:
1. Evidence-Based Medicine (EBM): education, research and promotion 2. Systematic review and meta-analysis research
3. Knowledge translation (KT) and shared-decision making (SDM)
4. EBM application: health technology assessment (HTA), comparative effectiveness analysis (CEA), clinical practice guideline (CPG), etc.
Major achievements Activities:
1. We form the East Asian Cochrane Alliance (EACA) by inviting representatives from Hong Kong, Japan, Korea, Singapore, and Taiwan with the aim to promote the activities of Cochrane systematic reviews since 2007.
2. Recognized by Cochrane Translation Group, Cochrane Taiwan is the leading position of translating Cochrane Systematic Review abstracts into Mandarin.
3. In 2016, we held 11 workshops and 7 lectures related to EBM. We also co-organized activities with Taiwan Joint Commission of Hospital Accreditation on 16th Healthcare Quality Improvement Circle and EBM competition among Ministry Hospitals. For training EBM related website search, we carried out the onsite teaching 7 times at Ministry Hospitals.
Academics:
1. During the study period, Directors of nursing (DON)s’ EBP knowledge and skills increased, but their beliefs and attitudes did not significantly change. Furthermore, the use of Internet-based resources, including web portals, electronic textbooks, electronic journals, and evidence-based online databases, increased. Most barriers significantly declined after the intervention.
2. Five eligible studies were retrieved and analyzed. We divided sentinel lymph node (SLN) metastasis into two categories: SLN micrometastasis and SLN macrometastasis. In patients with 1 or 2 SLN micrometastasis, no significant difference was observed in overall survival (OS), disease-free survival (DFS), or recurrence rate between the axillary lymph node dissection (ALND) and non-ALND group. For patients with 1 or 2 SLN marcometastasis, only one trial with a moderate risk of bias was included, and non-ALND was the preferred management overall. However, ALND might be appropriate for patients who placed a greater emphasis on longer-term survival at any cost.
In-service Master Program for Applied Evidence-Based Medicine (Graduate Institute of Clinical Medicine)
Total 30 credits (20 required credits including thesis and 10 elective credits) with multidisciplinary research team.
Representative figure
Major publications
[1] Chen C, Tam KW, Kuo KN. Choosing wisely in health care. J Formos Med Assoc. 2018 Jul 3.
[2] Hou WH, Wang JD, Hsieh CL, et al. Rasch Analysis of the 9-Item Shared Decision Making Questionnaire in Women With Breast Cancer. Cancer Nurs. 2018 Apr
[3] Shen WC, Loh EW, Tam KW, et al. Efficacy and Safety of Rituximab for the Treatment of Graves' Orbitopathy : A Meta-analysis of Randomized Controlled Trials. Pharmacotherapy. 2018 May
[4] Chou YY, Loh EW, Tam KW, et al. The gap between currently available evidence and awareness in clinical practice of wound care: It is the time to shower earlier. Surgery. 2018 Mar
[5] Loh EW, Chou YY, Tam KW, et al. Fluid Resuscitation in Patients With Severe Burns: A Meta-analysis of Randomized Controlled Trials. Acad Emerg Med. 2018 Mar
[6] Loh EW, Yen Y, Tam KW, et al. Tyrosine kinase inhibitors for advanced or metastatic thyroid cancer: a meta-analysis of randomized controlled trials. Curr Med Res Opin. 2018 May [7] Tam KW, Chen C, Hou WH, et al. Validation of the European
Health Literacy Survey Questionnaire in Women With Breast Cancer. Cancer Nurs. 2018 Mar/Apr
Staff and contact information
Chiehfeng (Cliff) Chen, M.D., M.P.H., Ph.D., Associate Professor and Director
Ken N. Kuo, M.D., EBM Consultant
Kelvin Ka-Wai Tam, M.D., Ph.D., Associate Director Joyce Kee-Hsin Chen, Ph.D. CEO
Tel: +886-2-2736-1661 ext. 7212 Fax: +886-2-6638-3879
Major research aims
Jin-Hua Chen Ph.D. Director The Research Center of Biostatistics is a research service facility under the College of Management in Taipei
Medical University. Jin-Hua Chen, the center director, collaborates with senior professor Kuang-Fu Cheng in research on statistical methodology of associations between genetics and diseases, and in research on meta-analysis statistical methods. The Center provides consulting on study design, data management, biostatistical issues and data analysis problems. Research fellows and biostatisticians in the Center collaborate closely with investigators and medical doctors within the University, and analyze the database of National Health Insurance program of Taiwan to investigate risk factors, diagnoses, treatments and prognosis for human diseases. The Center developed “Data Analysis & Guiding System-Cloud, DAGS‧C” and “I-Clinical”, which are web-based user-friendly statistical analyzing systems.
Major achievements
1. I-Clinical: helping investigators to choose the appropriate sample size, generate randomization plan from aspects of clinical studies and perform basic statistical analysis without the burden of downloading software.
2. Data Analysis & Guiding System-Cloud, DAGS‧C: a user- friendly statistical analyzing system. (http://www.r-web.com.tw/) 3. The purpose of our study was to find Bayesian estimates for the
Hurst dimension of a Fractional Brownian motion with a Beta prior when the process is observed at discrete times. Overestimation is observed though the overestimation is less severe as real H goes up. In addition, the estimated H decreases as Beta parameters go up given an Alpha value. In contrast, the estimated H increases as Alpha parameters go up given a Beta value. For the real-world data, the 2011 daily Taiwan stock index was used and the estimated Hurst index was 0.21.
4. A potential association between antidepressant and occurrence of dementia after controlling for the status of depression was observed. The hazard ratio (HR) of dementia among antidepressant users with depression was 2.42 (95% confidence interval (CI): 1.15-5.10), for those without depression was 4.05 (95% CI: 3.19-5.15), compared to antidepressant non-users respectively.
5. We found a prospective link between Chronic rhinosinusitis (CRS) and the subsequent development of cholesteatoma within a follow-up period of 8 years [representative figure]. After adjusting for potential confounders, patients with CRS had a 69% increased risk of cholesteatoma within 8 years, compared with those without CRS (HR, 1.69; 95% CI, 1.23-2.32).
6. We found that the risk of Parkinson disease (PD) was significantly higher in the autoimmune rheumatic diseases (ARDs) patients. The risk of PD was 1.37 times greater in ARD patients than in controls after adjustment for age, sex, and comorbidities. 7. Thoracic RT might be associated with overall survival in patients
with unresectable stage IIIB-IV EGFR-mutant lungadenocarcinomas who received and responded to EGFR TKI treatment. The adjusted hazard ratio derived for thoracic RT for lung tumor after EGFR TKI use and tumor response compared with EGFR TKI treatment alone was 0.72 (95% CI: 0.60-0.85).
Representative figures
(publications [3]) Cholesteatoma-Free Survival Rates Among Patients With Chronic Rhinosinusitis (CRS) and Those Serving as Controls. Significance at P < .001 was determined with a log-rank test.
Major publications
[1] Chen CY, Shafie K., Lin YK. Bayesian estimation of the Hurst parameter of fractional Brownian motion. Communications in Statistics-Simulation and Computation 2017; 46:4760-66. [2] Then CK, Chi NF, Chung KH, et al. Risk analysis of use of
different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan. PLoS ONE 2017;12: e0175187.
[3] Kuo CL, Yen YC, Chang WP, et al. Association between middle ear cholesteatoma and chronic rhinosinusitis. JAMA
Otolaryngol Head Neck Surg 2017; 143:757-63.
[4] Chang CC, Lin TM, Chang YS, et al. Autoimmune rheumatic diseases and the risk of Parkinson disease: a nationwide population-based cohort study in Taiwan. Ann Med. 2018;50:83-90.
[5] Yen YC, Hsu HL, Chang JH, et al. Efficacy of thoracic radiotherapy in patients with stage IIIB-IV epidermal growth factor receptor-mutant lung adenocarcinomas who received and responded to tyrosine kinase inhibitor treatment. Radiother Oncol 2018; [Epub ahead of print].
Staff and contact information
Jin-Hua Chen, Ph.D., Associate Professor and Director
Tel: +886-2-6638-2736 ext. 1186 Fax: +886-2-2735-8254
E-mail: biostat@tmu.edu.tw URL: http://biostat.tmu.edu.tw/
Research Groups
Anesthesiology 20
Cardiovascular Medicine 21
Emergency Medicine 23
Gastroenterology 25
Microbiology & Immunology Research 26
Neuroscience 28
Obesity Medicine 34
Oncology 35
Orthopedic 40
Pediatrics 43
Pulmonary Research 47
Radiology 50
Rehabilitation Medicine 53
Renal Medicine 55
Sleep Medicine 57
Tropical Medicine Research 59
Woman Health 60
Anesthesiology
Perioperative Medicine Research Team
Major research aims
Ta-Liang Chen M.D., Ph.D. Perioperative medicine was consisted of preoperative assessment for various comorbidities, intraoperative
management and adverse outcomes, such as postoperative complications and mortality. Using big sample size from Taiwan National Health Insurance Research Database (NHIRD, Taiwan), avoiding of selection and participation bias. We have studied the incidence, prevalence, managements, correlations and associations of various diseases and surgeries, and important information of healthcare utilization. Our team has published over 60 pieces of SCI papers with high impact factor (IF), 4 papers IF˚10, and 16 papers IF˚5 since 2012. Besides the perioperative issue, other important territories were also involved, such as traumatic brain injury, diabetes, stroke, mental disorders, and traditional Chinese medicine. In addition to the retrospective cohort studies, the evidence-based systematic review with meta-analysis was also further integrated to expect another new era of research in perioperative medicine.
Major achievements
1. Perioperative outcomes for patients with psychiatric diseases. 2. Risk factors and outcomes of diabetes, stroke, traumatic brain
injury, SLE, fractures, and epilepsy.
3. Prevalence, characteristics, associated factors, and outcomes of the usage of traditional Chinese medicine (TCM)
Representative data
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The propensity score-matched study demonstrated that diabetes increases postoperative mortality, consumption of medical resources, and complications, particularly for acute myocardial infarction and renal failure, in patients with diabetes undergoing noncardiac surgeries.o
The follow-up results showed that patients with epilepsy were 4.6 times more likely than the non-epilepsy group to experience gastrointestinal hemorrhage (13.4 vs 2.9 per 1000 person-years), with an adjusted HR of 2.97 (95% CI, 2.49-3.53) after controlling for demographic factors and comorbidities.p
Compared with controls had no mental disorders, the risk of mortality was significantly higher in schizophrenic patients with frequent psychiatric visits, previous psychiatric hospitalizations, and use of emergency services before surgery.o
p
Major publications
[1] Yeh CC, Liao CC, Chang YC, et al. Adverse outcomes after noncardiac surgery in patients with diabetes: a nationwide population-based retrospective cohort study. Diabetes Care 2013; 36:3216-21.
[2] Yeh CC, Wang HH, Chou YC, et al. High risk of gastrointestinal hemorrhage in patients with epilepsy: a nationwide cohort study. Mayo Clin Proc 2013; 88:1091-8.
[3] Liao CC, Shen WW, Chang CC, et al. Surgical adverse outcomes in patients with schizophrenia: a population-based study. Ann Surg 2013; 257:433-8.
[4] Lin JA, Liao CC, Lee YJ, et al. Adverse outcomes after major surgery in patients with systemic lupus erythematosus: a nationwide population-based study. Ann Rheum Dis 2014; 73: 1646-51.
[5] Liao CC, Lin CS, Shih CC, et al. Increased risk of fracture and postfracture adverse events in patients with diabetes: two nationwide population-based retrospective cohort studies. Diabetes Care 2014; 37:2246-52.
Staff and contact information
Chien-Chang Liao, Ph.D., M.P.H., Associate Professor
Tel: +886-2-2737-2181, ext.8310 Fax: +886-2-2736-7344
E-mail: jacky48863027@yahoo.com.tw; ccliao@tmu.edu.tw
Ta-Liang Chen, M.D., Ph.D., Professor
Tel: +886-2-2737-2181, ext.8310 Fax: +886-2-2736-7344 E-mail: tlc@tmu.edu.tw
Cardiovascular Medicine
Cardiovascular Research Team
Major research aims
Yi-Jen Chen M.D., Ph.D. Cardiaovascular disease remains one of the leading causes of death in the world. My lab has devoted to deal with
the cardiovascular disease especially in the field of cardiac arrhythmia, investigate the probable mechanisms and treatment either in basic research or in clinical applications. We had established a series of platform and animal models for research of the mechanism and potential treatment of cardiac disease. The research scope involves both atrial and ventricular arrhythmia and their potential etiologies such as renal failure, electrolytes imbalance, gender, dyslipidemia, chronic obstructive pulmonary disease, degenerated heart diseases (ex. Sinus node dysfunction), and the use of medication (ex. Non-Steroidal Anti-Inflammatory Drug (NSAID), novel oral anticoagulant (NOAC), etc), or their potential therapeutic agents such as Histone deacetylase (HDAC) inhibitor or antioxidant.
Major achievements
1. Discovery the therapeutic potential of HDAC inhibitor and antioxidant on treatment of atrial fibrillation, which may reduce atrial arrhythmogenesis through multiple target modifications. 2. Explore the role of renal failure, electrolytes imbalance, gender,
dyslipidemia, degenerated heart (ex. Sinus node dysfunction), and the use of medication (ex. NSAID) in the pathogenesis of atrial tachyarrhythmia. These studies point out the electrical interactions of sinus node and pulmonary vein cardiomyocytes and
dysregulated calcium homeostasis in the pathogenesis of atrial fibrillation (Figure 2).
3. Investigation of the mechanism how epicardial fat,
adipocytokines, and fatty acids modulating Ionic currents and electrophysiologic characteristics of atria, which may potentiate the atrial fibrillation occurrence (Figure 3).
4. Research the regional difference of electrophysiological properties and the impact of absence of androgen receptor in RVOT - the potential ventricular tachycardia origin, which may provide better understanding or inspire novel therapy for RVOT associated VT. 5. Study of aging effect on atrial arrhythmia including aging
associated cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF(Figure 1).
Representative figures
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Major publications
[1] Tsai WC, Lu YY, Chen YC, et al. Ablation of androgen receptor gene triggers right ventricular outflow tract ventricular tachycardia. Int J Cardiol 2015; 189:172-81.
[2] Huang SY, Chen YC, Kao YH, et al. Renal failure induces atrial arrhythmogenesis from discrepant electrophysiological
remodeling and calcium regulation in pulmonary veins, sinoatrial node, and atria. Int J Cardiol 2016; 202:846-57
[3] Hu YF, Chen YJ, Lin YJ, et al. Inflammation and the patho- genesis of atrial fibrillation. Nat Rev Cardiol 2015; 12:230- 43. [4] Lkhagva B, Kao YH, Chen YC, et al. Targeting histone
deacetylases: A novel therapeutic strategy for atrial fibrillation. Eur J Pharmacol 2016; 781:250-7.
[5] Chang CJ, Cheng CC, Chen YC, et al. Gap junction modifiers regulate electrical activities of the sinoatrial node and pulmonary vein: Therapeutic implications in atrial arrhythmogenesis. Int J Cardiol 2016; 221:529-36.
Staff and contact information Yi-Jen Chen M.D., Ph.D., Professor
Tel: +886-2-2930-7930 ext. 2818, 2819 Fax: +886-2-2933-9378
E-mail: yjchen@tmu.edu.tw
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Cardiovascular Medicine
Atherosclerosis and Vascular Biology Research Team
Major research aims
Chun-Yao Huang M.D., Ph.D. Base on the theory of inflammation and dyslipidemia we establish a series platform focusing on research to
investigate the pathophysiology, mechanisms and treatments on cardiovascular disease, especially for metabolic disorder-induced and infection-induced atherscloerosis. Incoperating the concept of translational medicine, we find clinical problems, investigate the probable mechanisms and treatment at laboratory, and return our findings to clinical applications finally. To increase the clinical care quality of patients is our ultimate goal.
Major achievements
1. We highlight the therapeutic vasculogenesis potential of the Dipeptidyl peptidase 4 (DPP-4) inhibitor, statin, and lycopene by promoting endothelial progenitor cell (EPC) functions (figure 1). 2. Previous studies on dyslipidemia focus on the transportation
function of each lipoproteins, We investigate the direct effects of oxidized low density lipoprotein (ox-LDL) and high density lipoprotein (HDL) on endothelial cell and EPCs. We explore oxLDL has concentration-dependent bi-phasic effects on EPCs function, and moderate to high concentrations of HDL paradoxically impaired EPCs tube formation in the absence of oxLDL. Under high ox-LDL condition, High HDL would revese the adverse effect driven by ox-LDL (figure 2).
3. Bacterial infection, such as C. pneumonia and P. gingivalis may act as a potent virulence factor, contributing to the tumori-genesis and atherotumori-genesis (figure 3) .
4. We explore several useful clinical biomarkers which can detect subclinical atherosclerosis for early intervention to prevent from the full brown cardiovascular disease.
Representative figures
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Staff and contact information
Chun-Yao Huang, M.D., Ph.D., Associate Professor
Tel: +886-2-2736-1661 ext. 3006 Fax: +886-2-6631-1502 E-mail: cyhuang@tmu.edu.tw
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Major publications
[1] Huang CY, Tsai CS, Chen CH, et al. Eotaxin-2 increased toll-like receptor 4 expression in endothelial cells in vitro and exacerbates high-cholesterol diet-induced atherogenesis in vivo. Am J Transl Res 2016; 8:5338-53.
[2] Tsai CS, Lin YW, Huang CY, et al. Thrombomodulin regulates monocye differentiation via PKCδ and ERK1/2 pathway in vitro and in atherosclerotic lesion. Sci Rep 2016; 6:38421.
[3] Huang CY, Shih CM, Tsao NW, et al. The GroEL protein of Porphyromonas gingivalis regulates atherogenic phenomena in endothelial cells mediated by toll-like receptor 4 expression. Am J Transl Res 2016; 8:384-404.
[4] Chiang KH, Cheng WL, Shih CM, et al. Statins, HMG-CoA Reductase Inhibitors, Improve Neovascularization by Increasing the Expression Density of CXCR4 in Endothelial Progenitor Cells. PLoS One 2015; 10:e0136405.
[5] Lin FY, Tsao NW, Shih CM, et al. The biphasic effects of oxidized-low density lipoprotein on the vasculogenic function of endothelial progenitor cells. PLoS One 2015; 10:e0123971. [6] Lu HY, Huang CY, Shih CM, et al. Dipeptidyl peptidase-4
inhibitor decreases abdominal aortic aneurysm formation through GLP-1- dependent monocytic activity in mice. PLoS One 2015; 10:e0121077.
[7] Lin FY, Huang CY, Lu HY, et al. The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization. Mol Oral Microbiol 2015; 30:198-216. [8] Sung LC, Chao HH, Chen CH, et al. Lycopene inhibits cyclic
strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase -1 in human umbilical vein endothelial cells. Clin Exp Pharmacol Physiol 2015; 42:632-9.
Emergency Medicine
Air Medical Transport Research Team
Major research aims
Shin-Han Tsai M.D., Ph.D.
Hon-Ping Ma M.D., Ms. Emergency Air Medical transport (EAMT) has rescued patients from remote islands for decades
because of the geographical limits in Taiwan. Debates persist regarding the cost-effectiveness, safety of helicopter transport, mortality, and benefit. Proper criteria are needed to determine when EAMT is warranted and most likely to benefit patients. Transport of critical patients by air has become an integral part of regionalized systems of healthcare. Allocation of manpower, software/hardware upgrading and incorporation of video-telemedicine system are keys to improve local healthcare capabilities. This has won the 2018 SNQ – Symbol of National Quality..
Major achievements
1. The preflight screening by National Aeromedical Approval Center (NAAC) has no patient safety or flight safety issue after 2002. (figure 1)
2. Emergency air medical transport (EAMT) became a major part of the modern trauma care system and most of remote-island patients were transferred via EAMT. (figure 2)
3. The overall mortality rate was 7.56% in 1684 airlifted patients. Among them, 26.3% were acute myocardial infarction and 25.8% were traumatic brain injury. (figure 3)
4. Male predominates in the head injury patients (M:F = 2.6:1) (figure 4)
5. Increasing utilization of EAMT in current National Health Care Scheme is necessary according to the NAAC database.
Representative figures
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Major publications[1] Tsai SH, Chen WL, Chiu WT, et al. Principles and direction of air medical transport in Taiwan. Ira J. Blumen, Daniel L. Lemkin. Principles and Direction of Air Medical Transport (2ed) 2015; Ch89: 940-944.
[2] Chen KC, Lu R, Iqbal U, et al. Interactions between Traditional Chinese Medicine and Western Drugs in Taiwan: A
Population-based Study. Computer Methods and Programs in Biomedicine 2015; 122:462-470.
[3] Chen WL, Chiu WT, Wu MS,et al. Translational research of telecare for the treatment of hepatitis C. Biomed Res Int. 2014; Epub.
[4] Liao KH, Sung CW, Chu SF, et al. Reduced power spectra of heart rate variability are correlated with anxiety in patients with mild traumatic brain injury. Psychiatry Res. 2016; 243:349-56. [5] Sung CW, Lee HC, Chiang YH, et al. Early dysautonomia
detected by heart rate variability predicts late depression in female patients following mild traumatic brain injury. Psychophysiology. 2016; 53: 455-64.
[6] Chang CH, Lee CY, Feng SW, et al. Effects of salivary oxidative markers on edentulous patients' satisfaction with prosthetic denture treatments: a pilot study. PLoS One 2016; 11:e0151605.
Staff and contact information
Hon-Ping Ma, M.D., Ms., Assistant Professor
Tel: +886-2-2249-0088 ext. 1230 Fax: +886-2-6631-1502 E-mail: acls2000@tmu.edu.tw
Emergency Medicine
Hyperglycemia Research Team
Major research aims
Chin-Wang Hsu M.D. Emergency department (ED) hyperglycemia has been observed to be a strong predictor of the prognosis of critical
illness and in-hospital outcomes.
1. Stress-induced hyperglycemia (SIH) is common in patients with critical illness, including sepsis, multiple trauma, major surgery, and acute myocardial infarction (AMI). In patients with critical illness ,SIH have a high of risk for adverse outcome and occurrence of diabetes mellitus in non diabetes patients.
2. The American Diabetes Association (ADA) indicated that patients with HbA1c of 5.7% to 6.4% might have a prediabetic status and an increased risk of diabetes and cardiovascular mortality. HbA1c may be considered an effective indicator that facilitates the early detection of patients with potential adverse prognosis after nonfatal MI. HbA1c may strengthen the accuracy of clinical care in early intervention and secondary prevention.
Major achievements
1. Additional observation studies to establish whether critically ill patients have undiagnosed Type 2 DM (T2DM) prior to the onset of critical illness and to better control for established risk factors are necessary.
2. Our study showed that HbA1c is a significant predictor of MACEs after AMI in nondiabetic patients. This biomarker may strengthen the accuracy of clinical care in early intervention and secondary prevention.
3. A high initial glucose level in the ED is an important and independent predictor of short-and long-term adverse prognoses in patients with first acute myocardial infarction.
Representative figures
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T2DM-free probability (a) and death (b) with and without certain critical illnesses.o
Receiver operating characteristic curve with the cutoff value of glycated hemoglobin for detecting major adverse cardiac events. Area under curve: 0.616, 95% confidence interval: 0.529 to 0.701; cutoff value: 5.78; P = .013 (sensitivity: 0.729 and specificity: 0.452).p
The Kaplan-Meier cumulative survival curves for patients during the follow-up period of 1 year, stratified by the 3 initial glucose levels (log-rank test, P=.0002).Major publications
[1] Hsu CW, Lin CS, Chen SJ, et al. Risk of type 2 diabetes mellitus in patients with acute critical illness: a population-based cohort study. Intensive Care Med 2016; 42:38-45.
[2] Chen CL, Yen DH, Lin CS, et al. Glycated hemoglobin level is an independent predictor of major adverse cardiac events after nonfatal acute myocardial infarction in nondiabetic patients: A retrospective observational study. Medicine (Baltimore) 2017; 96:e6743.
[3] Hsu CW, Chen HH, Sheu WH, et al. Initial serum glucose level as a prognostic factor in the first acute myocardial infarction. Ann Emerg Med 2007; 49:618-26.
Staff and contact information
Chin-Wang Hsu, M.D., Assistant Professor
Tel: +886-2-2930-7930, ext. 1211 Fax: +886-2-8662-1192
