Author(s): Huang, AC (Huang, An-Cheng); Lin, SY (Lin, Shuw-Yuan); Su, CC (Su, Chin- Cheng); Lin, SS (Lin, Song-Shei); Ho, CC (Ho, Chin-Chin); Hsia, TC (Hsia, Te-Chun); Chiu, TH (Chiu, Tsan-Hung); Yu, CS (Yu, Chun-Shu); Ip, SW (Ip, Siu-Wan); Lin, TP (Lin, Tsung- Ping); Chung, JG (Chung, Jing-Gung)
Title: Effects of Curcumin on N-bis(2-Hydroxypropyl) nitrosamine (DHPN)-induced Lung and Liver Tumorigenesis in BALB/c Mice In Vivo
Source: IN VIVO, 22 (6): 781-785 NOV-DEC 2008 Language: English
Document Type: Article
Author Keywords: Curcumin; DHPN (N-bis(2-hydroxypropyl)nitrosamine; tumorigenesis BALB/c mice; in vivo
KeyWords Plus: DIETARY CURCUMIN; CANCER CELLS; COLON CARCINOGENESIS;
CLINICAL-TRIAL; TUMOR-CELLS; APOPTOSIS; RATS; CHEMOPREVENTION;
FORESTOMACH; ACTIVATION
Abstract: Curcumin (diferuloylmethane), a phenolic compound front the plant Curcuma longa (Linn.) has been shown to exhibit antitumor activity and apoptosis in many human cancer cell lines including that of lung and liver cancer. In this study, curcumin was evaluated in BALB/c mice for its ability to inhibit pulmonary and liver adenoma formation and growth after they were orally treated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). Animals were treated with DHPN in water for approximately 14 days before multiple doses of curcumin were given intraperitoneally. It was found that 200 mu M curcumin reduced lung and liver tumor multiplicity by 37% (p<0.05) and 30% (p<0.05) respectively. The results indicated that
curcumin significantly inhibited pulmonary and liver adenoma formation and growth in BALB/c mice. The precise mechanism by which curcumin inhibits lung and liver tumorigenesis remains to be elucidated. Thus, curcumin appears to be a promising new chemotherapeutic and preventive agent for lung and liver cancer induced by DHPN.
Addresses: [Chung, Jing-Gung] China Med Univ, Dept Biol Sci & Biotechnol, Taichung 404, Taiwan; [Huang, An-Cheng] Yuan Lin Kuo Hosp, Dept Pharm, Yuanlin Town 510, Changhua County, Taiwan; [Su, Chin-Cheng] Tzu Chi Univ, Div Gen Surg, Buddhist Tzu Chi Gen Hosp, Hualien, Taiwan; [Lin, Song-Shei] Cent Taiwan Univ Sci & Technol, Dept Radiol Technol, Tainan, Taiwan; [Ho, Chin-Chin] Cent Taiwan Univ Sci & Technol, Dept Nursing, Tainan, Taiwan; [Hsia, Te-Chun] China Med Univ Hosp, Dept Internal Med, Taichung, Taiwan; [Chiu, Tsan-Hung] China Med Univ Hosp, Dept Obstet & Gynecol, Taichung, Taiwan; [Yu, Chun- Shu] China Med Univ, Sch Pharmacol, Taichung 404, Taiwan; [Lin, Tsung-Ping] China Med Univ, Grad Inst Pharmaceut Chem, Taichung 404, Taiwan; [Ip, Siu-Wan] China Med Univ, Dept Nutr, Taichung 404, Taiwan; [Chung, Jing-Gung] Asia Univ, Dept Biotechnol, Wufeng, Taichung County, Taiwan
Reprint Address: Chung, JG, China Med Univ, Dept Biol Sci & Biotechnol, 91 Hsueh Shih Rd, Taichung 404, Taiwan.
E-mail Address: [email protected]
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Publisher: INT INST ANTICANCER RESEARCH
Publisher Address: EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD
KAPANDRITI, PO BOX 22, ATHENS 19014, GREECE ISSN: 0258-851X
29-char Source Abbrev.: IN VIVO ISO Source Abbrev.: In Vivo Source Item Page Count: 5
Subject Category: Medicine, Research & Experimental ISI Document Delivery No.: 383ZH
