• 沒有找到結果。

第五章 討論

第五節 研究限制

本研究環境中家戶樣本數及採樣次數較少,由於採樣時間須 24 小 時,以致大多家戶參與意願不高。且由於採樣採家戶採樣點是以固定點 方式,可代表室內環境 BTEX 濃度,恐無法代表個人每天實際暴露量,

尚須進一步瞭解個人活動時間與空間之分布。另外,被動式採樣器較易 受氣象條件之影響,尤其在室外環境之採樣。另外 2 年研究對象之比較,

大都不相同,可能造成前、後結果比較上之困難。不過此 2 年均為當地 民眾自由參加,且當地民眾流動率較低,並不會影響暴露 BTEX 之濃度 差異。

第六章、結論與建議 第一節、結論

1. 高暴露組居民尿中 t,t-MA 之濃度最高 76.9μg/g cre.,低暴露 47.8μ g/g cre.,對照組則為 48.8μg/g cre.,經性別、年齡及其它變項控制後 高暴露組明顯高於對照組。且 96 年度各組別間皆明顯高於 95 年之 t,t-MA 之濃度。

2. 高暴露組居民室內空氣中 TVOC 之濃度為 31.65ppb、對照組

18.30ppb,高暴露組室外濃度則為 3.81ppb、對照組 2.07ppb,無論暴 露組或對照組室內環境空氣中 BTEX 濃度明顯高於室外,但高暴露組 與對照組室內、外環境 BTEX 濃度並無顯著性差異。另外,在室內為 環境中以廚房 BTEX 濃度較高,客廳濃度最低。

3. 在環境採樣對象中,高暴露組與對照組尿中 t,t-MA 之濃度無統計上 之差異。與其室內空氣中苯濃度之相關性分別為 0.56 與 0.87,但無 顯著性之相關。

4. 本研究所建立之中科附近住戶室內、外空氣中 BTEX 濃度及居民尿中 苯代謝物 t,t-MA 之濃度資料,可做為中部科學工業園區台中基地營 運背景之參考資料。

第二節、建議

1. 中科營運過程中必須長時間追蹤空氣污染之相關資料,藉此評估附近 居民之暴露程度,以及建立其它氣象、交通密度及工廠污染源排放等 背景資料,釐清污染物來源。儘早建立附近居民之相關健康指標,用 以評估排放之污染物濃度對身體健康使否造成威脅。

2. 中科管理局除須定期針對工廠進行污染物濃度排放管制及監控外,定 期提出相關報告外,亦與附近居民建立溝通平台,降低資訊不對等及 相關之抗爭。

3. 在高暴露組只有甲苯無論室內、外濃度皆高於對照組,且室內 BTEX 濃度之相關矩陣中,高暴露組相較於對照組可知甲苯與苯、乙苯、

TVOCs 之相關性皆較差,顯示高暴露組甲苯濃度易受外在環境之影 響。

4. 本研究為持續追蹤中科附近民眾暴露 BTEX 濃度與其代謝之研究,可 進一步整合其他研究報告,作為長期建立附近居民之健康風險評估及 環境監測之基本資料,以改善中科園區管制排放污染物之參考。

參考文獻 七月三日行政院環境保護署環署空字第 0910038996 號修正發佈第二 條附表,行政院環保署. 2002.

3. 劉沁瑋. 新竹科學工業園區空氣污染物總量排放推估及 ISCST3 擴散 模式應用. 國立交通大學碩士論文. 2002.

4. 勞工安全衛生研究所. 物質安全資料表,台北. 勞工安全衛生研究所.

2007.

5. International Agency for Research on Cancer (IARC) Moteocrocth.

Chemicals, industrial processes and industries associated with cancer in humans. Supplement 7, Lyon, France. 1987.

6. Martinez-Velazquez M, Maldonado V, Ortega A, et al.Benzene metabolites induce apoptosis in lymphocytes. Exp Toxicol Pathol.

2006;58(1):65-70.

7. Lan Q, Zhang L, Li G. Hematotoxicity in workers exposed to low levels of benzene. Science. 2004;306:1774-6.

8. Fung YS, Zucheng W. Determination organic compounds in air using a dehumidified and ventilated diffusive sampler, thermal desorption and gas chromatography with flame ionization detection. Analyst.

1991;121:1955-61.

9. Dwight WU, Chares EF. Boundary layer effect in diffusive monitoring.

Anal Chem. 1991;63(10):1011-3.

10. EPA US. The Determination of volatile organic compounds(VOCs) in ambient air using specially prepared canister with subsequent analysis by

gas chromatography. Compendium method TO - 14A. 1999.

11. EPA US. The Determination of volatile organic compounds(VOCs) in ambient air using specially prepared canister with subsequent analysis by gas Chromatography/Mass Spectrometry(GC/MS), Compendium method TO - 15. 1999.

12. 徐儆暉. 被動式採樣器之介紹. 勞工安全衛生簡訊 1993 第 5 期. 1993.

13. Martin H. Sorbent trapping of volatile organic compounds from air. J Chromatogr A. 2000;885:144.

14. 勞工安全衛生研究所. 行政院勞委會標準分析參考方法,台北. 勞工安 全衛生研究所採樣分析參考方法資料庫. 2007.

15. Pristas R. Passive badges for compliance monitoring internationally. Am Ind Hyg Assoc J. 1994;55:841-4.

16. 林嘉明, 石東生, 吳麗珠. 被動式採樣氣研究發展回顧. 勞工安全衛生 研究季刊. 1994;2(1):65-75.

17. 林嘉明, 石東生, 吳麗珠. 被動式採樣器性能評估準則之探討. 勞工安 全衛生研究季刊. 1994;2(2):67-84.

18. Elke K, Jermann E, Begerow J, et al. Determination of benzene, toluene, ethylbenzene and xylenes in indoor air at environmental levels using diffusive samplers in combination with headspace solid-phase

microextraction and high-resolution gas chromatography-flame ionization detection. J Chromatogr A. 1998;826(2):191-200.

19. 李志宏. 空氣中 BTEX 及媖之濃度分佈. 國立清華大學原子科學研究 所碩士論文. 1998.

20. Scherer G, Renner T, Meger M. Analysis and evaluation of trans,trans-muconic acid as a biomarker for benzene exposure. J Chromatogr B Biomed Sci Appl. 1998;717(1-2):179-99.

21. Johnson ES, Langard, Sverre Lin, et al. A critique of benzene exposure in

22. 謝俊明. 生物偵測. 勞工安全衛生簡訊. 1994(9).

23. Ong CN, Lee BL. Determination of benzene and its metabolites:

application in biological monitoring of environmental and occupational exposure to benzene. J Chromatogr B 1994;660:1-22.

24. Ong CN, Kok P, Lee BL, et al. Evaluation of biomarkers for occupational exposure to benzene. Occup Environ Med. 1995;52(8):528-33.

25. Inoue, Seiji K, Nakatsuka H, et al. Urinary t,t-muconic acid as an indicator of exposure to benzene. British Journal ofIndustrial Medicine.

1989;46:122-7.

26. 官嘉明. 以高效能液相層析儀測定尿中酚類代謝物作為低濃度本暴露 指標之研究. 高雄醫學院公共衛生學研究所碩士論文. 1992.

27. Boogaard PJ, Sittert NJ. Suitability of S-phenyl mercapturic acid and trans,trans- muconic acid as biomarkers for exposure to low

concentrations of Benzene. Environ Health Perspect. 1996;104:1151-7.

28. Lin LC, Chiung YM, Shih JF, et al. Validation of an online dual-loop cleanup device with an electrospray ionization tandem mass

spectrometry-based system for simultaneous quantitative analysis of urinary benzene exposure biomarkers trans, trans-muconic acid and S-phenylmercapturic acid. Anal Chim Acta. 2006;555(1):34-40.

29. Waidyanatha S, Rothman N, Li G, et al. Rapid determination of six urinary benzene metabolites in occupationally exposed and unexposed subjects. Anal Biochem. 2004;327(2):184-99.

30. Lee BL, Ong HY, Ong YB, et al. A sensitive liquid chromatographic method for the spectrophotometric determination of urinary

trans,trans-muconic acid. J Chromatogr B. 2005;818(2):277-83.

31. Qu Q, Melikian AA, Li G, et al. Validation of biomarkers in humans exposed to benzene: Urine metabolites. Am J Ind Med.

2000;37(5):522-31.

32. Lee BL, New AL, Kok PW, Ong HY, Shi CY, Ong CN. Urinary trans,trans-muconic acid determined by liquid chromatography:

Application in biological monitoring of benzene exposure. Clin Chem.

1993;39(9):1788-92.

33. Bartczak A, Kline SA, Yi R, et al. Evaluation of assays for the

identification and quantitation of muconic acid, a benzene metabollte in human urine. J Toxicol Environ Health 1994;42(3):245-58.

34. Melikian AA, Prahalad AK, Hoffmann D. Urinary trans,trans-muconic acid as an indicator of exposure to benzene in cigarette smokers. Cancer Epidemiol Biomarkers Prev. 1993;2(1):47-51.

35. Schroijen C., Baeyens W., Schoeters G., et al. Internal exposure to

pollutants measured in blood and urineof Flemish adolescents in function of area of residence. Chemosphere. 2008;71.

36. Gobba F, Rovesti S, Borella P, et al. Inter-individual variability of benzene metabolism to trans,trans-muconic acid and its implications in the

biological monitoring of occupational exposure. Sci Total Environ.

1997;199(1-2):41-8.

37. Jia C, Batterman S, Godwin C. VOCs in industrial, urban and suburban neighborhoods, Part 1: Indoor and outdoor concentrations, variation, and risk drivers. Atmos Environ. 2008;42:2083-100.

38. Jia C, Batterman S, Godwin C. VOCs in industrial, urban and suburban neighborhoods-Part 2: Factors affecting indoor and outdoor concentrations.

Atmos Environ. 2008;42:2101-16.

39. Sonja NS., Deborah H., Bennet T, et al. Differences in source emission rates of volatile organic compounds in inner-city residences of New York City and Los Angeles. J Expo Anal Environ Epidemiol.

2004;14:S95-S109.

40. Ken S, John LA., Gurumurthy R., et al. Comparison of personal, indoor, and outdoor exposures to hazardous air pollutants in three urban

communities. Sci Total Environ. 2004;38(2):423-30.

41. Simon K, Jamie P, Andrew P, et al. Spatial variations in the concentrations of traffic-related pollutants in indoor and outdoor air in Huddersfield, England. Atmos Environ. 2005;39(34):905-16.

42. 劉原良. Acetone、IPA、MEK 及 BTEX 之濃度分佈. 國立清華大學原

45. Chiu KH, Wu BZ, Chang CC. Distrubution of volatile organic compounds over a Semiconductor Industrial Park in Taiwan. Environ Sci Technol.

2005;39:973-83.

46. Isbell MA, Stolzberga RJ, Duffy LK. Indoor climate in interior Alaska:

simultaneous measurement of ventilation, benzene and toluene in

residential indoor air of two homes. SCI Total Environ. 2005;345:31-40.

47. Rehwagen M, Schlink U, Herbarth O. Seasonal cycle of VOCs in apartments. Indoor Air. 2003;13:283–91.

48. Schlink U, Rehwagen M, Damm M, et al. Seasonal cycle of indoor-VOCs:

comparison of apartments and cities. Atmos Environ. 2004;38:1181–90.

49. Edwards RD, Jantunen MJ. Benzene exposure in Helsinki, Finland. Atmos Environ. 2001;35:1411-20.

50. Fondelli MC, Bavazzano P, Grechi D, et al. Benzene exposure in a sample of population residing in a district of Florence, Italy. Sci Total Environ.

2008;392(1):41-9.

51. Manini P, De Palma G, Andreoli R, et al. Biological monitoring of low benzene exposure in Italian traffic policemen. Toxicology Letters.

2008;181(1):25-30.

52. Barr DB, Wilder LC, Caudill SP. Urinary creatinine concentrations in the U.S.population:implications for urinary biological monitoring

measurements. Environ Health Perspect. 2005;113.

53. (WHO) WHO. Biological monitoring of chemical exposure in the workplace. World Health Organization 1996.

54. Wiwanitkit V, Suwansaksri J, Soogarun S. Monitoring of urine trans, trans-muconic acid level among smokers and non-smokers. Respir Med.

2005;99(6):788-91.

55. Fustinoni S, Buratti M, Campo L, et al. Urinary t,t-muconic acid, S-phenylmercapturic acid and benzene as biomarkers of low benzene exposure. Chem Biol Interact. 2005;153-154:253-6.

56. Wallace LA, Pellizzari ED, Hartwell TD, et al. The team study: Personal exposures to toxic substances in air, drinking water, and breath of 400 residents of New Jersey, North Carolina, and North Dakota. Environ Res.

1987;43(2):290-307.

57. Rappaport SM, Waidyanatha S, Qu Q, et al. Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolism.

Cancer Res. 2002;62(5):1330-7.

58. Lin YS, McKelvey W, Waidyanatha S, et al. Variability of albumin adducts of 1,4-benzoquinone, a toxic metabolite of benzene, in human volunteers. Biomarkers. 2006;11:14-27.

59. 許麗秋. 尿中 BTEX 與其代謝產物關係之研究. 中國醫藥大學環境醫 學研究所. 台中 2000.

60. Qu Q, Shore R, Li G, et al. Biomarkers of benzene: Urinary metabolites in relation to individual genotype and personal exposure. Chem Biol Interact.

2005;153-154:85-95.

61. Liu L, Zhang Q, J F. The study of DNA oxidative damage in benzene-

exposed workers. Mutat Res. 1996;370:145-50.

62. 工業技術研究院環境與安全衛生技術發展中心. 有機氣體被動式採樣 器採樣分析簡介. 工業技術研究院.

63. David R. The role of metabolism and specific metabolites in

benzene-induced toxicity: evidence and issues. J Toxicol Environ Health A.

2000;61:357-72.

64.Bruckner, Warren, Bruckner JV, et al. Toxic effects of solvents and vapors.

In: CD Klaassen, Editor, Casarett & Doull's Toxicology The Basic Science of Poisons, McGraw-Hill, USA (2001). 2001.

65. Kivist H, Pekari K, Peltonen K, et al. Biological monitoring of exposure to benzene in the production of benzene and in a cokery. Sci Total Environ.

1997;199(1-2):49-63.

66. Fracasso ME, Doria D, Bartolucci GB, et al. Low air levels of benzene:

Correlation between biomarkers of exposure and genotoxic effects.

Toxicol Lett. 2009;In Press, Corrected Proof.

67. Xie J, Wang X, Sheng G, et al. Determination of tobacco smoking influence on volatile organic compounds constituent by indoor tobacco smoking simulation experiment. Atmos Environ. 2003;37(24):3365-74.

68. Wallace L.A major sources of benzene exposure. Environ Health Perspect.

1989;82:165-9.

69. Lin YS, Mckelvey W, Waidyanatha S, et al. Variability of albumin adducts of 1,4-benzoquinone, a toxic metabolite of benzene, in human volunteers. Biomarkers. 2006;11:14-27.

70. Wallace L. Environmental exposure to benzene: An update. Environ Health Perspect. 1996;104(6):1129-36.

71. Gordon SM, Wallace LA, Brinkman MC, et al. Volatile organic

compounds as breath biomarkers for active and passive smoking. Environ Health Perspect. 2002;110(7):689-98.

72. Johnson SH, G. Netto, G. Lucier, Bechtold W, Henderson R. Detection of

low level benzene exposure in supermarket wrappers by urinary muconic acid. Biomarkers. 1999;4:109-17.

73. Weaver VM, Davoli CT, Heller PJ, et al. Benzene exposure, assessed by urinary trans, trans-muconic acid, in urban children with elevated blood lead levels. Environmental Health Perspectives. 1996;104(3):318-23.

74. Weaver VM, Buckley T, Groopman JD. Lack of specificity of

trans,trans-muconic acid as a benzene biomarker after ingestion of sorbic acid-preserved foods. Cancer Epidemiol Biomark Prev. 2000;9:749-55.

75. Gobba F, Rovesti S, Borella P, et al. Inter-individual variability of benzene metabolism to trans,trans-muconic acid and its implications in the

biological monitoring of occupational exposure. Sci Total Environ 1997;199:41-8.

76. 行政院衛生署. 食品添加物使用範圍及限量暨規格標準,行政院衛生 署. 2009.

77. Ruppert T, Scherer G, Tricker AR, et al. trans,trans-muconic acid as a biomarker of non-occupational environmental exposure to benzene. Int Arch Occup Environ Health 1997;69:247-51.

78. Yu R, Weisel CP. Measurement of benzene in human breath associated with an environmental exposure. J Expo Anal Environ Epidemiol 1996;6.

79. Pezzagno G, Maestri L, Fiorentino ML. Trans,trans-muconic acid, a biological indicator to low levels of environmental benzene: some aspects of its specificity. Am J Ind Med. 1999;35:511-8.

80. Scherer G, Ruppert T, Daube H, et al. Contribution of tobacco smoke to environmental benzene exposure in Germany. Environ Int.

1995;21(6):779-89.

81. SKC. SKC 575-001and 575-001MC passive samplers methylene chloride method summary (25ppm PEL validation to NIOSH Protocol). SKC Technical note 1992.

82. 王文忻, 石東生, 何國榮. 作業環境有害物採樣分析參考方法驗證程 序第二版. 行政院勞工委員會. 2002 年 10 月公告.

83. 范智婷. 傢具行與一般居家 BTEX 及甲醛之暴露探討. 高雄醫學大學.

2003.

84. Perry R, Gee IL. Vehicle emissions and effects on air quality: indoors and outdoors. Indoor Environ 1994;3:224-36.

85. 行政院環保署. 光化學測站日平均查詢,行政院環保署 2007 年。.

86. Hinwood AL, Rodriguez C, Runnion T, et al. Risk factors for increased BTEX exposure in four Australian cities. Chemosphere.

2007;66(3):533-41.

87. Matiana RA, Pablo CF, Arthur MW, et al. Measurements of personal exposure to nitrogen dioxide in four Mexican cities in 1996. Air Waste Manag Assoc. 2002;52:50-7.

88. Simoni M, Jaakkola MS, Carrozzi L, et al.. Indoor air pollution and

respiratory health in the elderly. Eur J Respir Dis Suppl. 2003;40:15s-20s.

89. D'Souza JC, Jia C, Mukherjee B, et al. Ethnicity, housing and personal factors as determinants of VOC exposures. Atmos Environ.

2009;43(18):2884-92.

90. Baek SO., Kim YS., Perry R. Indoor air quality in homes, offices and restaurants in Korean urban areas--indoor/outdoor relationships. Atmos Environ. 1997;31(4):529-44.

91. 陳丁于. 台灣地區室內環境因子對建材揮發性有機物質逸散行為影響 之研究-以清漆為例. 國立成功大學. 2002.

92. Chatzis C, Alexopoulos EC, Linos A. Indoor and outdoor personal exposure to benzene in Athens, Greece. Sci Total Environ.

2005;349(1-3):72-80.

表一

表二

表三

表四

表五

平均數 80.67±128.75 44.88±43.93 60.38±73.57 中位數 43.21 38.46 37.81

表六 表六表六

表六、、、高、高高高暴露組暴露組暴露組暴露組、、、、低低低暴露組低暴露組暴露組暴露組及對照及對照及對照及對照組組組組居民尿中居民尿中居民尿中居民尿中t,t-MA 濃度之濃度之濃度之濃度之單單單單變項迴歸分析變項迴歸分析變項迴歸分析變項迴歸分析

表六、、、高、高高高暴露組暴露組暴露組暴露組、、、、低低低暴露組低暴露組暴露組暴露組及對照及對照及對照及對照組組組組居民尿中居民尿中居民尿中居民尿中t,t-MA 濃度之濃度之濃度之濃度之單單單單變項迴歸分析變項迴歸分析變項迴歸分析變項迴歸分析

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