結論

1. 推測 enterolactone、sesamin、茉莉甲醇萃物及菊花甲醇萃物可能透過抑制 CD36 mRNA 表現，減少細胞對 oxLDL 之攝入，以降低細胞內總膽固醇量，能因此 具有抑制泡沫細胞形成之潛力，而減緩動脈粥狀硬化進程。

2. 所有測試物 (除 enterolactone 外)，皆能顯著下降 IL-1β 及 TNFα 濃度，可能具 有抗發炎的作用。而 Enterolactone、genistein 及苜蓿芽乙酸乙酯萃物皆能顯著 抑制巨噬細胞分泌之 MCP-1 與 MMP-9 濃度，以及 MMP-9 活性，推測他們可 能藉由減少促發炎因子之形成、減少單核球聚集及平滑肌細胞移行，而具有 減緩斑塊之形成或使已形成之斑塊較不易破裂的可能潛力。

3. 所有測試物皆能抑制單核球對受到 oxLDL 刺激之內皮細胞間的黏附情形，推 測可以透過減少內皮細胞與單核球間的黏附，而可能具有減緩泡沫細胞生成 之效用。

含植物性雌激素活性測試物對動脈粥狀硬化相關因子之影響：實驗一 (PMA-differenitiated-THP-1)

enterolactone sesamin Genistein Yam EAE Alfalfa EAE Jasmine

extract

含植物性雌激素活性測試物對動脈粥狀硬化相關因子之影響：實驗二 (HAEC)

enterolactone sesamin Genistein Yam EAE Alfalfa EAE Jasmine extract

Chrysanthemum extract

使用濃度 1µM 50µM 25µM 50µg/ml 100µg/ml 100µg/ml 100µg/ml

Adhesion ↓ ↓ ↓ ↓ ↓ ↓ ↓

MCP-1 secretion NS ↓ NS NS ↓ NS ↓

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在文檔中 數種植物性雌激素對動脈粥狀硬化相關因子之影響 (頁 89-102)