Author(s): Su, CC (Su, Chin-Cheng); Yang, JS (Yang, Jai-Sing); Lu, CC (Lu, Chi-Cheng);
Chiang, JH (Chiang, Jo-Hua); Wu, CL (Wu, Chang-Lin); Lin, JJ (Lin, Jen-Jyh); Lai, KC (Lai, Kuang-Chi); Hsia, TC (Hsia, Te-Chun); Lu, HF (Lu, Hsu-Feng); Fan, MJ (Fan, Ming-Jen);
Chung, JG (Chung, Jing-Gung)
Title: Curcumin Inhibits Human Lung Large Cell Carcinoma Cancer Tumour Growth in a Murine Xenograft Model
Source: PHYTOTHERAPY RESEARCH, 24 (2): 189-192 FEB 2010 Language: English
Document Type: Article
Author Keywords: curcumin; human lung NCI-H460 cancer cells; xenograft transplantation;
in vivo
KeyWords Plus: I CLINICAL-TRIAL; DIETARY CURCUMIN; MICE; CHEMOPREVENTION;
APOPTOSIS; ANTITUMOR; PRODUCTS; AGENT
Abstract: Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI-H460 cells in vitro. However, there are no reports that curcumin can inhibit cancer cells in vivo. In this study, NCI-H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight). Each agent was injected once ever), 4 days intraperitoneally (i.p.), with treatment starting 4 weeks after inoculation with the NCI-H460 cells. Treatment with 30 mg/kg an 45 mg/kg of curcumin or with 8 mg/kg of doxorubicin resulted in a reduction in tumour incidence, size and weight compared with the control group. The findings indicate that curcumin can inhibit tumour growth in a NCI-H460 xenograft animal model in vivo. Copyright (C) 2010 John Wiley & Sons, Ltd.
Addresses: [Su, Chin-Cheng] Tzu Chi Univ, Buddhist Tzu Chi Gen Hosp, Dept Gen Surg, Hualien 970, Taiwan; [Yang, Jai-Sing] China Med Univ, Dept Pharmacol, Taichung 404, Taiwan; [Lu, Chi-Cheng; Chiang, Jo-Hua] Natl Chung Hsing Univ, Dept Life Sci, Taichung 402, Taiwan; [Wu, Chang-Lin; Chung, Jing-Gung] China Med Univ, Dept Biol Sci, Taichung 404, Taiwan; [Wu, Chang-Lin; Chung, Jing-Gung] China Med Univ, Dept Technol, Taichung 404, Taiwan; [Lin, Jen-Jyh] China Med Univ Hosp, Div Cardiol, Taichung 404, Taiwan; [Lin, Jen- Jyh] China Med Univ Hosp, Dept Med, Taichung 404, Taiwan; [Lai, Kuang-Chi] China Med Univ, Beigang Hosp, Dept Surg, Yunlin 651, Taiwan; [Lai, Kuang-Chi; Hsia, Te-Chun] China Med Univ Hosp, Dept Internal Med, Taichung 404, Taiwan; [Lu, Hsu-Feng] Cheng Hsin Rehabil Med Ctr, Dept Clin Pathol, Taipei 112, Taiwan; [Lu, Hsu-Feng] Fu Jen Catholic Univ, Coll Human Ecol, Taipei 510, Taiwan; [Fan, Ming-Jen; Chung, Jing-Gung] Asia Univ, Dept Biotechnol, Taichung 431, Taiwan
Reprint Address: Chung, JG, China Med Univ, Dept Biol Sci & Technol, 91 Hsueh Shih Rd,
Taichung 404, Taiwan.
E-mail Address: jgchung@mail.cmu.edu.tw Funding Acknowledgement:
Funding Agency Grant Number
China Medical University CMU96-086
National Science Council, Taiwan NSC95-2745-B-039-002-URD
This work was supported by grant CMU96-086 from the China Medical University and grant NSC95-2745-B-039-002-URD from the National Science Council, Taiwan.
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Publisher: JOHN WILEY & SONS LTD
Publisher Address: THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
ISSN: 0951-418X DOI: 10.1002/ptr.2905
29-char Source Abbrev.: PHYTOTHER RES ISO Source Abbrev.: Phytother. Res.
Source Item Page Count: 4
Subject Category: Chemistry, Medicinal; Pharmacology & Pharmacy ISI Document Delivery No.: 558WD
