Author(s): Chang, CH (Chang, Chao-Hsiang); Chiu, CF (Chiu, Chang-Fang); Wu, HC (Wu, Hsi-Chin); Tseng, HC (Tseng, Hsien-Chang); Wang, CH (Wang, Chung-Hsing); Lin, CC (Lin, Cheng-Chieh); Tsai, CW (Tsai, Chia-Wen); Liang, SY (Liang, Shiu-Yun); Wang, CL (Wang, Cheng-Li); Bau, DT (Bau, Da-Tian)
Title: Significant association of XRCC4 single nucleotide polymorphisms with prostate cancer susceptibility in Taiwanese males
Source: MOLECULAR MEDICINE REPORTS, 1 (4): 525-530 JUL-AUG 2008 Language: English
Document Type: Article
Author Keywords: XRCC4; single nucleotide polymorphism; prostate; DNA repair KeyWords Plus: BREAST-CANCER; P53; EPIDEMIOLOGY; RISK
Abstract: The DNA repair gene X-ray cross-complementing group 4 (XRCC4), a member of the non-homologous end-joining (NHEJ) repair system, plays a major role in the repair of the double-strand breaks of the DNA sequence. This gene is critical to the maintenance of overall genome stability, and is also thought to play a key role in human carcinogenesis. In this case- control study, several novel polymorphic variants of XRCC4, including C-1622T (rs7727691), G-1394T (rs6869366), C-571T (rs2075686) and intron3 DIP (rs28360071), were investigated, and the correlation of these variants to prostate cancer susceptibility in a Taiwanese
population was observed. A total of 134 prostate cancer patients were recruited along with 134 age-matched healthy controls, and the association of their selected genotypes with
susceptibility to prostate cancer was determined. The G-1394T variant of XRCC4 proved, after analysis of the frequencies of each variant in the prostate cancer and control groups, to be a significant single nucleotide polymorphism (SNP) in prostate carcinogenesis. Our data clearly indicate that the heterogeneous G of G-1394T increases the risk of suceptibility to prostate cancer (P=0.0106), while no difference in distribution of XRCC4 C-1622T (rs7727691), C-571T (rs2075686) or intron3 DIP (rs28360071) between the prostate cancer and control groups was found. In conclusion, our findings suggest that the G allele of XRCC4 G-1394T may be responsible for prostate carcinogenesis, and could be useful in the early detection and prevention of the disease.
Addresses: [Chang, Chao-Hsiang; Chiu, Chang-Fang; Wu, Hsi-Chin; Tseng, Hsien-Chang;
Wang, Chung-Hsing; Lin, Cheng-Chieh; Tsai, Chia-Wen; Liang, Shiu-Yun; Wang, Cheng-Li;
Bau, Da-Tian] China Med Univ Hosp, Terry Fox Canc Res Lab, Taichung 404, Taiwan; [Chiu, Chang-Fang] China Med Univ Hosp, Dept Hematol & Oncol, Taichung 404, Taiwan; [Wang, Chung-Hsing] China Med Univ Hosp, Dept Pediat, Taichung 404, Taiwan; [Chang, Chao- Hsiang; Wu, Hsi-Chin] China Med Univ Hosp, Dept Urol, Taichung 404, Taiwan; [Tseng, Hsien-Chang] China Med Univ Hosp, Dept Otolaryngol, Taichung 404, Taiwan; [Tsai, Chia- Wen; Bau, Da-Tian] China Med Univ, Grad Inst Chinese Med Sci, Taichung, Taiwan; [Lin,
Cheng-Chieh] Asia Univ, Coll Hlth Sci, Taichung, Taiwan
Reprint Address: Bau, DT, China Med Univ Hosp, Terry Fox Canc Res Lab, 2 Yuh Der Rd, Taichung 404, Taiwan.
E-mail Address: [email protected] Funding Acknowledgement:
Funding Agency Grant Number
China Medical University and Hospital DMR-97-063
National Science Council NSC 952320-B-039-014-MY3
We thank Yung-Shun Kuo, Po-Chi Hsu and Chiao-Lin Lin for their technical assistance. This study was supported by research grants from the China Medical University and Hospital (DMR-97-063) and the National Science Council (NSC 952320-B-039-014-MY3).
Cited References: *DEP HLTH TAIW, 2006, CANC REG SYST ANN RE.
BARRY MJ, 1992, J UROLOGY, V148, P1549.
BAU DT, 2007, ANTICANCER RES, V27, P1559.
BAU DT, 2007, ANTICANCER RES, V27, P2893.
BAU DT, 2007, CARCINOGENESIS, V28, P1726, DOI 10.1093/carcin/bgm109.
CHIU CF, ORAL ONCOL IN PRESS.
CHIU CF, 2008, ANN SURG ONCOL, V15, P514, DOI 10.1245/s10434-007-9674-3.
FU YP, 2003, CANCER RES, V63, P2440.
GAO YJ, 1998, CELL, V95, P891.
GAO YJ, 2000, NATURE, V404, P897.
GLEASON DF, 1974, J UROLOGY, V111, P58.
GRONBERG H, 2003, LANCET, V361, P859.
HSING AW, 2006, FRONT BIOSCI, V11, P1388.
MARI PO, 2006, P NATL ACAD SCI USA, V103, P18597, DOI 10.1073/pnas.0609061103.
MATLASHEWSKI GJ, 1987, MOL CELL BIOL, V7, P961.
THOMAS M, 1999, MOL CELL BIOL, V19, P1092.
VANHEEMST D, 2004, DNA REPAIR, V3, P43, DOI 10.1016/j.dnarep.2003.09.004.
Cited Reference Count: 17 Times Cited: 2
Publisher: SPANDIDOS PUBL LTD
Publisher Address: POB 18179, ATHENS, 116 10, GREECE ISSN: 1791-2997
29-char Source Abbrev.: MOL MED REP
ISO Source Abbrev.: Mol. Med. Rep.
Source Item Page Count: 6 Subject Category: Pathology ISI Document Delivery No.: 374QF
