• 沒有找到結果。

The Relationship between AMPK and HO-1 Expression Induced by Alpha-Lipoic Acid in Rat Aortic Smooth Muscle Cells

N/A
N/A
Info
下載
Protected

Academic year: 2021

Share "The Relationship between AMPK and HO-1 Expression Induced by Alpha-Lipoic Acid in Rat Aortic Smooth Muscle Cells"

Copied!
1
0
0

加載中.... (立即查看全文)

立即下載 ( 1 頁 )

全文

(1)

The Relationship between AMPK and HO-1 Expression Induced by Alpha-Lipoic Acid in Rat Aortic Smooth Muscle Cells

Ssu-hui Wu

1＊

, Pao-Yun Cheng

2

, Mao-Hsiung Yen

1＃

1

Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan.

2

School of Chinese Pharmaceutical Science and China Medical Resources, China Medical University, Taichung, Taiwan.

Heme oxygenase (HO) breakdown of heme and produce biliverdin and carbon monoxide (CO), followed by reduced sensitivity of tissues to oxidative stress.

In recently studies showed that induced heme oxygenase-1 (HO-1) expression as a therapeutic agent in multiple forms of cardiovascular diseases and

hypertension. Alpha-lipoic acid (ALA) is a natural antioxidant that scavenges reactive oxygen species (ROS) and regenerates or recycles endogenous antioxidants. In our lab recently researches found that ALA induced HO-1 expression and increase the AMP-activated protein kinase (AMPK) acitivity in rat aortic smooth muscle cells (A10 cells). But the relationship between AMPK and HO-1 was unknowed. The aim of this study was to inverstigate whether the role of AMPK in HO-1 induction and determined the relationship of basic leucine zipper transcription factor 1 (Bach-1) and Nuclear factor-erythroid 2- related factor 2 (Nrf2) expression in A10 cells by alpha-lipoic acid. The results showed that HO-1 expression occurred maximally at 30 μM and peaked at 6hrs in A10 cells. Meanwhile, phosphorylated-AMPK (p-AMPK) expression maximally at 30 μM, too. On the contrary, the expression of p-AMPK and HO-1 induced by ALA were all abolished in present of compound C (AMPK inhibitor).

Results indicated that AMPK may play an important role in the regulation of

HO-1 expression by ALA in A10 cells.

參考文獻

立即下載 ( PDF - 1 頁 - 55.27 KB )

相關文件

The Open Dentistry Journal

The aim of the present study was to study the cytological spectrum of lesions of the oral cavity and salivary glands, to evaluate the role of fine needle aspiration cytology as

1.Introduction LamiaOualha, andNabihaDouki RaouaaBelkacemChebil, YassineOueslati, MarwaMarzouk, FatmaBenFredj, OralLichenPlanusandLichenoidLesionsinSjogren’sSyndromePatients:AProspectiveStudy ClinicalStudy

The aim of this study was to investigate, through a prospective clinical study, the prevalence and characteristics of oral lichen planus (OLP) and lichenoid lesions (OLL) in

n j z s h A THESIS FOR THE DEGREE OF MASTER OF BUSSINESS ADMINISTRATION GRADUATE INSTITUTE OF MANAGEMENT SCIENCES NANHUA UNIVERSITY

The issues discussed in this study include (1) an investigation of the demographic difference among the style of leadership and EAPs、organizational commitment, and intention to quit,

• The study of the numerical relationship between chemical quantities in a chemical reaction is called stoichiometry.

• One technique for determining empirical formulas in the laboratory is combustion analysis, commonly used for compounds containing principally carbon and

This document is originally written in Chinese. In case of discrepancy between the text of this translated version and that of the Chinese version, the Chinese text shall prevail.

Teachers may consider the school’s aims and conditions or even the language environment to select the most appropriate approach according to students’ need and ability; or develop

1. a core approach in which the basic characteristics of political and economic structures are the focus.

Students are asked to collect information (including materials from books, pamphlet from Environmental Protection Department...etc.) of the possible effects of pollution on our

2 Overview and Contributions of the Paper

Wang, Solving pseudomonotone variational inequalities and pseudocon- vex optimization problems using the projection neural network, IEEE Transactions on Neural Networks 17

and the surprising structure of vortices

Define instead the imaginary.. potential, magnetic field, lattice…) Dirac-BdG Hamiltonian:. with small, and matrix