PF-127 affect the cementation and dissolution temperature of the aqueous solution factors
DICLOFENAC-SODIUM prescription of controlled-release
AbstractThe purpose of this study, first in assessing the impact of PF-127 aqueous solution of cementation and dissolution temperature factor.
Assessment factor package
Including a PF-127 dosage, ionic strength, phosphate concentration of the solution monitoring slow chirp and polyethylene glycol and pH value of fermentation (PEG 6000)
Add the consumption level. From the experimental results: PF-127 in the amount of increase and decrease the temperature and
increasing dissolution temperature cement, glue
Junction and the solution temperature range between the PF-127, with the increasing amount of increase. The ionic strength of the cementation and dissolution
Temperature is only slightly affected between. Phosphate buffer of pH value increase will also reduce the cementation and dissolution temperature but gel
Junction temperature is not as obvious as the solution temperature as, as the concentration of phosphate buffer solution twitter, and monitoring its impact
Class similar to the cement and solution temperature.
Furthermore, when the chirp at higher phosphate buffer solution pH (7.5) when the concentration of buffer
And decrease in melting temperature. Add PEG 6000 will cause the increase of cementation and dissolution temperature and the
decrease of temperature, film
Sound level is determined by the added: amount more, the distance between cementation and dissolution temperature becomes shorter.
The above factors in understanding the gradual dissolution of the cement and the degree of impact, further mixed solvent method in different proportions
Alcohol / buffer / PEG 400 mixed modulation, using the same principles of the triangle, may contain a ratio of 10% PEG 400
The following and up to 20 percent alcohol content found when the temperature both cementation and dissolution of the prescription, and PEG 6000
The added help to improve its bond temperature and reduce
dissolution temperature, and the prescription of alcohol, if PEG 6000
Add, cementation and dissolution temperatures rise and fall will be more apparent.
II.
In this study, the first solution in the dissolution of different types, including deionized water, various concentrations of sodium chloride and potassium chloride solution and
pH changes in solution of Diclofenac Sodium from Voltare SR's release, and also used two different kinds of
Class prepared with HPMC sustained release of Diclofenac Sodium.
The results showed that, Diclofenac Sod. With
NaCl and KCl concentration was increased to prolong drug release, while at the same concentration, to extend the extent of drug release
To the NaCl solution was significantly higher than KCl solution. Dl- clofenac Sodium concomitant solubility in different solvents
. Sodium Diclofenac Sodium as the common ion effect, therefore the solubility in NaCl solution, the decline in
Degree of KCl was stronger than that, the results of Jiyu to slow down the release of Diclofe nac Sodium. In order to model drugs from the
Through the stomach into the small intestine, select the solution pH changes from liquid to dissolve into the dissolution test students.
Because Diclofenac Sodium
By acidification to low solubility of Di-clofenac Acid, there is no drug release. When the pH value is different to the gut of the high acid
Age value, the drug release rate of gastric residence time and slow down, this may be due to large amounts of Diclofenac
Acid precipitation caused. Fortunately, if the two types of HPMC with the sustained release effect, and its rate is used with
HPMC viscosity reduction, and increase the drug release rate.
English Abstract
