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The antihypertensive effect of the berberine derivative 6-protoberberine in spontaneously hypertensive rats.

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The antihypertensive effect of the berberine derivative 6-protoberberine in spontaneously hypertensive rats.

劉如濟;陳保羅

Ju-Chi Liu;Paul Chan;Yi-Jen Chen;Brian Tomlinson;Sheu-Fang Hong;Juei-Tang Cheng

摘要

Abstract

Berberine is a natural isoquinoline alkaloid found in plants of the Ranunculaceae and Berberidaceae families. Extracts from berberine-containing plants have been used as traditional Chinese folk remedies for centuries. The antihypertensive effects of the berberine derivative 6-protoberberine (PTB-6) were studied in spontaneously hypertensive rats (SHRs). In conscious SHRs, PTB-6 lowered the systolic blood pressure in a dose-dependent manner (6-PTB: 5 mg/kg, -31.1 ± 1.6 mm Hg; 10 mg/kg, -42.4 ± 3.1 mm Hg). Cardiac output using the thermodilution method was reduced in PTB-6-treated anesthetized SHRs with a tendency to decrease in heart rate. Injection of PTB-6 into the intracerebral ventricles of SHRs lowered the systolic arterial blood pressure and heart rate. The berberine derivative PTB-6 is an effective antihypertensive agent. The mechanism of the antihypertensive effect of PTB-6 is probably through a central sympatholytic effect.s

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