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Fructus mume Diminishes Capsular Polysaccharide Biosynthesis in Klebsiella pneumoniae

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Fructus mume Diminishes Capsular Polysaccharide

Biosynthesis in Klebsiella pneumoniae

Tien-Huang Lin1,2, Su-Hua Huang3, Tzyy-Rong Jinn1, Ching-Ting Lin1*

1Graduate Institute of Chinese Medicine

, School of Chinese Medicine, China Medical University.

2

Division of urology, Department of surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation

3

Institute of Genomics and Bioinformatics, National Chung Hsing University, Tai Chung City, 40227, Taiwan, Republic of China

K. pneumoniae is the predominant pathogen isolated from liver abscesses of

diabetic patients in Asian countries. Capsular polysaccharide (CPS) is considered as the major determinant for K. pneumoniae virulence, especially K1 and K2 serotype. With the widespread of multiple-drug resistance K. pneumoniae, it is an increasing need for development of an antimicrobial approach to block the virulence factor production. In this study, we sought to demonstrate traditional Chinese medicine

Fructus mume not only possessed antibacterial activity against K. pneumoniae, but

also inhibited the CPS biosynthesis of K. pneumoniae. Results revealed that Fructus

mume dose-dependently decreased the bacterial mucoidy and the CPS amount. In

addition, the inhibitory effect of Fructus mume on CPS biosynthesis at the transcriptional level. Based on the role of bacterial CPS on anti-serum killing, Fructus

mume affect the ability of K. pneumoniae, through reduction of CPS amount, to resist

the bactericidal effects of serum. Furthermore, citric acid has been demonstrated to be a major organic acid of Fructus mume, we also found that citric acid has a stronger inhibitory role on CPS biosynthesis. Take together, these results indicate that Fructus

mume is an efficient antibacterial agent to increase the intracellular iron concentration

to diminish CPS biosynthesis and the effect also reflects bacterial resistance to serum killing. We suggest that Fructus mume might be useful for diminishing the virulence of K. pneumoniae.

Key words: Fructus mume, capsular polysaccharide, Klebsiella pneumonia, tradition

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