研發應用於磁振造影導引乳房腫瘤熱治療之高頻超音波環形陣列探頭

୯ҥᆵ᡼εᏢπᏢଣᄤᙴᏢଣᙴᏢπำᏢࣴز܌

ᅺγፕЎ

Institute of Biomedical Engineering

College of Engineering and College of Medicine National Taiwan University

Master Thesis

ࣴวᔈҔܭᅶਁ೷ቹᏤЇ٢܊ဍዦ዗ݯᕍϐ ଯᓎຬॣݢᕉ׎ତӈ௖ᓐ

Development and Investigation of High Frequency MR-guided Ring-Shaped Phased-Array Ultrasound Transducer for Breast

Tumor Thermal Therapy

ഋ߷ሎ

Guan-Ming Chen

ࡰᏤ௲௤ : ݅Ўᐝ റγ ഋඳݒ റγ Advisor : Win-Li Lin Ph.D.

Gin-Shin Chen Ph.D.

ύ๮҇୯ 102 ԃ 7 Д

ठ ठᖴ

ٿԃޑᅺγ؃ᏢғఱǴԏᛘၟ๱ྃД΋ଆቚߏǴԶྃДΨၟ๱೭ҁፕЎ΋ଆ ቚߏǴߏԿ೭ҁፕЎֹԋਔǴж߄๱೭ࢤᐕำޑ่״Ƕ΋ၡوٰޑ഻ࡗࠉ኷ǴϿ

΋ᗺ೿᝺ளёெǶ

җ૱གᖴࡰᏤ௲௤ ݅Ўᐝ Դৣ๏ךޑࡰᏤаϷдԖऐЈޑ஥ሦ๱ך຾Εຬॣ

ݢޑШࣚǴததӧፋ၉໔൩๏ΑךࡐӭჴᡍޑགྷݤǴൻൻ๓ᇨޑᡣךᏢ཮ӵՖ଺

ࣴزǶߚதགᖴ୯ৎፁғࣴزଣޑ ഋඳݒ റγǴࡑӧ୯ፁଣޑਔӀ္Ǵഋറγᕴ

ࢂࡉᓨޑᗺрჴᡍಒ࿯аϷᅴඵޑ௲ךӵՖࡑΓೀ٣Ƕགᖴ ഋ҉ᝬ ௲௤ჹܭҁፕ Ў๏ޑ܌Ԗࡌ᝼Ǵ٬ளҁፕЎૈ׳уֹ᏾Ƕ

གᖴჴᡍ࠻؂΋Տԋ঩ǴᏢߏۆ ဃഩ ǵ୯ᆢ ǵᘫ፣ ǵύम ǵۑঢ় ǵࣁύ ǵ ߝݒ ǵդᏦ ǵᄪᖰ ǵᛄЎ Ǵჴᡍ࠻ԖգॺǴωԖΓ໺܍ჴᡍ࠻ޑᆒઓǹԶჴᡍ

࠻ޑӕᏢ ݥԃ ǵቼએ ǵ☰∺ ǵൈ݅ ǵҲ੿ ǴԖգॺ΋ଆঅፐǵ଺ჴᡍǵϕ࣬ග ᒬჴᡍ຾ࡋǴ੿ޑࡐགᖴգॺǹԶჴᡍ࠻ޑᏢ׌ॺǴࡏᑟ ǵߪᒆ ǵηᆢ ǵޚྼ Ǵ ᖴᖴգॺ஥๏ჴᡍ࠻೚ӭ኷፪ǹ୯ፁଣޑ ᛬޹ ǵျߞ ǵᎄεঢ ǵዐዐ ǵৎᅴ ǵ

໡ำ ǵߞד ǵ࢙Ꮜ ǵऍἃ ǵλ໵ ǵޱ୯ ฻Ǵᖴᖴգॺၟך΋ଆ૸ፕჴᡍၶډޑ

ୢᚒǹགᖴѳਔ΋ଆᖄӝ໒཮ޑႝᐒ܌ ഩ๔ ฻ΓǴӧ໒ֹ཮ࡕᗋ཮΋ଆ໕၉΋พǶ ӧ೭ٿԃϐύǴ΋ۓόёલϿޑ൩ࢂךޑৎΓǴགᖴգॺค࡜Ѐޑ᠋ךܤ࡜Ǵ ᗋਔதᜢЈךޑჴᡍ຾ࡋǴᡣգॺӧπբԆ࿛ϐᎩǴᗋाϩЈډך೭ঁٽη΢Ǵ

੿ޑߚதགᖴգॺǹനࡕགᖴ ችӼ ޑᡏፊǴᡣךӧཱུࡋԆ࿛ϐᎩǴᗋૈԖ٤ᇸ᚞ǵ ז኷ޑਔӀǶ

ᖴᖴգॺǶ

ᄔ ᄔा

ଯமࡋᆫข܄ຬॣݢ(High-Intensity Focused Ultrasound, HIFU)ࢂճҔᖂݢ໺

ሀޑ੝܄ၲډߚߟΕԄݯᕍဍዦޑਏ݀Ƕҁࣴزଞჹ٢܊ဍዦ໒วΑ΋঺ଯᓎଯ மࡋᆫข܄ᕉ׎ຬॣݢඤૈᏔǴයఈૈଞჹഗ೽ޑ٢܊ဍዦౢғᆫขਏ݀ǴԶჹ

ۭ೽ޑ٢܊ဍዦૈࡼа዗ݯᕍǶ

ӧ HIFU ඤૈᏔޑ׷਑ᒧ᏷Бय़Ǵ٬ҔޑࢂፄӝᓸႝഏౠǴځڀԖफ़եᖂߔל Ъගଯᐒႝጠӝ߯ኧޑᓬᗺǹඤૈᏔޑЁκࣁъ৩ 100mmǵᆫขъ৩ 100mmǵଯ 25mmǵπբᓎ౗ࣁ 2.5MHzǴЪஒځᕉ׎ຬॣݢඤૈᏔϩԋ 16 ঁൂϡǶඤૈᏔޑ

੝܄Бय़Ǵჹځໆෳᓸႝ߯ኧ d33ǵᖂߔלаϷႝᖂᙯඤਏ౗Ǵٰᡍ᛾ඤૈᏔޑᒡ рਏ౗аϷᛙۓ܄Ƕ

Ҟ߻܌໒วޑଯᓎຬॣݢᕉ׎ඤૈᏔคݤԖਏஒႝф౗ᙯඤԋᖂф౗Ǵόૈ

ၲډ HIFU ฻ભޑу዗ਏ݀ǴՠϝૈჹಔᙃуྕǶќѦӧүᡏჴᡍ่݀᛾ჴԜᕉ׎

ຬॣݢඤૈᏔૈஒૈໆ໣ύӧޔ৩ 6 cm ޑНጤϐύЈՏ࿼Ƕ

ᜢᗖӷ : ᕉ׎ଯᓎຬॣݢඤૈᏔǵ዗ݯᕍǵ٢܊ဍዦǵፄӝᓸႝ׷਑ǵତӈԄ௖ᓐ

Abstract

High Intensity Focused Ultrasound (HIFU) can achieve a non-invasive treatment

using sound wave transmission to heat the desired region. In this study, we tried to

develop a ring-shaped HIFU transducer for breast tumors to generate thermal lesions in

the tip region of the breast and to execute thermal therapy in the bottom of the breast.

Using piezocomposite material for ultrasonic transducer can lower the acoustic

impedance as well as increase the electro-mechanical coupling factor. The size of

transducer is 100 mm in radius, 100 mm in radius of curvature, 25 mm in height and

2.5 MHz in working frequency. The transducer consists of 16 elements. To verify the

output efficiency and stability, we measured the piezoelectric parameter d33, acoustic

impedance and electro-acoustic efficiency.

At the present, the high frequency ring-shaped ultrasound transducer cannot reach

the requirements for a HIFU, while it can heat fresh pork tissues. This ultrasound

transducer can transmit the acoustic power to the center of a 6 cm gelatin phantom to

effectively raise the temperature.

Keywords: ring-shaped phased-array ultrasound transducer, hyperthermia, breast tumors,

piezocomposite material, HIFU

Ҟ Ҟᒵ

ठᖴ ...i

ᄔा ... ii

Abstract ... iii

Ҟᒵ ... iv

კҞᒵ ... vii

߄Ҟᒵ ... x

ಃ 1 ക ᆣፕ ... 1

1.1 ٢ᕎ ... 1

1.2 ዗ݯᕍޑว৖ ... 3

1.3 ᅶਁᏤЇϐଯமࡋᆫข܄ຬॣݢ ... 3

1.4 ࣴزҞޑ ... 4

ಃ 2 ക ׷਑ᆶБݤ ... 5

2.1 ᓸႝਏᔈ ... 5

2.1.1 ᓸႝ׷਑ ... 7

2.1.2 1-3 ፄӝᓸႝ׷਑ ... 7

2.1.3 ᓸႝ׷਑಍ஷБำԄ ... 9

2.1.4 ᓸႝ׷਑੝܄ୖኧ ... 11

2.2 ຬॣݢඤૈᏔ ... 13

ಃ 3 ക ᅶਁ೷ቹ࣬৒ϐඤૈᏔᇙഢϷ੝܄ໆෳБݤ ... 14

3.1 ᅶਁ೷ቹ࣬৒ϐຬॣݢඤૈᏔ ... 14

3.2 ඤૈᏔ೛ी ... 15

3.3 ඤૈᏔޑ׷਑Ϸځᇙഢ ... 15

3.3.1 ࡷᒧ੝܄࣬ӕޑᓸႝഏౠ ... 16

3.3.2 ᇙբԋፄӝ׷਑ ... 17

3.3.3 πբᓎ౗ϐᒧ᏷ ... 17

3.3.4 ዗ᓸԋࠠ ... 18

3.3.5 ؈ᑈᏤႝቫ ... 19

3.3.6 ࠾းԋඤૈᏔ ... 21

3.4 ߔלϰଛႝၡ ... 22

3.4.1 LC ႝၡߔלϰଛ ... 24

3.5 ඤૈᏔ੝܄ϯໆෳ ... 24

3.5.1 ᓸႝᔈᡂதኧ d33ໆෳ ... 24

3.5.2 ፄӝᓸႝഏౠϐᖂߔל ... 25

3.5.3 ႝᖂᙯඤਏ౗ ... 26

3.6 ඤૈᏔу዗ਏ݀ჴᡍ ... 27

3.6.1 ಔᙃүᡏჴᡍ ... 27

3.6.2 ᚆᡏ୏ނჴᡍ ... 29

ಃ 4 ക ่݀ᆶ૸ፕ ... 31

4.1 ඤૈᏔᇙբ ... 31

4.1.1 ᅶਁ೷ቹ࣬৒ϐຬॣݢඤૈᏔ ... 31

4.1.2 ᓸႝഏౠࡷᒧ ... 32

4.1.3 ፄӝ׷਑඲࣬კ ... 33

4.1.4 ፄӝᓸႝഏౠࠆࡋ ... 33

4.1.5 ᕉ׎ඤૈᏔᐒᄬ ... 36

4.1.6 ߔלϰଛႝၡ ... 37

4.2 ඤૈᏔ੝܄ໆෳ ... 39

4.2.1 ፄӝᓸႝഏౠޑᓸႝᔈᡂ߯ኧ d33ໆෳ ... 39

4.2.2 ᖂߔלໆෳ ... 40

4.3 ඤૈᏔу዗ჴᡍ่݀ ... 49

4.3.1 ಔᙃүᡏჴᡍ ... 50

4.3.2 ᚆᡏ୏ނჴᡍ ... 52

ಃ 5 ക ่ፕᆶ҂ٰ৖ఈ ... 54

ୖԵЎ᝘ ... 55

კ

კҞᒵ

კ 2.1 ҅ᓸႝਏᔈ ... 6

კ 2.2 ଍ᓸႝਏᔈ ... 6

კ 2.3 1-3 ፄӝ׷਑Ңཀკ ... 8

კ 2.4 ፄӝ׷਑่ᄬҢཀკ ... 8

კ 2.5 ᓸႝ߯ኧᆶӚᡂኧ໔ޑᜢ߯ ... 10

კ 3.1 ᕉࠠඤૈᏔҥᡏკ ... 14

კ 3.2 ፄӝᓸႝഏౠᇙբࢬำ ... 16

კ 3.3 ᓸႝഏౠ҅ຎკ ... 16

კ 3.4 ༤ΕᐋિࡕޑፄӝᓸႝഏౠТЁκҢཀკ ... 17

კ 3.5(a)(b)ኳڀᐒఓᇙკೕ਱ ... 19

კ 3.6 ዗ᓸԋࠠำׇკ ... 19

კ 3.7 у΢ᏤႝቫϐፄӝᓸႝഏౠТ ... 20

კ 3.8 ᘢᗓس಍Ңཀკ ... 20

კ 3.9 Ѥϩϐ΋ᕉ׎ຬॣݢඤૈᏔᐒᄬҥᡏკ ... 21

კ 3.10 ᕉ׎ຬॣݢඤૈᏔᐒᄬҢཀკ ... 22

კ 3.11 ߔלϩ݋ሺໆ(୯ፁଣᙴπಔගٮ)ෳϐፄӝᓸႝഏౠߔלᆶ࣬فკ ... 22

კ 3.12 ᓸႝഏౠޑ฻ਏႝၡኳࠠ ... 23

კ 3.13 ߔלϰଛҢཀკ ... 24

კ 3.14 d₃₃Meter(୯ፁଣᙴπಔගٮ)Ҕܭໆෳᓸႝ׷਑ϐᓸႝᔈᡂதኧ ... 25

კ 3.15 ᖂೲໆෳҢཀკ ... 26

კ 3.16 ႝᖂᙯඤਏ౗ໆෳҢཀკ ... 27

კ 3.17 (a)(b) ޔ৩ 1cm ޑ༝ࢊࠠНጤ ... 28

კ 3.18 ޔ৩ 6cm ޑ༝ࢊࠠНጤ ... 28

კ 3.20 ᚆᡏ፜Ժу዗ჴᡍࢎᄬკ ... 30

კ 4.1 ᕉ׎ຬॣݢඤૈᏔϷځϰଛႝၡ ... 31

კ 4.2 ܫ࿼ܭᅶਁ೷ቹس಍ϐຬॣݢඤૈᏔ ... 32

კ 4.3 ༤Εᐋિࡕޑፄӝᓸႝഏౠ඲࣬კ ... 33

კ 4.4 όӕፄӝᓸႝഏౠࠆࡋਔჹᔈޑӅਁᓎ౗ ... 34

კ 4.5 ፄӝᓸႝഏౠࠆࡋໆෳБݤ ... 34

კ 4.6 Ѥϩϐ΋ޑᕉ׎ຬॣݢඤૈᏔᐒᄬ ... 36

კ 4.7 ϰଛႝၡϐႝၡҢཀკ ... 37

კ 4.8 16 ൂϡޑຬॣݢඤૈᏔޑϰଛႝၡჴᡏ ... 38

კ 4.9 ፄӝᓸႝഏౠӚൂϡᖂߔל ... 40

კ 4.10 ൂϡ΋ޑႝᖂᙯඤਏ౗ ... 41

კ 4.11 ൂϡΒޑႝᖂᙯඤਏ౗ ... 41

კ 4.12 ൂϡΟޑႝᖂᙯඤਏ౗ ... 42

კ 4.13 ൂϡѤޑႝᖂᙯඤਏ౗ ... 42

კ 4.14 ൂϡϖޑႝᖂᙯඤਏ౗ ... 43

კ 4.15 ൂϡϤޑႝᖂᙯඤਏ౗ ... 43

კ 4.16 ൂϡΎޑႝᖂᙯඤਏ౗ ... 44

კ 4.17 ൂϡΖޑႝᖂᙯඤਏ౗ ... 44

კ 4.18 ൂϡΐޑႝᖂᙯඤਏ౗ ... 45

კ 4.19 ൂϡΜޑႝᖂᙯඤਏ౗ ... 45

კ 4.20 ൂϡΜ΋ޑႝᖂᙯඤਏ౗ ... 46

კ 4.21 ൂϡΜΒޑႝᖂᙯඤਏ౗ ... 46

კ 4.22 ൂϡΜΟޑႝᖂᙯඤਏ౗ ... 47

კ 4.23 ൂϡΜѤޑႝᖂᙯඤਏ౗ ... 47

კ 4.24 ൂϡΜϖޑႝᖂᙯඤਏ౗ ... 48

კ 4.25 ൂϡΜϤޑႝᖂᙯඤਏ౗ ... 48

კ 4.26 ዗ႝଽশ࿼ܭᚆύЈᗺ 1cm ೀ ... 49

კ 4.27 ዗ႝଽশ࿼ܭᚆύЈᗺ 2cm ೀ ... 49

კ 4.28 ஒޔ৩ 1cm Нጤ࿼ܭඤૈᏔύЈϐჴᡍ ... 50

კ 4.29 όӕ໺ଌф౗ჹНጤύЈޑྕࡋᡂϯ ... 50

კ 4.30 ᒡΕф౗ࣁ 200W ϐόӕՏ࿼ྕࡋᡂϯკ ... 51

კ 4.31 ᒡΕф౗ࣁ 250W ϐόӕՏ࿼ྕࡋᡂϯკ ... 51

კ 4.32 ஒٚԼԺ࿼ܭඤૈᏔύЈϐᚆᡏჴᡍ ... 52

კ 4.33 όӕф౗ΠٚԼԺྕࡋᡂϯ ... 53

߄

߄Ҟᒵ

߄ 1.1 ٢ᕎϩය ... 2

߄ 2.1 Ӛᅿᓸႝ߯ኧۓက ... 10

߄ 2.2 PZT-4 ϐᓸႝୖኧ ... 12

߄ 3.1 Epoxy 301 ޑೕ਱ ... 15

߄ 3.2 ႝᏤ౗നӳޑ߻ϖӜߎឦ ... 20

߄ 3.3 ғނಔᙃکځдϟ፦ޑຬॣݢୖኧ ... 29

߄ 4.1 16 Тᓸႝഏౠ PZT-4 ޑᓸႝ߯ኧ d33ॶ ... 32

߄ 4.2 16 Тፄӝᓸႝഏౠޑѳ֡ࠆࡋϷӅਁᓎ౗ ... 35

߄ 4.3 ҂ϰଛ߻ϐ 16 Тፄӝᓸႝഏౠޑߔלॶ ... 37

߄ 4.4 уΕϰଛႝၡࡕޑ 16 ൂϡϐඤૈᏔᆶф౗ܫεᏔ่ӝࡕޑᒡр่݀ .... 38

߄ 4.5 16 ൂϡፄӝᓸႝഏౠޑ d₃₃ ... 39

ಃ

ಃ1കġ ᆣፕ

ߏයаٰǴൾ܄ဍዦ΋ޔࢂΓᜪటှ،ޑፐᚒǴԶζ܄٢ᕎࢂӄౚᕎੱวғ

౗ಃΒՏǴ໻ԛܭޤᕎǶਥᏵम୯ᕎੱࣴزڐ཮(Cancer Research UK)ޑၗ਑Ǵӧ 2008 ԃਔǴ٢ᕎࣁӄౚᕎੱวғ౗ޑಃΒՏǵठԝ౗ࣁಃϖՏǴЪӧς໒วޑ୯ ৎύ٢ᕎ՞܌ԖᕎੱޑКٯ׳ࢂК໒วύޑଯǶӧѠ᡼Ǵ٢ᕎ՞ζ܄ᕎੱԝΫ౗

ޑಃѤՏǶ

1.1 ٢ᕎ

٢ᕎ߃ය໻Ԗคภ܄ဍ༧Ǵ۳۳΋૓Γό཮ཀ᛽ډԾρςᑡ஻٢ᕎǴՠҗܭ ӚԄᙴᏢບᘐπڀޑวܴǴӵ٢܊ X Ӏឪቹೌ(mammography)ǵ٢܊ຬॣݢǵႝ

တᘐቫ௟ඔǵਡᅶ೷ቹǴӧղᘐࢂցᑡੰςԖεεޑ຾؁Ƕ

྽೏ᙴғว౜ᑡ஻٢ᕎਔǴᙴғ཮ଞჹੰΓҞ߻ޑੰݩ຾ՉϩයǶਥᏵ Tumor-Node-Metastasis(TNM)س಍ޑۓကǴ٢ᕎϩයҗচว܄ဍዦޑελ(Primary Tumor)ǵֽ೽రЃ่ᙯ౽ޑ௃׎(Regional Lymph Nodes)ǵᇻೀᙯ౽௃׎(Distant Metastasis)ٰϩයǴӵ߄ 1.1Ǻ

߄ 1.1 ٢ᕎϩය

ಃ႟ය ٢ᕎಒझϝӧ٢ဏᆅ୷ۭቫϣۘ҂ᙯ౽

ಃ΋ය ဍዦλܭٿϦϩаΠޑ੆ዎᕎǴЪ๛ΠరЃ่คᕎಒ

хᙯ౽

ಃΒය A ဍዦελӧٿϦϩϐϖϦϩǵరЃۘ҂ᙯ౽܈ޣဍዦ

ελӧٿϦϩаΠǵԖరЃᙯ౽Ǵՠۘ҂ڰۓǶ

ಃΒය B ဍዦελຬၸϖϦϩ܈ޣဍዦελӧٿϦϩԿϖϦ

ϩǵԖరЃᙯ౽Ǵՠۘ҂ڰۓǶ

ಃΟය A ဍዦελӧϖϦϩаΠǵరЃςᙯ౽Ǵՠۘ҂ڰۓ܈

ޣဍዦλܭϖϦϩǴՠӕୁ๛Πᙯ౽ޑరЃςวғݠ ᗹǶ

ಃΟය B คፕဍዦελǴѝाరЃᙯ౽ᘉණډᙹମ΢రЃ่

ಃѤය คፕဍዦελǵరЃ่ᙯ౽ᆶցǴѝाวғᇻೀᙯ

౽ǴӵǺطǵޤǵମᓝ฻ߡࢂǶ

౜Ϟޑ٢ᕎݯᕍБԄϝࢂа٢܊ਥନೌ(Radical Mastectomy)ࣁЬࢬ[1]Ǵځд தـޑӵܫ৔ጕݯᕍ(Radiotherapy)ǵϯᏢݯᕍ(Chemotherapy)ǵລᅟᆾᕍݤǶӧᒿ

๱ᙴᏢޑ຾؁аϷགྷݤޑׯᡂǴჹܭ٢܊ߥӸֹ᏾ࡋޑा؃ຫٰຫଯǴу΢ࣽᏢ ޑᇡޕаϷჹཥמೌޑௗڙࡋගଯǴଓ؃നλߟΕԄ(minimally invasive)ǴࣗԿࢂ

ֹӄߚߟΕԄ(noninvasive)ޑݯᕍǴςࢂ΋ި౰Չޑ॥਻Ƕ౜ϞޑനλߟΕԄаϷ ߚߟΕԄޑБݤςว৖р৔ᓎᐨ؟ೌ(Radiofrequency AblationǴRFA)ǵ໔፦ႜ৔ᕍ ݤ(Interstitial Laser AblationǴILA)ǵհএᕍݤ(Cryoablation)ǵ༾ݢ੃ᑼݯᕍ

(Microwave Thermotherapy)аϷଯமࡋᆫขຬॣݢݯᕍ(High Intensity Focused UltrasoundǴHIFU)൳ᅿБݤǶ

1.2 ዗ ዗ݯᕍޑว৖

ӧΜΎШइਔǴ൩ς࿶ԖЎ᝘ࡰрΓॺၮҔ዗៓ᕉݯᕍ٢ᕎǶӧΜΐШइቺ ୯Γว౜Ϗࢥ܌ЇวޑଯᐨǴ཮٬ளဍዦ੃ଏǶӧ 1984 ԃҗ S.A.Sapareto ک W.C.Dewey ӧ International Journal of Radiation Oncology Biology Physics ගрΑಒ झӸࢲ౗ᆶ዗Ꮚໆޑᜢ߯[2]ǴSapareto ک Dewey Ԝ΋ࣴزᡉҢಒझεऊӧ 43ʚǴ

΋λਔǴӸࢲ౗൩཮եԿ 1%аΠǴԶྕࡋ؂΢ϲ 1ʚǴӸࢲ౗Ξ෧Ͽ׳ӭǶ

1.3 ᅶਁᏤЇϐଯமࡋᆫข܄ຬॣݢ

ຬॣݢᔈҔܭݯᕍᕎੱЬाϩԋٿᅿǺ(΋)዗ݯᕍ(Hyperthermia)ǴճҔຬॣݢ ࣁᖂݢޑচ౛ǴڀԖऀ೸ಔᙃޑ੝܄ஒૈໆ໺ډဍዦǴ٬ဍዦᆢ࡭ӧ 43^ǶC ΋ঁλ ਔǴЪ೯த཮མଛϯᏢݯᕍ܈ܫ৔ጕݯᕍ[3]Ƕ(Β)዗Ћೌ(Thermal Surgery)ࢂஒૈ

ໆமࡋ׳ଯޑຬॣݢ໺ډဍዦǴ೷ԋځזೲྕϲԿ 56^ǶCǴ٬ளဍዦಔᙃౢғόё

଍ޑᏉڰ܄ᚯԝ(coagulation necrosis)Ǵਔ໔೯தӧኧࣾϣǴΨӢԜჹܭ዗Ћೌޑྕ

ࡋ௓ڋࢂሡाߚதᆒྗޑǶଯமࡋᆫข܄ຬॣݢࣁ΋ᅿၲԋ዗ЋೌޑБݤǴ೸ၸ

೛ीຬॣݢඤૈᏔޑ൳Ֆ׎ރٰ׎ԋ΋ঁ൳ՖᆫขύЈǴ٬ளຬॣݢඤૈᏔ໺ሀ ଯமࡋӧᆫขύЈߕ߈ૈໆཱུଯǶ౜Ϟჹଯமࡋᆫข܄ຬॣݢޑྕࡋቹႽЬाԖ ٿᅿǺ(΋)ຬॣݢ೷ቹ(Ultrasound Imaging)Ǵځ٬Ҕ B mode ޑຬॣݢቹႽ྽բᏤ ЇǴՠӢࣁ౜Ϟמೌ΢όૈၲډᆒྗޑྕࡋ௓ڋǴӢԜӧଛӝଯமࡋᆫข܄ຬॣ

ݢ೯த཮٬Ҕ(Β)ᅶਁ೷ቹ(Magnetic Resonance ImagingǴMRI)Ǵځёаၲډྕࡋ ᅱ௓аѦǴᗋૈୀෳډಔᙃޑᚯԝǶаᅶਁ೷ቹᏤЇϐଯமࡋᆫข܄ຬॣݢس಍

(Magnetic Resonance Image guided High Intensity Focused UltrasoundǴMRIgHIFU) ςᔈҔӧ೚ӭᅿဍዦ΢ǴӵǺη৐Լዦǵ߻ӈဏᕎǵମᕎǵطᕎǵတᕎаϷ٢ᕎǴ ӧ 2004 ԃऍ୯१ࠔᛰނᆅ౛ֽ(Food and Drug AdministrationǴFDA)೯ၸΑҗ InSightec Ϧљಃ΋Ѡᅶਁ೷ቹᏤቹϐଯமࡋᆫข܄ຬॣݢٰݯᕍη৐Լዦ[4]Ƕ

܊ဍዦݯᕍ΢Ǵ٬ҔޑຬॣݢඤૈᏔࣁൂ΋ൂϡޑౚय़ᆫขࠠǵъ৩ 10 ϦϩǵԔ

౗ъ৩ 8 Ϧϩǵᏹբᓎ౗ӧ 1.5MHz[5]Ǵځ่݀᛾ჴΑ MRIgHIFU ᔈҔܭ٢܊ဍ ዦޑёՉ܄Ƕ၀ი໗ӧ 2004 ԃว߄ΑཥࠠຬॣݢඤૈᏔޑኳᔕǴ٬Ҕъ৩ࣁ 7 Ϧ ϩޑъౚࠠǵ191 ঁൂϡޑ࣬ՏତӈԄຬॣݢඤૈᏔ[6]Ǵځ่݀᛾ჴԜ΋ཥࠠඤૈ

ᏔКൂ΋ൂϡޑඤૈᏔ׳Ԗਏ౗Ǵݯᕍਔ໔׳อǶ

1.4 ࣴ ࣴزҞޑ

җܭຬॣݢԖ๱ߚߟΕԄޑᓬᗺǴу΢೚ӭԖᜢຬॣݢ዗ЋೌޑࣴزǴ᛾ჴ Αຬॣݢ዗ݯᕍዴჴૈჹ٢ᕎԖਏޑݯᕍǶฅԶӧ٬ҔъౚࠠຬॣݢඤૈᏔ཮Ԗ

೽ϩᖂݢ໺ԿԻମǴЪӢࣁԻମޑ֎ԏ߯ኧК೬ಔᙃεޑӭǴ೭ኬޑ੝܄཮೷ԋ ԻମܴᡉޑྕϲǴ຾΋؁໾্ډ஻ޣǶӢԜᕉࠠ(ring-shaped)ຬॣݢඤૈᏔ೏ගрǶ ᕉࠠඤૈᏔځ൳Ֆ੝܄࡞ѯૈᗉ໒ԜୢᚒǴ׳ԖЎ᝘ଞჹᕉࠠඤૈᏔޑ੝܄଺௖

૸کځᆫขᗺޑኳᔕ[7, 8]Ǵځ่݀೿᛾ܴΑᕉ׎ඤૈᏔଞჹ٢ᕎޑёՉ܄Ƕҁჴ ᡍ࠻ӧ 2011 ԃਔ໒วрᕉ׎࣬ՏତӈԄᆫขຬॣݢඤૈᏔǴځπբᓎ౗ࣁ 1MHzǴ 16 ঁൂϡޑᓸႝഏౠǴᕉ׎ъ৩ࣁ 10 ϦϩǵᓸႝഏౠޑԔ౗ъ৩ 10 Ϧϩǵଯ 2 ϦϩǶҁࣴزӧܭ໒วр׳ଯᓎޑᅶਁ೷ቹ࣬৒ϐᕉ׎࣬ՏତӈԄᆫขຬॣݢඤ

ૈᏔǴຬॣݢҗܭᓎ౗ϲଯǴᆫข੝܄཮׳ᆒྗǴૈԖਏᕭอݯᕍਔ໔аϷჹܭ Ёκၨεޑ٢܊ૈݯᕍௗ߈ܭ߄य़ޑဍዦǴԶჹЁκၨλޑ٢܊ૈౢғᆫขޑਏ

݀Ƕ

ಃ

ಃ2കġ ׷਑ᆶБݤ

ຬॣݢඤૈᏔ܌٬Ҕޑ׷਑ࢂࣁڀԖᓸႝ੝܄ޑ׷਑Ǵځҗ٬ҔޣѦу๏ඤ

ૈᏔႝૈǴ٬ளඤૈᏔౢғᐒఓૈǶԖਏޑճҔԜ΋੝܄Ǵ٬ளᓸႝ׷਑ቶݱᔈ ҔܭғࢲύǴٯӵຬॣݢඤૈᏔǵᖂયǵॣៜǵഝլ॥ǵߚઇᚯ܄ᔠෳ฻ǶԶଞ ჹຬॣݢඤૈᏔԶقǴҞޑޑόӕǴځ೛ी܌ԵໆޑӢનΨόӕǴٯӵຬॣݢቹ ႽඤૈᏔ཮ݙख़ӧϸ৔ӣٰޑݢǵᓎቨεǶԶҁࣴز߾ࢂаᒡрଯф౗྽բҞ኱Ǵ ӢԜ཮ݙख़ӧځૈໆޑᙯඤਏ౗Ƕ

2.1 ᓸႝਏᔈ

ᓸႝਏᔈ(piezoelectric effect)ӧ 1880 ԃҗ Pierre Curie ک Jacques Curie л׌ว

౜Ǵऩ׷਑ᏱԖૈஒႝૈᆶᐒఓૈϕඤޑ౜ຝǴջᆀࣁᓸႝ׷਑Ƕ

Զᓸႝਏᔈϩԋ(1)҅ᓸႝਏᔈ(direct piezoelectric effect)Ϸ(2)଍ᓸႝਏᔈ(converse piezoelectric effect)ǴӵΠǶ

(1)҅ᓸႝਏᔈ

྽ᓸႝ׷਑ڙډ΋ѦΚਔǴ܌ౢғޑᔈΚ٬ள׷਑ύޑ඲ᡏౢғ׎ᡂǴठ٬

ϣ೽চӃޑ҅ॄႝ಻ຯᚆׯᡂǴ຾Զ٬ளচӃϣ೽ޑཱུϯႝ൑ׯᡂǶԶ඲ᡏѦҗ ܭཱུϯႝ൑ޑׯᡂǴ٬ளӧᓸႝ׷਑߄य़ႝཱུޑԾҗႝηౢғ΋ܢלޑႝՏৡǴ Ԝᅿਏᔈջࣁ҅ᓸႝਏᔈǴӵკ 2.1Ƕ

(2)଍ᓸႝਏᔈ

଍ᓸႝਏᔈ߾ࢂ྽ჹᓸႝ׷਑ࡼϒ΋ႝ൑Ǵځ཮ౢғ΋׎ᡂޑ౜ຝǶऩࢂѦ уႝ൑ᆶځཱུϯБӛ΋ኬޑ၉Ǵᓸႝ׷਑཮ݮ๱ཱུϯБӛ՜ߏᡂ׎ǴϸϐҭฅǶ

ࡺ྽ჹԜ׷਑Ѧу΋Ҭࢬႝ൑Ǵ߾׷਑཮ౢғ۳ൺޑ׎ᡂǴӵკ 2.2Ƕ

კ 2.1 ҅ᓸႝਏᔈ

კ 2.2 ଍ᓸႝਏᔈ

2.1.1 ᓸ ᓸႝ׷਑

ᓸႝ׷਑ऩࡪނ౛่ᄬٰϩᜪૈϩԋӵΠ[9]Ǵ

΋.ൂ඲ᜪ(single crystal)Ǻҡम(SiO2)ǵႝ਻ҡǵ౷ለ᎖(LiSO4ǸH2O,LSH)ǵ✔ለ

᎖(LiNbO₃)ǵⷿለ᎖(Li₂GeO₃)฻Ƕ

Β.ଯϩηᆫӝނᜪ(polymer)ǺᆫୃࢧΌ౎(PVDF)฻Ƕ

Ο.ഏౠᜪ(ceramic)Ǻ⑲ለ᎕(BaTiO₃)ǵ⑲ለႉ(PbTiO₃)ǵ⯗⑲ለႉ(PZT)฻

΢ॊӚϩᜪ೿ԖᓬલᗺǴٯӵൂ඲ᜪڀԖؼӳޑྕࡋ੝܄ǵᐒఓࠔ፦ӢηεǴ ՠځᇙำ֚ᜤǹଯϩηᆫӝނᜪԖၟНၨௗ߈ޑᖂᏢߔלǴՠځᓸႝୖኧλǴЪ ሡाၨଯޑཱུϯႝᓸǶӧᙴᏢ΢ҔޑຬॣݢඤૈᏔЬाࢂ௦Ҕഏౠᜪޑᓸႝ׷਑Ǵ চӢԖ[9]

(1)ᐒႝጠӝ߯ኧଯ (2)БߡуπԋӚᅿ׎ރ (3)ڀНྋ܄ǵऐለᡵ (4)ᐒఓமࡋၨε

(5)ё೸ၸୖᚇ׷਑ଛБٰׯᡂ੝܄฻

2.1.2 1-3 ፄӝᓸႝ׷਑

ҁࣴز܌٬Ҕޑ׷਑ࣁ PZT-4 ᆶᐋિ(Epoxy)ޑፄӝ׷਑ǶԶፄӝ׷਑ӅԖ 10 ᅿಔӝБԄ[10]Ǵҁჴᡍ٬Ҕޑࢂ 1-3 ፄӝᓸႝ׷਑[11, 12]Ǵځύ 1 ࢂࡰЬ୏ϡન

׷਑ѝӧ y Бӛ΢Ԗۯ՜ǹԶ 3 ࢂࡰ೏୏ϡન߾ӧ x, y, z ঁБӛ೿Ԗۯ՜Ǵӵკ 2.3Ƕഏౠᜪᓸႝ׷਑ PZT-4 ޑᖂߔלࣁ 35.1MRaylǴԶፄӝᓸႝഏౠ೯தᏱԖК ഏౠᜪᓸႝ׷਑׳եޑᖂߔלǴӆޣፄӝᓸႝഏౠޑᐒႝጠӝ߯ኧКഏౠᜪᓸႝ

׷਑ٰޑଯ[13]Ƕ

კ 2.3 1-3 ፄӝ׷਑Ңཀკ

Ў᝘[14]ύගډǴӧᇙբ 1-3 ፄӝᓸႝഏౠਔǴഏౠᡏᑈК(Volume Fraction, VF) کഏౠቨଯК(Aspect Ratio, AR)ޑόӕ཮ቹៜᇙբрٰޑፄӝ׷਑੝܄Ǵځۓကࣁ

VF = ൬ W W + K൰

ଶ

(1) AR =W

H (2)

WǺᓸႝഏౠࢊቨࡋǹKǺᐋિቨࡋǹHǺፄӝᓸႝഏౠࠆࡋ

ӵკ 2.4 ܌ҢǴკύᝊᙔՅࣁᓸႝഏౠࢊǵලՅޑࣁᐋિǴ᎜୏วғӧ Y ືБӛǶ

კ 2.4 ፄӝ׷਑่ᄬҢཀკ

ჹ HIFU ඤૈᏔԶقǴϦԄ(1)ຫଯ߄Ңᓸႝഏౠ՞᏾ঁፄӝ׷਑ޑКٯຫଯǹ ԶϦԄ(2)ຫଯ߄Ңፄӝ׷਑ޑቨଯКຫଯǶ೯தӧଯமࡋᆫข܄ຬॣݢඤૈᏔޑ

೛ीԵໆ΢Ǵ཮ᒧ᏷ଯഏౠᡏᑈКǵեഏౠቨଯКǶ

2.1.3 ᓸ ᓸႝ׷਑಍ஷБำԄ

܌ԖڀԖᓸႝਏᔈޑ׷਑೿ёаҔᓸႝ಍ஷБำԄٰှញځ੝܄Ƕҗܭᓸႝ

׷਑Ԗᐒఓૈکႝૈᙯඤޑ੝܄ӸӧǴځ܌ाԵቾޑᡂኧԖѤঁǴϩձࣁᔈΚ Tǵ ᔈᡂ Sǵႝ൑ EǵႝՏ౽ DǴਥᏵ܌ᒧ᏷ޑԾᡂኧϷᔈᡂኧޑόӕǴᓸႝ಍ஷБำ ԄૈϩԋѤᅿǺ

d ࠠ

S = s^ET + d_tE ' G7İ^TE g ࠠ

S = s^DT + gtD E = -J7ȕ^TD e ࠠ

T = c^ES - e_tE D = eS + İ^SE h ࠠ

T = c^DS - htD E = -hS + ȕ^SD

җკ 2.5 ׳ёаమཱϐ໔ޑඤᆉᜢ߯[15]

კ 2.5 ᓸႝ߯ኧᆶӚᡂኧ໔ޑᜢ߯

ځύޑୖኧۓကӵ߄ 2.1[16]

߄ 2.1 Ӛᅿᓸႝ߯ኧۓက

಄ဦ ۓက

dǵgǵeǵh ᓸႝதኧ

dtǵgtǵetǵht ϩձࣁ dǵgǵeǵh ޑᙯ࿼ંତ

s^E ႝ൑ڰۓਔޑࢋ܄தኧ

s^D ႝՏ౽ڰۓਔޑࢋ܄தኧ

c^E ႝ൑ڰۓਔޑখ܄தኧ

c^D ႝՏ౽ڰۓਔޑখ܄தኧ

İ^T ᔈΚڰۓਔޑϟႝ߯ኧ

İ^S ᔈᡂڰۓਔޑϟႝ߯ኧ

ȕ^T ᔈΚڰۓਔޑϸᇨႝ߯ኧ

ȕ^S ᔈᡂڰۓਔޑϸᇨႝ߯ኧ

җόӕޑᔈҔБӛǴ཮ᒧ᏷όӕޑᓸႝ಍ஷБำԄٰ߄ၲǶ

暣⟜ E

ㅱ≃ T

暣ỵ䦣 D

ㅱ嬲 S

S = sTġ T = cSġ

T = eEġ E = gTġ

D = eSġ S = gDġ D = ɸEġ E = ɴDġ

D = dTġ

T = hDġ

S = dEġ E = hSġ

2.1.4 ᓸ ᓸႝ׷਑੝܄ୖኧ

ӧ٬Ҕᓸႝ׷਑ᇙբԋຬॣݢඤૈᏔਔǴᒧҔޑ׷਑ਥᏵҞޑԶׯᡂǴӢԜ ନΑᓸႝୖኧаѦǴҁ࿯܌ගډޑ੝܄ୖኧΨૈ๏ࣴวΓ঩բࣁ׷਑ᒧ᏷ޑղ ᘐǶ

(1).ᐒႝጠӝӢኧ(electro-mechanical coupling factor,K)

ᐒႝጠӝӢኧࢂࡰႝૈکᐒఓૈϐ໔ૈໆᙯඤޑૈΚǴۓကࣁᓯӸޑᐒఓૈ

(ႝૈ)ᆶѦуႝૈ(ᐒఓૈ)КॶޑѳБਥǶԶᐒႝጠӝӢኧᆶ׷਑ਁ୏ኳԄԖᜢǴ ჹଯமࡋᆫข܄ຬॣݢඤૈᏔԶقǴਁ୏БӛӧࠆࡋБӛǴЪځѬБӛਁ୏όڙ ज़ڋޑᐒႝጠӝ߯ኧ K33ࢂ೛ीޣനӧЯޑǶ౛ፕ΢ଯᐒႝጠӝӢኧ K33߄Ңଯႝ

ᖂᙯඤਏ౗Ƕ

K = ቆᓯӸޑᐒఓૈ

Ѧуႝૈ ቇ

ଵൗଶ

= ቆ ᓯӸႝૈ

Ѧуᐒఓૈቇ

ଵൗଶ

(3)

(2).ϟႝཞ઻GLHOHFWULFORVVWDQJHQWWDQį

ϟႝཞ઻ࢂඔॊᓸႝ׷਑ӧҬࢬႝ൑ϟႝՉࣁޑཞ઻Ƕ྽ᓸႝ׷਑ڙډѦ уҬࢬႝ൑ਔǴ඲ᡏϣޑཱུϯ౜ຝ཮ᒿ๱Ҭࢬႝ൑БӛޑׯᡂԶᡂϯǴՠऩѦ уҬࢬႝ൑ᓎ౗ၸזਔǴᏤठ඲ᡏཱུϯޑೲࡋคݤၟ΢Ҭࢬႝ൑ޑׯᡂǴԜਔ

཮ౢғཱུϯᅉǴԜ΋౜ຝ཮Ꮴठϟႝཞ઻ޑวғǴ٬ள೽ϩૈໆ੃઻௞Ƕҁࣴ

زύ೸ၸෳໆᓸႝ׷਑ӧᓎ౗ӧ 1kHz ਔޑߔלჴ೽Ϸ຀೽ளډ[14]Ǵځж߄๱

ӧߚӅਁਔૈໆཞ઻ǴϦԄӵΠ

tan į =X

R (4)

X Ǻᓸႝ׷਑ӧ 1kHz ਔޑႝלǹ R Ǻᓸႝ׷਑ӧ 1kHz ਔޑႝߔ

(3). ᖂߔל(acoustic impedance, Za)

ᖂߔלۓကࣁݢՉ࿶ޑϟ፦ஏࡋᆶݢӧϟ፦ύޑೲࡋ४ᑈǶҗܭόӕޑᖂ Ꮲϟय़ӧᖂݢ໺ሀਔ཮೷ԋૈໆޑ઻ཞǴࡺӧ٬ҔຬॣݢඤૈᏔว৔ᖂݢޑਔ

ংǴ཮׆ఈᓸႝ׷਑ޑᖂߔלૈၟಔᙃௗ߈Ƕ

Za = ȡ × c (5)

ȡǺϟ፦ஏࡋǹcǺϟ፦ޑᖂೲ

(4). ᓸႝதኧ d33(piezoelectric constant)

ᓸႝதኧ d33[17]ࢂᐒႝጠӝਔ΋ঁߚதख़ाޑୖኧǶ٩ྣόӕޑ߄ҢБԄ

ૈ߄Ңࣁᓸႝᔈᡂதኧ܈ࢂᓸႝႝ಻தኧǶᓸႝᔈᡂதኧ(piezoelectric strain constant)ࢂࡰႝ൑மࡋޑᡂϯ܌ЇଆޑᔈᡂᡂϯǹԶᓸႝႝ಻தኧ(piezoelectric charge constant)ࢂࡰᔈΚᡂϯਔ܌ЇଆޑႝՏ౽ᡂϯǶd33Π኱ޑಃ΋ঁ 3 ߄Ңႝ

ໆБӛǴಃΒঁ 3 ߄ҢΚᏢໆБӛǴ߄ 2.2 ࣁપ PZT-4 ޑᓸႝୖኧǶ ߄ 2.2 PZT-4 ϐᓸႝୖኧ

ஏࡋ(g/cm³) ᓸႝᔈᡂதኧ d33 ጠӝӢኧ kd

PZT-4 7.5 289 33.4

(5). ႝᖂᙯඤਏ౗(electro-acoustic conversion efficiency)

ႝᖂᙯඤਏ౗ࢂࡰᒡΕޑႝф౗ᙯඤԋᖂф౗ޑૈΚǴѬૈޔௗޑղᘐඤ

ૈᏔޑᒡрਏ౗ǶځϦԄࣁ

ႝᖂᙯඤਏ౗= ቆᒡрᖂф౗

ᒡΕႝф౗ ቇ × 100% (6)

2.2 ຬ ຬॣݢඤૈᏔ

ຬॣݢඤૈᏔӧ 1917 ԃਔǴA.Langevin ൩аҡम඲ᡏٰᇙբНΠᖂݢඤૈᏔǶ ԶຬॣݢඤૈᏔᔈҔ࣬྽ቶݱǴٯӵҔܭങဂ௖ෳǵࢱృᏔǵ׷਑၂ᡍǵٛห᝾

ൔǵЈࡓी฻ǶऩаځૈໆᙯඤޑࠠᄊёϩࣁΟᜪ[15]Ǻ

΋.ġᖂݢว৔ᜪ(transmitter)

Ьाࢂஒᖂݢ໺рǴ܌ሡ੝܄ࣁૈהڙଯޑႝΚᒡΕǵᐒఓமࡋεǵᐒႝጠӝ ӢኧεǵϟႝཞѨλǵᐒఓࠔ፦Ӣηε฻Ƕ

Β.ġᖂݢௗԏᜪ(receiver)

Ьाࢂाஒ܌ௗԏډޑᖂݢᙯඤԋႝૻဦٰೀ౛Ǵ܌ሡ੝܄ࣁᓸႝୖኧ g ाεǵ ଯϟႝ߯ኧǵྕࡋ߯ኧλ฻Ƕ

Ο.ġว৔ௗԏӅҔᜪ

ёӕਔว৔ϷௗԏᖂݢǶ

ҁჴᡍޑຬॣݢඤૈᏔࣁᖂݢว৔ᜪǶ

ಃ

ಃ3കġ ᅶਁ೷ቹ࣬৒ϐඤૈᏔᇙഢϷ੝܄ໆෳБݤ

ҁࣴزޑჴᡍЋೌ೛ीࢂஒ஻ޣа९ޮޑ࠮༈Ǵ٬ள٢܊ԾฅࠟΠǴӆஒᕉ

׎ඤૈᏔൎᙅϐǴਥᏵੰ؞Տ࿼౽୏௖ᓐٰၲډݯᕍޑҞޑǴЪӢࣁࢂाམଛᅶ

ਁ೷ቹٰ྽բྕࡋቹႽᏤЇǴӢԜᗋाԵቾډ׷਑ࢂց཮Ԗᅶ܄ޑυᘋǶ܌аඤ

ૈᏔޑ೛ीԵໆஒ཮ቹៜډݯᕍޑਏ݀Ƕҁჴᡍ܌೛ीޑඤૈᏔࢂ΋ஒ 16 Тፄӝ ᓸႝഏౠ௨ӈԋԔ౗ъ৩ࣁ 10cm ޑ༝Ǵଯࡋࣁ 2.5cm ޑ൳Ֆ่ᄬǴа಄ӝόӕε λޑ٢܊ЁκǶԶӧѦෘБय़ࢂ೛ीԋ҅ΖᜐࠠǴ٠ЪϩԋѤঁൂϡǴӵკ 3.1Ƕ

კ 3.1 ᕉࠠඤૈᏔҥᡏკ

3.1 ᅶਁ೷ቹ࣬৒ϐຬॣݢඤૈᏔ

ᅶਁ೷ቹس಍ޑচ౛ࢂஒނᡏܫΕமεޑᓉᅶ൑ύǴѦу΋৔ᓎેፂ٬ځނ ᡏޑణচη௽ᙯБӛׯᡂǴౢғӅਁǴԜਔচηਡ൩཮ញܫрૈໆǴฅࡕѐϩ݋

ૈໆᐟวࡕܫрޑႝᅶݢߞဦǴӆ࿶җႝတၮᆉಔӝԋቹႽǶӢԜाၲډᅶਁ೷

ቹ࣬৒൩Ѹ໪ஒඤૈᏔޑᇙբ׷਑೿όૈр౜Ԗᅶ܄ޑނ፦Ƕҁࣴز܌٬Ҕޑᅶ

ਁ೷ቹس಍(Version syngo MR 2004A, Siemens, Germany)ࢂҗ୯ৎፁғࣴزଣ܌ග ٮǶ

3.2 ඤ ඤૈᏔ೛ी

җܭᕉ׎ޑ൳Ֆ׎ރаϷᖂݢ໺ሀޑ੝܄Ǵ٬ளӧ೛ी HIFU ᕉ׎ඤૈᏔਔǴ

ૈᇙբр΋ᆫขύЈǴऩݢՉ࿶ၡ৩΢ؒԖ૰෧Ǵ߾ӧᆫขύЈᗺ΢ૈໆന໣ύǴ

ࢂ HIFU ᐨ؟ਔനத٬Ҕډޑ൳ՖՏ࿼Ƕҁࣴز܌೛ीޑᕉ׎൳Ֆࣁъ৩ 100mmǴ Ѧෘࢂࣁ҅Ζᜐ׎ǴЬाࢂଛӝᐒఓԄѳѠԶ೛ीǴӵკ 3.1ǶԶπբᓎ౗ࣁ 2.5MHz ޑԵໆࢂӢࣁᓎ౗ϲଯ೷ԋ֎ԏ߯ኧᡂεǶаԜނ౛੝܄Ǵӧय़ჹЁκၨεޑ٢

܊ਔǴૈݯᕍ߄ቫޑဍዦǹԶय़ჹЁκၨλޑ٢܊ਔǴځϝᏱԖᆫขޑਏ݀Ƕ

3.3 ඤૈᏔޑ׷਑Ϸځᇙഢ

ӧதـޑᖂݢว৔ᜪຬॣݢඤૈᏔޑ׷਑ᒧ᏷Ǵ೯த཮٬Ҕ PZT-4ǴӢࣁѬᏱ ԖၨଯޑᐒႝጠӝӢኧǵၨեޑϟႝཞ઻аϷၨଯޑᐒఓࠔ፦ӢηǶჴᡍύޑ PZT-4 ᓸႝഏౠࢂہૼౠૈިҽԖज़Ϧљ(ਲ༜)܌ᇙ೷Ǵҁჴᡍࢂஒ PZT-4 کᐋિ

(Epoxy 301, Epoxy Technology, USA)ᇙբԋፄӝᓸႝഏౠЬाࢂҗܭ

(1) .ᏱԖКഏౠᜪᓸႝ׷਑׳եޑᖂߔלǴ׳ௗ߈ܭΓᡏᖂߔל(1.5Mrayl)Ƕ (2) .ёаቚуᓸႝഏౠޑל៻மࡋǴ٬ځૈᇙբԋόӕޑ൳Ֆ׎ރǶ

ᐋિޑ੝܄ӵΠ߄ 3.1

߄ 3.1 Epoxy 301 ޑೕ਱

ஏࡋ 1.15g/cm³

ᖂೲ 2650m/s

ᖂߔל 3.05MRayls

ᒧۓ׷਑ࡕǴௗ๱൩ࢂ΋سӈޑᇙբࢬำǴځࢬำࣁკ 3.2

კ 3.2 ፄӝᓸႝഏౠᇙբࢬำ Ӛ؁ᡯӧᇙբ΢཮ԵໆޑӢનஒ΋΋ϟಏǺ

3.3.1 ࡷ ࡷᒧ੝܄࣬ӕޑᓸႝഏౠ

җܭҁࣴز܌٬ҔޑຬॣݢඤૈᏔࢂҗ 16 Тᓸႝഏౠൂϡ܌௨ӈԶԋǴӢԜ ӧԾՉᇙ೷ӚൂϡਔǴ׆ఈ؂ঁൂϡޑϡҹ੝܄೿ၨࣁ࣬՟ǴӢԜךॺ཮ჹुᇙ ޑᓸႝഏౠ଺ d33ޑෳ၂ǴаԜ੝܄բࣁԵໆѐࡷᒧр੝܄ௗ߈ޑ 16 Тᓸႝഏౠ ѐ຾ՉᇙբǶҁࣴزύޑ؂ঁൂϡᓸႝТǴځҗቷ୘ගٮޑচۈ൳ՖЁκࣁߏ 45mm کቨ 25mm ࠆࡋࣁ 1.3mm ޑߏБ׎Ǵӵკ 3.3 ܌ҢǶ

კ 3.3 ᓸႝഏౠ҅ຎკ

ࡷᒧ੝܄࣬ӕ ޑᓸႝഏౠ

ᇙբԋፄӝ׷

਑

πբᓎ౗ϐᒧ

᏷!

уΕᏤႝቫ ዗ᓸԋࠠ! ࠾းԋඤૈᏔ!

3.3.2 ᇙ ᇙբԋፄӝ׷਑

߻य़ക࿯ගډǴᇙբԋፄӝᓸႝഏౠਔǴऩགྷाځႝᖂᙯඤਏ౗ၨଯǴ߾ VF ຫεຫӳǵAR եܭ 0.47Ǵҁჴᡍޑ AR ࣁ 0.47ǵVF ࣁ 56ʘǶჴբ΢܌٬ҔޑБ ݤࢂ Dice and Fill[12]ǴځуπБݤࢂ٬Ҕ඲༝ϪപᐒӧᓸႝഏౠТ΢Ϫрቨࡋࣁ 0.1mm ᕳሜǴԶߥ੮ 0.3mm ޑ҅Б׎ഏౠǴԶۭ೽ࠆࡋεऊ੮ 0.5mmǴ׎ԋࡐӭ ਥߏБഏౠࢊǴӵკ 3.4ǴځύԪՅࣁ༤ΕޑᐋિǴԶᆘՅࣁ੮ΠޑഏౠࢊǶځу Εႝ൑ޑБӛаϷ᎜୏Бӛࣣӧ Y БӛǶ

კ 3.4 ༤ΕᐋિࡕޑፄӝᓸႝഏౠТЁκҢཀკ

3.3.3 ^{πբᓎ౗ϐᒧ᏷}

ҁࣴزޑຬॣݢඤૈᏔځπբᓎ౗ࣁ 2.5MHzǴҗЎ᝘[18]ளޕᓸႝഏౠޑന εӅਁᓎ౗ӵΠ

Ӆਁᓎ౗= ᖂೲ

Β७ޑᓸႝഏౠࠆࡋ (7)

җԜᜢ߯ԄǴ೸ၸ،ۓᓸႝഏౠޑࠆࡋǴջૈளډ೛ीޑᓎ౗Ƕऩ׷਑ࣁપ PZT-4Ǵ җԜ౛ፕϦԄёளډӅਁᓎ౗ࣁ 2.5MHz ਔޑࠆࡋࣁ 0.936mmǶՠӧҁჴᡍύҔޑ

׷਑٠ߚપഏౠᜪᓸႝ׷਑ǴӢԜ೸ၸԜϦԄӃ଺ঁಉౣޑ՗ीǴӧу΢଺ჴᡍǴ ջૈளډჴሞޑࠆࡋǶ

3.3.4 ^{዗ ዗ᓸԋࠠ}

ҁࣴزύޑፄӝᓸႝഏౠǴӧ،ۓӳځჹᔈޑӅਁᓎ౗ࠆࡋࡕǴाעӚঁᓸ

ႝТ዗ᓸԋԔࠠǶځ؁ᡯࣁӃஒኳڀу዗Կ 70ʚǴӆஒፄӝᓸႝഏౠܫΕኳڀύ ъλਔǴ٬ځ೬ϯǶӆעኳڀу዗Կ 80ʚǴ٠ஒኳڀᓸᆙǴ࡭ុ΋λਔǴ٬ፄӝ ᓸႝഏౠۓࠠԋԔ౗ 10cm ޑࠠރǶനࡕ࿼ܭ࠻ϣऊѤλਔǶኳڀೕ਱ࣁკ 3.5 ܌ ҢǶу዗ำׇӵკ 3.6Ƕ

(a)

(b)

კ 3.5(a)(b)ኳڀᐒఓᇙკೕ਱

კ 3.6 ዗ᓸԋࠠำׇკ

3.3.5 ؈ ؈ᑈᏤႝቫ

ࣁΑ٬ளፄӝᓸႝഏౠ΢ޑӚഏౠࢊૈӕਔπբǴу΢ᏤႝቫࢂѸ໪ޑǴԶ Ꮴႝቫߎឦޑᒧ᏷Ǵ೯தࢂයఈߎឦޑႝᏤ౗(Electric Conductivity)ຫଯຫӳǴӵ ߄ 3.2 ܌ҢǶԶҁჴᡍޑᏤႝቫ٬ҔޑߎឦࢂߎکልǴЪࣁΑᡣௗ᝻ፄӝᓸႝഏౠ ޑߎቫૈԖ׳ӳޑߕ๱ΚǴ཮ӧፄӝᓸႝഏౠکߎቫٿϟय़ύуΕ΋ቫሐ྽բߚ ߎឦϟय़аϷߎឦϟय़ޑߕ๱ቫ(Adhesive layer)Ǵӵკ 3.7 ܌ҢǶჴᡍҔޑ؈ᑈߎ ឦБԄϩձҔނ౛਻࣬؈ᑈ(Physical Vapor Deposition, PVD)ύޑᘢᗓ؈ᑈ

(Sputtering Deposition)ٰ؈ᑈሐکߎکႝᗓ؈ᑈ(Electroplating Deposition, EPD)ٰ

߄ 3.2 ႝᏤ౗നӳޑ߻ϖӜߎឦ

20ʚਔޑႝᏤ౗(S/m) ሌ(Ag) 6.30x10⁷

ል(Cu) 5.98x10⁷ ߎ(Au) 4.52x10⁷

᎑(Al) 3.50x10⁷

້(Ca) 2.82x10⁷

კ 3.7 у΢ᏤႝቫϐፄӝᓸႝഏౠТ

კ 3.8 ᘢᗓس಍Ңཀკ

3.3.6 ࠾ ࠾းԋඤૈᏔ

നࡕԜ΋؁ᡯࢂाஒፄӝᓸႝഏౠکٛᅶᐒᄬಔӝǴֹԋ΋ঁຬॣݢඤૈᏔ [16]Ƕҁჴᡍޑᐒᄬ׷਑΋ۓाҔคᅶ܄ޑǴց߾ஒඤૈᏔܫΕᅶਁ೷ቹਔǴ཮೷

ԋቹႽૻဦޑυᘋаϷҗܭமᅶ൑ౢғޑ०ቸਏᔈǴԶჴᡍޑඤૈᏔᐒᄬ׷਑Ҕ ޑࢂᓸլΚǶӵკ 3.9 ࣁѤϩϐ΋ޑᕉ׎ຬॣݢඤૈᏔᐒᄬǴҗѰ΢კૈว౜ځࢂ

җ 8 ТᓸլΚಔԋǴᓸլΚکᓸլΚϐ໔аෛү྽բᗹ๱ᏊǴࣁޑࢂૈׯ๓ᐒᄬ ޑٛН܄ǶӧඤૈᏔޑϣ೽ࢂόૈᏱԖନΑޜ਻аѦޑϟ፦Ǵց߾Ԗёૈ཮Ꮴठ ຬॣݢӕਔΨӛϣ೽໺ሀǴԶ߈΋؁೷ԋ่ᄬ΢ޑόᛙۓаϷफ़եᒡрф౗Ǵკ 3.10 ࣁ᏾ঁᕉ׎ຬॣݢඤૈᏔᐒᄬǶ

კ 3.9 Ѥϩϐ΋ᕉ׎ຬॣݢඤૈᏔᐒᄬҥᡏკ

კ 3.10 ᕉ׎ຬॣݢඤૈᏔᐒᄬҢཀკ

3.4 ߔ ߔלϰଛႝၡ

җܭፄӝᓸႝഏౠόࢂ΋ঁጕ܄ߚਔᡂس಍Ǵځߔל཮ᒿ๱ᓎ౗ԶᡂϯǶऩ

׆ఈඤૈᏔૈԖനεޑႝᖂᙯඤਏ౗аϷനӳޑᒡр߄౜Ǵ൩Ѹ໪ஒҬࢬႝྍӧ ፄӝᓸႝഏౠޑӅਁᓎ౗Π០୏Ǵ٬Ҕߔלϩ݋ሺ(Impedance Analyzers 6500B, UK)

ૈளډ׷਑ޑߔלکᓎ౗ᜢ߯კǴӵკ 3.11 ܌ҢǶ

კ 3.11 ߔלϩ݋ሺໆ(୯ፁଣᙴπಔගٮ)ෳϐፄӝᓸႝഏౠߔלᆶ࣬فკ

Զӧႝૻဦ໺ᒡਔǴऩགྷाளډനεޑф౗ᙯඤǴӧҬࢬႝྍϷॄၩϐ໔Ѹ

໪ၲډߔלϰଛǴΨ൩ࢂᇥѸ໪ᡣႝၡޑ੝܄ߔלکॄၩޑߔלೱុǴց߾ӧॄ

ၩᆄஒ཮วғϸ৔Ǵ೷ԋᒡрф౗ޑΠफ़аϷϸ৔ԿႝྍᆄǴ೷ԋႝྍޑཞᚯǶ ᓸႝഏౠޑ฻ਏႝၡኳࠠࣁკ 3.12[16]ǴԶਥᏵനεф౗ᙯඤচ౛ளޕǴѳ֡ᒡр ф౗ࣁ

P = R_ୗV_ୗ^ଶ

(R_ୗ+ R_୐)^ଶ+ (X_ୗ+ X_୐)^ଶ (8)

R_SࣁߞဦᆄޑႝߔॶǹX_SࣁߞဦᆄޑႝלॶǹV_Sࣁߞဦᆄޑᒡрႝᓸǹ RLࣁॄၩᆄޑႝߔॶǹX_LࣁॄၩᆄޑႝלॶǶ

ाڗள P ޑനεॶǴѸ໪ஒႝלٗ໨฻ܭ႟ǹӆҗᆉ൳ό฻Ԅளډႝߔ໨ޑനλ ॶࣁߞဦᆄޑႝߔॶکᒡрᆄޑႝߔॶ΋ኬǴ᏾౛ӵΠ

൜ R_ୗ = R_୐

X_ୗ = െX_୐ (9)

Ԝਔளډޑനεф౗ࣁ

P = V_ୗ^ଶ

4R_ୗ (10)

კ 3.12 ᓸႝഏౠޑ฻ਏႝၡኳࠠ

3.4.1 LC ႝ ႝၡߔלϰଛ

ӧၲԋߔלϰଛޑჴբ΢Ǵ௦Ҕޑࢂ LC ႝၡߔלϰଛǴځӃளډፄӝᓸႝഏ ౠޑߔלॶ ZLǴӆ೸ၸႝག L Ϸႝ৒ C ٰፓ᏾ځߔלॶǴӵკ 3.13Ƕҗܭҁࣴز

܌٬Ҕޑф౗ܫεᏔϐ੝܄ߔלჴ೽ࣁ 50 ኻۅǵ຀೽ࣁ 0 ኻۅǴࡺаԜբࣁߔל ϰଛޑҞ኱Ƕ

კ 3.13 ߔלϰଛҢཀკ

3.5 ඤૈᏔ੝܄ϯໆෳ

ӧ٬ҔຬॣݢඤૈᏔ଺ҺՖჴᡍਔǴ೿Ѹ໪኱ݙځೕ਱аϷπբᓎ౗฻ǴӢ Ԝҁჴᡍჹځ଺΋سӈޑ੝܄ϯໆෳǶଞჹᓸႝᔈᡂதኧǵᖂߔלаϷႝᖂᙯඤ ਏ౗଺ໆෳǴᡍ᛾ჹԜඤૈᏔӧ HIFU ਔޑ٬Ҕਏ݀Ƕ

3.5.1 ᓸႝᔈᡂதኧ d

ໆෳ

Ԝॶޑελޔௗᜢ߯๱׷਑ҁيࢂցૈԖਏஒѦуႝ൑܌ౢғޑ଍ᓸႝਏᔈ ᙯඤԋ࣬ӕႝ൑БӛޑᔈΚǴҗܭҁࣴز٬Ҕޑࢂፄӝ׷਑ǴӢԜ׳ሡा೸ၸໆ

ෳԜॶٰᔠᡍځૈΚǶҗ d33Meter(PM3500,KCF Technologies,USA)ёෳளᓸႝᔈ ᡂதኧǴӵკ 3.14Ǵځচ౛ࢂ೸ၸკύѰᜐޑ௖ଞౢғҬࢬᔈΚ٬ளᓸႝ׷਑ౢ

ғ΋ႝ൑ԶෳளځॶǶ

კ 3.14 d₃₃Meter(୯ፁଣᙴπಔගٮ)Ҕܭໆෳᓸႝ׷਑ϐᓸႝᔈᡂதኧ

3.5.2 ^{ፄ ፄӝᓸႝഏౠϐᖂߔל}

җ߻य़ക࿯ගډޑϦԄ(5)ளޕట؃ளᖂߔלѸ໪Ӄளډຬॣݢӧ׷਑ύޑᖂ ೲаϷ׷਑ޑஏࡋǶෳᖂೲޑБݤӵკ 3.15Ǵ२Ӄ٬ҔેፂౢғᏔ٬ளඤૈᏔౢ

ғຬॣݢǴ٠ஒેፂౢғᏔޑᒡрૻဦӕਔ໺๏ҢݢᏔǴӧຬॣݢ࿶ၸຯᚆ L ໺ ሀԿН᠋Ꮤ(Hydrophone)ௗԏࡕǴӧҢݢᏔ΢ᡉҢрௗԏډޑૻဦǴٿঁݢࠠКၨ

ջёаளޕຬॣݢӧ࿶ၸຯᚆ L ޑਔ໔ t₀Ǵ຾΋؁ளډНύޑᖂೲ V₀Ǵӆஒፄӝ ᓸႝഏౠܫ࿼ܭඤૈᏔکН᠋Ꮤϐ໔Ǵӕኬ΢ॊ؁ᡯǴ٠у຾׷਑ޑࠆࡋ d ٰԵ ቾǴёаӧҢݢᏔ΢ளډќ΋ঁਔ໔ tǴжΕϦԄջё؃рፄӝᓸႝഏౠޑᖂೲ VǴ

௢ᏤӵΠǺ

t_ଵ+ t_ଶ+ t_ୢ= t (11) L1

V_଴ +L2 V_଴ +d

V= t (12)

tdǺຬॣݢ࿶ၸፄӝᓸႝഏౠޑਔ໔ǹt1Ǻຬॣݢ࿶ၸ L1 ޑਔ໔ǹ t₂Ǻࣁຬॣݢ࿶ၸ L2 ޑਔ໔ǹtǺຬॣݢ࿶ၸ L ޑਔ໔ǹ

V0ǺຬॣݢӧНύޑᖂೲǹdǺፄӝᓸႝഏౠޑࠆࡋǹ

L2Ǻᚈӛፄӝᓸႝഏౠ҅य़ԿН᠋Ꮤޑຯᚆǹ

კ 3.15 ᖂೲໆෳҢཀკ

Զҁჴᡍෳໆ׷਑ޑஏࡋБݤࢂஒፄӝᓸႝഏౠܫ࿼ܭ༾ໆΚϺગ(radiation force balance, RFB)΢Ǵෳளځख़ໆǴӆѐନаځᡏᑈ

3.5.3 ႝ ႝᖂᙯඤਏ౗

ႝᖂᙯඤਏ౗ࢂࡰᒡΕޑႝф౗ᙯඤԋᖂф౗ޑૈΚǴځӃҗૻဦౢғᏔ (function generator)วр΋۰ݢૻဦǴ࿶җф౗ܫεᏔ(power amplifier)ܫεၲډଯ ф౗ޑᒡрǴӆҗф౗ी(power meter)ໆෳځᒡрႝф౗(forward power, FWD)ک ϸ৔ႝф౗(reflected power, REL)ǹҗ༾ໆΚϺѳ(radiation force balance, RFB)ෳள ᖂф౗Ǵӵკ 3.16ǴжΕႝᖂᙯඤਏ౗ϦԄǴӵΠ

Ș = M × g × C

FWD െ REL (13)

ȘǺႝᖂᙯඤਏ౗ǹMǺ༾ໆΚϺѳໆෳډޑ፦ໆǹgǺख़Κуೲࡋǹ CǺຬॣݢӧϟ፦ύޑ໺ሀೲࡋ

კ 3.16 ႝᖂᙯඤਏ౗ໆෳҢཀკ

3.6 ඤ ඤૈᏔу዗ਏ݀ჴᡍ

ӧଯᓎຬॣݢᕉ׎ඤૈᏔᇙբֹԋࡕǴӃ೸ၸόӕЁκޑಔᙃүᡏٰᡍ᛾ځ у዗ޑਏ݀Ǵ٠૶ᒵځӧүᡏ΢όӕՏ࿼ޑྕࡋᆶਔ໔ᡂϯǶௗ๱຾ډᚆᡏ୏ނ ჴᡍǴ࿶җԜ΋سӈޑჴᡍǴջૈ׳ΑှԜຬॣݢඤૈᏔޑჴሞ߄౜௃ݩǶ

3.6.1 ಔᙃүᡏჴᡍ

ҁჴᡍ܌٬ҔޑಔᙃүᡏࢂྕࡋགᔈࠠНጤǴځӧྕࡋଯܭ࣬ᙯ౽ྕࡋ(lower critical solution temperature, LCST)ਔǴНጤޑ౧Н܄ቚуǴ཮җচҁޑъ೸ܴᡂԋ қՅషᐜރǶҁჴᡍҔޑྕࡋགᔈࠠНጤࢂୖԵЎ᝘[19]ޑࠠဦ PNAA3Ǵځ LCST ࣁ 41ʚǵ૰෧߯ኧࣁ 1.09Np/mǴӢԜӧྕࡋଯܭځ LCST ਔǴջૈ೸ၸНጤޑᡂ Յᆶցளޕྕࡋࢂցຬၸ 41ʚǶ

ࣁᡍ᛾Ԝଯᓎຬॣݢᕉ׎ඤૈᏔჹЁκၨλޑಔᙃᏱԖᆫขޑфૈǴᇙբЁ κࣁޔ৩ 1cm ޑ༝ࢊࠠНጤǴӵკ 3.17ǹԶଞჹЁκၨεޑಔᙃǴట᛾ჴჹځԖ у዗߄य़ޑਏ݀ǴӢԜᇙբΑޔ৩ࣁ 6cm ޑ༝ࢊࠠНጤǴӵკ 3.18Ƕჴᡍࢎᄬკ

(cavitation)ޑౢғǶԶࣁΑᅱෳྕࡋᡂϯǴஒ዗ႝଽකΕНጤύЈǴаջਔϸᔈྕ

ࡋᡂϯǶ

კ 3.17 (a)(b) ޔ৩ 1cm ޑ༝ࢊࠠНጤ

კ 3.19 ಔᙃүᡏу዗ჴᡍࢎᄬკ

3.6.2 ᚆ ᚆᡏ୏ނჴᡍ

ຬॣݢ໺࿶ғނಔᙃǴӢځזೲ۳ൺޑ᎜୏Ǵ೷ԋಔᙃ໔ޑነᔔԶౢғ዗ૈǴ ٠٬ளຬॣݢૈໆ૰෧ǴЪ٬ளֽ೽ޑಔᙃౢғྕϲǴ྽ֽ೽ྕࡋຬၸೈқ፦ᡂ

܄ྕࡋ 43ʚਔǴಔᙃஒ཮ౢғᚯԝޑ౜ຝǶฅԶόӕಔᙃჹຬॣݢޑ૰෧߯ኧΨ όӕǴ೯த֎ԏ߯ኧ཮ऊ฻ܭ૰෧߯ኧǴӵ߄ 3.3Ƕүྣಔᙃүᡏу዗ჴᡍǴஒߏ کቨࣁ 1.3cmǴଯ 1cm ޑߏБࢊࠠٚԼԺڗжНጤٰ଺ඤૈᏔу዗ჴᡍǴკ 3.21 ࣁᚆᡏ୏ނу዗ჴᡍࢎᄬǶ

߄ 3.3 ғނಔᙃکځдϟ፦ޑຬॣݢୖኧ

ᖂೲ(m/s) ᖂߔל(MRayl) ૰෧߯ኧ(dB/cm/MHz)

ޜ਻ 331 0.004 12

Н 1540 1.54 0.0022

િެ 1450 1.38 0.63

ԼԺ 1585 1.7 3.3

კ 3.20 ᚆᡏ፜Ժу዗ჴᡍࢎᄬკ

ಃ

ಃ4കġ ่݀ᆶ૸ፕ

ҁകஒϟಏඤૈᏔᇙբǵ੝܄ϯໆෳǵу዗ਏ݀ჴᡍޑ่݀аϷ૸ፕǶ

4.1 ඤૈᏔᇙբ

კ 4.1 ࣁ᏾঺ᕉ׎ඤૈᏔǴӧځᇙբၸำύᗋሡԵቾᏤጕޑऐႝࢬ[16]ǵᏤጕ ޑߏࡋǵڙډ܎רਔᏤጕޑᔈΚϩթ฻Ƕ

ҁ࿯ஒ཮ଞჹᕉ׎ຬॣݢඤૈᏔޑᇙբၸำύޑၨख़ाޑ೽ϩբ௖૸Ƕ

კ 4.1 ᕉ׎ຬॣݢඤૈᏔϷځϰଛႝၡ

4.1.1 ᅶਁ೷ቹ࣬৒ϐຬॣݢඤૈᏔ

კ 4.2 ࣁᕉ׎ຬॣݢඤૈᏔޑᅶਁ೷ቹቹႽǴҗԜკёளޕҁჴᡍ܌ᇙբ ޑඤૈᏔࢂڀԖᅶਁ೷ቹ࣬৒܄ޑǶ

კ 4.2 ܫ࿼ܭᅶਁ೷ቹس಍ϐຬॣݢඤૈᏔ

4.1.2 ᓸ ᓸႝഏౠࡷᒧ

ஒुᇙޑᓸႝഏౠଞჹᓸႝ߯ኧ d33բࡷᒧǴӧ 50 Т PZT-4 ύࡷрॶനଯЪ നௗ߈ޑ 16 ТǶ

߄ 4.1 16 Тᓸႝഏౠ PZT-4 ޑᓸႝ߯ኧ d33ॶ

ጓဦ d33(10^-12C/N) ጓဦ d33(10^-12C/N)

1 346 9 349

2 347 10 349

3 347 11 349

4 348 12 349

5 348 13 349

6 348 14 351

7 348 15 351

8 349 16 351

ѳ֡ॶ 348.7 ኱ྗৡ 1.4 ᡂ౦߯ኧ 0.4%

җ߄ 4.1 ёаዴۓჴᡍ׷਑ࡷᒧޑ 16 ঁᓸႝഏౠൂϡ੝܄ࢂߚத࣬߈ޑǴӧ

᏾ঁඤૈᏔޑᇙբ΢ᏱԖ׳ӳޑ֡΋܄Ƕ

4.1.3 ^{ፄ ፄӝ׷਑඲࣬კ}

Ԝ΋่݀ࢂࣁΑዴᇡہૼቷ୘уπޑࠔ፦ǴჴᡍБԄࢂஒ༤ֹᐋિޑፄӝᓸ

ႝഏౠܫӧ඲࣬ሺܡឪǴӵკ 4.3Ƕ

კ 4.3 ༤Εᐋિࡕޑፄӝᓸႝഏౠ඲࣬კ

W ޑ೛ۓॶࣁ 300umǴԶ K ޑ೛ۓॶࣁ 100umǶჴሞໆෳډ W ޑѳ֡ॶࣁ 307.76umǵ኱ྗৡࣁ 0.92umǴԶ K ޑѳ֡ॶࣁ 97.98umǵ኱ྗৡࣁ 1.96umǴӢԜ ёаளޕǴуπࠔ፦ᗨฅᆒዴࡋ(Accuracy)کᆒஏࡋ(Precision)೿ࢂߚதଯޑǶ

4.1.4 ፄӝᓸႝഏౠࠆࡋ

೸ၸϦԄ(7)ளډ 2.5MHz ᓸႝഏౠޑ౛ፕࠆࡋǴฅԶࣁ؃ྗዴǴ؃ளࠆࡋޑ БԄǴനࡕࢂаჴሞуπ٠ໆෳӭᗺ؃ளǴӵკ 4.4

კ 4.4 όӕፄӝᓸႝഏౠࠆࡋਔჹᔈޑӅਁᓎ౗

җკ 4.4 ёޕၰፄӝᓸႝഏౠޑӅਁᓎ౗ࢂᆶځࠆࡋԋϸКǴӆޣటளډӅਁ

ᓎ౗ӧ 2.5MHz ޑፄӝᓸႝഏౠǴځࠆࡋᔈࣁ 0.64mmǶҗܭҁჴᡍӧೀ౛ 16 Тፄ ӝᓸႝഏౠਔࢂаΓπБԄуπǴӢԜӚТޑࠆࡋ཮Ԗ٤೚ᇤৡǶჹԜᇤৡελ ޑղᘐǴࢂ௦ڗ؂ТፄӝᓸႝഏౠӚڗΐᗺѐբ಍ीϩ݋Ǵӵკ 4.5 ܌ҢǴԶளډ ޑӚТࠆࡋޑ಍ीኧᏵаϷჹᔈޑӅਁᓎ౗ӵ߄ 4.2Ƕ

კ 4.5 ፄӝᓸႝഏౠࠆࡋໆෳБݤ

2.59

2.52

2.4

2.32

2.23

2 2.1 2.2 2.3 2.4 2.5 2.6 2.7

0.62 0.64 0.66 0.68 0.7

Ӆਁᓎ౗!

)NI{*!

ፄӝᓸႝഏౠࠆࡋ)nn*!

߄ 4.2 16 Тፄӝᓸႝഏౠޑѳ֡ࠆࡋϷӅਁᓎ౗

ጓဦ ѳ֡ॶ(um) ኱ྗৡ(um) ᡂ౦߯ኧ Ӆਁᓎ౗(MHz)

1 641.9 9.1 1.4% 2.49

2 642.7 10.3 1.6% 2.46

3 646.3 9.4 1.5% 2.47

4 638.0 6.3 1.0% 2.50

5 628.8 9.4 1.5% 2.60

6 646.2 9.0 1.4% 2.53

7 652.8 9.5 1.4% 2.50

8 637.7 16.7 2.6% 2.58

9 648.7 10.7 1.6% 2.54

10 651.6 14.9 2.3% 2.56

11 641.6 10.4 1.6% 2.50

12 631.4 12.8 2.0% 2.52

13 637.7 17.2 2.7% 2.58

14 642.2 5.1 0.8% 2.53

15 651.6 6.3 1.0% 2.51

16 640.6 10.4 1.6% 2.58

Кၨጓဦ 4 ک 7 ཮ว౜ᗨฅٿޣޑӅਁᓎ౗ࣣࣁ 2.5MHzǴՠጓဦ 7 ޑѳ֡ࠆ ࡋࣁ 652.8umǴ౛ፕ΢ᔈ၀཮եܭ 2.5MHzǴϐ܌аໆෳрٰޑӅਁᓎ౗ϝࣁ 2.5MHz ࢂӢࣁځࠆࡋޑ኱ྗৡၨεǴ߄Ңځࠆࡋၨόѳ֡ǴቹៜΑځӅਁᓎ౗Ƕ

4.1.5 ᕉ ᕉ׎ඤૈᏔᐒᄬ

٬Ҕ೸ܴޑᓸլΚࢂࣁΑБߡᢀჸᐒᄬޑٛНਏ݀ޑӳᚯǴऩԖНᅖΕᐒᄬ ϣ೽ஒ٬ளႝᖂᙯඤਏ౗फ़եǶԶஒᕉ׎ඤૈᏔܨԋѤ༧࣬ӕελޑѤϩϐ΋ඤ

ૈᏔǴࢂࣁΑБߡᆢঅǴӵკ 4.6Ƕ

კ 4.6 Ѥϩϐ΋ޑᕉ׎ຬॣݢඤૈᏔᐒᄬ

җܭᓸլΚϐ໔ޑᗹӝБԄࢂаෛүǴځӧٿᓸլΚ໔ޑᗹӝ΢Ԗ࣬྽ӳޑ ߕ๱ΚǴׯ๓ΑඤૈᏔᓎᓎ຾Нޑ֚ᘋǴЪჹܭፄӝᓸႝഏౠޑۓՏ׳у৒ܰǶ

4.1.6 ߔ ߔלϰଛႝၡ

ፄӝᓸႝഏౠඤૈᏔ࠾းֹԋࡕǴஒځ࿼ܭѐ਻НύǴໆෳځߔלॶǴӵ߄ 4.3Ƕ࿶җीᆉளډԜ 16 ТፄӝᓸႝഏౠϐϰଛႝၡࣣѝሡӃՍᖄ΋ႝ৒ԿॄၩᆄǴ ӆ٠ᖄќ΋ႝ৒ܭࡕᆄǴӵკ 4.7Ƕკ 4.8 ࣁ 16 ൂϡޑຬॣݢඤૈᏔϐϰଛႝၡჴ ᡏკǶ

߄ 4.3 ҂ϰଛ߻ϐ 16 Тፄӝᓸႝഏౠޑߔלॶ

ጓဦ ߔלჴ೽ȍ ߔל຀೽ȍ ጓဦ ߔלჴ೽ȍ ߔל຀೽ȍ

1 15.74 50.36 9 14.43 49.53

2 14.96 50.28 10 14.54 48.94

3 14.90 51.13 11 14.18 49.42

4 14.80 50.16 12 13.57 49.40

5 17.27 49.84 13 16.24 52.30

6 21.32 47.26 14 13.37 48.98

7 14.17 50.12 15 13.51 49.85

8 17.08 52.05 16 14.82 51.17

კ 4.7 ϰଛႝၡϐႝၡҢཀკ

კ 4.8 16 ൂϡޑຬॣݢඤૈᏔޑϰଛႝၡჴᡏ

߄ 4.4 уΕϰଛႝၡࡕޑ 16 ൂϡϐඤૈᏔᆶф౗ܫεᏔ่ӝࡕޑᒡр่݀

ጓဦ ໺ଌф౗

(W)

ᒡΕф౗

(W)

ᒡрਏ౗

(%)

ጓဦ ໺ଌф౗

(W)

ᒡΕф౗

(W)

ᒡрਏ౗

(%)

1 35 30 85.7 9 37 30 81.1

2 40 33 82.5 10 39 33 84.6

3 37 32 86.5 11 39 32 82.1

4 38 33 86.8 12 43 33 76.7

5 40 33 82.5 13 35 30 85.7

6 37 31 83.8 14 37 31 83.8

7 40 33 82.5 15 39 31 79.5

8 39 30 76.9 16 35 30 85.7

җ߄ 4.4 ளޕǴҗф౗ܫεᏔ໺ଌрޑф౗(transmitted power)ک࿶ၸϰଛႝၡ ϐࡕޑᒡΕф౗(forward power)ϐК౗ࣣଯܭ 75%Ǵځ߄Ңஒ཮Ԗऊ 25%ޑ໺ଌф

౗ϸ৔ӣډႝྍᆄǴ೭ࢂӢࣁӧႝ৒ҁيӸӧ΋ᇤৡॶǴЪፄӝᓸႝഏౠޑߔל

ࢂ཮ᒿ๱ཱུϯ੝܄ޑׯᡂԶԖ܌ᡂϯǴӢԶ೷ԋߔלϰଛόֹऍǶ

4.2 ඤ ඤૈᏔ੝܄ໆෳ

ҁ࿯ஒໆෳதـޑຬॣݢඤૈᏔ੝܄ୖኧǴаᔠෳځඤૈᏔ߄౜ޑᓬӍǶ

4.2.1 ፄӝᓸႝഏౠޑᓸႝᔈᡂ߯ኧ d

ໆෳ

೸ၸ d₃₃meter ૈזೲໆෳډፄӝᓸႝഏౠޑᓸႝᔈᡂ߯ኧ d33Ǵᡣ೛ीޣૈז ೲޕၰԜ׷਑ޑᓸႝ੝܄ӳᆶᚯǶ

߄ 4.5 16 ൂϡፄӝᓸႝഏౠޑ d₃₃

ጓဦ d33(10^-12C/N) ጓဦ d33(10^-12C/N)

1 308 9 301

2 302 10 317

3 303 11 307

4 308 12 308

5 301 13 313

6 315 14 312

7 311 15 309

8 312 16 310

ѳ֡ॶ 309.2 ኱ྗৡ 4.5 ᡂ౦߯ኧ 1.5%

җ߄ 4.5 ک߄ 4.1 Кၨёว౜Ǵ༤ΕᐋિࡕǴځ᏾ᡏޑᓸႝᔈᡂ߯ኧ཮फ़ե 13%

4.2.2 ᖂ ᖂߔלໆෳ

ऩᖂߔלຫௗ߈Γᡏ೬ಔᙃޑѳ֡ᖂߔל(1.5MRayl)Ǵ߾ځૈ຾ΕΓᡏޑᖂૈ

൩ຫӭǶҁჴᡍӃჹ 16 ТፄӝᓸႝഏౠෳᖂೲǴӆڗϐ४аፄӝᓸႝഏౠޑஏࡋǴ

؃ளᖂߔלǶ

კ 4.9 ፄӝᓸႝഏౠӚൂϡᖂߔל

җკ 4.9 ёаளޕǴబуᐋિࡕޑፄӝᓸႝഏౠᖂߔלΠफ़೚ӭǴPZT-4 ޑᖂ ߔלࣁ 35.1MRaylǴԶ 16 ঁፄӝᓸႝഏౠൂϡޑᖂߔלऊӧ 20MRayl Կ 23MRaylǴ ӢԜૈԖ׳ӳޑᖂߔלϰଛਏ݀Ǵ

0 5 10 15 20 25 30 35 40

1 2 3 4 5 6 7 8 9 10111213141516 ᖂߔל!

)NSbzm*!

ፄӝᓸႝഏౠጓဦ!

ᓸႝഏౠQ[U.5!

ፄӝᓸႝഏౠ!

4.2.3 ႝ ႝᖂᙯඤਏ౗ໆෳ

კ 4.10 ൂϡ΋ޑႝᖂᙯඤਏ౗

კ 4.11 ൂϡΒޑႝᖂᙯඤਏ౗

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45

0 1 2 3 4 5 6

0 5 10 15 20 25

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗)

*X

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

0 0.05 0.1 0.15 0.2 0.25 0.3

0 0.5 1 1.5 2 2.5 3 3.5 4

0 5 10 15 20

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗)

*X

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

კ 4.12 ൂϡΟޑႝᖂᙯඤਏ౗

კ 4.13 ൂϡѤޑႝᖂᙯඤਏ౗

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4

0 0.5 1 1.5 2 2.5 3 3.5 4 4.5

0 5 10 15 20

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗) X*

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45

0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5

0 5 10 15 20

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗) X*

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

კ 4.14 ൂϡϖޑႝᖂᙯඤਏ౗

კ 4.15 ൂϡϤޑႝᖂᙯඤਏ౗

0 0.05 0.1 0.15 0.2 0.25 0.3

0 0.5 1 1.5 2 2.5 3

0 5 10 15 20

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗)

*X

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45

0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5

0 5 10 15 20

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗)

*X

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

კ 4.16 ൂϡΎޑႝᖂᙯඤਏ౗

კ 4.17 ൂϡΖޑႝᖂᙯඤਏ౗

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45

0 1 2 3 4 5 6

0 5 10 15 20

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗)

*X

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45

0 0.5 1 1.5 2 2.5 3 3.5 4 4.5

0 5 10 15

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗)

*X

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

კ 4.18 ൂϡΐޑႝᖂᙯඤਏ౗

კ 4.19 ൂϡΜޑႝᖂᙯඤਏ౗

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45

0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5

0 5 10 15 20

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗) X*

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4

0 0.5 1 1.5 2 2.5 3 3.5 4 4.5

0 5 10 15 20

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗)

*X

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

კ 4.20 ൂϡΜ΋ޑႝᖂᙯඤਏ౗

კ 4.21 ൂϡΜΒޑႝᖂᙯඤਏ౗

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4

0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5

0 5 10 15 20

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗)

*X

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4

0 0.5 1 1.5 2 2.5 3 3.5 4

0 5 10 15

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗)

*X

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

კ 4.22 ൂϡΜΟޑႝᖂᙯඤਏ౗

კ 4.23 ൂϡΜѤޑႝᖂᙯඤਏ౗

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35

0 0.5 1 1.5 2 2.5 3 3.5

0 5 10 15 20

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗)

*X

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35

0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5

0 5 10 15 20

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗)

*X

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

კ 4.24 ൂϡΜϖޑႝᖂᙯඤਏ౗

კ 4.25 ൂϡΜϤޑႝᖂᙯඤਏ౗

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45

0 1 2 3 4 5 6

0 5 10 15 20

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗)

*X

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4

0 0.5 1 1.5 2 2.5 3 3.5 4 4.5

0 5 10 15 20

ႝ ᖂ ᙯ ඤ ਏ

౗

! ᖂ

ф

౗)

*X

!

ႝф౗)X*!

ᖂф౗!

ႝᖂᙯඤਏ౗!

ᢀჸ΢य़ΜϤ஭კǴૈว౜ᒿ๱ႝф౗ޑගଯǴځႝᖂᙯඤਏ౗཮೴ᅌᡂեǴ Ӣࣁᒿ๱ᒡΕф౗ޑගଯǴ᎜୏ޑ൯ࡋᡂεǴ຾Զ೷ԋຫٰຫեޑᙯඤਏ౗Ƕ

4.3 ඤ ඤૈᏔу዗ჴᡍ่݀

ᙖҗ዗ႝଽ྽բྕࡋགᔈᏔǴӧόӕᒡΕф౗ޑచҹΠǴᢀჸүᡏаϷٚԼ ԺޑύЈᗺྕࡋᡂϯǶќѦӧүᡏჴᡍύǴჹޔ৩ 6cm ޑүᡏǴஒ዗ႝଽশӧຯ ᚆύЈᗺ 0cmǵ1cmǵ2cm ޑՏ࿼ǴаᢀჸԜΟՏ࿼ޑྕࡋᡂϯǴӵკ 4.26ǵ4.27Ƕ

კ 4.26 ዗ႝଽশ࿼ܭᚆύЈᗺ 1cm ೀ

კ 4.27 ዗ႝଽশ࿼ܭᚆύЈᗺ 2cm ೀ

4.3.1 ಔ ಔᙃүᡏჴᡍ

ӵკ 4.28Ǵஒޔ৩ 1cm ޑНጤܫ࿼ܭᕉ׎ຬॣݢඤૈᏔޑύЈǴϩձ೛ۓ໺

ଌф౗ࣁ 240Wǵ270Wǵ300Wǵ310WǴ؂ 5 ࣾइᒵ΋ԛྕࡋǴᢀჸځ 60 ࣾϣޑ

ྕࡋᡂϯǴӵკ 4.29Ƕ

ௗ๱ஒޔ৩ 6cm ޑНጤܫ࿼ܭᕉ׎ຬॣݢඤૈᏔޑύЈǴϩձаᒡΕф౗ࣁ 200W ک 250WǴ዗ႝଽᘍܫՏ࿼ຯᚆύЈ 0cmǵ1cmǵ2cm ٰ଺КၨǴځ่݀ӵ კ 4.30ǵ4.31Ƕ

კ 4.28 ஒޔ৩ 1cm Нጤ࿼ܭඤૈᏔύЈϐჴᡍ

კ 4.29 όӕ໺ଌф౗ჹНጤύЈޑྕࡋᡂϯ

25 27 29 31 33 35

0 5 10 15 20 25 30 35 40 45 50 55 60

ྕ ࡋ( ɗ)

ਔ໔(t)

240W 270W 300W 310W

კ 4.30 ᒡΕф౗ࣁ 200W ϐόӕՏ࿼ྕࡋᡂϯკ

კ 4.31 ᒡΕф౗ࣁ 250W ϐόӕՏ࿼ྕࡋᡂϯკ

җკ 4.29 ёаว౜Ǵஒځ໺ଌф౗уଯ٠҂ૈ೷ԋ׳ଯޑྕϲǴ௢ᘐࢂӢࣁ ԜଯᓎඤૈᏔ܌ౢғޑᆫขᗺߚதλǴӢԜӧশ࿼዗ႝଽਔǴѸ໪ाԖ׳ᆒྗޑ ΟືۓՏѳѠǴց߾คݤୀෳډᆫขᗺޑྕࡋᡂϯǶ

җკ 4.30 ߄Ңӧ 2.5MHzǴଞჹޔ৩ 6cm ޑНጤүᡏ٠คу዗߄य़ޑ่݀Ǵ ӢࣁკύᡉҢஒ዗ႝଽশӧύЈೀޑྕࡋᡂϯКশӧᚆύЈ 1cmǵ2cm ೿ाεޑ

24 25 26 27 28 29 30

0 5 10 15 20 25 30 35 40 45 50 55 60

ྕ ࡋ ᡂ ϯ( ɗ)

ਔ໔(t)

ύЈᗺ ᚆύЈᗺ1cm ᚆύЈᗺ2cm

24 24.5 25 25.5 26 26.5 27 27.5 28 28.5 29

0 5 10 15 20 25 30 35 40 45 50 55 60

ྕ ࡋ ᡂ ϯ( ɗ)

ਔ໔(t)

ύЈᗺ ᚆύЈ1cm ᚆύЈ2cm

4.3.2 ᚆ ᚆᡏ୏ނჴᡍ

ࣁΑளډܴᡉޑϲྕਏ݀Ǵҁჴᡍᒧ᏷а૰෧߯ኧၨଯޑٚԼԺ྽բᚆᡏ୏

ނჴᡍޑ׷਑Ǵٰᡍ᛾ຬॣݢඤૈᏔჹᚆᡏޑу዗ਏ݀Ƕ

კ 4.32 ஒٚԼԺ࿼ܭඤૈᏔύЈϐᚆᡏჴᡍ

ஒٚԼԺϪԋ 1.3×1.3×1cm³ޑελǴඤૈᏔᒡΕႝф౗ࣁ 70 ґǵ100 ґǵ150 ґǴу዗ਔ໔ࣁ 60 ࣾǴԶྕࡋໆෳࢂஒ዗ႝଽܫ࿼ܭٚԼԺޑ္य़Ǵӵკ 4.32Ǵ ځྕࡋᡂϯ่݀ࣁკ 4.33Ƕ

კ 4.33 όӕф౗ΠٚԼԺྕࡋᡂϯ

җ่݀ᡉҢрځπբਔ໔ 60 ࣾǴᒡΕႝф౗ 70W ޑྕࡋ΢ϲΑ 5.6 ࡋǹᒡΕ

ႝф౗ 100W ޑྕࡋ΢ϲΑ 5.7 ࡋǹԶᒡΕႝф౗ 150W ޑྕࡋ΢ϲΑ 8.6 ࡋǴΟ ಔኧᏵ᛾ܴΑԜඤૈჹᚆᡏޑዴԖуྕਏ݀Ƕ

ijij ijĵ ijķ ijĹ Ĵı Ĵij Ĵĵ

ı Ķ IJı IJĶ ijı ijĶ Ĵı ĴĶ ĵı ĵĶ Ķı ĶĶ ķı ਔ໔)u*

ྕࡋ )ʚ*

ĸıŘ IJııŘ IJĶıŘ

ಃ

ಃ5കġ ่ፕᆶ҂ٰ৖ఈ

ҁࣴزֹԋΑჹ 1-3 ፄӝᓸႝഏౠᔈҔܭଯᓎᕉ׎ຬॣݢତӈඤૈᏔޑᇙբǴ ΨଞჹඤૈᏔޑ੝܄բΑ΋سӈޑෳ၂ǴዴۓԜඤૈᏔࢂૈᛙۓޑπբаϷӳޑ ᓸႝ੝܄Ƕՠӧүᡏу዗ࠠᄊჴᡍύǴ٠όૈၲډႣයޑזೲྕϲਏ݀ǹᚆᡏ୏

ނჴᡍύǴҗܭٚԼԺޑ૰෧߯ኧၨεǴӢԜૈளډၨܴᡉޑྕࡋᡂϯǴՠϝό ӵႣයǶ

җޔ৩ 6cm ޑүᡏჴᡍёаளޕԜଯᓎຬॣݢᕉ׎ඤૈᏔޑπբᓎ౗ӧ 2.5MHz ਔǴϝࣁᆫขࠠඤૈᏔ

ଞჹܭځୃեޑႝᖂᙯඤਏ౗Ǵૈ೸ၸуεځഏౠᡏᑈКٰׯ๓ǴՠՔᒿޑ ᖂߔלϲଯϷᇙբ΢ޑ֚ᜤǴځύ໔ޑѳᑽᗺǴԖᒘཥޑ೛ीޣ຾΋؁௖૸ǹӧ Ҟ߻س಍္ᗋԖ΋ঁϝёаׯ๓ޑӦБǴࢂࣁஒႝၡߔלϰଛᆄޑϰଛႝၡϰଛ ள׳ௗ߈ф౗ܫεᏔ܌೛ीޑ੝ቻߔלǴӢࣁԜϰଛό౛གྷ೷ԋΑф౗ܫεᏔᆄ ᒡΕޑф౗཮ϸ৔ӣܫεᏔǴ٬ள௖ᓐᆄޑᒡΕф౗फ़եǶ

ୖ

ୖԵЎ᝘

1. Brenin, D.R.,

Focused ultrasound ablation for the treatment of breast cancer.

Ann Surg Oncol, 2011. 18(11): p. 3088-94.

2. Sapareto, S.A. and W.C. Dewey, Thermal dose determination in cancer therapy.

Int J Radiat Oncol Biol Phys, 1984. 10(6): p. 787-800.

3. Kim, Y.S., et al., High-intensity focused ultrasound therapy: an overview for

radiologists. Korean J Radiol, 2008. 9(4): p. 291-302.

4. Hynynen, K.,

MRI-guided focused ultrasound treatments. Ultrasonics, 2010.

50(2): p. 221-9.

5. Hynynen, K., et al., MR imaging-guided focused ultrasound surgery of

fibroadenomas in the breast: a feasibility study. Radiology, 2001. 219(1): p.

176-85.

6. M. Malinen, T.H., K. Hynynen, and J.P. Kaipio, Simulation study for thermal

dose optimization in ultrasound surgery of the breast. Med Phys, 2004. 31: p.

1296-1307.

7. Bakker, J.F., et al., An ultrasound cylindrical phased array for deep heating in

the breast: theoretical design using heterogeneous models. Phys Med Biol, 2009.

54(10): p. 3201-15.

8. Ho, C.S., et al., Thermal therapy for breast tumors by using a cylindrical

ultrasound phased array with multifocus pattern scanning: a preliminary numerical study. Phys Med Biol, 2007. 52(15): p. 4585-99.

9. ໱ऩ, ຬᖂບᘐ೛ഢচ౛ᆶ೛ी. 1993 ԃ 4 Д: ύ୯ᙴ⚓ࣽמрހޗ.

10. Klicker, K.A., J.V. Biggers, and R.E. Newnham, Composites of PZT and Epoxy

for Hydrostatic Transducer Applications. Journal of the American Ceramic

11. ቅߞד, 1-3ᓸႝፄӝ׷਑ᔈҔܭଯமࡋᆫขຬॣݢඤૈᏔϐࣴز, in ᐒఓ πำᏢسᅺγ੤. 2011, ύ๮εᏢ: ཥԮѱ.

12. Savakus, H.P., K.A. Klicker, and R.E. Newnham, PZT-epoxy piezoelectric

transducers: A simplified fabrication procedure. Materials Research Bulletin,

13. Clipsham, T.J. and T.W. Button, 1-3 Piezocomposites realised from small feature

size, high aspect ratio, hot embossed moulds. Part II: piezocomposite

fabrication. Microsystem Technologies, 2010. 16(11): p. 1983-1988.

14. Chen, G.S., et al., Experimental analysis of 1-3 piezocomposites for

high-intensity focused ultrasound transducer applications. IEEE Trans Biomed

љ.

16. ݅դᏦ, ᕉ׎࣬ՏତӈᆫขԄຬॣݢ่ӝᅶਁ೷ቹس಍ᔈҔܭ٢܊ဍዦݯ ᕍޑࣴز, in ᙴᏢπำᏢࣴز܌. 2011, ᆵ᡼εᏢ: Ѡчѱ.

17. ᖴۢԋ, ᓸႝႝ಻தኧ

d33

18. Duck FA, B.A., Starritt HC, Ultrasound in Medicine. 1998: Institute of Physics Publishing.

19. ᑵက҅, ྕࡋགᔈࠠНጤᔈҔܭᆫขࠠຬॣݢ዗ݯᕍϐࣴز

. εӕεᏢ ᐒ