Potential Mechanism of Blood Vessels
Protection by Resveratrol, a Red Wine
Component
阮淑慧
Huang HM;Liang YC;Cheng TH;Chen CH;Juan SH
摘要
Abstract
Resveratrol-mediated heme oxgenase-1 (HO-1) induction has been shown to occur in primary neuronal cultures and has been implicated as having potential neuroprotective action. Further, antioxidant properties of resveratrolhave been reported to protect against coronary heart disease. We attempted to examine the HO-1 inducing potency of resveratrol and the regulatory mechanism of its induction in rat aortic smooth muscle cells (RASMC). We showed that resveratrol-induced HO-1 expression was concentration- and
time-dependent. The level of HO-1 expression and its promoter activity mediated by resveratrol was attenuated by nuclear factor-kappa B (NF-κB) inhibitors, but not by mitogen-activated protein kinase (MAPK) inhibitors. Deletion of NF-KB binding sites in the promoter region strongly reduced luciferase activity. Collectively, we suggest that resveratrol-mediated HO-1 expression occurs, at least in part, through the NF-KB pathway.
