Traditional Chinese Medicine Prescription Liver Disease Research
Abstract
Liver disease in Taiwan is endangering people's health a major enemies, but not the clinical treatment of hepatitis drugs not found
. Chinese medicine in the treatment of acute hepatitis, there are many excellent clinical effectiveness of prescription storm, "Long Dan Xie Gan" is the
One of them, unfortunately the lack of scientific evidence. In this thesis, Long Dan Xie Gan biological test, the active ingredient and
Standardized prescribing the three parts of the research phase of the conclusions stemming from the following:
1. Bioassay: the number of medical books in order to Shen's respect for life and recorded the prescription side, on the suppression of carbon tetrachloride-induced liver disorder
Production use, with the most significant activity. Prescription Coptis, Akebia, rhubarb, Bupleurum, blue, gardenia all have hepatoprotective
Effect. Square analysis by the addition and subtraction Bupleurum and peel essential for the prescription medicine, in particular, show that use of the prescription before
To maximize efficiency, most active investment approach for the dose to 5g crude drug / kg, twice a day dosing. Another mound by disease
Biopsy, drug treatment group showed smaller necrotic areas.
2. The active ingredient of: prescription by the active components and column chromatography separation, coupled with the biological test, and use of thin
Layer chromatography and high performance liquid
chromatography analysis of active ingredients and strength order of oleanolic acid>
geniposide> hesperidin> saikosaponin> berberine> emodin> chrysophanol.
Another
Role of the active ingredient compound, showing all the strongest when the active ingredient combinations.
3. Prescription Standardization: Using thin-layer chromatography scanner and high speed liquid chromatography, qualitative and quantitative analysis of prescription activity into
Points berberine, emodin, chrysophanol, saikosaponin, sennoside A, hesperidin
, Geniposide.
English Abstract
