• 沒有找到結果。

Resistin promotes MMP-2 production and migration in human chondrosarcoma cells through AMPK/p38 pathways

N/A
N/A
Info
下載
Protected

Academic year: 2021

Share "Resistin promotes MMP-2 production and migration in human chondrosarcoma cells through AMPK/p38 pathways"

Copied!
1
0
0

加載中.... (立即查看全文)

立即下載 ( 1 頁 )

全文

(1)

Resistin promotes MMP-2 production and migration in human chondrosarcoma

cells through AMPK/p38 pathways.

Ho-Ning Huang

1

, Yuan-Li Huang

1

, Chen-Ming Su

2

,Chih-hish Tang

2

1

Department of Biotechnology, College of Health Science, Asia University, Wufeng, Taichung City, Taiwan.

2

Abstruse

Graduate Institute of Basic Medical Science, China Medical University and Hospital, Taichung, Taiwan.

Tumor malignancy is associated with several cellular properties including

proliferation and ability to metastasize. Resistin the most potent pro-inflammatory and

plays a crucial role in migration and metastasis of human cancer cells. We found that

treatment of human chondrosarcoma (JJ012 cells) with resistin increased migration

and expression of matrix metalloproteinase (MMP)-2. Resistin-mediated cell

migration and MMP-2 expression were reduced by pretreatment with inhibitors of

AMP-activated protein kinase (AMPK) and p38 mitogen-activated protein kinases

(p38) as well as the AMPK inhibitor and the p38 inhibitor. In addition, resistin

treatment induced phosphorylation of AMPK and p38. Taken together, these results

suggest that resistin activated AMPK/p38 resulting in increased MMP-2 expression

and migration in human chondrosarcoma cells.

參考文獻

立即下載 ( PDF - 1 頁 - 19.83 KB )

相關文件

臺中榮民總醫院 臨床訓練科

CASE (Center of Advanced Medical Simulation and Education) is a multidisciplinary medical simulation center aims to give high quality education with new training methodologies by

住院醫師任臨床教師計畫之重要性

Affiliated Address: Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital. 1650 Taiwan Boulevard Sect.. 7DLFKXQJ9

T aichung V e terans General Hospital

Center for Faculty Development, Department of medical education, Taichung Veterans General hospital 1 School of Medicine, National Yang-Ming University, Taipei, Taiwan 2.

第 4 卷 第 1 期 二〇一七年四月 VOL. 4 NO. 1 April 2017

Feng-Jui Hsieh (Department of Mathematics, National Taiwan Normal University) Hak-Ping Tam (Graduate Institute of Science Education,. National Taiwan

2021年台灣腦中風學會與台灣癲癇醫學會之 中風後癲癇治療指引

1 Department of Neurology and Stroke Center, Taipei Medical University-Shuang Ho Hospital; Taipei Neuroscience Institute; School of Medicine, College of Medicine, Taipei

中榮醫教投稿須知

Center for Faculty Development, Department of Medical Education, Taichung Veterans General Hospital 1 Department of Nursing, Hungkuang University, Taichung, Taiwan 2. Section

實證醫學基本核心能力指標架構之建置

Center for Faculty Development, Department of Medical Education, Taichung Veterans General Hospital 2 School of Medicine, National Yang-Ming University, Taipei, Taiwan 3.

追求卓越，持續創新 教學是中榮的核心價值和資產 -

After the SARS crisis in 2003, there is a huge and on-going reform in the post-graduate medical training program to improve the medical service in Taiwan. Our institute has