Author(s): Lin, WT (Lin, Wan-Teng); Huang, CC (Huang, Chi-Chang); Lin, TJ (Lin, Tien-Jen);
Chen, JR (Chen, Jiun-Rong); Shieh, MJ (Shieh, Ming-Jer); Peng, HC (Peng, Hsiang-Chi);
Yang, SC (Yang, Suh-Ching); Huang, CY (Huang, Chih-Yang)
Title: Effects of beta-carotene on antioxidant status in rats with chronic alcohol consumption Source: CELL BIOCHEMISTRY AND FUNCTION, 27 (6): 344-350 AUG 2009
Language: English Document Type: Article
Author Keywords: alcoholic liver disease; antioxidant capacity; beta-carotene; lipid peroxidation; oxidative stress
KeyWords Plus: ALPHA-TOCOPHEROL; LIVER-DISEASE; LIPID-PEROXIDATION;
OXIDATIVE STRESS; ASCORBIC-ACID; IN-VIVO; ETHANOL; ENZYMES; DIET
Abstract: This study examined the effects of beta-carotene on antioxidant status in rats with chronic alcohol consumption. At the beginning of experiment (week 0), according to both the plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, rats (n = 24) were divided into 3 groups and fed with a standard diet (group C), a diet containing ethanol (group E), or a diet containing ethanol and beta-carotene (group E+B). After 10 weeks, plasma AST and ALT, fat accumulation in the liver, antioxidant enzyme activities in
erythrocytes and the liver, malondialdehyde (MDA), and alpha-tocopherol and retinol in plasma and hepatic samples were analyzed. The chronic alcohol diet significantly increased AST and ALT levels in plasma, and these changes were prevented by supplementing the diet with beta-carotene. Glutathione (GSH) in erythrocytes and in the liver was significantly elevated in rats fed with a diet containing beta-carotene. The results indicate that beta- carotene supplementation can prevent ethanol-induced liver damage and increase GSH concentrations in erythrocytes and the liver. Copyright (C) 2009 John Wiley & Sons, Ltd.
Addresses: [Chen, Jiun-Rong; Shieh, Ming-Jer; Peng, Hsiang-Chi; Yang, Suh-Ching] Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei 11031, Taiwan; [Lin, Wan-Teng] Tunghai Univ, Coll Agr, Dept Hospitality Management, Taichung 40704, Taiwan; [Huang, Chi-Chang] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan; [Lin, Tien-Jen] Municipal Wan Fang Hosp, Dept Surg, Div Neurosurg, Taipei, Taiwan; [Lin, Tien-Jen] Taipei Med Univ, Grad Inst Injury Prevent, Taipei 11031, Taiwan; [Huang, Chih-Yang] Grad Inst Chinese Med Sci, Grad Inst Basic Med Sci, Taichung, Taiwan; [Huang, Chih-Yang] China Med Univ, Taichung, Taiwan; [Huang, Chih- Yang] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan
Reprint Address: Yang, SC, Taipei Med Univ, Sch Nutr & Hlth Sci, 250 Wu Xin St, Taipei 11031, Taiwan.
E-mail Address: [email protected]; [email protected] Funding Acknowledgement:
Funding Agency Grant Number
National Science Council of Taiwan NSC89-2320-B-038-034
This study is supported by the National Science Council of Taiwan (NSC89-2320-B-038-034).
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Publisher: JOHN WILEY & SONS LTD
Publisher Address: THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
ISSN: 0263-6484 DOI: 10.1002/cbf.1579
29-char Source Abbrev.: CELL BIOCHEM FUNCT ISO Source Abbrev.: Cell Biochem. Funct.
Source Item Page Count: 7
Subject Category: Biochemistry & Molecular Biology; Cell Biology ISI Document Delivery No.: 488XX
