經過了針灸安全性 182、183、舒適性 184及甩尾鎮痛179等一系列的 研究，我們確定電針在良好的參數控制下是一項安全又可靠的治療工 具，頗適合臨床推廣運用，而其療效評估更是能否在鎮痛領域中獨顯 風騷的關鍵；現代麻醉技術已經可使病人在手術當中免於疼痛，但在 術後疼痛的緩解效果上卻不是很理想。本研究室先前在臨床止痛上以 結合目前常用的病人自控式止痛法(PCA)探討電針在下腹部手術術後 疼痛的緩解效應 185，證實電針組在恢復室中第一次要求止痛藥的時 間間隔較對照組和偽假電針組為長，的確可延長術後疼痛的發生時 間；且術後一至二十四小時內 PCA 按鈕總次數和嗎啡總需求量均明 顯降低。而在鴉片類相關副作用的研究中，結果顯示電針組噁心、暈 眩的發生率亦明顯減少，可知電計組 PCA 嗎啡需求量的減少，而使 鴉片類相關副作用發生率降低。再經過本次一系列電針刺激與一氧化 氮合成酵素抑制劑 L-NAME 脊髓給藥之鎮痛研究後，我們證實在福 馬林刺激所引起這種頑固性疼痛的鎮痛效果上取得了良好的成效，不 僅可以抑制第二階段的週邊發炎性疼痛反應，對第一階段的中樞反射 性疼痛亦可以輕鬆達到鎮痛的效果，這與早先其他的研究認為第一階 段的中樞反射性疼痛不容易抑制，或須高劑量的藥物如（L-NAME 3000 nM）才有可能達到抑制效果是一項重大的突破，如前所述降低 藥物劑量即所以降低副作用，本研究證實可以結合電針治療的方式降 低 L-NAME 所需的劑量，輕鬆達到完美的止痛效果，將可作為臨床 使用之參考，並驗證了傳統針灸治療的偉大。爾後我們將繼續精研電 針配穴及電針頻率與強度的最佳動物與臨床鎮痛模式，達到針灸劑量 化(acupuncture dosage)的科研目標。作為臨床止痛的指引。
傷害性刺激誘導的中樞內 c-fos 基因的蛋白表達可被一些鎮痛物 質如嗎啡、內源性阿片? 、5-HT、生長抑素、NMDA 受體的拮抗劑 及電針等所抑制，提示 c-fos 不僅是一個"標誌物"，而且也參與了疼
痛的調制 181。電針刺激可透過神經傳導直接在脊髓背角產生抑制作 用，或通過局部迴路抑制性調制間接作用於傷害性感受神經元，更或 是激活下行抑制系統而抑制脊髓背角傷害性感受神經元的傳遞等機 轉達到鎮痛作用，並配合 L-NAME 對 NO 的抑制阻斷疼痛訊息的傳 遞與擴大等機制，阻斷一級、二級與三級等疼痛分子訊息的傳遞，庶 免造成疼痛過敏、觸物感痛以及疼痛時間延長等慢性疼痛的主要症 狀，而臨床上包括手術後疼痛(post operative pain)及幻肢痛(phantom pain)等頑固疼痛，也可以藉由本研究為其臨床止痛開啟一道曙光。
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