[PDF] Top 20 CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin-dependent pathway

... with CCN3 increased p65 translocation into nucleus and p65 binding to NF-B site on MMP-13 ...Ly294002 and Akt inhibitor reduced CCN3-mediated p65 translocation ... See full document

... subunit in the adhesion, extravasation and migration of T24 human bladder carcinoma ...phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-beta1 in ... See full document

... mAb and FAK(Y397F) mutant, indicating that the a 5 b 1 integrin and FAK occur as the upstream molecules involved in WISP-1-induced activation of ...with chondrosarcoma distant ... See full document

... Jun and Fos families of transcription ...dimerization through their leucine zipper ...that CCN6 induced c-Jun phosphorylation. In addition, c-Jun siRNA abolished the CCN6-induced ... See full document

... INTRODUCTION: Chondrosarcoma is characterized by a high malignant and metastatic ...proliferation, motility and promote invasion of tumor ...activity in human ... See full document

... NF-IL-6, and AP-1 box in the 5' region of the IL-6 gene ...occurs in a highly stimulus-specific or cell-specific manner ...AP-1 and NF-B activation contributes to CTGF- induced IL-6 ... See full document

... PI3K/Akt pathway is a major cascade mediating activation of the NF-B signaling pathway in human cancer cells [Sliva, ...phosphorylation in human chondrosarcoma ... See full document

... activity and integrin ...role in the expression of integrin and migration of human chondrosarcoma ...suggested, and all of them rely on sequentially ... See full document

... NF-κB路徑增加αvβ3 integrin的表現及人類軟骨肉瘤細胞移行 BMP- 7 promotes αvβ3 integrin expression and cell motility through c-Src, PI3K/Akt, and NF-κB signaling ... See full document

... ABSTRACT Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant ...present in eukaryotic cells, and plays a crucial role in ... See full document

... Abstract Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant ...metastasis. Chondrosarcoma shows a predilection for metastasis to the ... See full document

... expressed in a variety of malignancies, insights into the mechanisms related to the anti-tumor activity of AR targeted therapy might help improve chondrosarcoma ...therapy. In chondrosarcoma, ... See full document

... cartilage and bone formation. In recent years, BMP-7 is also defined as a potent promoter of cell motility, invasion, and ...BMP-7 and its cellular function in ... See full document

... novel and adequate therapy strategies are necessary . Tumor invasion and metastasis are the critical steps in determining the aggressive phenotype of human ...Mortality in cancer ... See full document

... inhibitor, and mitogen-activated protein kinase (MEK) inhibitors (PD98059 and U0126) inhibited the Cyr61-induced increase of the migration and MMP-3 up-regulation of OSCC ...MEK, ... See full document

... MIF in chondrosarcoma are mostly ...molecules in mammalian cells and have been associated with metastasis of cancer ...increased cell surface expression of v3 ... See full document

... the expression of α6β1 integrin and the migration ability in human chondrosarcoma ...activities and the expression of α6β1 integrin were inhibited by the ... See full document

... INTRODUCTION: Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant ...tumor and accounts for about 25% of all malignant bone ...commonly ... See full document

... 5 integrin in human cancer cells ...migration and 5 integrin expression in human chondrosarcoma cells and that inhibitors of the ... See full document

... locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the ...status and outcomes of ...of human chondrosarcoma cells is mostly ...migration ... See full document