Author(s): Peng, CT (Peng, Ching-Tien); Chang, JS (Chang, Jeng-Sheng); Wu, KH (Wu, Kang-Hsi); Tsai, CH (Tsai, Chang-Hai); Lin, HS (Lin, Huan-Sheng)
Title: Mechanisms of and obstacles to iron cardiomyopathy in thalassemia Source: FRONTIERS IN BIOSCIENCE, 13: 5975-5987 MAY 2008
Language: English Document Type: Review
Author Keywords: beta-thalassemia; iron cardiomyopathy; iron cardiotoxicity;
cardioprotective chelation therapy; mechanism; review
KeyWords Plus: SICKLE-CELL-DISEASE; HOMOZYGOUS BETA-THALASSEMIA;
CONGESTIVE-HEART-FAILURE; LOADED CARDIAC MYOCYTES; TRANSFERRIN-BOUND IRON; MYOCARDIAL IRON; MAGNETIC-RESONANCE; PULMONARY-HYPERTENSION;
DIASTOLIC FUNCTION; CHELATING THERAPY
Abstract: Thalassemia is anemia of variable severity, arising from mutations of genes encoding the hemoglobin alpha and beta chains. Severe thalassemia is associated with iron overload, tissue lesions, and high risk for cardiovascular complications, and iron-mediated cardiomyopathy is the main cause of death in this condition. Thalassemia major (TM) patients exhibit cardiovascular abnormalities consistent with chronic anemia; these include
enlargement of the ventricular chambers, increased cardiac output, and reduced total vascular resistance. Cardiac iron overload in TM patients due to long-term transfusion can cause further chamber dilation, decreased contractility, and arrhythmia. Paradoxically, many such patients remain asymptomatic until decompensation occurs. For decades, magnetic
resonance imaging and echocardiography have been performed to detect advanced cardiac dysfunction; however, reliable evaluation tools for the early detection of cardiac abnormalities are currently in demand. This article reviews the mechanisms underlying the development of heart disease in thalassemia and strategies for therapeutic intervention in TM patients with congestive heart failure.
Addresses: [Peng, Ching-Tien] China Med Univ Hosp, Dept Lab Med, Taichung 40414, Taiwan; [Peng, Ching-Tien; Chang, Jeng-Sheng; Wu, Kang-Hsi; Tsai, Chang-Hai] China Med Univ Hosp, Dept Pediat, Taichung 40414, Taiwan; [Peng, Ching-Tien; Tsai, Chang-Hai] Asia Univ, Dept Biotechnol & Bioinformat, Taichung, Taiwan; [Peng, Ching-Tien; Wu, Kang-Hsi;
Lin, Huan-Sheng] Taiwan Thalassemia Assoc, Taichung, Taiwan
Reprint Address: Peng, CT, China Med Univ Hosp, Dept Lab Med & Pediat, 2 Yuh Der Rd, Taichung 40414, Taiwan.
E-mail Address: [email protected]
Cited References: *NOV INC, 1998, SWITZ DESF R PROD MO.
ABRAHAM WT, 2003, CIRCULATION, V108, P2596, DOI 10.1161/01.CIR.0000096580.26969.9A.
ADVANI R, 1992, BLOOD, V79, P1058.
AESSOPOS A, 2001, BLOOD, V97, P3411.
AESSOPOS A, 2004, EUR J HAEMATOL, V73, P359.
ALDOURI MA, 1990, ACTA HAEMATOL-BASEL, V84, P113.
ANDERSON LJ, 2001, EUR HEART J, V22, P2171.
ANDERSON LJ, 2002, LANCET, V360, P516.
ANDERSSON AJ, 2004, FRONT ECOL ENVIRON, V2, P348.
BACON BR, 1985, HEPATOLOGY, V5, P789.
BAROSI G, 1989, EUR J HAEMATOL, V42, P382.
BORER JS, 1977, AM J CARDIOL, V39, P184.
BORGNAPIGNATTI C, 1998, ANN NY ACAD SCI, V850, P227.
BORGNAPIGNATTI C, 2004, HAEMATOLOGICA, V89, P1187.
BORGNAPIGNATTI C, 2006, BLOOD, V107, P3733, DOI 10.1182/blood-2005-07-2933.
BRITTENHAM GM, 1994, NEW ENGL J MED, V331, P567.
BUJA LM, 1971, AM J MED, V51, P209.
CHEUNG YF, 2002, CIRCULATION, V106, P2561, DOI 10.1161/01.CIR.0000037225.92759.A7.
DAVIS BA, 2000, BLOOD, V95, P1229.
DAVIS BA, 2004, BLOOD, V104, P263, DOI 10.1182/blood-2003-08-2841.
DERCHI G, 2005, HAEMATOL-HEMATOL J, V90, P452.
ELDOR A, 2002, BLOOD, V99, P36.
ENGLE MA, 1964, CIRCULATION, V30, P698.
ENGLE MA, 1969, ANN NY ACAD SCI, V119, P694.
ESPOSITO BP, 2003, BLOOD, V102, P2670.
FELKER GM, 2000, NEW ENGL J MED, V342, P1077.
FITCHETT DH, 1980, CARDIOVASC RES, V14, P719.
FORNI GL, 2003, EUR J HEART FAIL, V5, P607, DOI 10.1016/S1388-9842(03)00102-8.
FUCHAROEN S, 1997, HEMOGLOBIN, V21, P299.
GABUTTI V, 1996, ACTA HAEMATOL-BASEL, V95, P26.
GALANELLO R, 2006, HAEMOTOLOGIA, V91, P1159.
GHARZUDDINE WS, 2002, EUR J ECHOCARDIOGR, V3, P47.
GLADWIN MT, 2004, NEW ENGL J MED, V350, P886.
GLICKSTEIN H, 2005, BLOOD, V106, P3242, DOI 10.1182/blood-2005-02-0460.
GUTTERIDGE JMC, 1989, CLIN HAEMATOL, V2, P195.
HAHALIS G, 2001, AM HEART J, V141, P428.
HAHALIS G, 2002, EUR HEART J, V23, P147.
HAHALIS G, 2002, J AM COLL CARDIOL S, V39, A220.
HUANG YC, 2006, HEMOGLOBIN, V30, P229, DOI 10.1080/03630260600642559.
HUMBERT M, 2004, NEW ENGL J MED, V351, P1425.
HUNT SA, 2001, J AM COLL CARDIOL, V38, P2101.
IANCU TC, 1987, BRIT J EXP PATHOL, V68, P53.
JOHNSTON DL, 1989, AM J MED, V87, P40.
JOOTAR P, 1990, SE ASIAN J TROP MED, V21, P269.
KARVOUNIS HI, 2001, AM HEART J, V141, P281.
KATTAMIS A, 2006, BLOOD CELL MOL DIS, V36, P21, DOI 10.1016/j.bcmd.2005.11.002.
KIM E, 1995, TOXICOL APPL PHARM, V130, P57.
KOERNER MM, 2005, EUR J HAEMATOL, V74, P84.
KONTOGHIORGHES GJ, 2000, TRANSFUS SCI, V23, P211.
KREMASTINOS DT, 1993, CIRCULATION, V88, P1127.
KREMASTINOS DT, 2001, AM J MED, V111, P349.
KURYSHEV YA, 1999, CIRCULATION, V100, P675.
KYRIACOU K, 2000, ULTRASTRUCT PATHOL, V24, P75.
LAURITA KR, 2003, J LAB CLIN MED, V142, P83, DOI 10.1016/S0022-2143(03)00060-X.
LINK G, 1989, J LAB CLIN MED, V113, P103.
LINK G, 1993, J LAB CLIN MED, V121, P127.
LINK G, 1996, J LAB CLIN MED, V127, P272.
LINK G, 1998, J LAB CLIN MED, V131, P466.
LITTERA R, 2002, BLOOD, V100, P1516.
LIU Y, 2001, CARDIOVASC TOXICOL, V1, P299.
LIU Y, 2003, J MOL CELL CARDIOL, V35, P505, DOI 10.1016/S0022-2828(03)00072-5.
LIVREA MA, 1996, BLOOD, V88, P3608.
LOREY F, 2000, J PEDIAT HEMATOL ONC, V22, P564.
MISKIN H, 2003, EUR J HAEMATOL, V70, P398.
MODELL B, 2000, LANCET, V355, P2051.
MOURAD FH, 2003, BRIT J HAEMATOL, V121, P187.
NIENHUIS AW, 2003, ANN NY ACAD SCI, V996, P101.
NITENBERG A, 1998, CIRCULATION, V97, P736.
OLIVIERI NF, 1994, NEW ENGL J MED, V331, P574.
OLIVIERI NF, 1997, BLOOD, V89, P739.
OLIVIERI NF, 1999, NEW ENGL J MED, V341, P99.
OLIVIERI NF, 2000, J PEDIAT HEMATOL ONC, V22, P593.
OUDIT GY, 2003, NAT MED, V9, P1187, DOI 10.1038/nm920.
PARKES JG, 1993, J LAB CLIN MED, V122, P36.
PARKES JG, 1997, TOXICOLOGY, V117, P141.
PARKES JG, 2000, J MOL CELL CARDIOL, V32, P233.
PENG CT, 2003, EUR J HAEMATOL, V70, P392.
PENNELL DJ, 2006, BLOOD, V107, P3738, DOI 10.1182/blood-2005-07-2948.
PEPE A, 2006, J MAGN RESON IMAGING, V23, P662, DOI 10.1002/jmri.20566.
PIGA A, 2003, HAEMATOLOGICA, V88, P489.
PIGA A, 2006, HAEMATOL-HEMATOL J, V91, P873.
POGWIZD SM, 2004, TRENDS CARDIOVAS MED, V14, P61.
POOTRAKUL P, 2003, BRIT J HAEMATOL, V122, P305.
RANDELL EW, 1994, J BIOL CHEM, V269, P16046.
RRUSSELL LK, 2005, J MOL CELL CARDIOL, V38, P81.
SCHELLHAMMER PF, 1967, CIRCULATION, V35, P631.
SELDEN C, 1980, BRIT J HAEMATOL, V44, P593.
SERMSAPPASUK P, 2006, EUR J PHARM SCI, V28, P243, DOI 10.1016/j.ejps.2006.02.007.
SEYMOUR CA, 1978, BRIT J HAEMATOL, V40, P239.
SHILOH H, 1992, J LAB CLIN MED, V119, P428.
SONAKUL D, 1980, SE ASIAN J TROP MED, V11, P516.
SONAKUL D, 1984, SE ASIAN J TROP MED, V15, P554.
SONAKUL D, 1988, BIRTH DEFECTS, V23, P177.
STUHNESEKALEC L, 1992, ANAL BIOCHEM, V205, P278.
SYLVIE V, 2003, BLOOD, V102, A952.
VACCARI M, 2002, CHEST, V121, P506.
VECCHIO C, 1995, SEMIN HEMATOL, V32, P288.
VOGEL M, 2003, EUR HEART J, V24, P113, DOI 10.1016/S0195-668X(02)00381-0.
VOSKARIDOU E, 2004, BRIT J HAEMATOL, V126, P736, DOI 10.1111/j.1365- 2141.2004.05104.x.
WANG ZYJ, 2005, RADIOLOGY, V234, P749, DOI 10.1148/radiol.2343031084.
WEATHERALL DJ, 2001, B WORLD HEALTH ORGAN, V79, P704.
WESTWOOD MA, 2005, J CARDIOVASC MAGN R, V7, P46.
WOLFE L, 1985, NEW ENGL J MED, V312, P1600.
WOOD JC, 2004, BLOOD, V103, P1934, DOI 10.1182/blood-2003-06-1919.
WOOD JC, 2004, MAGNET RESON MED, V51, P607, DOI 10.1002/mrm.10735.
WOOD JC, 2005, CIRCULATION, V112, P535, DOI 10.1161/CIRCULATIONAHA.104.504415.
WORWOOD M, 1980, BRIT J HAEMATOL, V46, P409.
WU KH, 2004, ANN HEMATOL, V83, P471, DOI 10.1007/s00277-003-0820-0.
YUAN J, 1992, BLOOD, V79, P3007.
YUSUF S, 1991, NEW ENGL J MED, V325, P293.
ZURLO MG, 1989, LANCET, V2, P27.
Cited Reference Count: 111 Times Cited: 2
Publisher: FRONTIERS IN BIOSCIENCE INC
Publisher Address: C/O NORTH SHORE UNIV HOSPITAL, BIOMEDICAL RESEARCH CENTER, 350 COMMUNITY DR, MANHASSET, NY 11030 USA
ISSN: 1093-9946 DOI: 10.2741/3130
29-char Source Abbrev.: FRONT BIOSCI ISO Source Abbrev.: Front. Biosci.
Source Item Page Count: 13
Subject Category: Biochemistry & Molecular Biology; Cell Biology ISI Document Delivery No.: 301GS
