1. Kunz, B. A., Kohalmi, S. E., Kunkel, T.A., Mathews, C. K., McIntosh, E. M.
& Reidy, J. A. (1994) International Commission for Protection Against Environmental Mutagens and Carcinogens Deoxyribonucleoside triphosphate levels:
a critical factor in the maintenance of genetic stability. Mutat. Res. 318:1-64.
2. Bebenek, K., Roberts, J. D. & Kunkel, T. A. (1992) The effects of dNTP pool imbalances on frameshift fidelity during DNA replication. J. Biol. Chem. 267: 3589-96.
3. Niida, H., Shimada, M., Murakami, H. & Nakanishi, M. (2010) "Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells." Cancer Sci. 101: 2505-2509.
4. Ayusawa, D., Shimizu, K., Koyama, H., Kaneda, S., Takeishi, K. & Seno, T. (1986)
"Cell-cycle-directed regulation of thymidylate synthase messenger RNA in human diploid fibroblasts stimulated to proliferate." J. Mol. Biol. 190: 559-567.
5. Daws, T. D. & Fuchs, J. A. (1984) Isolation and characterization of an Escherichia coli mutant deficient in dTMP kinase activity. J. Bacteriol. 157:440-4.
6. Chimploy, K. & Mathews, C. K. (2001) Mouse ribonucleotide reductase control:
influence of substrate binding upon interactions with allosteric effectors. J. Biol.
Chem. 276:7093-100.
7. Nordlund, P. & Reichard, P. (2006) "Ribonucleotide reductases." Annu. Rev.
Biochem. 75: 681-706.
8. Rofougaran, R., Vodnala, M. & Hofer, A. (2006) "Enzymatically active mammalian ribonucleotide reductase exists primarily as an alpha6beta2 octamer." J. Biol. Chem.
281: 27705-27711.
9. Fairman, J. W., Wijerathna, S. R., Ahmad, M. F., Xu, H., Nakano, R., Jha, S., Prendergast, J., Welin, R. M., Flodin, S., Roos, A., Nordlund, P., Li, Z., Walz, T. &
Dealwis, C. G. (2011) "Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization." Nat. Struct. Mol.
Biol. 18:316-322.
10. Eriksson, S., Graslund, A., Skog, S., Thelander, L. & Tribukait, B. (1984) "Cell cycle-dependent regulation of mammalian ribonucleotide reductase. The S phase-correlated increase in subunit M2 is regulated by de novo protein synthesis." J. Biol.
Chem. 259: 11695-11700.
11. McIntosh, E. M. & Haynes, R. H. (1986) "Sequence and expression of the dCMP deaminase gene (DCD1) of Saccharomyces cerevisiae." Mol. Cell Biol. 6:1711-1721.
12. McIntosh, E. M. & Haynes, R. H. (1984) "Isolation of a Saccharomyces cerevisiae mutant strain deficient in deoxycytidylate deaminase activity and partial characterization of the enzyme." J. Bacteriol. 158: 644-649.
13. Giroir, L. E. & Deutsch, W. A. (1987) "Drosophila deoxyuridine triphosphatase.
Purification and characterization." J. Biol. Chem. 262: 130-134.
14. Bianchi, V., Pontis, E. & Reichard, P. (1987) "Regulation of pyrimidine deoxyribonucleotide metabolism by substrate cycles in dCMP deaminase-deficient V79 hamster cells." Mol. Cell. Biol. 7: 4218-4224.
15. Rode, W., Scanlon, K. J., Moroson, B. A. & Bertino, J. R. (1980) Regulation of thymidylate synthetase in mouse leukemia cells (L1210). J. Biol.
Chem. 255: 1305-11.
16. Liu, J., Schmitz, J. C., Lin, X., Tai, N., Yan, W., Farrell, M., Bailly, M., Chen, Tm.
& Chu, E. (2002) Thymidylate synthase as a translational regulator of cellular gene expression. Biochim. Biophys. Acta. 1587: 174-82.
17. Bello, L. J. (1974) Regulation of thymidine kinase synthesis in human cells. Exp.
Cell. Res. 89: 263-74.
18. Sherley, J. L. & Kelly, T. J. (1988) Regulation of human thymidine kinase during the cell cycle. J. Biol. Chem. 26: 8350-8.
19. Ke, P. Y. & Chang, Z. F. (2004) Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway. Mol. Cell. Biol. 24 :514-26.
20. Lee, L. S. & Cheng, Y. (1977) Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia. J. Biol. Chem. 252: 5686-91.
21. Huang, S. H., Tang, A., Drisco, B., Zhang, S. Q., Seeger, R., Li, C. & Jong, A. (1994) Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. DNA Cell Biol. 13: 461-71.
22. Reynes, J. P., Tiraby, M., Baron, M., Drocourt, D. & Tiraby, G. (1996) "Escherichia coli thymidylate kinase: molecular cloning, nucleotide sequence, and genetic organization of the corresponding tmk locus." J. Bacteriol. 178: 2804-2812.
23. Coppock, D. L. & Pardee, A. B. (1987) Control of thymidine kinase mRNA during the cell cycle. Mol. Cell Biol. 7: 2925–2932.
24. Ostermann, N., Schlichting, I., Brundiers, R., Konrad, M., Reinstein, J., Veit, T., Goody, R. S. & Lavie, A. (2000) Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate. Structure. 8: 629-42.
25. Brundiers, R., Lavie, A., Veit, T., Reinstein, J., Schlichting, I., Ostermann, N., Goody, R. S. & Konrad, M. (1999) Modifying human thymidylate kinase to potentiate azidothymidine activation. J. Biol. Chem. 274: 35289-92.
26. Lavie, A., Vetter, I. R., Konrad, M., Goody, R. S., Reinstein, J.& Schlichting, I. (1997) Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation. Nat. Struct. Biol. 4: 601-4.
27. Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reinstein, J., Goody, R. S., Konrad, M. & Schlichting, I. (2000) "Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP." J. Mol. Biol. 304: 43-53.
28. Furman, P. A., Fyfe, J. A., Clair, M. H. St, Weinhold, K., Rideout, J. L., Freeman, G.
A., Lehrman, S. N., Bolognesi, D. P., Broder, S., Mitsuya, H. and et al. (1986)
"Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase." Proc. Natl.
Acad. Sci. 83: 8333-8337.
29. Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, C., Konrad, M. &
Lavie, A. (2003) "Structures of human thymidylate kinase in complex with prodrugs:
implications for the structure-based design of novel compounds." Biochemistry 42:
2568-2577.
30. Haouz, A., Vanheusden, V., Munier-Lehmann, H., Froeyen, M., Herdewijn, P., Van Calenbergh, S. & Delarue, M. (2003) "Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism." J. Biol. Chem. 278: 4963-4971.
31. Munier-Lehmann, H., Chaffotte, A., Pochet, S. & Labesse, G. (2001) "Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes." Protein Sci. 10: 1195-1205.
32. Garg, D., Henrich, S., Salo-Ahen, O. M., Myllykallio, H., Costi, M. P. & Wade, R.
C. (2010) "Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs." J. Med. Chem. 53: 6539-6549.
33. Longley, D. B., Harkin, D. P. & Johnston, P. G. (2003) "5-fluorouracil: mechanisms of action and clinical strategies." Nat. Rev. Cancer 3: 330-338.
34. Sandmair, A. M., Loimas, S., Puranen, P., Immonen, A., Kossila, M., Puranen, M., Hurskainen, H., Tyynela, K., Turunen, M., Vanninen, R., Lehtolainen, P., Paljarvi, L., Johansson, R., Vapalahti, M. & Yla-Herttuala, S. (2000) "Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses." Hum. Gene Ther. 11: 2197-2205.
35. Hu, C. M. & Chang, Z. F. (2010) "A bioluminescent method for measuring thymidylate kinase activity suitable for high-throughput screening of inhibitor." Anal.
Biochem. 398: 269-271.
36. Harrap, K. R., Hill, B. T., Furness, M. E. & Hart, L. I. (1971) "Sites of action of amethopterin: intrinsic and acquired drug resistance." Ann. N. Y. Acad. Sci. 186: 312-324.
37. Hitchings, G. H. (1971) "Folate antagonists as antibacterial and antiprotozoal agents." Ann. N. Y. Acad. Sci. 186: 444-451.
38. Schmitz, S. H., Scheding, S., Voliotis, D., Rasokat, H., Diehl, V. & Schrappe, M.
(1994) "Side effects of AZT prophylaxis after occupational exposure to HIV-infected blood." Ann. Hematol. 69: 135-138.
39. Pommier, Y., Leo, E., Zhang, H. & Marchand, C. (2010) "DNA topoisomerases and their poisoning by anticancer and antibacterial drugs." Chem. Biol. 17: 421-433.
40. Kaeser, M. D., Pebernard, S. & Iggo, R. D. (2003) Regulation of p53 stability and function in HCT116 colon cancer cells. J. Biol. Chem. 279: 7598-605.
41. Zhou, M., Gu, L., Li, F., Zhu, Y., Woods, W. G. & Findley, H. W. (2002) DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells. J. Pharmacol Exp. Ther. 303: 124-31.
42. Ravizza, R. , Gariboldi, M. B., Passarelli, L. & Monti, E. (2004) Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin. BMC
Cancer. 4: 92.
43. Hu, C. M., Yeh, M. T., Tsao, N., Chen, C. W., Gao, Q. Z., Chang, C. Y., Lee, M. H., Fang, J. M., Sheu, S. Y., Lin, C. J., Tseng, M. C., Chen, Y. J. & Chang, Z. F. (2012) Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair. Cancer Cell. 22: 36-50.
44. Hu, C. M. & Chang Z. F. (2008) "Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status." Cancer Res. 68: 2831-2840.
45. Niida, H., Katsuno, Y., Sengoku, M., Shimada, M., Yukawa, M., Ikura, M., Ikura, T., Kohno, K., Shima, H., Suzuki, H., Tashiro, S. & Nakanishi, M. (2010) "Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase." Genes Dev. 24: 333-338.
46. Traut, T. W. (1994) "Physiological concentrations of purines and pyrimidines." Mol.