Arthritis Research of Traditional Chinese Medicines Study of the Chinese medicinal prescriptions for rheumatoid arthritis
AbstractRheumatoid arthritis (Rheumatoid arthritis, RA) is an ancient and full of mysterious autoimmune disease. Although a detailed knowledge of the pathogen has not yet systemic disease, but its features for the value-added and chronic synovial inflammation, eventually leading to articular cartilage and related organizations were corrosion damage; Moreover, they result in joint deformities, disability.
Because the damage caused by the human body are chronic, it is often overlooked.
According to the Arthritis Foundation estimated that in 1975 alone, and then the United States alone there are 2000 people suffering from arthritis, a chronic disease is second only to heart disease; in 1984, the United States, rheumatoid arthritis patients, about 400 ~ 6 million. Very much regret that this and not very precise in Taiwan, the statistics, but Taiwan's weather, the temperature difference between morning and evening and noon, mountain and sea climate more humid, moisture residents suffering the pain and cold and so snowy, cold wind strength, humidity is high, rheumatoid arthritis is a very common disease.
Rheumatoid arthritis population of about humanity 2 ~ 3%, widely distributed in the individual swelling and age groups, in particular, occurs in 20 to 40 years old, male and female is about three times that. Most of the patients died of complications caused by the the ratio was not high, but the cause of joint pain, redness and swelling, but gives the patient great hardship. Attendant problems such as L 1) around the joint swelling, stiffness and pain. (2) fever, anemia, general malaise. (3) Drug-induced stomach pain, nausea, diarrhea, and tinnitus. (4) extra-articular symptoms such as mental disease, pericarditis, pleural effusion, scleritis, and blood vessels go far. (5) mental problems such as depression, anxiety and stress, the
medical community is often referred to as "pain cocktail." In addition, patients with depression caused by mobility, more so
physically handicapped patients confined to wheelchairs and
sickness all day long, resulting in personal social problems such as unemployment and suicide, which encompasses the broad, people have this disease becoming more important.
The trigger for RA, including shock, fatigue, trauma, infection, feeling cold and dampness, genetic factors and so on. In recent years, due to various studies, in addition to the observation of
comparative anatomy and various clinical and biochemical testing of and by the immunological discussion, but the patient has been further inflamed synovium of the process, and will appear abnormal immune response following L 1) abnormal patients in common, and blood and synovial fluid appears autoantibodies (autoantibody), and these antibodies are and complement activation. (2) the first from the synovial membrane can be determined from the patient is responsible for some of the immune aggregation of monocytes (monocytoid cell) and lymphocytes (lymphocyte), these cells can lead to local immune response. (3) The cells can produce soluble medium (soluble me-diator), inflammatory cells to provide nutrients, and produce enough to destroy cartilage enzyme (enzyme).
The pathogenic mechanism of RA (pathogenic mechanism) was:
macrophages (macrophage) to external or internal stimuli, such as viruses (virus), bacteria (bactera), lymph motilin (lymphokines) of
stimulation, cells secrete factors - I (interleukin-1) caused by heat, and produce inflammatory chemical medium (chemical mediators) and the destruction of tissue enzymes; side also stimulate B cells (B cell) antibodies, and to T cells (T cell) value Then a series inflammation, cell infiltration (infiltration), synovial hypertrophy and cartilage degradation diseases.
At present the RA etiology (etiology) not yet fully understood, it is still based on the experience of modern medical treatment.
However, it can only be a temporary failure to cure, and have our well-known adverse side-effects (Table 1), and even more unbearable than the original disease. Contrast, traditional Chinese medicine has a special point of view and different from modern medicine and the treatment does not focus on the pathogenesis of the organ, but
rather focus on improving the overall conditions of patients.
Because of the role of traditional Chinese medicine with compound conditioning, so we look forward to this disease, immune system deficiencies, develop effective and less side effects known to find traditional Chinese medicine to reduce the suffering of patients during long-term treatment.
According to traditional Chinese medical theory, RA is a "polio."
"Bi were also closed, has been closed by the blood for the evil may not pass the disease also." (Jing Yue Quan Shu) "via" long record:
"wind, cold, wet, three hybrid Stagnation also, its trend were to line Bi Sheng, the winner for the Tongbi cold, humidity winner as the paralysis. "You Yue:" Bi is the bone, the emphasis vein, the blood clotting and not flow; is the flexor tendon is not stretched, while the meat is heartless is that skin is cold pain who are cold and more.
"The main symptoms of polio, the skin, joint pain, swelling, burning or local swelling. If long time, diseases, and vulnerable to physical Spasm or joint deformation. Road treatment should be subject to wind, cold, wet embolism explore the clear, the "disease of
governance" principles are imposed expelling wind, and cold,
dampness, to heat the agent, a fundamental therapy, the pain from the only ; the disease since the addition is wrong! Therefore, the concept of the above, from the Treatise on the Golden Chamber, the daughter side, the medical side Annals other books, selected 12 kinds of prescriptions (Table 2) for biological activity. Although the RA as autoimmune disease, but disease for the development of synthetic drugs, do not proceed from immunology, and more from the improvement of edema, inflammation of the clinical symptoms.
Many patients because of intolerable pain and only resort to
doctors, so of animal model set, also from the pain started, then is the anti-inflammatory, anti-edema. Looking forward to get a good analgesic, anti-inflammatory, anti-edema effect, to the blood or synovial in-depth study, the antibody and cellular elements of the change, but the tentacles extend into the realm of immunology.
This paper first assessment of prescription medicine commonly used in clinical treatment, the most significant effect of the
prescription for the Maxing Yi-Gan Tang. The prescription ephedra
oil, almonds, Coix seed, consisting of licorice, herbs not only easy to get, and have significant analgesic, anti-edema effect, even with immunosuppression.
As is the clinical practice of Chinese medicine prescriptions for the treatment of drug research and development of a system for the
"Chinese proprietary quality standard" methods, we use the natural separation, by column chromatography (column chrom-atography), together with biological activity (bio-assay) of the tracking method to physical activity as an index, dividing one part from the activity, and high-speed liquid chromatography (High performance liquid
chromatography, HPLG) and the standard for the trace characterization of the active ingredient and quantitative analysis. This method can be applied to the present is affected by the quality control of
traditional Chinese medicine preparation, so not only can ensure its quality and efficacy, but also enhance the standard of the
pharmaceutical industry of traditional Chinese medicine, the health protection of citizens.
