本研究比較雷射針灸組和偽雷射針灸組的療效,結果 BDI 的分數在 治療前後沒有統計上的顯著差異。在 FIQ 方面,以治療前為基點,比較 雷射針灸組和偽雷射針灸組在每次評估時間點和基點的差值,結果三週 治療後兩組在 FIQ 的總分、疼痛、疲倦等皆有明顯改善且有達統計上的 差異(p<0.05)。
雷射針灸組在 BDI、FIQ 總分和次項的分數,三週治療後及完成治 療後的一個月都比治療前進步,但只有疼痛在三週治療後改善的程度達 統計上的意義。偽雷射針灸組在所有評估項目都沒有統計上的顯著。所 以本研究結果發現雷射針灸八能改善纖維肌痛症患者的症狀。
參考資料
1. Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L.The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum.
1995;38(1):19-28.
2. Julius Sim and Nicola Adams. Systematic review of randomized
controlled trials of nonpharmacological interventions for fibromyalgia.
The Clinical Journal of Pain. 2002;18:324-336.
3. Bombardier, Charles H. Buchwald, Dedra. Chronic fatigue, chronic fatigue syndrome, and fibromyalgia: disability and health-care use. Med care. 1996;34(9):924-930.
4. Christophe Deluze, Lorenzo Bosia, Angelica Zirbs, Alex Chantraine, Thomas L Vischer. Electroacupunture in fibromyalgia:results of a controlled trial. BMJ. 1992;.305(21):1249-1251.
5. Nassim P. Assefi, Karen J. Sherman, Clemma Jacobsen, Jack Goldberg, Wayne R. Smith, Dedra Buchwald. A randomized clinical trial of
acupuncture compared with sham acupuncture in fibromyalgia. Ann Intern Med. 2005;143:10-19.
6. Brain M. Beriman, Jeanette Ezzo, Victoria Hadhazy, James P.Swyers. Is acupuncture effective in the treatment of fibromyalgia. J Fam Practice.
1999;48(3):213-218.
7. 黃維三:難經發揮,初版,正中書局,台北,2001,頁291-297。
8. Fatma Inamici, Muhammad B. Yunus. History of Fibromyalgia: Past to Present. Current Pain and Headache Reports. 2004;8:369-378.
9. Moldofsky H: Musculoskeletal symptoms and non-REM sleep
disturbance in patients with "fibrositis syndrome" and healthy subjects.
Psychosom Med. 1975;37:341-351.
10. Yunus M . Primary fibromyalgia (fibrositis): clinical study of 50 patients with matched normal controls. Semin Arthritis Rheum. 1981;11:151-171 11. Wolfe, F. Smythe, H A. Yunus, M B. Bennett, R M. Bombardier, C.
Goldenberg, D L. Tugwell, P. Campbell, S M. Abeles, M. Clark, P.The
American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990 ;33(12):1863-4
12. Baldry, Peter, Yunus. Muhammad B., Inanici. Fatma. Myofascial pain and fibromyalgia syndromes:a clinical guide to diagnosis and management.
Churchill Livingstone, 2001.
13. Philip Mease. Fibromyalgia syndrome: review of clinical presentation pathogenesis, outcome measures, and treatment. J Rheumatol. 2005;
32(suppl 75):6-21.
14. E. Mayhew and E. Ernst. Acupuncture for fibromyalgia-a systematic review of randomized clinical trials. Rheumatology. 2006;1-4.
15. David P Martin; Christopher D Sletten; Brent A Williams; Ines H Berger.
Improvement in fibromyalgia symptoms with acupuncture: results of a randomized controlled trial. Mayo Clin Proc. 2006; 81(6):749-757.
16. Guo X, Jia J. Comparison of therapeutic effects on fibromyalgia
syndrome between dermal-neurological electric stimulation and electric acupuncture. Chinese J Clin Rehab. 2005;9:171-173.
17. Laura C. Holdcraft, Nassim Assefi, Dedra Buchwald. Complementary and alternative medicine in fibromyalgia and related syndromes. Best Practice& Research Clin Rheum. 2003;17(4):667-683.
18. Margareta Sandberg, Britt Larsson, Lars-Goran Lindberg, Bjorn Gerdle.
Peripheral effect of needle stimulation (acupuncture) on skin and muscle blood flow in fibromyalgia. European J Pain. 2004;8:163-171.
19. Richard E. Harris, Xiaoming Tian, David A. Williams, Thomas X. Tian, Thomas R. Cupps, Frank Petzke, Kimberly H. Groner, Pinaki Biswas, Richard H. Gracely, Daniel J. Clauw. Treatment of fibromyalgia with formula acupuncture:investigation of needle placement, needle
stimulation, and treatment frequency. J Alternative & Complementary Med. 2005;11(4):663-671.
20. A Gur, M. Karakoc, K.nas, R. Cevik, J. Sarac, E. Demir. Efficacy of low
power laser therapy in fibromyalgia:a single-blind, placebo-controlled trial. Lasers Med Sci. 2002;17:57-61.
21. 吳濤:針刺激發點與傳統配穴針灸對纖維肌痛綜合征的療效比較。上 海針灸雜誌 1998; (17),4,p19-20.
22. 郭瑩,孫遠征:背部透穴法治療纖維肌痛綜合征。中國針灸 2005;
(2),2,p98-100。
23. Gur A, Karakoc M, Nas K, Cevik R, Sarac J, Ataoglu S. Effects of low power laser and low dose amitriptyline therapy on clinical symptoms and quality of life in fibromyalgia: a single-blind, placebo-controlled trial.
Rheumatol Int. 2002;22(5):188-193.
24. Burckhardt, C.S., Clark, S.R., Bennett, R.M. The fibromyalgia impact questionnaire (FIQ): development and validation. J Rheumatol.
1991;18:728-733.
25. 董桂蘭:八脈交會穴的特點及其臨床應用。江蘇中醫 1998;19(3):34-35。
26. Peter Whittaker. Laser acupuncture: past, present, and future. Lasers in Med Sci. 2004;19:69-80.
27. Axel Finckh, Alfredo Morabia, Christophe Deluze, and Thomas Vischer.
Validation of questionnaire-based response criteria of treatment dfficacy in the fibromyalgia syndrome. Arthritis Care and Research.
1998;11(2):116-123.
28. 顧新,佟方,李京平,李晶:疼痛的評定。現代康復 2000;4(1):86-87。
29. Ali Gur, Aysegul Jale Sarac, Remzi Cevik, Ozlem Altindag, Serdar Sarac.
Efficacy of 904nm gallium arsenide low level laser therapy in the
management of chronic myofascial pain in the neck: a double-blind and randomize-controlled trial. Lasers in Surgery and Med. 2004;35:229-235.
30. Daniel J.Wallace, Daniel J. Clauw. Fibromyalgia and other central pain syndromes. Lippincott Williams & Wikins, 2005.
31. Jeffrey R. Basford, Charles G. Sheffield, William S. Harmsen. Laser therapy: a randomized, controlled trial of the effects of low-intensity
Nd:YAG laser irradiation on musculoskeletal back pain. Arch Phys Med Rehabil. 1999;80:647-652.
32. 明.李時珍:奇經八脈考,收入何清湖等編《中華醫書集成》(北京:
中醫古籍出版社,1999。
33. 程士德:內經,初版,知音出版社,台北,民88,頁385-397。
34. 林昭庚:新針灸大成,第三版,中國醫藥學院針灸研究中心,台中,
民85,頁448-481。
附錄1 貝氏憂鬱量表中文版
附錄2.1 纖維肌痛症影響問卷(英文)
附錄2.2 纖維肌痛症影響問卷(中文)
Treatment of Fibromyalgia with Laser Acupuncture
Shu-Wen Weng
Major Professor: Te-Mao Li
Institute of Acupuncture Sciences, China Medical University
ABSTRACT
Fibromyalgia (FM) is a common chronic pain condition in the rheumatologic diseases. It is female predominant, characterized by widespread pain, accompanied by sleep disturbance and irritable bowel syndrome. There was no consistently effective medical treatments approved, it is common for patients to search for complementary and alternative treatment such as exercise program, behavioral intervention and acupuncture.
In Taiwan, studies of FM is few, however, many patients have tried acupuncture to alleviate chronic pain. Since its difficult to blind patients by way sham of acupuncture. We choose laser acupuncture to deal the patients in this study. In《Nanjing難經》, it was stated that the eight extra meridians are interlated with the twelve regular meridians and perform the functions of dominating, connecting and adjusting the twelve regular meridians.
Acupoints were based on traditional literature and used the Eight Confluent acupoints
.
This will be a randomized, controlled trial to include laser acupuncture, and sham procedure.Fifteen FM patients were recruited from the China Medical Hospital.
The patients were diagnosed according to the ACR criteria of 1990 by experienced physicians. They were randomized to laser acupuncture group(n=8) and shame laser acupuncture group(n=7) , and treated for three times a week for three weeks.
There were no significant improvement in Beck Depression Inventory-II (BDI-II) scores between two groups. Fibromyalgia impact questionnaire(FIQ) total scores and subscale of pain and fatigue scored were significant improved in laser acupuncture group compared with shame group at 3 weeks (p<0.05). We found that laser acupuncture was effective at reducing FM symptoms in this outcome study.
Keywords: laser acupuncture, fibromyalgia, Beck Depression Inventory
,
fibromyalgia impact questionnaire
謝辭
終於完成這份論文,要感謝的人很多。感謝指導教授李德茂老師以及林 昭庚老師在學術與課業上的指導,並在研究不順遂時給予許多幫助與鼓 勵。感謝中國附設醫院陳俊宏醫師熱心協助受試者的篩選,還有中醫部 蘇珊玉醫師、李育臣醫師、黃頌儼醫師等人的協助。感謝李采娟老師在 統計學上的指導,亦感謝許昇峰老師以及其他授課老師在各方面的指 導。最後還要感謝我的家人對我的支持及包容。