[PDF] Top 20 Mechanisms involved in the antiplatelet activity of tetramethylpyrazine in human platelets.

... seizures in pregnant women with hypertension (Lucas et al, 1995). The principal objective of this study was to describe the detailed mechanisms involved in the ... See full document

... inhibited the intracellular free Ca2+ rise of Fura 2-AM loaded platelets stimulated by collagen (5 ...mM), tetramethylpyrazine has also been shown to influence the binding of ... See full document

... At a higher concentration (1.0 mM), tetramethylpyrazine has also been shown to influence the binding of FITC-triflavin to platelet glycoprotein IIb/IIIa complex. Triflavin, a specific [r] ... See full document

... In this study, ketamine concentration-dependently (100-350 microM) inhibited platelet aggregation both in washed human platelet suspensions and platelet-rich plasma stimulated by agoni[r] ... See full document

... Abstract In this study, magnesium sulphate dose-dependently ...aggregation in human platelets stimulated by ...with the binding of fluorescein isothiocanate-triflavin to ... See full document

... (1) Magnesium sulphate may initially induce membrane fluidity changes with resulting interference of fibrinogen binding to the GPIIb/IIIa complex, followed by inhibition of phosphoinos[r] ... See full document

... agent. The aim of this study was to systematically examine the inhibitory mechanisms of midazolam in platelet ...METHODS: The inhibitory mechanisms of ... See full document

... These results indicate that the antiplatelet activity of LTA may be involved in the following pathways: LTA's effects may initially be due to induction of conformational changes in th[r] ... See full document

... These results indicate that the antiplatelet activity of LTA may be involved in the following pathways: LTA's effects may initially be due to induction of conformational changes in the[r] ... See full document

... is in accord with the concept that intracellular Ca 2+ release is responsible for platelet aggregation ...Although the action mechanisms of various platelet aggrega- tion agonists, such ... See full document

... In conclusion, these results indicate that the antiplatelet activity of rutin may involve the following pathways: rutin inhibited the activation of phospholipase C, followed by inhibit[r] ... See full document

... increase the formations of cyclic AMP and nitric oxide/cyclic GMP in ...platelets. In conclusion, these results indicate that the antiplatelet activity of ... See full document

... 英文摘要 Tetramethylpyrazine (TMP) is one of the active ingredient of a Chinese herbal ...medicine. In this study, TMP was tested for its antiplatelet activities in ... See full document

... Tetramethylpyrazine (TMP) 是由天然物 "川芎" 中所萃取純化之生物鹼，本 篇論 文主要的研究目的，在於探討 TMP 抑制血小板凝集反應之作用機轉。 在人類血小板懸浮液中，TMP (0.5-1.5 mM) 隨著濃度的增加而有效地抑制由 多種 ... See full document

... delay human ageing, but also has been convinced for it’s effects on cancer ...decrease the risks of prostate cancer, breast cancer, lung cancer, and so ...During the process of platelet ... See full document

... concentrations of Mg2+ above the normal range have been shown to reduce platelet aggregation (Gawaz et ...al.,1994), the underlying pathophysiological mechanisms are still poorly ... See full document

... phosphorylation of a protein of Mr 47,000 (P47), a marker of protein kinase C activation, was triggered by PDBu (150 ...nM) in [-32P] ATP-labeled human platelets. In ... See full document

... nM) in [ -32P] ATP-labeled human platelets. In conclusion, our study suggested that the possible pathways of anti-platelet activity of C-PC may involve the ... See full document

... increased the cGMP level, but not increased cyclic AMP formation in washed human ...platelets. In conclusion, we suggest that the mechanisms of a-NF may be ... See full document

... midazolam in platelet aggregation were explored by means of analysis of the platelet glycoprotein IIb-IIIa complex, phosphoinositide breakdown, intracellular Ca+2 mobilization, measurement ... See full document